AU2017229591B2 - Calpain modulators and methods of production and use thereof - Google Patents

Calpain modulators and methods of production and use thereof Download PDF

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Publication number
AU2017229591B2
AU2017229591B2 AU2017229591A AU2017229591A AU2017229591B2 AU 2017229591 B2 AU2017229591 B2 AU 2017229591B2 AU 2017229591 A AU2017229591 A AU 2017229591A AU 2017229591 A AU2017229591 A AU 2017229591A AU 2017229591 B2 AU2017229591 B2 AU 2017229591B2
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AU
Australia
Prior art keywords
substituted
heteroaryl
group
aryl
ring structure
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Ceased
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AU2017229591A
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AU2017229591A1 (en
Inventor
Brad Owen BUCKMAN
Shendong Yuan
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Blade Therapeutics Pty Ltd
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Blade Therapeutics Pty Ltd
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Publication of AU2017229591A1 publication Critical patent/AU2017229591A1/en
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Assigned to Blade Therapeutics Pty Ltd reassignment Blade Therapeutics Pty Ltd Request for Assignment Assignors: BLADE THERAPEUTICS, INC.
Ceased legal-status Critical Current
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D245/00Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D245/00Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D273/00Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2017229591A 2016-03-09 2017-03-08 Calpain modulators and methods of production and use thereof Ceased AU2017229591B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662306040P 2016-03-09 2016-03-09
US62/306,040 2016-03-09
PCT/US2017/021288 WO2017156074A1 (fr) 2016-03-09 2017-03-08 Modulateurs de calpaïne et leurs méthodes de production et d'utilisation

Publications (2)

Publication Number Publication Date
AU2017229591A1 AU2017229591A1 (en) 2018-10-25
AU2017229591B2 true AU2017229591B2 (en) 2021-08-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017229591A Ceased AU2017229591B2 (en) 2016-03-09 2017-03-08 Calpain modulators and methods of production and use thereof

Country Status (2)

Country Link
AU (1) AU2017229591B2 (fr)
WO (1) WO2017156074A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017292646A1 (en) 2016-07-05 2019-02-07 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
CA3038331A1 (fr) 2016-09-28 2018-04-05 Blade Therapeutics, Inc. Modulateurs de calpain et leurs utilisations therapeutiques
EP3564211A1 (fr) 2018-05-03 2019-11-06 Landsteiner Genmed, S.L. Derives de dipeptidyl ketoamide meta-methoxyphenyl et leurs utilisations
CN113773228A (zh) * 2021-10-28 2021-12-10 上海吉奉生物科技有限公司 一种n-苄氧羰基-3-碘-l-丙氨酸甲酯的合成方法
EP4234014A1 (fr) * 2022-02-28 2023-08-30 Insusense ApS Carbamates et/ou urées dérivés d'acides amninés pour le traitement de maladies liées à la sortiline
CN115124448A (zh) * 2022-07-20 2022-09-30 杭州国瑞生物科技有限公司 一种一锅法合成d-焦谷氨酸衍生物的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008048121A2 (fr) * 2006-10-18 2008-04-24 Lincoln University Composés et compositions
WO2013166319A1 (fr) * 2012-05-02 2013-11-07 Kansas State University Research Foundation Composés macrocycliques et peptidomimétiques en tant qu'antiviraux à large spectre contre des protéases 3c ou de type 3c de picornavirus, calicivirus et coronavirus
WO2015179441A2 (fr) * 2014-05-20 2015-11-26 Rqx Pharmaceuticals, Inc. Antibiotiques macrocycliques à large spectre

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008048121A2 (fr) * 2006-10-18 2008-04-24 Lincoln University Composés et compositions
US20110021434A1 (en) * 2006-10-18 2011-01-27 Andrew David Abell Macrocyclic Cysteine Protease Inhibitors and Compositions Thereof
WO2013166319A1 (fr) * 2012-05-02 2013-11-07 Kansas State University Research Foundation Composés macrocycliques et peptidomimétiques en tant qu'antiviraux à large spectre contre des protéases 3c ou de type 3c de picornavirus, calicivirus et coronavirus
US20150133368A1 (en) * 2012-05-02 2015-05-14 Kansa State University Research Foundation Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3c or 3c-like proteases of picornaviruses, caliciviruses and coronaviruses
WO2015179441A2 (fr) * 2014-05-20 2015-11-26 Rqx Pharmaceuticals, Inc. Antibiotiques macrocycliques à large spectre

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
ABELL, A. D. et al., "Molecular modeling, synthesis, and biological evaluation of macrocyclic calpain inhibitors", Angewandte Chemie , International Edition, (2009), vol. 48, no. 8, pages 1455 - 1458 *
CHEN, H. et al., "New Tripeptide-Based Macrocyclic Calpain Inhibitors Formed by N- Alkylation of Histidine", Chemistry & Biodiversity, (2012), vol. 9, no. 11, pages 2473 - 2484 *
DAMALANKA, V. C. et al., "Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease", Journal of Medicinal Chemistry, (2016), vol. 59, no. 5, pages 1899 - 1913 *
JONES, M. A. et al., "Efficient large-scale synthesis of CAT811, a potent calpain inhibitor of interest in the treatment of cataracts", Australian Journal of Chemistry, (2009), vol. 62, no. 7, pages 671 - 675 *
JONES, S. A. et al., "A Template-Based Approach to Inhibitors of Calpain 2, 20S Proteasome, and HIV-1 Protease", ChemMedChem, (2013), vol. 8, no. 12, pages 1918 - 1921 *
JONES, S. A. et al., "The Preparation of Macrocyclic Calpain Inhibitors by Ring Closing Metathesis and Cross Metathesis", Australian Journal of Chemistry, (2014), vol. 67, no. 8 - 9, pages 1257 - 1263 *
MANDADAPU, S. R. et al., "Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus", Bioorganic & Medicinal Chemistry Letters, (2013), vol. 23, no. 13, pages 3709 - 3712 *
MORTON, J. D. et al., "A macrocyclic calpain inhibitor slows the development of inherited cortical cataracts in a sheep model", Investigative Ophthalmology & Visual Science, (2013), vol. 54, no. 1, pages 389 - 395 *
PEHERE, A D. et al., "New cylindrical peptide assemblies defined by extended parallel beta- sheets", Organic & Biomolecular Chemistry, (2013), vol. 11, no. 3, pages 425 - 429 *
PEHERE, A. D. et al., "New beta-strand templates constrained by Huisgen cycloaddition", Organic Letters, (2012), vol. 14, no. 5, pages 1330 - 1333 *
PEHERE, A.D. et al., "Synthesis and Extended Activity of Triazole-Containing Macrocyclic Protease Inhibitors", Chemistry - A European Journal, (2013), vol. 19, no. 24, pages 7975 - 7981 *
STUART, B. G. et al., "Molecular Modeling: A Search for a Calpain Inhibitor as a New Treatment for Cataractogenesis", Journal of Medicinal Chemistry, (2011), vol. 54, no. 21, pages 7503 - 7522 *
WALKER, M. A. et al., "General method for the synthesis of cyclic peptidomimetic compounds", Tetrahedron Letters, (2001), vol. 42, no. 34, pages 5801 - 5804 *

Also Published As

Publication number Publication date
WO2017156074A1 (fr) 2017-09-14
AU2017229591A1 (en) 2018-10-25

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Owner name: BLADE THERAPEUTICS PTY LTD

Free format text: FORMER APPLICANT(S): BLADE THERAPEUTICS, INC.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired