AU2016348418B8 - Compositions comprising IL6R antibodies for the treatment of uveitis and macular edema and methods of using same - Google Patents

Compositions comprising IL6R antibodies for the treatment of uveitis and macular edema and methods of using same Download PDF

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Publication number
AU2016348418B8
AU2016348418B8 AU2016348418A AU2016348418A AU2016348418B8 AU 2016348418 B8 AU2016348418 B8 AU 2016348418B8 AU 2016348418 A AU2016348418 A AU 2016348418A AU 2016348418 A AU2016348418 A AU 2016348418A AU 2016348418 B8 AU2016348418 B8 AU 2016348418B8
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Australia
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subject
antibody
corticosteroid
uveitis
administered
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AU2016348418A
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AU2016348418B2 (en
AU2016348418A8 (en
AU2016348418A1 (en
Inventor
Ronald BUGGAGE
Karen W. Chu
Valerle CORP DIT GENTI
Kristine A. Erickson
Dominique MERY-MIGNARD
Preethi Aavali Sridhara Sundaram
Rafael VARONA
Robert L. Vitti
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Sanofi Biotechnology SAS
Regeneron Pharmaceuticals Inc
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Sanofi Biotechnology SAS
Regeneron Pharmaceuticals Inc
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Publication of AU2016348418A1 publication Critical patent/AU2016348418A1/en
Priority to AU2023233110A priority Critical patent/AU2023233110A1/en
Publication of AU2016348418B2 publication Critical patent/AU2016348418B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2016348418A 2015-11-03 2016-11-03 Compositions comprising IL6R antibodies for the treatment of uveitis and macular edema and methods of using same Active AU2016348418B8 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023233110A AU2023233110A1 (en) 2015-11-03 2023-09-20 Compositions comprising IL6R antibodies for the treatment of uveitis and macular edema and methods of using same

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562250269P 2015-11-03 2015-11-03
US62/250,269 2015-11-03
EP16306166.6 2016-09-14
EP16306166 2016-09-14
US201662408391P 2016-10-14 2016-10-14
US62/408,391 2016-10-14
PCT/US2016/060344 WO2017079443A1 (en) 2015-11-03 2016-11-03 Compositions comprising il6r antibodies for the treatment of uveitis and macular edema and methods of using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2023233110A Division AU2023233110A1 (en) 2015-11-03 2023-09-20 Compositions comprising IL6R antibodies for the treatment of uveitis and macular edema and methods of using same

Publications (4)

Publication Number Publication Date
AU2016348418A1 AU2016348418A1 (en) 2018-06-21
AU2016348418B2 AU2016348418B2 (en) 2023-10-12
AU2016348418A8 AU2016348418A8 (en) 2023-10-19
AU2016348418B8 true AU2016348418B8 (en) 2023-10-19

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AU2016348418A Active AU2016348418B8 (en) 2015-11-03 2016-11-03 Compositions comprising IL6R antibodies for the treatment of uveitis and macular edema and methods of using same
AU2023233110A Pending AU2023233110A1 (en) 2015-11-03 2023-09-20 Compositions comprising IL6R antibodies for the treatment of uveitis and macular edema and methods of using same

Family Applications After (1)

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AU2023233110A Pending AU2023233110A1 (en) 2015-11-03 2023-09-20 Compositions comprising IL6R antibodies for the treatment of uveitis and macular edema and methods of using same

Country Status (13)

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US (2) US10968278B2 (enExample)
EP (1) EP3371224A1 (enExample)
JP (4) JP7272794B2 (enExample)
KR (1) KR20180073680A (enExample)
CN (1) CN108473583A (enExample)
AU (2) AU2016348418B8 (enExample)
BR (1) BR112018008900A8 (enExample)
CA (1) CA3003874A1 (enExample)
IL (1) IL319993A (enExample)
MX (2) MX2018005589A (enExample)
SG (1) SG11201803654TA (enExample)
TW (3) TWI729022B (enExample)
WO (1) WO2017079443A1 (enExample)

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JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
TWI729022B (zh) * 2015-11-03 2021-06-01 法商賽諾菲生物技術公司 用於治療葡萄膜炎及黃斑水腫之包含ｉｌ６ｒ抗體的組合物與其使用方法
MX2021002422A (es) 2018-08-29 2021-07-15 Regeneron Pharma Métodos y composiciones para el tratamiento de sujetos que padecen artritis reumatoide.
EP3917618A1 (en) 2019-01-31 2021-12-08 Sanofi Biotechnology Anti-il-6 receptor antibody for treating juvenile idiopathic arthritis
EP3959240A1 (en) 2019-04-24 2022-03-02 Sanofi Biotechnology Methods of diagnosis and treatment of rheumatoid arthritis
AU2020288561A1 (en) 2019-06-04 2021-12-23 Regeneron Pharmaceuticals, Inc. Compositions and methods for treating pain in subjects with rheumatoid arthritis
US20200405883A1 (en) 2019-06-20 2020-12-31 Baxalta Incorporated Method of treatment with viral-based gene therapy
CN116528892A (zh) * 2020-10-28 2023-08-01 再生生物股份有限公司 用于眼部适应症的载体化抗TNF-α抗体
KR20250093319A (ko) * 2022-10-24 2025-06-24 에프. 호프만-라 로슈 아게 Il-6 길항제에 대한 반응 예측

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US5795965A (en) 1991-04-25 1998-08-18 Chugai Seiyaku Kabushiki Kaisha Reshaped human to human interleukin-6 receptor
AU700819B2 (en) 1994-10-07 1999-01-14 Chugai Seiyaku Kabushiki Kaisha Rheumatoid arthritis remedy containing IL-6 antagonist as effective component
PL187733B1 (pl) 1996-02-26 2004-09-30 Advanced Res & Tech Inst Zastosowanie inhibitora anhydrazy węglanowej
US6659982B2 (en) 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
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US8895521B2 (en) 2004-05-06 2014-11-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods and compositions for the treatment of uveitis
US8080248B2 (en) * 2006-06-02 2011-12-20 Regeneron Pharmaceuticals, Inc. Method of treating rheumatoid arthritis with an IL-6R antibody
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TWI589299B (zh) * 2011-10-11 2017-07-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法
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TWI729022B (zh) 2015-11-03 2021-06-01 法商賽諾菲生物技術公司 用於治療葡萄膜炎及黃斑水腫之包含ｉｌ６ｒ抗體的組合物與其使用方法

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Also Published As

Publication number Publication date
EP3371224A1 (en) 2018-09-12
US10968278B2 (en) 2021-04-06
TWI729022B (zh) 2021-06-01
AU2016348418B2 (en) 2023-10-12
AU2016348418A8 (en) 2023-10-19
JP2025020227A (ja) 2025-02-12
TWI786636B (zh) 2022-12-11
TW202138001A (zh) 2021-10-16
MX2022011972A (es) 2022-10-20
MX2018005589A (es) 2018-11-09
KR20180073680A (ko) 2018-07-02
IL319993A (en) 2025-06-01
US20170166646A1 (en) 2017-06-15
WO2017079443A1 (en) 2017-05-11
AU2023233110A1 (en) 2023-10-05
JP7581399B2 (ja) 2024-11-12
CA3003874A1 (en) 2017-05-11
JP2021193120A (ja) 2021-12-23
WO2017079443A8 (en) 2017-07-06
JP2018532804A (ja) 2018-11-08
CN108473583A (zh) 2018-08-31
BR112018008900A2 (pt) 2018-11-06
TW201729828A (zh) 2017-09-01
JP2023062062A (ja) 2023-05-02
TW202339795A (zh) 2023-10-16
SG11201803654TA (en) 2018-05-30
AU2016348418A1 (en) 2018-06-21
JP7272794B2 (ja) 2023-05-12
US20210301027A1 (en) 2021-09-30
BR112018008900A8 (pt) 2019-02-26

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Free format text: IN VOL 32 , NO 23 , PAGE(S) 3352 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME SANOFI BIOTECHNOLOGY, REGENERON PHARMACEUTICALS, INC., APPLICATION NO. 2016348418, UNDER INID (72) CORRECT THE CO-INVENTOR TO MERY-MIGNARD, DOMINIQUE

Free format text: IN VOL 57 , NO 40 , PAGE(S) 5858 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME SANOFI BIOTECHNOLOGY, REGENERON PHARMACEUTICALS, INC., APPLICATION NO. 2016348418, UNDER INID (72) CORRECT THE CO-INVENTOR MERY-MIGNARD, DOMINIQUE

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