AU2017229591B2 - Calpain modulators and methods of production and use thereof - Google Patents
Calpain modulators and methods of production and use thereof Download PDFInfo
- Publication number
- AU2017229591B2 AU2017229591B2 AU2017229591A AU2017229591A AU2017229591B2 AU 2017229591 B2 AU2017229591 B2 AU 2017229591B2 AU 2017229591 A AU2017229591 A AU 2017229591A AU 2017229591 A AU2017229591 A AU 2017229591A AU 2017229591 B2 AU2017229591 B2 AU 2017229591B2
- Authority
- AU
- Australia
- Prior art keywords
- substituted
- heteroaryl
- group
- aryl
- ring structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662306040P | 2016-03-09 | 2016-03-09 | |
US62/306,040 | 2016-03-09 | ||
PCT/US2017/021288 WO2017156074A1 (fr) | 2016-03-09 | 2017-03-08 | Modulateurs de calpaïne et leurs méthodes de production et d'utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2017229591A1 AU2017229591A1 (en) | 2018-10-25 |
AU2017229591B2 true AU2017229591B2 (en) | 2021-08-19 |
Family
ID=59790788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2017229591A Ceased AU2017229591B2 (en) | 2016-03-09 | 2017-03-08 | Calpain modulators and methods of production and use thereof |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2017229591B2 (fr) |
WO (1) | WO2017156074A1 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2017292646A1 (en) | 2016-07-05 | 2019-02-07 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
CA3038331A1 (fr) | 2016-09-28 | 2018-04-05 | Blade Therapeutics, Inc. | Modulateurs de calpain et leurs utilisations therapeutiques |
EP3564211A1 (fr) | 2018-05-03 | 2019-11-06 | Landsteiner Genmed, S.L. | Derives de dipeptidyl ketoamide meta-methoxyphenyl et leurs utilisations |
CN113773228A (zh) * | 2021-10-28 | 2021-12-10 | 上海吉奉生物科技有限公司 | 一种n-苄氧羰基-3-碘-l-丙氨酸甲酯的合成方法 |
EP4234014A1 (fr) * | 2022-02-28 | 2023-08-30 | Insusense ApS | Carbamates et/ou urées dérivés d'acides amninés pour le traitement de maladies liées à la sortiline |
CN115124448A (zh) * | 2022-07-20 | 2022-09-30 | 杭州国瑞生物科技有限公司 | 一种一锅法合成d-焦谷氨酸衍生物的方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008048121A2 (fr) * | 2006-10-18 | 2008-04-24 | Lincoln University | Composés et compositions |
WO2013166319A1 (fr) * | 2012-05-02 | 2013-11-07 | Kansas State University Research Foundation | Composés macrocycliques et peptidomimétiques en tant qu'antiviraux à large spectre contre des protéases 3c ou de type 3c de picornavirus, calicivirus et coronavirus |
WO2015179441A2 (fr) * | 2014-05-20 | 2015-11-26 | Rqx Pharmaceuticals, Inc. | Antibiotiques macrocycliques à large spectre |
-
2017
- 2017-03-08 AU AU2017229591A patent/AU2017229591B2/en not_active Ceased
- 2017-03-08 WO PCT/US2017/021288 patent/WO2017156074A1/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008048121A2 (fr) * | 2006-10-18 | 2008-04-24 | Lincoln University | Composés et compositions |
US20110021434A1 (en) * | 2006-10-18 | 2011-01-27 | Andrew David Abell | Macrocyclic Cysteine Protease Inhibitors and Compositions Thereof |
WO2013166319A1 (fr) * | 2012-05-02 | 2013-11-07 | Kansas State University Research Foundation | Composés macrocycliques et peptidomimétiques en tant qu'antiviraux à large spectre contre des protéases 3c ou de type 3c de picornavirus, calicivirus et coronavirus |
US20150133368A1 (en) * | 2012-05-02 | 2015-05-14 | Kansa State University Research Foundation | Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3c or 3c-like proteases of picornaviruses, caliciviruses and coronaviruses |
WO2015179441A2 (fr) * | 2014-05-20 | 2015-11-26 | Rqx Pharmaceuticals, Inc. | Antibiotiques macrocycliques à large spectre |
Non-Patent Citations (13)
Title |
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ABELL, A. D. et al., "Molecular modeling, synthesis, and biological evaluation of macrocyclic calpain inhibitors", Angewandte Chemie , International Edition, (2009), vol. 48, no. 8, pages 1455 - 1458 * |
CHEN, H. et al., "New Tripeptide-Based Macrocyclic Calpain Inhibitors Formed by N- Alkylation of Histidine", Chemistry & Biodiversity, (2012), vol. 9, no. 11, pages 2473 - 2484 * |
DAMALANKA, V. C. et al., "Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease", Journal of Medicinal Chemistry, (2016), vol. 59, no. 5, pages 1899 - 1913 * |
JONES, M. A. et al., "Efficient large-scale synthesis of CAT811, a potent calpain inhibitor of interest in the treatment of cataracts", Australian Journal of Chemistry, (2009), vol. 62, no. 7, pages 671 - 675 * |
JONES, S. A. et al., "A Template-Based Approach to Inhibitors of Calpain 2, 20S Proteasome, and HIV-1 Protease", ChemMedChem, (2013), vol. 8, no. 12, pages 1918 - 1921 * |
JONES, S. A. et al., "The Preparation of Macrocyclic Calpain Inhibitors by Ring Closing Metathesis and Cross Metathesis", Australian Journal of Chemistry, (2014), vol. 67, no. 8 - 9, pages 1257 - 1263 * |
MANDADAPU, S. R. et al., "Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus", Bioorganic & Medicinal Chemistry Letters, (2013), vol. 23, no. 13, pages 3709 - 3712 * |
MORTON, J. D. et al., "A macrocyclic calpain inhibitor slows the development of inherited cortical cataracts in a sheep model", Investigative Ophthalmology & Visual Science, (2013), vol. 54, no. 1, pages 389 - 395 * |
PEHERE, A D. et al., "New cylindrical peptide assemblies defined by extended parallel beta- sheets", Organic & Biomolecular Chemistry, (2013), vol. 11, no. 3, pages 425 - 429 * |
PEHERE, A. D. et al., "New beta-strand templates constrained by Huisgen cycloaddition", Organic Letters, (2012), vol. 14, no. 5, pages 1330 - 1333 * |
PEHERE, A.D. et al., "Synthesis and Extended Activity of Triazole-Containing Macrocyclic Protease Inhibitors", Chemistry - A European Journal, (2013), vol. 19, no. 24, pages 7975 - 7981 * |
STUART, B. G. et al., "Molecular Modeling: A Search for a Calpain Inhibitor as a New Treatment for Cataractogenesis", Journal of Medicinal Chemistry, (2011), vol. 54, no. 21, pages 7503 - 7522 * |
WALKER, M. A. et al., "General method for the synthesis of cyclic peptidomimetic compounds", Tetrahedron Letters, (2001), vol. 42, no. 34, pages 5801 - 5804 * |
Also Published As
Publication number | Publication date |
---|---|
WO2017156074A1 (fr) | 2017-09-14 |
AU2017229591A1 (en) | 2018-10-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1 | Assignment before grant (sect. 113) |
Owner name: BLADE THERAPEUTICS PTY LTD Free format text: FORMER APPLICANT(S): BLADE THERAPEUTICS, INC. |
|
FGA | Letters patent sealed or granted (standard patent) | ||
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |