AU2017248186B2 - Pyrimido-diazepinone kinase scaffold compounds and methods of treating PI3K-mediated disorders - Google Patents

Pyrimido-diazepinone kinase scaffold compounds and methods of treating PI3K-mediated disorders Download PDF

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AU2017248186B2
AU2017248186B2 AU2017248186A AU2017248186A AU2017248186B2 AU 2017248186 B2 AU2017248186 B2 AU 2017248186B2 AU 2017248186 A AU2017248186 A AU 2017248186A AU 2017248186 A AU2017248186 A AU 2017248186A AU 2017248186 B2 AU2017248186 B2 AU 2017248186B2
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alkyl
compound
optionally substituted
kinase
pi3k
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AU2017248186A1 (en
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Fleur M. FERGUSON
Nathanael S. Gray
Jing Ni
Tinghu Zhang
Jean Zhao
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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AU2017248186A 2016-04-07 2017-04-07 Pyrimido-diazepinone kinase scaffold compounds and methods of treating PI3K-mediated disorders Active AU2017248186B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662319459P 2016-04-07 2016-04-07
US62/319,459 2016-04-07
PCT/US2017/026522 WO2017177092A1 (en) 2016-04-07 2017-04-07 Pyrimido-diazepinone kinase scaffold compounds and methods of treating pi3k-mediated disorders

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AU2017248186A1 AU2017248186A1 (en) 2018-10-04
AU2017248186B2 true AU2017248186B2 (en) 2021-10-21

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US (1) US11155556B2 (OSRAM)
EP (1) EP3440084B1 (OSRAM)
JP (1) JP6968819B2 (OSRAM)
KR (1) KR20180132812A (OSRAM)
CN (1) CN109311901A (OSRAM)
AU (1) AU2017248186B2 (OSRAM)
CA (1) CA3020172A1 (OSRAM)
WO (1) WO2017177092A1 (OSRAM)

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AU2019225806A1 (en) * 2018-02-20 2020-07-16 Dana-Farber Cancer Institute, Inc. Inhibitors of EGFR and methods of use thereof
CA3087716A1 (en) * 2018-02-20 2019-08-29 Dana-Farber Cancer Institute, Inc. Inhibitors of egfr and methods of use thereof
JP2021514011A (ja) * 2018-02-20 2021-06-03 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｅｇｆｒ阻害剤の組合せ医薬製剤およびその使用法
CN110787168B (zh) * 2019-11-06 2022-06-24 中国医科大学 一种小分子化合物C29H28Cl2N6O在大肠杆菌性脑膜炎中的应用
AU2021212770A1 (en) * 2020-01-30 2022-08-18 Shangpharma Innovation Inc. Strad-binding agents and uses thereof
CN114539263B (zh) * 2020-11-11 2023-04-25 暨南大学 一类含氮并杂环化合物及其药用组合物和应用

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CA2986441A1 (en) * 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
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EP3440084A4 (en) 2019-11-20
US11155556B2 (en) 2021-10-26
EP3440084A1 (en) 2019-02-13
WO2017177092A1 (en) 2017-10-12
CN109311901A (zh) 2019-02-05
CA3020172A1 (en) 2017-10-12
JP6968819B2 (ja) 2021-11-17
AU2017248186A1 (en) 2018-10-04
KR20180132812A (ko) 2018-12-12
US20190106424A1 (en) 2019-04-11
JP2019510801A (ja) 2019-04-18
EP3440084B1 (en) 2022-12-21

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