AU2016317768A1 - Methods for the modulation of LGALS3BP to treat systemic lupus erythematosus - Google Patents

Methods for the modulation of LGALS3BP to treat systemic lupus erythematosus Download PDF

Info

Publication number
AU2016317768A1
AU2016317768A1 AU2016317768A AU2016317768A AU2016317768A1 AU 2016317768 A1 AU2016317768 A1 AU 2016317768A1 AU 2016317768 A AU2016317768 A AU 2016317768A AU 2016317768 A AU2016317768 A AU 2016317768A AU 2016317768 A1 AU2016317768 A1 AU 2016317768A1
Authority
AU
Australia
Prior art keywords
leu
ser
ala
gly
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2016317768A
Other languages
English (en)
Inventor
Julie DEMARTINO
Jonathan DERRY
Melinda GENEST
Nuruddeen LEWIS
Shinji OKITSU
Jaromir Vlach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2016317768A1 publication Critical patent/AU2016317768A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2016317768A 2015-08-31 2016-08-30 Methods for the modulation of LGALS3BP to treat systemic lupus erythematosus Abandoned AU2016317768A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562212163P 2015-08-31 2015-08-31
US62/212,163 2015-08-31
PCT/US2016/049378 WO2017040464A1 (en) 2015-08-31 2016-08-30 Methods for the modulation of lgals3bp to treat systemic lupus erythematosus

Publications (1)

Publication Number Publication Date
AU2016317768A1 true AU2016317768A1 (en) 2018-02-22

Family

ID=56883878

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016317768A Abandoned AU2016317768A1 (en) 2015-08-31 2016-08-30 Methods for the modulation of LGALS3BP to treat systemic lupus erythematosus

Country Status (9)

Country Link
US (1) US20180251559A1 (enExample)
EP (1) EP3344283A1 (enExample)
JP (2) JP2018526443A (enExample)
CN (1) CN107921112A (enExample)
AU (1) AU2016317768A1 (enExample)
CA (1) CA2994180A1 (enExample)
HK (1) HK1252815A1 (enExample)
IL (1) IL257755A (enExample)
WO (1) WO2017040464A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018156448A1 (en) * 2017-02-21 2018-08-30 The Board Of Regents Of The Uiversity Of Texas System Prediction and treatment of immunotherapeutic toxicity
KR101946884B1 (ko) * 2017-04-25 2019-02-13 고려대학교 산학협력단 대사체 분석을 이용한 베체트병의 진단방법
EP4174086A4 (en) * 2020-06-30 2024-07-24 The Asan Foundation ANTIBODIES SPECIFICALLY BINDING TO LGALS3BP AND USE THEREOF
KR102704018B1 (ko) * 2020-06-30 2024-09-06 재단법인 아산사회복지재단 Lgals3bp에 특이적으로 결합하는 항체 및 이의 용도
KR20230160803A (ko) 2021-03-24 2023-11-24 에이지씨 가부시키가이샤 축전 디바이스 전극용 프라이머, 프라이머층 형성용의 조성물, 축전 디바이스용 전극 및 이차 전지
WO2025075163A1 (ja) * 2023-10-04 2025-04-10 国立大学法人東北大学 自己反応性dn2b細胞が産生する自己抗体およびその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200001247T2 (tr) * 1997-01-10 2002-06-21 Biogen Inc. Anti-CD40L bileşikleri ile lupus nefritis tedavisi.
CA2470763A1 (en) * 2001-12-18 2003-06-26 Mondobiotech Laboratories Anstalt Novel pharmaceutical composition of interferon gamma or pirfenidone with molecular diagnostics for the improved treatment of interstitial lung diseases
US8163896B1 (en) * 2002-11-14 2012-04-24 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
ES2244270A1 (es) * 2003-01-31 2005-12-01 Pilar Universidad Autonoma De Madrid Nueva estrategia de regulacion inmune fundamentada en la molecula inducible durante la activacion leucocitaria cd69.
WO2004076682A2 (en) * 2003-02-26 2004-09-10 Surromed, Inc. Targets for controlling cellular growth and for diagnostic methods
EP2566878A4 (en) * 2010-03-26 2013-10-23 Jolla Inst Allergy Immunolog METHOD OF INHIBITING INFLAMMATORY AND INFLAMMATORY DISEASES BY GAL-3BP (BTBD17B, LGALS3BP, GALECTIN-3 BINDING PROTEIN, MAC-2 BINDING PROTEIN)
JP2013527834A (ja) * 2010-03-29 2013-07-04 マサチューセッツ インスティテュート オブ テクノロジー 抗炎症因子
EP2646826A1 (en) * 2010-11-30 2013-10-09 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patienten Zorg Method for prognosticating the clinical response of a patient to b-lymphocyte inhibiting or depleting therapy in interferon driven diseases such as sle

Also Published As

Publication number Publication date
JP2021050217A (ja) 2021-04-01
CN107921112A (zh) 2018-04-17
WO2017040464A1 (en) 2017-03-09
HK1252815A1 (zh) 2019-06-06
EP3344283A1 (en) 2018-07-11
CA2994180A1 (en) 2017-03-09
IL257755A (en) 2018-04-30
JP2018526443A (ja) 2018-09-13
US20180251559A1 (en) 2018-09-06

Similar Documents

Publication Publication Date Title
AU2016317768A1 (en) Methods for the modulation of LGALS3BP to treat systemic lupus erythematosus
Vacas et al. High-mobility group box 1 protein initiates postoperative cognitive decline by engaging bone marrow-derived macrophages
US12397037B2 (en) Methods and compositions for immunomodulation
Domingo Overlapping effects of new monoclonal antibodies for severe asthma
US20220062320A1 (en) Preventing and treating amyloid- beta deposition by stimulation of innate immunity
JP2016035474A (ja) 炎症および自己免疫疾患を治療するための組成物および方法
JP2011528332A (ja) 哺乳動物ベータ・デフェンシンを用いた炎症性疾患の処置
Ishikawa et al. Commercial bovine proteoglycan is highly arthritogenic and can be used as an alternative antigen source for PGIA model
WO2015123493A2 (en) Compositions and methods for modulatuion of immune response
Alvarez et al. Nociceptor Interleukin 33 Receptor/ST2 signaling in vibration-induced muscle pain in the rat
Summers et al. Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis
Gushchina et al. Alleviation of neuropathic pain by over‐expressing a soluble colony‐stimulating factor 1 receptor to suppress microgliosis and macrophage accumulation
Lu et al. Experimental and clinical advances in immunotherapy strategies for spinal cord injury target on MAIs and their receptors
Sun et al. Intraarticular injection of dexamethasone promotes bone erosion in collagen-induced arthritis in mice through up-regulation of RANKL expression.
Singh et al. Tuning immune suppression in systemic autoimmunity with self-derived peptides
CN111662972A (zh) Traf3通过抑制il-17信号防治关节炎
US20250381244A1 (en) Methods and compositions for immunomodulation
Gushchina et al. Alleviation of neuropathic pain by over-expressing a soluble colony-stimulating factor 1 receptor
CA2994796A1 (en) Methods and compounds for the alleviation and/or prevention of pain
CN117298277A (zh) Dexras1抑制剂及其应用
John Increased plasma cell differentiation, hyper-responsiveness to TLR9, and loss of peripheral B cell tolerance in mice lacking the transcription factor Ets-1.
Ishikawa et al. Research Article Systemic Administration of Proteoglycan Protects BALB/c Retired Breeder Mice from Experimental Arthritis
Minkiewicz ATP activation of the NLRP2 inflammasome in human astrocytes
Cen et al. Novel inflammatory and immunomodulatory mediators in sepsis
US20090317357A1 (en) Methods for treating or preventing autoimmune disease using histamine h1 receptor-blocking agents

Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application