AU2017233841B9 - Pyrimidines and variants thereof, and uses therefor - Google Patents

Pyrimidines and variants thereof, and uses therefor Download PDF

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Publication number
AU2017233841B9
AU2017233841B9 AU2017233841A AU2017233841A AU2017233841B9 AU 2017233841 B9 AU2017233841 B9 AU 2017233841B9 AU 2017233841 A AU2017233841 A AU 2017233841A AU 2017233841 A AU2017233841 A AU 2017233841A AU 2017233841 B9 AU2017233841 B9 AU 2017233841B9
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compound
mmol
formula
mixture
meo
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AU2017233841B2 (en
AU2017233841A1 (en
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Anthony P. FORD
Joel R. Gever
Ronald Charles Hawley
Prabha Ibrahim
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Afferent Pharmaceuticals Inc
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Afferent Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Neurology (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Addiction (AREA)
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AU2017233841A 2016-03-14 2017-03-09 Pyrimidines and variants thereof, and uses therefor Active AU2017233841B9 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662308157P 2016-03-14 2016-03-14
US62/308,157 2016-03-14
US201662363630P 2016-07-18 2016-07-18
US62/363,630 2016-07-18
PCT/US2017/021477 WO2017160569A1 (en) 2016-03-14 2017-03-09 Pyrimidines and variants thereof, and uses therefor

Publications (3)

Publication Number Publication Date
AU2017233841A1 AU2017233841A1 (en) 2018-09-06
AU2017233841B2 AU2017233841B2 (en) 2021-09-02
AU2017233841B9 true AU2017233841B9 (en) 2021-09-09

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AU2017233841A Active AU2017233841B9 (en) 2016-03-14 2017-03-09 Pyrimidines and variants thereof, and uses therefor

Country Status (10)

Country Link
US (1) US10822311B2 (OSRAM)
EP (1) EP3430000B1 (OSRAM)
JP (1) JP6968810B2 (OSRAM)
KR (2) KR102489454B1 (OSRAM)
CN (1) CN108834412B (OSRAM)
AU (1) AU2017233841B9 (OSRAM)
MA (1) MA43821A (OSRAM)
MX (1) MX390482B (OSRAM)
RU (1) RU2761439C2 (OSRAM)
WO (1) WO2017160569A1 (OSRAM)

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WO2017160569A1 (en) 2016-03-14 2017-09-21 Afferent Pharmaceuticals Inc. Pyrimidines and variants thereof, and uses therefor
CA3018180C (en) 2016-03-25 2024-02-20 Ronald Charles Hawley Pyrimidines and variants thereof, and uses therefor
US10676444B2 (en) * 2016-12-20 2020-06-09 Afferent Pharmaceuticals, Inc. Crystalline salts and polymorphs of a P2X3 antagonist
KR101938800B1 (ko) 2017-03-29 2019-04-10 주식회사 레고켐 바이오사이언스 피롤로벤조디아제핀 이량체 전구체 및 이의 리간드-링커 접합체 화합물
CN107540699A (zh) * 2017-10-16 2018-01-05 康化（上海）新药研发有限公司 一种2‑氨基‑3‑氟吡啶‑4‑硼酸盐酸盐的合成方法
WO2020047603A1 (en) * 2018-09-06 2020-03-12 Monash University Method of treating a sleep breathing disorder
US20210346391A1 (en) * 2018-10-10 2021-11-11 Bellus Health Cough Inc. Treatment of pruritus with p2x3 modulators
US20220096641A1 (en) 2019-01-03 2022-03-31 Legochem Biosciences, Inc. Pyrrolobenzodiazepine dimer compound with improved safety and use thereof
KR20200084802A (ko) 2019-01-03 2020-07-13 주식회사 레고켐 바이오사이언스 안전성이 향상된 피롤로벤조디아제핀 이량체 화합물 및 이의 용도
WO2020174283A1 (en) 2019-02-25 2020-09-03 Bellus Health Cough Inc. Treatment with p2x3 modulators
AU2020265969B2 (en) 2019-04-30 2025-10-02 Beijing Tide Pharmaceutical Co., Ltd. Solid form of diaminopyrimidine compound or hydrate thereof, preparation method therefor, and application thereof
EP3960178B1 (en) * 2019-04-30 2026-03-18 Beijing Tide Pharmaceutical Co., Ltd. Method for treating endometriosis-associated pain by using diaminopyrimidine compound
CN114008027B (zh) * 2019-04-30 2024-02-20 北京泰德制药股份有限公司 二氨基嘧啶类化合物的盐、其固体形式及其制备方法和用途
SG11202111877TA (en) * 2019-04-30 2021-11-29 Beijing Tide Pharmaceutical Co Ltd Method for treating cough by using diaminopyrimidine compound
EP3981765A4 (en) 2019-06-06 2023-05-31 Beijing Tide Pharmaceutical Co., Ltd. P2X3 AND/OR P2X2/3 RECEPTOR ANTAGONIST, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
GB202006382D0 (en) 2020-04-30 2020-06-17 Spermatech As Use

Citations (1)

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