AU2016316846B2 - Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens - Google Patents

Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens Download PDF

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Publication number
AU2016316846B2
AU2016316846B2 AU2016316846A AU2016316846A AU2016316846B2 AU 2016316846 B2 AU2016316846 B2 AU 2016316846B2 AU 2016316846 A AU2016316846 A AU 2016316846A AU 2016316846 A AU2016316846 A AU 2016316846A AU 2016316846 B2 AU2016316846 B2 AU 2016316846B2
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group
hapten
antibody
caged
conjugate
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AU2016316846A1 (en
Inventor
Yuri Belosludtsev
Traci D. Degeer
Wendy J. French
Junshan HAO
Brian Daniel Kelly
Adrian MURILLO
Nathan Walter Polaske
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Ventana Medical Systems Inc
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Ventana Medical Systems Inc
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Priority to AU2021218128A priority Critical patent/AU2021218128B2/en
Priority to AU2023201682A priority patent/AU2023201682B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2016316846A 2015-08-28 2016-08-26 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens Active AU2016316846B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021218128A AU2021218128B2 (en) 2015-08-28 2021-08-19 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
AU2023201682A AU2023201682B2 (en) 2015-08-28 2023-03-17 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562211590P 2015-08-28 2015-08-28
US62/211,590 2015-08-28
US201662301489P 2016-02-29 2016-02-29
US62/301,489 2016-02-29
PCT/US2016/049153 WO2017040349A1 (en) 2015-08-28 2016-08-26 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens

Related Child Applications (1)

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AU2021218128A Division AU2021218128B2 (en) 2015-08-28 2021-08-19 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens

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Publication Number Publication Date
AU2016316846A1 AU2016316846A1 (en) 2018-02-22
AU2016316846B2 true AU2016316846B2 (en) 2021-07-08

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Application Number Title Priority Date Filing Date
AU2016316846A Active AU2016316846B2 (en) 2015-08-28 2016-08-26 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
AU2021218128A Active AU2021218128B2 (en) 2015-08-28 2021-08-19 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
AU2023201682A Active AU2023201682B2 (en) 2015-08-28 2023-03-17 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens

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AU2021218128A Active AU2021218128B2 (en) 2015-08-28 2021-08-19 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
AU2023201682A Active AU2023201682B2 (en) 2015-08-28 2023-03-17 Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens

Country Status (7)

Country Link
US (6) US11053266B2 (cg-RX-API-DMAC7.html)
EP (1) EP3341734B1 (cg-RX-API-DMAC7.html)
JP (2) JP6880001B2 (cg-RX-API-DMAC7.html)
CN (3) CN107923915B (cg-RX-API-DMAC7.html)
AU (3) AU2016316846B2 (cg-RX-API-DMAC7.html)
CA (1) CA2996798A1 (cg-RX-API-DMAC7.html)
WO (2) WO2017040349A1 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

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EP3341734B1 (en) * 2015-08-28 2024-08-07 Ventana Medical Systems, Inc. Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
WO2020121304A1 (en) * 2018-12-10 2020-06-18 Ariel Scientific Innovations Ltd. Therapeutic conjugates
CN110632040B (zh) * 2019-05-10 2022-03-29 长沙理工大学 一种血清中前列腺特异性抗原的分析方法
EP4022624A1 (en) * 2019-08-28 2022-07-06 Ventana Medical Systems, Inc. Assessing antigen retrieval and target retrieval progression quantitation with vibrational spectroscopy
JP2023524568A (ja) * 2020-05-07 2023-06-12 ヴェンタナ メディカル システムズ， インク． 腫瘍試料中のｅｇｆｒおよびｅｇｆｒリガンドの発現を評価するための組織化学的システムおよび方法
CN116783485A (zh) * 2021-01-15 2023-09-19 文塔纳医疗系统公司 储存稳定的笼状半抗原
CN114994329A (zh) * 2022-04-28 2022-09-02 杭州广科安德生物科技有限公司 一种检测肿瘤组织中p185蛋白与p95蛋白表达水平的方法

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Also Published As

Publication number Publication date
CN107923915A (zh) 2018-04-17
US20220089622A1 (en) 2022-03-24
AU2023201682B2 (en) 2023-12-07
US11345719B2 (en) 2022-05-31
CN107923915B (zh) 2021-05-04
CA2996798A1 (en) 2017-03-09
EP3341734B1 (en) 2024-08-07
US20180186821A1 (en) 2018-07-05
US11053266B2 (en) 2021-07-06
WO2017040349A1 (en) 2017-03-09
AU2021218128A1 (en) 2021-09-09
WO2018039605A1 (en) 2018-03-01
US20250066397A1 (en) 2025-02-27
AU2021218128B2 (en) 2022-12-22
US12173019B2 (en) 2024-12-24
JP2019532275A (ja) 2019-11-07
AU2016316846A1 (en) 2018-02-22
US20210309680A1 (en) 2021-10-07
CN116338167A (zh) 2023-06-27
JP2018528425A (ja) 2018-09-27
JP7033122B2 (ja) 2022-03-09
AU2023201682A1 (en) 2023-04-13
CN109791144B (zh) 2023-04-18
JP6880001B2 (ja) 2021-06-02
EP3341734A4 (en) 2019-02-06
EP3341734A1 (en) 2018-07-04
US20210221833A1 (en) 2021-07-22
US20190233447A1 (en) 2019-08-01
CN109791144A (zh) 2019-05-21

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