AU2017247006B2 - Radiotherapy improvements - Google Patents
Radiotherapy improvements Download PDFInfo
- Publication number
- AU2017247006B2 AU2017247006B2 AU2017247006A AU2017247006A AU2017247006B2 AU 2017247006 B2 AU2017247006 B2 AU 2017247006B2 AU 2017247006 A AU2017247006 A AU 2017247006A AU 2017247006 A AU2017247006 A AU 2017247006A AU 2017247006 B2 AU2017247006 B2 AU 2017247006B2
- Authority
- AU
- Australia
- Prior art keywords
- individual
- tumours
- irradiated
- radiotherapy
- tumour
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662318946P | 2016-04-06 | 2016-04-06 | |
| US62/318,946 | 2016-04-06 | ||
| AUPCT/AU2016/050674 | 2016-07-28 | ||
| PCT/AU2016/050674 WO2017173474A1 (en) | 2016-04-06 | 2016-07-28 | Improvements in cancer treatment |
| US201762461559P | 2017-02-21 | 2017-02-21 | |
| US62/461,559 | 2017-02-21 | ||
| PCT/AU2017/050299 WO2017173496A1 (en) | 2016-04-06 | 2017-04-06 | Radiotherapy improvements |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2017247006A1 AU2017247006A1 (en) | 2018-11-01 |
| AU2017247006B2 true AU2017247006B2 (en) | 2022-05-12 |
Family
ID=60000154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017247006A Ceased AU2017247006B2 (en) | 2016-04-06 | 2017-04-06 | Radiotherapy improvements |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11229703B2 (OSRAM) |
| EP (1) | EP3439642A4 (OSRAM) |
| JP (1) | JP2019513826A (OSRAM) |
| AU (1) | AU2017247006B2 (OSRAM) |
| CA (1) | CA3058492A1 (OSRAM) |
| WO (1) | WO2017173496A1 (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3439642A4 (en) * | 2016-04-06 | 2019-11-13 | Noxopharm Limited | IMPROVEMENTS IN RADIOTHERAPY |
| CA3169406A1 (en) | 2020-01-28 | 2021-08-05 | Reflexion Medical, Inc. | Joint optimization of radionuclide and external beam radiotherapy |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005049008A1 (en) * | 2003-11-19 | 2005-06-02 | Novogen Research Pty Ltd | Combinational radiotherapy and chemotherapy compositions and methods |
| WO2006032086A1 (en) * | 2004-09-21 | 2006-03-30 | Novogen Research Pty Ltd | Chroman derivatives, medicaments and use in therapy |
| WO2015069562A1 (en) * | 2013-11-07 | 2015-05-14 | Humanetics Corporation | Genistein cancer treatment regimen maximizing cancer radiation therapy benefits |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPO203996A0 (en) * | 1996-08-30 | 1996-09-26 | Novogen Research Pty Ltd | Therapeutic uses |
| AUPQ008299A0 (en) | 1999-04-30 | 1999-05-27 | G.J. Consultants Pty Ltd | Isoflavone metabolites |
| US20090233999A1 (en) * | 1999-09-06 | 2009-09-17 | Novogen Research Pty Ltd | Compositions and therapeutic methods involving isoflavones and analogues thereof |
| AUPQ266199A0 (en) * | 1999-09-06 | 1999-09-30 | Novogen Research Pty Ltd | Compositions and therapeutic methods involving isoflavones and analogues thereof |
| AUPR363301A0 (en) * | 2001-03-08 | 2001-04-05 | Novogen Research Pty Ltd | Dimeric isoflavones |
| US8178123B2 (en) | 2001-08-29 | 2012-05-15 | Femina Pharma Incorporated | Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration |
| AUPR846401A0 (en) * | 2001-10-25 | 2001-11-15 | Novogen Research Pty Ltd | 6-Hydroxy isoflavones, derivatives and medicaments involving same |
| CN1646119A (zh) | 2002-04-09 | 2005-07-27 | 诺沃根研究有限公司 | 涉及异黄-3-烯和异黄烷结构的治疗方法和组合物 |
| EP1545206B1 (en) | 2002-07-24 | 2020-03-04 | Children's Hospital Medical Center | Compositions and products containing enantiomeric equol, and methods for their making |
| AU2002951833A0 (en) * | 2002-10-02 | 2002-10-24 | Novogen Research Pty Ltd | Compositions and therapeutic methods invloving platinum complexes |
| AU2002952453A0 (en) * | 2002-11-01 | 2002-11-21 | Novogen Research Pty Ltd | Aminated isoflavonoid derivatives and uses thereof |
| MXPA06003066A (es) * | 2003-09-18 | 2006-06-20 | Combinatorx Inc | Combinaciones de farmacos para el tratamiento de neoplasmas. |
| US20050154452A1 (en) | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
| US7434690B2 (en) | 2004-04-30 | 2008-10-14 | Cutispharma, Inc. | Container and method for the preparation, storage and dispensing of compounded suppositories |
| US8080675B2 (en) * | 2004-09-21 | 2011-12-20 | Marshall Edwards, Inc. | Chroman derivatives, medicaments and use in therapy |
| AU2005287865B2 (en) * | 2004-09-21 | 2012-02-16 | Marshall Edwards, Inc. | Substituted chroman derivatives, medicaments and use in therapy |
| DE102005009515A1 (de) | 2005-02-25 | 2006-09-07 | Exner, Heinrich, Dr. | Verfahren zur Herstellung einer Zubereitung einer DMSO-haltigen festen Silikonölemulsion zur Bindung von reaktiven Sauerstoffverbindungen im Körper von Menschen und Tieren |
| JP2008537545A (ja) | 2005-03-24 | 2008-09-18 | ノボジェン リサーチ ピーティーワイ リミテッド | イソフラボノイド二量体 |
| WO2007035515A2 (en) | 2005-09-15 | 2007-03-29 | Umd, Inc. | A method of intraepithelial and systemic exposure of therapeutic agents following vaginal and oral cavity administration |
| US20070196381A1 (en) | 2006-02-17 | 2007-08-23 | Natures Benefit, Inc. | Herbal compositions, methods of stimulating immunomodulation and enhancement of immunomodulating agents using the herbal compositions |
| CA2668008A1 (en) | 2006-10-30 | 2008-05-08 | Novogen Research Pty Ltd | Prevention and reversal of chemotherapy-induced peripheral neuropathy |
| WO2009003229A1 (en) | 2007-06-29 | 2009-01-08 | Novogen Research Pty Ltd | 2-substituted isoflavonoid compounds, medicaments and uses |
| WO2010022467A1 (en) | 2008-08-29 | 2010-03-04 | Novogen Research Pty Ltd | Immunomodulating activities |
| EP2365955B1 (en) | 2008-11-14 | 2014-12-31 | Heartlink Limited | Aryl di-substituted propenone compounds |
| KR20110004525A (ko) | 2009-07-08 | 2011-01-14 | 동의대학교 산학협력단 | 제니스테인과 trail을 포함하는 간암 치료용 조성물 |
| ES2365960B1 (es) | 2010-03-31 | 2012-06-04 | Palobiofarma, S.L | Nuevos antagonistas de los receptores de adenosina. |
| AU2012323924A1 (en) * | 2011-10-14 | 2014-05-29 | The Ohio State University | Methods and materials related to ovarian cancer |
| RS59013B1 (sr) * | 2013-03-13 | 2019-08-30 | Oncoceutics Inc | 7-benzil-10-(2-metilbenzil)-2,6,7,8,9,10-heksahidroimidazo[1,2-a]pirido[4,3-d]pirimidin-5(3h)-on za upotrebu u lečenju kancera |
| BR112016018099B8 (pt) * | 2014-02-07 | 2023-01-17 | Novogen ltd | Compostos funcionalizados de benzopiranos e uso dos mesmos |
| SI3334431T1 (sl) | 2015-08-11 | 2020-01-31 | Novartis Ag | 5-bromo-2,6-di-(1h-pirazol-l-il)pyrimidin-4-amin za uporabo v zdravljenju raka |
| WO2017079746A2 (en) * | 2015-11-07 | 2017-05-11 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer |
| EP3939583A1 (en) * | 2016-04-06 | 2022-01-19 | Noxopharm Limited | Improvements in cancer treatment with isoflavonoids |
| EP3439642A4 (en) * | 2016-04-06 | 2019-11-13 | Noxopharm Limited | IMPROVEMENTS IN RADIOTHERAPY |
| EP3439644B1 (en) | 2016-04-06 | 2022-01-12 | Noxopharm Limited | Isoflavonoid composition with improved pharmacokinetics |
| AU2017254774B2 (en) * | 2016-04-22 | 2021-10-21 | Noxopharm Limited | Chemotherapy improvements |
| EP3806846A1 (en) | 2018-06-15 | 2021-04-21 | Board of Regents, The University of Texas System | Methods of treating and preventing breast cancer with s-equol |
| JP2021535187A (ja) | 2018-06-15 | 2021-12-16 | ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | S−エクオールを用いた黒色腫の処置及び予防方法 |
| WO2020051644A1 (en) | 2018-09-13 | 2020-03-19 | Norbio No. 2 Pty Ltd | Treatment of peripheral nervous tissue inflammation |
-
2017
- 2017-04-06 EP EP17778480.8A patent/EP3439642A4/en not_active Withdrawn
- 2017-04-06 CA CA3058492A patent/CA3058492A1/en not_active Abandoned
- 2017-04-06 AU AU2017247006A patent/AU2017247006B2/en not_active Ceased
- 2017-04-06 US US16/091,706 patent/US11229703B2/en active Active
- 2017-04-06 JP JP2019503597A patent/JP2019513826A/ja active Pending
- 2017-04-06 WO PCT/AU2017/050299 patent/WO2017173496A1/en not_active Ceased
-
2021
- 2021-12-14 US US17/644,211 patent/US20220105182A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005049008A1 (en) * | 2003-11-19 | 2005-06-02 | Novogen Research Pty Ltd | Combinational radiotherapy and chemotherapy compositions and methods |
| WO2006032086A1 (en) * | 2004-09-21 | 2006-03-30 | Novogen Research Pty Ltd | Chroman derivatives, medicaments and use in therapy |
| WO2015069562A1 (en) * | 2013-11-07 | 2015-05-14 | Humanetics Corporation | Genistein cancer treatment regimen maximizing cancer radiation therapy benefits |
Non-Patent Citations (6)
| Title |
|---|
| "Phase I Study of Idronoxil Combined With Radiation Treatment in Men With Metastatic Prostate Cancer", ClinicalTrials.gov archive [online], NCT03041285 on 1 February 2017, URL: https://clinicaltrials.gov/archive/NCT03041285/2017_02_01, * |
| GRUCA et al., "Synthetic Genistein Glycosides Inhibiting EGFR phosphorylation Enhance the Effect of Radiation in HCT 116 Colon Cancer Cells", Molecules, (2014), vol. 19, no. 11, pages 18558 - 18573 * |
| KIM et al., "Genistein decreases cellular redox potential, partially supresses cell growth in HL-60 leukemia cells and sensitizes cells to γ-irradiation-induced cell death", Molecular Medicine Reports, (2014), vol. 10, no. 6, pp. 2786-2792 * |
| LUDGATE, "Optimizing Cancer Treatments to Induce an Acute Immune Response: Radiation Abscopal Effects, PAMPS, and DAMPs", Clinical Cancer Research, (2012), vol. 18, no. 17, pages 4522 - 4525 * |
| RAFFOUL et al., "Radiosensitization of prostate cancer by soy isoflavones", Current Cancer Drug Targets, (2007-12-01), vol. 7, no. 8, doi:10.2174/156800907783220408, ISSN 1568-0096, pages 759 - 765 * |
| SHIN et al., "Sensitization of the Apoptotic Effect of y-Irradiation in Genistein- pretreated CaSki Cervical Cancer Cells", Journal of Microbiology & Biotechnology, (2008), vol. 18, no. 3, pages 523 - 531 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20220105182A1 (en) | 2022-04-07 |
| WO2017173496A1 (en) | 2017-10-12 |
| AU2017247006A1 (en) | 2018-11-01 |
| EP3439642A1 (en) | 2019-02-13 |
| US20190262451A1 (en) | 2019-08-29 |
| JP2019513826A (ja) | 2019-05-30 |
| US11229703B2 (en) | 2022-01-25 |
| CA3058492A1 (en) | 2017-10-12 |
| EP3439642A4 (en) | 2019-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |