AU2016296920B2 - CD34+CD41dim megakaryocytes progenitors and uses thereof for producing proplatelet-bearing MKs and/or platelets - Google Patents

CD34+CD41dim megakaryocytes progenitors and uses thereof for producing proplatelet-bearing MKs and/or platelets Download PDF

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AU2016296920B2
AU2016296920B2 AU2016296920A AU2016296920A AU2016296920B2 AU 2016296920 B2 AU2016296920 B2 AU 2016296920B2 AU 2016296920 A AU2016296920 A AU 2016296920A AU 2016296920 A AU2016296920 A AU 2016296920A AU 2016296920 B2 AU2016296920 B2 AU 2016296920B2
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cells
cell population
mks
cd41dim
platelets
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AU2016296920A1 (en
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Nathalie BROUARD
Christian Gachet
François LANZA
Catherine STRASSEL
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Institut National de la Sante et de la Recherche Medicale INSERM
Etablissement Francais du Sang
Universite de Strasbourg
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Institut National de la Sante et de la Recherche Medicale INSERM
Etablissement Francais du Sang
Universite de Strasbourg
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2501/10—Growth factors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
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    • C12N2501/60—Transcription factors
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2016296920A 2015-07-23 2016-07-22 CD34+CD41dim megakaryocytes progenitors and uses thereof for producing proplatelet-bearing MKs and/or platelets Active AU2016296920B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1557020 2015-07-23
FR1557020A FR3039166B1 (fr) 2015-07-23 2015-07-23 Progeniteurs de megacaryocytes cd34+cd41dim et leurs utilisations pour produire des plaquettes et/ou des mk portant des proplaquettes
PCT/EP2016/067594 WO2017013262A1 (en) 2015-07-23 2016-07-22 Cd34+cd41dim megakaryocytes progenitors and uses thereof for producing proplatelet-bearing mks and/or platelets

Publications (2)

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AU2016296920A1 AU2016296920A1 (en) 2018-02-15
AU2016296920B2 true AU2016296920B2 (en) 2022-05-26

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US (3) US11236303B2 (enExample)
EP (1) EP3334822B1 (enExample)
JP (2) JP7068162B6 (enExample)
CN (1) CN107922924B (enExample)
AU (1) AU2016296920B2 (enExample)
CA (1) CA2993596A1 (enExample)
FR (1) FR3039166B1 (enExample)
WO (1) WO2017013262A1 (enExample)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
FR3039166B1 (fr) * 2015-07-23 2018-10-26 Institut National De La Sante Et De La Recherche Medicale Progeniteurs de megacaryocytes cd34+cd41dim et leurs utilisations pour produire des plaquettes et/ou des mk portant des proplaquettes
MX2020007071A (es) 2018-01-05 2020-11-11 Platelet Biogenesis Inc Composiciones y metodos para producir megacariocitos.
WO2020006539A1 (en) 2018-06-29 2020-01-02 Platelet Biogenesis, Inc. Compositions for drug delivery and methods of use thereof
FR3101885B1 (fr) 2019-10-11 2024-11-08 Francais Du Sang Ets Systeme pour la liberation de plaquettes et procede de liberation de plaquettes
CN115868454B (zh) * 2022-12-23 2025-09-02 中国医学科学院血液病医院(中国医学科学院血液学研究所) 基于免疫缺陷小鼠移植检测人巨核偏向造血干细胞功能方法

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WO2004024875A2 (en) * 2002-09-13 2004-03-25 The Board Of Trustees Of The Leland Stanford Junior University Mammalian megakaryocyte progenitor cell
WO2009119105A1 (ja) 2008-03-28 2009-10-01 国立大学法人東京大学 ＧＰＩｂα＋ＧＰＶ＋ＧＰＶＩ＋血小板のインビトロ調製法
WO2012129109A2 (en) 2011-03-18 2012-09-27 New York Blood Center, Inc. Megakaryocyte and platelet production from stem cells
US9920295B2 (en) 2012-02-21 2018-03-20 The Trustees Of The University Of Pennsylvania Bioreactor for isolation of rare cells and methods of use
US9074186B2 (en) 2012-08-15 2015-07-07 Boston Medical Center Corporation Production of red blood cells and platelets from stem cells
GB201220937D0 (en) * 2012-11-21 2013-01-02 Airbus Uk Ltd Modular structural assembly
WO2014138485A1 (en) * 2013-03-08 2014-09-12 Irm Llc Ex vivo production of platelets from hematopoietic stem cells and the product thereof
FR3039166B1 (fr) * 2015-07-23 2018-10-26 Institut National De La Sante Et De La Recherche Medicale Progeniteurs de megacaryocytes cd34+cd41dim et leurs utilisations pour produire des plaquettes et/ou des mk portant des proplaquettes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIU B ET AL: "A potential activity of valproic acid in the stimulation of interleukin-3-mediated megakaryopoiesis and erythropoiesis", EXPERIMENTAL HEMATOLOGY, ELSEVIER INC, US, vol. 38, no. 8. *
MCGRATH KATHLEEN E ED - SANCHEZ ANA ET AL: "Utilization of imaging flow cytometry to define intermediates of megakaryopoiesis in vivo and in vitro", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 423, 17, DOI: 10.1016/J.JIM.2015.03.002 *

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Publication number Publication date
JP2018519845A (ja) 2018-07-26
CA2993596A1 (en) 2017-01-26
EP3334822A1 (en) 2018-06-20
US20240417686A1 (en) 2024-12-19
EP3334822B1 (en) 2025-10-15
US20180216068A1 (en) 2018-08-02
US11236303B2 (en) 2022-02-01
JP2021177774A (ja) 2021-11-18
JP7068162B2 (ja) 2022-05-16
AU2016296920A1 (en) 2018-02-15
WO2017013262A1 (en) 2017-01-26
CN107922924A (zh) 2018-04-17
US20220135946A1 (en) 2022-05-05
FR3039166A1 (enExample) 2017-01-27
FR3039166B1 (fr) 2018-10-26
CN107922924B (zh) 2022-01-11
JP7068162B6 (ja) 2023-12-20

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