AU2017273726B2 - Use of EZH2 inhibitors for treating cancer - Google Patents

Use of EZH2 inhibitors for treating cancer Download PDF

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Publication number
AU2017273726B2
AU2017273726B2 AU2017273726A AU2017273726A AU2017273726B2 AU 2017273726 B2 AU2017273726 B2 AU 2017273726B2 AU 2017273726 A AU2017273726 A AU 2017273726A AU 2017273726 A AU2017273726 A AU 2017273726A AU 2017273726 B2 AU2017273726 B2 AU 2017273726B2
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Australia
Prior art keywords
cancer
alkyl
day
inhibitor
subject
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Expired - Fee Related
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AU2017273726A
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AU2017273726A1 (en
Inventor
Scott RIBICH
Michael THOMENIUS
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Epizyme Inc
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Epizyme Inc
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Publication of AU2017273726A1 publication Critical patent/AU2017273726A1/en
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Publication of AU2017273726B2 publication Critical patent/AU2017273726B2/en
Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2017273726A 2016-06-01 2017-06-01 Use of EZH2 inhibitors for treating cancer Expired - Fee Related AU2017273726B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662344338P 2016-06-01 2016-06-01
US62/344,338 2016-06-01
PCT/US2017/035391 WO2017210395A1 (en) 2016-06-01 2017-06-01 Use of ezh2 inhibitors for treating cancer

Publications (2)

Publication Number Publication Date
AU2017273726A1 AU2017273726A1 (en) 2018-12-06
AU2017273726B2 true AU2017273726B2 (en) 2023-10-19

Family

ID=60477941

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017273726A Expired - Fee Related AU2017273726B2 (en) 2016-06-01 2017-06-01 Use of EZH2 inhibitors for treating cancer

Country Status (6)

Country Link
US (2) US11786533B2 (enExample)
EP (1) EP3464643A4 (enExample)
JP (1) JP7121660B2 (enExample)
AU (1) AU2017273726B2 (enExample)
CA (1) CA3025933A1 (enExample)
WO (1) WO2017210395A1 (enExample)

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EP3464643A4 (en) 2016-06-01 2020-04-01 Epizyme Inc USE OF EZH2 INHIBITORS FOR THE TREATMENT OF CANCER
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EP3630080A4 (en) * 2017-06-02 2021-03-10 Epizyme, Inc. USE OF EZH2 INHIBITORS TO TREAT CANCER
JP7399079B2 (ja) 2017-09-05 2023-12-15 エピザイム，インコーポレイティド 癌を処置するための併用療法
JP7025556B2 (ja) 2018-01-31 2022-02-24 ミラティ セラピューティクス， インコーポレイテッド Ｐｒｃ２阻害剤
WO2019241742A1 (en) * 2018-06-14 2019-12-19 Board Of Regents, The University Of Texas System Combination of ezh2 inhibitor and checkpoint therapy for the treatment of cancer
JP7624404B2 (ja) 2019-04-22 2025-01-30 ミラティ セラピューティクス，インク． Ｐｒｃ２阻害剤としてのナフチリジン誘導体
JP7541538B2 (ja) 2019-06-05 2024-08-28 ミラティ セラピューティクス，インク． 癌を処置するためのｐｒｃ２阻害剤としてのイミダゾ［１，２－ｃ］ピリミジン誘導体
WO2021063331A1 (zh) * 2019-09-30 2021-04-08 江苏恒瑞医药股份有限公司 EZH2抑制剂与含有TGF-β受体的融合蛋白联合在制备治疗肿瘤的药物中的用途
KR102505664B1 (ko) 2019-10-31 2023-03-03 재단법인 대구경북첨단의료산업진흥재단 Ezh2 저해제　및　e3 리가제 바인더를 포함하는 화합물 및 이를 유효성분으로 함유하는 ezh2 관련 질환의 예방 또는 치료용 약학적 조성물
CN111303133A (zh) * 2020-03-25 2020-06-19 清华大学 降解ezh2蛋白的小分子化合物
US20240139175A1 (en) * 2020-12-23 2024-05-02 Cascade Prodrug Inc. Combination therapy with a vinca alkaloid n-oxide and an immune checkpoint inhibitor
EP4643863A1 (en) * 2022-12-30 2025-11-05 Tsinghua University Pharmaceutical composition and use thereof
WO2024238381A1 (en) * 2023-05-12 2024-11-21 Taipei Medical University Dual ezh2-hsp90 inhibitors

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Also Published As

Publication number Publication date
EP3464643A4 (en) 2020-04-01
US20220288085A1 (en) 2022-09-15
WO2017210395A1 (en) 2017-12-07
EP3464643A1 (en) 2019-04-10
US20240139203A1 (en) 2024-05-02
JP7121660B2 (ja) 2022-08-18
AU2017273726A1 (en) 2018-12-06
US11786533B2 (en) 2023-10-17
CA3025933A1 (en) 2017-12-07
JP2019517491A (ja) 2019-06-24

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MK25 Application lapsed reg. 22.2i(2) - failure to pay acceptance fee