AU2016335086B2 - Quinoxaline and pyridopyrazine derivatives as pI3Kbeta inhibitors - Google Patents
Quinoxaline and pyridopyrazine derivatives as pI3Kbeta inhibitors Download PDFInfo
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- AU2016335086B2 AU2016335086B2 AU2016335086A AU2016335086A AU2016335086B2 AU 2016335086 B2 AU2016335086 B2 AU 2016335086B2 AU 2016335086 A AU2016335086 A AU 2016335086A AU 2016335086 A AU2016335086 A AU 2016335086A AU 2016335086 B2 AU2016335086 B2 AU 2016335086B2
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D241/40—Benzopyrazines
- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15189163 | 2015-10-09 | ||
| EP15189163.7 | 2015-10-09 | ||
| EP16174710.0 | 2016-06-16 | ||
| EP16174710 | 2016-06-16 | ||
| PCT/EP2016/073962 WO2017060406A1 (en) | 2015-10-09 | 2016-10-07 | Quinoxaline and pyridopyrazine derivatives as pi3kbeta inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2016335086A1 AU2016335086A1 (en) | 2018-04-12 |
| AU2016335086B2 true AU2016335086B2 (en) | 2020-08-27 |
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ID=57104028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016335086A Active AU2016335086B2 (en) | 2015-10-09 | 2016-10-07 | Quinoxaline and pyridopyrazine derivatives as pI3Kbeta inhibitors |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10526316B2 (enExample) |
| EP (1) | EP3359533B1 (enExample) |
| JP (1) | JP6912460B2 (enExample) |
| KR (1) | KR102630111B1 (enExample) |
| CN (1) | CN108349946B (enExample) |
| AU (1) | AU2016335086B2 (enExample) |
| BR (1) | BR112018007068B1 (enExample) |
| CA (1) | CA2999818C (enExample) |
| EA (1) | EA037401B1 (enExample) |
| ES (1) | ES2905673T3 (enExample) |
| IL (1) | IL258513B (enExample) |
| MA (1) | MA45896A (enExample) |
| MX (1) | MX382601B (enExample) |
| WO (1) | WO2017060406A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016335086B2 (en) * | 2015-10-09 | 2020-08-27 | Janssen Pharmaceutica Nv | Quinoxaline and pyridopyrazine derivatives as pI3Kbeta inhibitors |
| LT3472160T (lt) | 2016-06-16 | 2021-04-26 | Janssen Pharmaceutica Nv | Biciklinio piridino, pirazino ir pirimidino dariniai kaip pi3k beta inhibitoriai |
| CN110461827A (zh) | 2017-03-29 | 2019-11-15 | 詹森药业有限公司 | 作为PI3K-β抑制剂的喹喔啉和吡啶并吡嗪衍生物 |
| MD3762368T2 (ro) | 2018-03-08 | 2022-07-31 | Incyte Corp | Compuși diol aminopirazină ca inhibitori ai PI3K-Y |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| CN111892597B (zh) * | 2020-09-01 | 2023-07-25 | 山西天宏达安医药科技有限公司 | 一种喹喔啉基吡啶并吡嗪类化合物及其制备方法与应用 |
| WO2024026419A1 (en) * | 2022-07-27 | 2024-02-01 | Black Diamond Therapeutics, Inc. | Quinoxaline derivatives as pik3 alpha modulators |
| US20240391882A1 (en) * | 2023-05-12 | 2024-11-28 | Mirati Therapeutics, Inc. | Substituted Quinoxalines |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| MX2009009031A (es) * | 2007-02-22 | 2009-08-31 | Merck Serono Sa | Compuestos de quinoxalina y uso de los mismos. |
| CN101965335B (zh) | 2008-01-04 | 2015-01-14 | 英特利凯恩有限责任公司 | 某些化学实体、组合物和方法 |
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| CA2775942A1 (en) | 2009-09-29 | 2011-04-07 | Xcovery Holding Company Llc | Pi3k (delta) selective inhibitors |
| US8399460B2 (en) * | 2009-10-27 | 2013-03-19 | Astrazeneca Ab | Chromenone derivatives |
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| SMT201700158T1 (it) | 2010-10-06 | 2017-05-08 | Glaxosmithkline Llc Corp Service Company | Derivati benzimidazolici come inibitori della chinasi pi3 |
| US9127000B2 (en) | 2011-02-23 | 2015-09-08 | Intellikine, LLC. | Heterocyclic compounds and uses thereof |
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| WO2013028263A1 (en) | 2011-08-24 | 2013-02-28 | Glaxosmithkline Llc | Pyrazolopyrimidine derivatives as pi3 kinase inhibitors |
| US8778937B2 (en) | 2011-12-20 | 2014-07-15 | Glaxosmithkline Llc | Benzimidazole boronic acid derivatives as PI3 kinase inhibitors |
| US8906910B2 (en) | 2011-12-20 | 2014-12-09 | Glaxosmithkline Llc | Imidazopyridine derivatives as PI3 kinase |
| GB201212513D0 (en) | 2012-07-13 | 2012-08-29 | Ucb Pharma Sa | Therapeutic agents |
| MX2017008076A (es) | 2014-12-19 | 2018-01-09 | Janssen Pharmaceutica Nv | DERIVADOS DE IMIDAZOPIRIDAZINA ENLAZADOS A HETEROCICLILO COMO INHIBIDORES DE PI3Kß. |
| EP3233862B1 (en) | 2014-12-19 | 2019-07-03 | Janssen Pharmaceutica NV | Imidazopyridazine derivatives as pi3kbeta inhibitors |
| AU2016335086B2 (en) | 2015-10-09 | 2020-08-27 | Janssen Pharmaceutica Nv | Quinoxaline and pyridopyrazine derivatives as pI3Kbeta inhibitors |
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| Bioorganic & Medicinal Chemistry Letters, 2012, 22(20), 6368-72 * |
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| IL258513B (en) | 2020-08-31 |
| KR20180061258A (ko) | 2018-06-07 |
| MX382601B (es) | 2025-03-13 |
| EP3359533B1 (en) | 2021-11-17 |
| US20190062311A1 (en) | 2019-02-28 |
| US20200079763A1 (en) | 2020-03-12 |
| EA201890906A1 (ru) | 2018-09-28 |
| CN108349946A (zh) | 2018-07-31 |
| MA45896A (fr) | 2019-06-19 |
| CN108349946B (zh) | 2021-05-18 |
| ES2905673T3 (es) | 2022-04-11 |
| MX2018004304A (es) | 2018-05-01 |
| BR112018007068B1 (pt) | 2024-01-02 |
| US11267804B2 (en) | 2022-03-08 |
| JP6912460B2 (ja) | 2021-08-04 |
| EA037401B1 (ru) | 2021-03-24 |
| CA2999818C (en) | 2023-11-07 |
| KR102630111B1 (ko) | 2024-01-25 |
| EP3359533A1 (en) | 2018-08-15 |
| AU2016335086A1 (en) | 2018-04-12 |
| IL258513A (en) | 2018-05-31 |
| US10526316B2 (en) | 2020-01-07 |
| JP2018535199A (ja) | 2018-11-29 |
| BR112018007068A2 (pt) | 2018-10-23 |
| WO2017060406A1 (en) | 2017-04-13 |
| CA2999818A1 (en) | 2017-04-13 |
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