AU2017203070B2 - An Antifungal Formulation - Google Patents
An Antifungal Formulation Download PDFInfo
- Publication number
- AU2017203070B2 AU2017203070B2 AU2017203070A AU2017203070A AU2017203070B2 AU 2017203070 B2 AU2017203070 B2 AU 2017203070B2 AU 2017203070 A AU2017203070 A AU 2017203070A AU 2017203070 A AU2017203070 A AU 2017203070A AU 2017203070 B2 AU2017203070 B2 AU 2017203070B2
- Authority
- AU
- Australia
- Prior art keywords
- formulation
- use according
- oil
- amount
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Many people suffer from fungal infection of the skin, especially of the feet. The infection may manifest with peeling, redness, itching, burning, blisters and sores. It is known to use various oils for treatment however formulating them into a convenient easy-to-apply watery product presents challenges given that oil and water normally do not mix well. It is an object of a preferred form of the invention to go at least some way towards addressing this by way of an antifungal formulation comprising: • tea tree oil; " neem oil; * glycerol; * surfactant; and " water.
Description
FIELD OF THE INVENTION
A preferred form of the invention relates to an antifungal formulation for human use, preferably although not necessarily for spray-on application.
BACKGROUND
Many people suffer from fungal infection of the skin, especially of the feet. The infection may manifest with peeling, redness, itching, burning, blisters and sores. It is known to use various oils for treatment however formulating them into a convenient easy-to-apply watery product presents challenges given that oil and water normally do not mix well. It is an object of an object of a preferred form of the invention to go at least some way towards addressing this problem.
The term “comprising” if and when used in this document in relation to a combination of features should not be taken to rule out the option of there being other features. It should not be interpreted in a necessarily limiting way.
SUMMARY OF THE INVENTION
In one aspect, the invention resides in the use of:
• tea tree oil;
• neem oil;
• glycerol;
• surfactant; and • water as ingredients in the manufacture of a formulation for use on humans for treating fungal skin conditions, wherein the formulation comprises a combination of such ingredients.
Optionally the surfactant (eg a solubiliser) comprises decyl glucoside and/or sorbitan oleate.
Optionally the formulation includes lavender oil and/or ginger oil.
2017203070 03 May 2018
Optionally the formulation includes vinegar, for example apple cider vinegar.
Optionally the formulation includes sodium chloride for facilitating controlling stability and/or viscosity characteristics.
Optionally the formulation is contained within and is able to be delivered as a spray from a spray dispenser.
Optionally the tea tree oil is present in an amount of 4 - 6% by weight of the finished formulation.
Optionally the neem oil is present in an amount of 0.8 - 1.2% by weight of the finished formulation.
Optionally the surfactant is present in an amount of 20 - 30% by weight of the finished formulation.
Optionally the decyl glucoside is present in an amount of 15 - 25% by weight of the finished formulation.
Optionally the sorbitan oleate is present in an amount of 4 - 6% by weight of the finished formulation.
Optionally the lavender oil is present in an amount of 0.8 - 1.2% by weight of the finished formulation.
Optionally the ginger oil is present in an amount of 0.8 - 1.2% by weight of the finished formulation.
Optionally the apple cider vinegar is present in an amount of 1 - 1.5% by weight of the finished formulation.
According to another aspect of the invention there is provided a method of forming a formulation as above, comprising the steps:
a) mixing at least the tea tree oil and neem oil with the glycerol to form a sludge;
b) mixing in at least the surfactant to form a slurry; and
2017203070 09 May 2017
Optionally the lavender oil and/or ginger oil is mixed in at step a).
DETAILED DESCRIPTION
In a preferred form of the invention the antifungal formulation uses tee tree oil and neem oil as active ingredients. Lavender oil and ginger oil may be added (it is hypothesised that they may also contribute some antifungal activity). All of the oils are mixed with glycerol as a solvent/solubilser to form a sludge (eg to ‘wet-out’ the oils). Decyl glucoside is then added as a surfactant/solubilser with low energy mixing. Sorbitan oleate is also added as a surfactant/solubilser with further low energy mixing. At this point the combination is in the form of a slurry. A water and sodium chloride mixture is then added with low energy mixing to complete the formulation as a homogenous non-viscous liquid suitable for delivery by way of a hand-held spray dispenser. It can be sprayed onto human skin to treat fungal conditions.
In some embodiments vinegar may be added for pH adjustment after the above otherwise complete mixture has been formed.
In a particularly preferred embodiment of the invention the following ingredients are used in the amounts indicated:
Ingredient | Function | Amount |
Tea tree oil (Melaleuca oil) | Antifungal | 50 mg/ml |
Neem oil (Azadirachta indica seed oil) | Antifungal | 10 mg/ml |
Lavender oil | Antifungal | 10 mg/ml |
Ginger oil (Zingiber officinale flower and/or leaf oil) | Antifungal | 10mg/ml |
Glycerol | Solvent / solubilising / wetting agent | 50 mg/ml |
Decyl glucoside | Surfactant / solubilising agent | 200 mg/ml |
2017203070 09 May 2017
Sorbitan oleate | Surfactant / solubilising agent | 50 mg/ml |
Sodium chloride | Facilitates stability and provides viscosity adjustment | 5 mg/ml |
Apple cider vinegar | pH adjustment | 12.5 mg/ml |
Purified water | Solvent | To volume |
In other embodiments of the invention any or all of the above ingredients may be varied in the amount used, depending on the desired characteristics for the end product.
While decyl glucoside and sorbitan oleate are the preferred surfactants (eg solubilisers), in other embodiments they may be replaced by one or more other suitable surfactants, for example polyglyceryl-6 caprylate, polyglyceryl-4 caprate, polyglyceryl-4 cocoate and/or polyglyceryl-6 ricinoleate.
Peferred embodiments of the invention may be used for treating tinea, athletes’ foot, Jock Itch and/or nail fungal infections
While some preferred forms of the invention have been described by way of example it should be appreciated that modifications and improvements can occur without departing from the scope of the following claims.
Claims (22)
- THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS:1. The use of:• tea tree oil;• neem oil;• glycerol;• surfactant; and • water as ingredients in the manufacture of a formulation for the therapeutic and/or prophylactic treatment of fungal human skin conditions being one or more of tinea, athletes’ foot, jock itch and nail fungal infections.
- 2. A use according to claim 1, wherein the formulation is for the therapeutic and/or prophylactic treatment of human skin conditions being one or more of athletes’ foot, jock itch and/or nail fungal infections.
- 3. A use according to claim 1, wherein the formulation is for the therapeutic and/or prophylactic treatment of human skin conditions being one or more of athletes’ foot and nail fungal infections.
- 4. A use according to claim 1, wherein the formulation is for the therapeutic and/or prophylactic treatment of fungal human skin conditions comprising athletes’ foot.
- 5. A use according to claim 1, wherein the surfactant comprises decyl glucoside and/or sorbitan oleate.
- 6. A use according to claim 1 or 2, wherein the formulation also comprises lavender oil and/or ginger oil.
- 7. A use according to claim 1,2 or 3, wherein the formulation also comprises vinegar.
- 8. A use according to claim 1,2 or 3, wherein the formulation also comprises apple cider vinegar.2017203070 20 Mar 2019
- 9. A use according to any one of the preceding claims, wherein the formulation also comprises sodium chloride for controlling desired viscosity and stability characteristics.
- 10. A use according to any one of the preceding claims, wherein the formulation is contained within and able to be delivered as a spray from a spray dispenser.
- 11. A use according to any one of the preceding claims, wherein the tea tree oil is present in an amount of 4 - 6% by weight of the finished formulation.
- 12. A use according to any one of the preceding claims, wherein the neem oil is present in an amount of 0.8 - 1.2% by weight of the finished formulation.
- 13. A use according to any one of the preceding claims, wherein the surfactant is present in an amount of 20 - 30% by weight of the finished formulation.
- 14. A use according to any one of the preceding claims, wherein decyl glucoside is present in an amount of 15 - 25% by weight of the finished formulation.
- 15. A use according to any one of the preceding claims, wherein sorbitan oleate is present in an amount of 4 - 6% by weight of the finished formulation.
- 16. A use according to any one of the preceding claims, wherein lavender oil is present in an amount of 0.8 - 1.2% by weight of the finished formulation.
- 17. A use according to any one of the preceding claims, wherein ginger oil is present in an amount of 0.8 - 1.2% by weight of the finished formulation.
- 18. A use according to any one of the preceding claims, wherein apple cider vinegar is present in an amount of 1 - 1.5% by weight of the finished formulation.
- 19. A use according to claim 1, wherein the formulation comprises the following ingredients in or about the amounts indicated:2017203070 20 Mar 2019
Ingredient Amount Tea tree oil 50 mg/ml Neem oil 10 mg/ml Lavender oil 10 mg/ml Ginger oil 10 mg/ml Glycerol 50 mg/ml Decyl glucoside 200 mg/ml Sorbitan oleate 50 mg/ml Sodium chloride 5 mg/ml Apple cider vinegar 12.5 mg/ml Purified water To volume - 20. A use according to any one of the preceding claims, wherein the formulation is produced by taking the steps:a) mixing at least the tea tree oil and neem oil with the glycerol to form a sludge;b) mixing in at least the surfactant to form a slurry; andc) mixing in at least the water to form a homogenous spray-on liquid.
- 21. A use according to claim 20, wherein producing the formulation further includes mixing in lavender oil and/or ginger oil at step a).
- 22. A use according to any one of the preceding claims wherein the formulation is sprayed on the skin.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2017203070A AU2017203070B2 (en) | 2017-05-09 | 2017-05-09 | An Antifungal Formulation |
AU2019200904A AU2019200904A1 (en) | 2017-05-09 | 2019-02-08 | An Antifungal Formulation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2017203070A AU2017203070B2 (en) | 2017-05-09 | 2017-05-09 | An Antifungal Formulation |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2019200904A Division AU2019200904A1 (en) | 2017-05-09 | 2019-02-08 | An Antifungal Formulation |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2017203070A1 AU2017203070A1 (en) | 2018-11-29 |
AU2017203070B2 true AU2017203070B2 (en) | 2019-04-04 |
Family
ID=64332245
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2017203070A Active AU2017203070B2 (en) | 2017-05-09 | 2017-05-09 | An Antifungal Formulation |
AU2019200904A Abandoned AU2019200904A1 (en) | 2017-05-09 | 2019-02-08 | An Antifungal Formulation |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2019200904A Abandoned AU2019200904A1 (en) | 2017-05-09 | 2019-02-08 | An Antifungal Formulation |
Country Status (1)
Country | Link |
---|---|
AU (2) | AU2017203070B2 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090162304A1 (en) * | 2007-12-20 | 2009-06-25 | Dileva Rose Marie | Compositions and methods for treating skin conditions in mammals |
US20140057881A1 (en) * | 2010-12-20 | 2014-02-27 | Andrew Tuan Anh Le | Composition for the Treatment of Skin Conditions |
US20140287064A1 (en) * | 2009-04-28 | 2014-09-25 | Karen G. Swenholt | Compositions for improving the appearance and/or treating fungal infections of nails, mucus membranes and the integument |
US20160310526A1 (en) * | 2008-12-22 | 2016-10-27 | Clearcrescent Technologies, Llc | Chlorite-Containing Compositions |
-
2017
- 2017-05-09 AU AU2017203070A patent/AU2017203070B2/en active Active
-
2019
- 2019-02-08 AU AU2019200904A patent/AU2019200904A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090162304A1 (en) * | 2007-12-20 | 2009-06-25 | Dileva Rose Marie | Compositions and methods for treating skin conditions in mammals |
US20160310526A1 (en) * | 2008-12-22 | 2016-10-27 | Clearcrescent Technologies, Llc | Chlorite-Containing Compositions |
US20140287064A1 (en) * | 2009-04-28 | 2014-09-25 | Karen G. Swenholt | Compositions for improving the appearance and/or treating fungal infections of nails, mucus membranes and the integument |
US20140057881A1 (en) * | 2010-12-20 | 2014-02-27 | Andrew Tuan Anh Le | Composition for the Treatment of Skin Conditions |
Non-Patent Citations (9)
Title |
---|
Apple Cider Vinegar Antifungal Spray [retrieved from internet on 11 June 2018]<URL: https://web.archive.org/web/20170307075419/https://draxe.com/antifungal-spray/> published 7 March 2017 as per Wayback Machine * |
Everyuth Naturals Purifying Neem Face Wash [retrieved from internet on 7 June 2018]<URL: https://www.makeupera.com/everyuth-naturals-purifying-neem-face-wash-review/> published on 2 October 2015 * |
Health911TM Health Conditions Athlete’s Foot [retrieved from internet on 30 May 2018]<URL: https://web.archive.org/web/20160823192440/http://www.health911.com/athletes_foot> published on 23 August 2016 as per Wayback Machine * |
Kotemeier U. et al., "Thickening Agents for Surfactant Systems", SOFW-Journal, 2010, Vol. 136, pages 32-38 * |
Mintel GNPD, Bugs Off Body Spray, Record ID: 3295187, published July 2015 [retrieved from internet on 4 June 2018]. Available at: http://www.gnpd.com/sinatra/home/ * |
Mintel GNPD, Dandruff Control Shampoo, Record ID 1819013, published June 2012, [retrieved from the internet on 3 January 2019]. Available at: http://www.gnpd.com/sinatra/home/ * |
Mintel GNPD, Herbal Outdoor Spray, Record ID: 1626884, published September 2011 [retrieved from internet on 4 June 2018]. Available at: http://www.gnpd.com/sinatra/home/ * |
Mintel GNPD, Neem Ayurvedic Anti-Dandruff Shampoo, Record ID: 3874407, published March 2016 [retrieved from internet on 3 January 2018]. Available at: http://www.gnpd.com/sinatra/home/ * |
Mintel GNPD, Organic Natural Protection Spray, Record ID: 4257609, published August 2016 [retrieved from internet on 4 June 2018]. Available at: http://www.gnpd.com/sinatra/home/ * |
Also Published As
Publication number | Publication date |
---|---|
AU2017203070A1 (en) | 2018-11-29 |
AU2019200904A1 (en) | 2019-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106665700B (en) | Plant-source disinfection composition, disinfectant and preparation method thereof | |
CN102037966A (en) | Eugenol biological pesticide and preparation method thereof | |
CN106614636A (en) | Sterilization composition containing benziothiazolinone and flutolanil | |
CN108078863A (en) | A kind of bactericidal composition and Baby Care composition based on plant extracts | |
CN104782641A (en) | Zhongshengmycin-containing biological sterilization composition and application thereof | |
AU2017203070B2 (en) | An Antifungal Formulation | |
CN103719123A (en) | Ultra-low volume liquid containing composite of pyraclostrobin and morpholine bactericide | |
Khan et al. | Antifungal activity of Ajawain seeds (Trachyspermum ammi) | |
WO2018208173A1 (en) | An antifungal formulation | |
KR100778368B1 (en) | Women's aroma oil composition comprising Artemisia spp. essential oil | |
JPH0352805A (en) | Antimicrobial spray | |
CN108651505A (en) | A kind of composition pesticide containing guadipyr and (R)-4-isopropenyl-1-methyl-1-cyclohexene | |
US8703212B2 (en) | Base material for pharmaceutical and/or cosmetic cream (herbal composition for itchy or infected skin) | |
US20040146587A1 (en) | Topical composition for relief of pain and minor skin irritations | |
CN106417313A (en) | Bactericidal composition containing amisulbrom and fluopicolide | |
CN105340897A (en) | Bactericidal composition containing penthiopyrad and meptyldinocap | |
CN104770380A (en) | Tetramycin and difenoconazole containing sterilizing aqueous agent and preparation method thereof | |
CN106172401B (en) | It is a kind of to eliminate propargite on citrus using the propargite preparation for generating phytotoxicity | |
CN109362767A (en) | A kind of fungicide, preparation method and applications | |
CN106386795B (en) | metalaxyl-M and propamocarb hydrochloride compounded aqueous solution and application thereof | |
JP2017105712A (en) | Virus diffusion prevention agent | |
US11696889B2 (en) | Botanical antimicrobial composition | |
CN108651458A (en) | A kind of bactericidal composition containing carvacrol and hexaconazole | |
CN105638670A (en) | Germicidal composition prepared from triflumizole and SYP-Z048 | |
CN108849933A (en) | A kind of composition pesticide containing (R)-4-isopropenyl-1-methyl-1-cyclohexene and paichongding |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted | ||
NB | Applications allowed - extensions of time section 223(2) |
Free format text: THE TIME IN WHICH TO GAIN ACCEPTANCE HAS BEEN EXTENDED TO 09 APR 2019 |
|
FGA | Letters patent sealed or granted (standard patent) |