AU2016318163B2 - Genetically-engineered drug resistant T cells and methods of using the same - Google Patents

Genetically-engineered drug resistant T cells and methods of using the same Download PDF

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Publication number
AU2016318163B2
AU2016318163B2 AU2016318163A AU2016318163A AU2016318163B2 AU 2016318163 B2 AU2016318163 B2 AU 2016318163B2 AU 2016318163 A AU2016318163 A AU 2016318163A AU 2016318163 A AU2016318163 A AU 2016318163A AU 2016318163 B2 AU2016318163 B2 AU 2016318163B2
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cells
cancer
cell composition
cell
subject
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AU2016318163A1 (en
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G. Yancey Gillespie
Lawrence S. Lamb
H. Trent SPENCER
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Emory University
UAB Research Foundation
Childrens Healthcare of Atlanta Inc
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Emory University
UAB Research Foundation
Childrens Healthcare of Atlanta Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
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    • A61K39/0005—Vertebrate antigens
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    • A61K39/001169—Tumor associated carbohydrates
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • C12N9/10—Transferases (2.)
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
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    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
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    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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    • A—HUMAN NECESSITIES
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AU2016318163A 2015-09-03 2016-09-06 Genetically-engineered drug resistant T cells and methods of using the same Active AU2016318163B2 (en)

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US201562214071P 2015-09-03 2015-09-03
US62/214,071 2015-09-03
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EP3970736A1 (en) 2009-11-02 2022-03-23 Emory University Drug resistant immunotherapy for treatment of a cancer
WO2018107134A1 (en) * 2016-12-09 2018-06-14 The Uab Research Foundation Chimeric chlorotoxin receptors
GB201715918D0 (en) * 2017-09-29 2017-11-15 Tc Biopharm Ltd Modified CAR-T
US20210163989A1 (en) * 2018-07-05 2021-06-03 Emory University Transduction of innate immunocompetent cells using aav6
BR112021000437A2 (pt) * 2018-07-13 2021-04-06 Kyoto University Métodos para produzir uma célula t gama delta e para prevenir ou tratar tumor, célula t gama delta, população de célula, medicamento, agente de extermínio para uma célula, e, uso da célula
US20210346430A9 (en) * 2018-08-26 2021-11-11 Oaiscell Biotechnologies Method for treating glioblastoma
EP3877514A4 (en) * 2018-11-08 2022-11-23 IN8bio, Inc. COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER

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EP3344760B1 (en) 2022-01-12
EP4295914A2 (en) 2023-12-27
JP7662588B2 (ja) 2025-04-15
IL282220A (en) 2021-05-31
US20250073228A1 (en) 2025-03-06
JP2022184987A (ja) 2022-12-13
IL257763A (en) 2018-04-30
ES2910709T3 (es) 2022-05-13
JP7186615B2 (ja) 2022-12-09
JP2018526453A (ja) 2018-09-13
US20180250337A1 (en) 2018-09-06
AU2022235516A1 (en) 2022-10-13
CN108291209A (zh) 2018-07-17
CA2997547A1 (en) 2017-03-09
HK1255325A1 (en) 2019-08-16
EP4006146B1 (en) 2023-09-06
EP4006146A1 (en) 2022-06-01
EP3344760A1 (en) 2018-07-11
WO2017041106A1 (en) 2017-03-09
AU2016318163A1 (en) 2018-03-29
KR20180086183A (ko) 2018-07-30
IL282220B (en) 2022-06-01
ES2965437T3 (es) 2024-04-15
US12005078B2 (en) 2024-06-11
EP3344760A4 (en) 2019-06-05
EP4295914A3 (en) 2024-04-10

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