AU2016282210B2 - Electroporation system for controlled localized therapeutics delivery - Google Patents

Electroporation system for controlled localized therapeutics delivery Download PDF

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Publication number
AU2016282210B2
AU2016282210B2 AU2016282210A AU2016282210A AU2016282210B2 AU 2016282210 B2 AU2016282210 B2 AU 2016282210B2 AU 2016282210 A AU2016282210 A AU 2016282210A AU 2016282210 A AU2016282210 A AU 2016282210A AU 2016282210 B2 AU2016282210 B2 AU 2016282210B2
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AU
Australia
Prior art keywords
electroporation
probe
electrodes
array
electric field
Prior art date
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AU2016282210A
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English (en)
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AU2016282210A1 (en
Inventor
Cherylea BROWNE
Edward Norman CRAWFORD
Gary David Housley
Nigel Hamilton Lovell
Jeremy PINYON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NewSouth Innovations Pty Ltd
Original Assignee
NewSouth Innovations Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2015902456A external-priority patent/AU2015902456A0/en
Application filed by NewSouth Innovations Pty Ltd filed Critical NewSouth Innovations Pty Ltd
Publication of AU2016282210A1 publication Critical patent/AU2016282210A1/en
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Publication of AU2016282210B2 publication Critical patent/AU2016282210B2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0541—Cochlear electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056—Transvascular endocardial electrode systems
    • A61N1/057—Anchoring means; Means for fixing the head inside the heart
    • A61N1/0573—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook
    • A61N1/0575—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00107—Coatings on the energy applicator
    • A61B2018/00154—Coatings on the energy applicator containing and delivering drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00767—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Neurology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Robotics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
AU2016282210A 2015-06-25 2016-06-24 Electroporation system for controlled localized therapeutics delivery Active AU2016282210B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015902456 2015-06-25
AU2015902456A AU2015902456A0 (en) 2015-06-25 Electroporation system for controlled localized therapeutics delivery
PCT/AU2016/050546 WO2016205895A1 (en) 2015-06-25 2016-06-24 Electroporation system for controlled localized therapeutics delivery

Publications (2)

Publication Number Publication Date
AU2016282210A1 AU2016282210A1 (en) 2017-12-21
AU2016282210B2 true AU2016282210B2 (en) 2021-05-06

Family

ID=57584417

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016282210A Active AU2016282210B2 (en) 2015-06-25 2016-06-24 Electroporation system for controlled localized therapeutics delivery

Country Status (7)

Country Link
US (1) US11213671B2 (enExample)
EP (1) EP3313505A4 (enExample)
JP (2) JP6987642B2 (enExample)
CN (1) CN107708796B (enExample)
AU (1) AU2016282210B2 (enExample)
NZ (1) NZ737871A (enExample)
WO (1) WO2016205895A1 (enExample)

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JP6987642B2 (ja) * 2015-06-25 2022-01-05 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 治療学的物質の局所的送達を制御する電気穿孔法システム
DE102016110137A1 (de) * 2016-06-01 2017-12-07 Medizinische Hochschule Hannover Formadaptives medizinisches Implantat sowie Verwendung einer elektrischen Signalquelle
EP3366653A1 (en) * 2017-02-23 2018-08-29 Ibanez Botella, Juan Miguel System for water disinfection using electroporation
GB2568287A (en) 2017-11-10 2019-05-15 Sisaf Ltd Apparatus and methods for the transdermal delivery of active agents
CN109893244B (zh) * 2017-12-08 2024-04-19 Igea有限公司 电穿孔过程使用的手持件的可扩展电极的操纵和控制系统
CN111869238B (zh) * 2018-03-13 2022-05-13 科利耳有限公司 耳蜗中的电场使用方法及系统
US11376423B2 (en) 2018-05-15 2022-07-05 Cochlear Limited Medical electroporation
CN109157280A (zh) * 2018-08-10 2019-01-08 重庆大学 不可逆电穿孔组织消融效果动态实时评估设备
JP7489116B2 (ja) * 2018-12-13 2024-05-23 ニューサウス イノヴェイションズ プロプライエタリィ リミティッド 分子エレクトロトランスファーを制御するための方法及びシステム
CA3124709C (en) * 2019-02-04 2025-04-08 Univ Rutgers DEVICE AND METHOD FOR ELECTROTRANSFERRING TISSUE USING A MICROELECTRODE
ES2913759T3 (es) * 2019-06-13 2022-06-06 Lonza Cologne Gmbh Método y dispositivo para controlar el nivel de llenado en una cámara
AU2020367208A1 (en) * 2019-10-18 2022-04-14 Newsouth Innovations Pty Limited Electrotransfer therapeutic delivery device, system and method
US11690671B1 (en) * 2022-12-09 2023-07-04 Field Medical, Inc. Tissue ablation catheter with an insulator between inner and outer electrodes
US12329447B2 (en) 2022-12-09 2025-06-17 Field Medical, Inc. Tissue ablation catheter with an insulator between inner and outer electrodes
CN119950008A (zh) * 2025-02-05 2025-05-09 天津市鹰泰利安康医疗科技有限责任公司 一种用于软骨组织的不可逆电穿孔重生的智能化控制方法及系统

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2014201511A1 (en) * 2013-06-21 2014-12-24 Gary David Housley Method and apparatus for close-field electroporation

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US7127284B2 (en) * 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
US8209006B2 (en) 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
EP1682217A4 (en) * 2003-11-13 2008-04-30 Alza Corp SYSTEM UDN PROCEDURE FOR THE TRANSDERMAL LEVY
JP2006296511A (ja) * 2005-04-15 2006-11-02 Transcutaneous Technologies Inc 外用剤、外用剤の塗布方法、イオントフォレーシス装置及び経皮パッチ
US20080045880A1 (en) * 2006-02-11 2008-02-21 Rune Kjeken Device and method for single-needle in vivo electroporation
EP1981581B1 (en) * 2006-02-11 2016-04-13 Genetronics, Inc. Device for single-needle in vivo electroporation
US9198733B2 (en) * 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US20120191032A1 (en) 2009-07-15 2012-07-26 Newsouth Innovations Pty. Limited Method of providing agents to the cochlea
US20120089009A1 (en) * 2010-10-11 2012-04-12 Omary Reed A Methods and apparatus to deliver nanoparticles to tissue using electronanotherapy
EP3473296B1 (en) * 2011-06-28 2020-08-05 Inovio Pharmaceuticals, Inc. A minimally invasive dermal electroporation device
CN102329819B (zh) * 2011-09-27 2012-12-19 西北农林科技大学 一种siRNA 转染哺乳类动物胚胎的电穿孔方法
JP6987642B2 (ja) * 2015-06-25 2022-01-05 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 治療学的物質の局所的送達を制御する電気穿孔法システム

Patent Citations (1)

* Cited by examiner, † Cited by third party
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WO2014201511A1 (en) * 2013-06-21 2014-12-24 Gary David Housley Method and apparatus for close-field electroporation

Also Published As

Publication number Publication date
CN107708796B (zh) 2021-10-26
JP2021191422A (ja) 2021-12-16
CN107708796A (zh) 2018-02-16
WO2016205895A1 (en) 2016-12-29
EP3313505A1 (en) 2018-05-02
HK1250676A1 (zh) 2019-01-11
AU2016282210A1 (en) 2017-12-21
EP3313505A4 (en) 2018-06-06
NZ737871A (en) 2023-02-24
JP6987642B2 (ja) 2022-01-05
US20180169399A1 (en) 2018-06-21
JP2018518314A (ja) 2018-07-12
US11213671B2 (en) 2022-01-04

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