AU2016303610A1 - Combination therapy using acamprosate and D-cycloserine - Google Patents
Combination therapy using acamprosate and D-cycloserine Download PDFInfo
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- AU2016303610A1 AU2016303610A1 AU2016303610A AU2016303610A AU2016303610A1 AU 2016303610 A1 AU2016303610 A1 AU 2016303610A1 AU 2016303610 A AU2016303610 A AU 2016303610A AU 2016303610 A AU2016303610 A AU 2016303610A AU 2016303610 A1 AU2016303610 A1 AU 2016303610A1
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- cycloserine
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- therapeutic agent
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000004983 pleiotropic effect Effects 0.000 description 1
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- 238000012545 processing Methods 0.000 description 1
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- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 238000006268 reductive amination reaction Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003989 repetitive behavior Effects 0.000 description 1
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- 238000012552 review Methods 0.000 description 1
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- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 1
- 230000003997 social interaction Effects 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 229940063673 spermidine Drugs 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
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- 239000011701 zinc Chemical class 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2022202218A AU2022202218A1 (en) | 2015-08-04 | 2022-04-01 | Combination Therapy Using Acamprosate And D-Cycloserine |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201562200864P | 2015-08-04 | 2015-08-04 | |
| US62/200,864 | 2015-08-04 | ||
| PCT/US2016/045547 WO2017024129A1 (en) | 2015-08-04 | 2016-08-04 | Combination therapy using acamprosate and d-cycloserine |
Related Child Applications (1)
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| AU2022202218A Division AU2022202218A1 (en) | 2015-08-04 | 2022-04-01 | Combination Therapy Using Acamprosate And D-Cycloserine |
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| AU2016303610A Abandoned AU2016303610A1 (en) | 2015-08-04 | 2016-08-04 | Combination therapy using acamprosate and D-cycloserine |
| AU2022202218A Abandoned AU2022202218A1 (en) | 2015-08-04 | 2022-04-01 | Combination Therapy Using Acamprosate And D-Cycloserine |
Family Applications After (1)
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| AU2022202218A Abandoned AU2022202218A1 (en) | 2015-08-04 | 2022-04-01 | Combination Therapy Using Acamprosate And D-Cycloserine |
Country Status (11)
| Country | Link |
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| US (2) | US20180221315A1 (enExample) |
| EP (1) | EP3331518A4 (enExample) |
| JP (2) | JP2018526345A (enExample) |
| KR (1) | KR20180034442A (enExample) |
| AU (2) | AU2016303610A1 (enExample) |
| CA (1) | CA2993614A1 (enExample) |
| HK (1) | HK1255584A1 (enExample) |
| IL (1) | IL257035A (enExample) |
| SG (1) | SG10201914045QA (enExample) |
| WO (1) | WO2017024129A1 (enExample) |
| ZA (1) | ZA201800558B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3331518A4 (en) * | 2015-08-04 | 2019-04-03 | Confluence Pharmaceuticals, LLC | COMBINATION THERAPY WITH ACAMPROSATE AND D-CYCLOSERIN |
| IL270654B2 (en) | 2017-05-17 | 2024-07-01 | Confluence Pharmaceuticals Llc | Formulations of homotaurines and salts thereof |
| MX394876B (es) | 2017-05-25 | 2025-03-24 | Glytech Llc | Formulaciones para el tratamiento del trastorno de estres post-traumatico. |
| US11291654B2 (en) * | 2018-09-13 | 2022-04-05 | Syneurx International (Taiwan) Corp. | Formulations of cycloserine compounds and applications thereof |
| JP2025069475A (ja) * | 2022-03-08 | 2025-05-01 | ソシウム株式会社 | Ｔｄｐ－４３の凝集の抑制剤、ｔｄｐ－４３が過剰発現している細胞の細胞死の抑制剤、及びｔｄｐ－４３の凝集を伴う疾患の治療又は予防剤 |
| CN119212703A (zh) * | 2023-04-27 | 2024-12-27 | 寿协株式会社 | 肌萎缩性侧索硬化症的治疗剂或预防剂 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2328197C (en) * | 1998-04-14 | 2007-11-20 | The General Hospital Corporation | Methods for treating neuropsychiatric disorders |
| US20100216734A1 (en) * | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| JP2010532331A (ja) * | 2007-07-05 | 2010-10-07 | アンセルム（アンスチチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） | 抗痙攣医薬組成物 |
| US9463172B2 (en) * | 2009-02-12 | 2016-10-11 | Indiana University Research & Technology Corporation | Material and methods for treating developmental disorders including comorbid and idiopathic autism |
| WO2010099217A1 (en) * | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| KR20130002292A (ko) * | 2011-06-28 | 2013-01-07 | 주식회사 비보존 | 다중 타겟팅의 상승 효과를 유발하는 유효물질의 조합 및 그 용도 |
| IL255343B2 (en) * | 2015-05-04 | 2024-10-01 | Confluence Pharmaceuticals Llc | Sprinkle formulations of acamprosate |
| EP3331518A4 (en) * | 2015-08-04 | 2019-04-03 | Confluence Pharmaceuticals, LLC | COMBINATION THERAPY WITH ACAMPROSATE AND D-CYCLOSERIN |
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2016
- 2016-08-04 EP EP16833870.5A patent/EP3331518A4/en not_active Withdrawn
- 2016-08-04 WO PCT/US2016/045547 patent/WO2017024129A1/en not_active Ceased
- 2016-08-04 HK HK18114711.9A patent/HK1255584A1/zh unknown
- 2016-08-04 CA CA2993614A patent/CA2993614A1/en not_active Abandoned
- 2016-08-04 SG SG10201914045QA patent/SG10201914045QA/en unknown
- 2016-08-04 AU AU2016303610A patent/AU2016303610A1/en not_active Abandoned
- 2016-08-04 JP JP2018504281A patent/JP2018526345A/ja active Pending
- 2016-08-04 KR KR1020187002542A patent/KR20180034442A/ko not_active Ceased
- 2016-08-04 US US15/749,705 patent/US20180221315A1/en not_active Abandoned
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2018
- 2018-01-21 IL IL257035A patent/IL257035A/en unknown
- 2018-01-26 ZA ZA201800558A patent/ZA201800558B/en unknown
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2020
- 2020-06-02 US US16/890,533 patent/US20200360316A1/en not_active Abandoned
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2021
- 2021-06-22 JP JP2021103459A patent/JP2021152060A/ja active Pending
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2022
- 2022-04-01 AU AU2022202218A patent/AU2022202218A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2993614A1 (en) | 2017-02-09 |
| KR20180034442A (ko) | 2018-04-04 |
| US20180221315A1 (en) | 2018-08-09 |
| ZA201800558B (en) | 2019-10-30 |
| EP3331518A4 (en) | 2019-04-03 |
| EP3331518A1 (en) | 2018-06-13 |
| US20200360316A1 (en) | 2020-11-19 |
| JP2018526345A (ja) | 2018-09-13 |
| SG10201914045QA (en) | 2020-03-30 |
| WO2017024129A1 (en) | 2017-02-09 |
| HK1255584A1 (zh) | 2019-08-23 |
| IL257035A (en) | 2018-03-29 |
| JP2021152060A (ja) | 2021-09-30 |
| AU2022202218A1 (en) | 2022-04-21 |
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