AU2016335086B2 - Quinoxaline and pyridopyrazine derivatives as pI3Kbeta inhibitors - Google Patents

Quinoxaline and pyridopyrazine derivatives as pI3Kbeta inhibitors Download PDF

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AU2016335086B2
AU2016335086B2 AU2016335086A AU2016335086A AU2016335086B2 AU 2016335086 B2 AU2016335086 B2 AU 2016335086B2 AU 2016335086 A AU2016335086 A AU 2016335086A AU 2016335086 A AU2016335086 A AU 2016335086A AU 2016335086 B2 AU2016335086 B2 AU 2016335086B2
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4alkyl
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substituted
hydrogen
het
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AU2016335086A1 (en
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Patrick Rene Angibaud
Didier Jean-Claude Berthelot
Thierry François Alain Jean Jousseaume
Lieven Meerpoel
Christophe Meyer
Olivier Alexis Georges Querolle
Matthieu Philippe Victor Willot
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Janssen Pharmaceutica NV
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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AU2016335086A 2015-10-09 2016-10-07 Quinoxaline and pyridopyrazine derivatives as pI3Kbeta inhibitors Ceased AU2016335086B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15189163.7 2015-10-09
EP15189163 2015-10-09
EP16174710.0 2016-06-16
EP16174710 2016-06-16
PCT/EP2016/073962 WO2017060406A1 (en) 2015-10-09 2016-10-07 Quinoxaline and pyridopyrazine derivatives as pi3kbeta inhibitors

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AU2016335086A1 AU2016335086A1 (en) 2018-04-12
AU2016335086B2 true AU2016335086B2 (en) 2020-08-27

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EP (1) EP3359533B1 (OSRAM)
JP (1) JP6912460B2 (OSRAM)
KR (1) KR102630111B1 (OSRAM)
CN (1) CN108349946B (OSRAM)
AU (1) AU2016335086B2 (OSRAM)
BR (1) BR112018007068B1 (OSRAM)
CA (1) CA2999818C (OSRAM)
EA (1) EA037401B1 (OSRAM)
ES (1) ES2905673T3 (OSRAM)
IL (1) IL258513B (OSRAM)
MA (1) MA45896A (OSRAM)
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JP6912460B2 (ja) * 2015-10-09 2021-08-04 ヤンセン ファーマシューティカ エヌ．ベー． ＰＩ３Ｋβ阻害剤としてのキノキサリンおよびピリドピラジン誘導体
KR102472453B1 (ko) 2016-06-16 2022-11-29 얀센 파마슈티카 엔.브이. Pi3k 베타 저해제로서의 이환식 피리딘, 피라진, 및 피리미딘 유도체
EP3601254B1 (en) 2017-03-29 2022-05-25 Janssen Pharmaceutica NV Quinoxaline and pyridopyrazine derivatives as pi3k-beta inhibitors
MD3762368T2 (ro) 2018-03-08 2022-07-31 Incyte Corp Compuși diol aminopirazină ca inhibitori ai PI3K-Y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
CN111892597B (zh) * 2020-09-01 2023-07-25 山西天宏达安医药科技有限公司 一种喹喔啉基吡啶并吡嗪类化合物及其制备方法与应用
WO2024026419A1 (en) * 2022-07-27 2024-02-01 Black Diamond Therapeutics, Inc. Quinoxaline derivatives as pik3 alpha modulators
KR20260009874A (ko) * 2023-05-12 2026-01-20 미라티 테라퓨틱스, 인크. 치환된 퀴녹살린

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009021083A1 (en) * 2007-08-09 2009-02-12 Smithkline Beecham Corporation Quinoxaline derivatives as pi3 kinase inhibitors

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007103756A2 (en) 2006-03-02 2007-09-13 Smithkline Beecham Corporation Thiazolones for use as pi3 kinase inhibitors
WO2008014219A2 (en) 2006-07-24 2008-01-31 Smithkline Beecham Corporation Thiozolidinedione derivatives as p13 kinase inhibitors
US8614215B2 (en) * 2007-02-22 2013-12-24 Merck Serono Sa Quinoxaline inhibitors of phosphoinositide-3-kinases (PI3Ks)
CA2711558C (en) 2008-01-04 2016-12-13 Intellikine, Inc. Phosphatidyl inositol-3 kinase inhibiting compounds
MY162604A (en) 2009-08-17 2017-06-30 Intellikine Llc Heterocyclic compounds and uses thereof
CN102741253A (zh) 2009-09-29 2012-10-17 艾科睿控股公司 PI3K(δ)选择性抑制剂
US8399460B2 (en) * 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives
UY33304A (es) 2010-04-02 2011-10-31 Amgen Inc Compuestos heterocíclicos y sus usos
ES2616238T3 (es) 2010-10-06 2017-06-12 Glaxosmithkline Llc, Corporation Service Company Derivados de bencimidazol como inhibidores de PI3 quinasa
EP2678016B1 (en) 2011-02-23 2016-08-10 Intellikine, LLC Heterocyclic compounds and uses thereof
US8530470B2 (en) * 2011-04-13 2013-09-10 Astrazeneca Ab Chromenone derivatives
US9096605B2 (en) 2011-08-24 2015-08-04 Glaxosmithkline Llc Pyrazolopyrimidine derivatives as PI3 kinase inhibitors
US8778937B2 (en) 2011-12-20 2014-07-15 Glaxosmithkline Llc Benzimidazole boronic acid derivatives as PI3 kinase inhibitors
WO2013095761A1 (en) 2011-12-20 2013-06-27 Glaxosmithkline Llc Imidazopyridine derivatives as pi3 kinase inhibitors
GB201212513D0 (en) 2012-07-13 2012-08-29 Ucb Pharma Sa Therapeutic agents
MX2017008076A (es) 2014-12-19 2018-01-09 Janssen Pharmaceutica Nv DERIVADOS DE IMIDAZOPIRIDAZINA ENLAZADOS A HETEROCICLILO COMO INHIBIDORES DE PI3Kß.
HUE045220T2 (hu) 2014-12-19 2019-12-30 Janssen Pharmaceutica Nv Imidazopiridazin-származékok mint PI3Kbéta inhibitorok
JP6912460B2 (ja) 2015-10-09 2021-08-04 ヤンセン ファーマシューティカ エヌ．ベー． ＰＩ３Ｋβ阻害剤としてのキノキサリンおよびピリドピラジン誘導体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009021083A1 (en) * 2007-08-09 2009-02-12 Smithkline Beecham Corporation Quinoxaline derivatives as pi3 kinase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Bioorganic & Medicinal Chemistry Letters, 2012, 22(20), 6368-72 *

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