JP6987642B2 - 治療学的物質の局所的送達を制御する電気穿孔法システム - Google Patents

治療学的物質の局所的送達を制御する電気穿孔法システム Download PDF

Info

Publication number
JP6987642B2
JP6987642B2 JP2017566740A JP2017566740A JP6987642B2 JP 6987642 B2 JP6987642 B2 JP 6987642B2 JP 2017566740 A JP2017566740 A JP 2017566740A JP 2017566740 A JP2017566740 A JP 2017566740A JP 6987642 B2 JP6987642 B2 JP 6987642B2
Authority
JP
Japan
Prior art keywords
electroporation
array
electric field
pulse
probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017566740A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018518314A (ja
JP2018518314A5 (enExample
Inventor
デビッド ハウスリー ゲリー
ハミルトン ラベル ナイジェル
ピニョン ジェレミー
ノーマン クロウフォード エドワード
ブラウン シェリリー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unisearch Ltd
Original Assignee
Unisearch Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2015902456A external-priority patent/AU2015902456A0/en
Application filed by Unisearch Ltd filed Critical Unisearch Ltd
Publication of JP2018518314A publication Critical patent/JP2018518314A/ja
Publication of JP2018518314A5 publication Critical patent/JP2018518314A5/ja
Priority to JP2021134401A priority Critical patent/JP2021191422A/ja
Application granted granted Critical
Publication of JP6987642B2 publication Critical patent/JP6987642B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0541—Cochlear electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056—Transvascular endocardial electrode systems
    • A61N1/057—Anchoring means; Means for fixing the head inside the heart
    • A61N1/0573—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook
    • A61N1/0575—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00107—Coatings on the energy applicator
    • A61B2018/00154—Coatings on the energy applicator containing and delivering drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00767—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Robotics (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
JP2017566740A 2015-06-25 2016-06-24 治療学的物質の局所的送達を制御する電気穿孔法システム Active JP6987642B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021134401A JP2021191422A (ja) 2015-06-25 2021-08-19 治療学的物質の局所的送達を制御する電気穿孔法システム

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015902456 2015-06-25
AU2015902456A AU2015902456A0 (en) 2015-06-25 Electroporation system for controlled localized therapeutics delivery
PCT/AU2016/050546 WO2016205895A1 (en) 2015-06-25 2016-06-24 Electroporation system for controlled localized therapeutics delivery

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021134401A Division JP2021191422A (ja) 2015-06-25 2021-08-19 治療学的物質の局所的送達を制御する電気穿孔法システム

Publications (3)

Publication Number Publication Date
JP2018518314A JP2018518314A (ja) 2018-07-12
JP2018518314A5 JP2018518314A5 (enExample) 2019-06-27
JP6987642B2 true JP6987642B2 (ja) 2022-01-05

Family

ID=57584417

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017566740A Active JP6987642B2 (ja) 2015-06-25 2016-06-24 治療学的物質の局所的送達を制御する電気穿孔法システム
JP2021134401A Pending JP2021191422A (ja) 2015-06-25 2021-08-19 治療学的物質の局所的送達を制御する電気穿孔法システム

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021134401A Pending JP2021191422A (ja) 2015-06-25 2021-08-19 治療学的物質の局所的送達を制御する電気穿孔法システム

Country Status (7)

Country Link
US (1) US11213671B2 (enExample)
EP (1) EP3313505B1 (enExample)
JP (2) JP6987642B2 (enExample)
CN (1) CN107708796B (enExample)
AU (1) AU2016282210B2 (enExample)
NZ (1) NZ737871A (enExample)
WO (1) WO2016205895A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021191422A (ja) * 2015-06-25 2021-12-16 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 治療学的物質の局所的送達を制御する電気穿孔法システム

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102016110137A1 (de) * 2016-06-01 2017-12-07 Medizinische Hochschule Hannover Formadaptives medizinisches Implantat sowie Verwendung einer elektrischen Signalquelle
EP3366653A1 (en) * 2017-02-23 2018-08-29 Ibanez Botella, Juan Miguel System for water disinfection using electroporation
GB2568287A (en) 2017-11-10 2019-05-15 Sisaf Ltd Apparatus and methods for the transdermal delivery of active agents
CN109893244B (zh) * 2017-12-08 2024-04-19 Igea有限公司 电穿孔过程使用的手持件的可扩展电极的操纵和控制系统
US12005254B2 (en) 2018-03-13 2024-06-11 Cochlear Limited Electrical field usage in cochleas
US11376423B2 (en) 2018-05-15 2022-07-05 Cochlear Limited Medical electroporation
CN109157280A (zh) * 2018-08-10 2019-01-08 重庆大学 不可逆电穿孔组织消融效果动态实时评估设备
US20220054827A1 (en) * 2018-12-13 2022-02-24 Newsouth Innovations Pty Limited Method and system for controlling molecular electrotransfer
CN113613711B (zh) * 2019-02-04 2024-09-17 新泽西州立罗格斯大学 使用微电极进行组织电转移的装置
DK3750983T3 (da) * 2019-06-13 2022-05-09 Lonza Cologne Gmbh Fremgangsmåde og anordning til overvågning af påfyldningsniveauet i et kammer
WO2021072507A1 (en) * 2019-10-18 2021-04-22 Newsouth Innovations Pty Limited Electrotransfer therapeutic delivery device, system and method
EP4121161A4 (en) 2020-03-20 2024-10-16 Inovio Pharmaceuticals, Inc. VACUUM-ASSISTED ELECTROPORATION DEVICES AND CORRESPONDING SYSTEMS AND METHODS
CN116194174A (zh) * 2020-07-20 2023-05-30 科利耳有限公司 刺激和电穿孔组件
US12006507B2 (en) * 2020-07-22 2024-06-11 Nantcell, Inc. Electroporation with active compensation
EP4200010B1 (en) 2020-08-20 2026-02-18 Cochlear Limited Electroporation shield for implantable electrodes
CN115420911B (zh) * 2022-07-22 2025-12-23 华东理工大学 一种利用扫描电化学显微镜（secm）检测不可逆电穿孔程度的方法
US12329447B2 (en) 2022-12-09 2025-06-17 Field Medical, Inc. Tissue ablation catheter with an insulator between inner and outer electrodes
US11690671B1 (en) * 2022-12-09 2023-07-04 Field Medical, Inc. Tissue ablation catheter with an insulator between inner and outer electrodes
CN119950008A (zh) * 2025-02-05 2025-05-09 天津市鹰泰利安康医疗科技有限责任公司 一种用于软骨组织的不可逆电穿孔重生的智能化控制方法及系统

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7127284B2 (en) * 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
CA2546282A1 (en) * 2003-11-13 2005-06-02 Alza Corporation System and method for transdermal delivery
JP2006296511A (ja) * 2005-04-15 2006-11-02 Transcutaneous Technologies Inc 外用剤、外用剤の塗布方法、イオントフォレーシス装置及び経皮パッチ
US20080045880A1 (en) * 2006-02-11 2008-02-21 Rune Kjeken Device and method for single-needle in vivo electroporation
CA3063263C (en) * 2006-02-11 2024-01-16 Genetronics, Inc. Device and method for single-needle in vivo electroporation
US9198733B2 (en) * 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
EP3488837B1 (en) 2009-07-15 2024-11-27 NewSouth Innovations Pty Limited Electroporation apparatus for providing agents to the cochlea
US20120089009A1 (en) * 2010-10-11 2012-04-12 Omary Reed A Methods and apparatus to deliver nanoparticles to tissue using electronanotherapy
DK3473296T3 (da) * 2011-06-28 2020-11-09 Inovio Pharmaceuticals Inc Minimalt invasiv dermal elektroporeringsenhed
CN102329819B (zh) * 2011-09-27 2012-12-19 西北农林科技大学 一种siRNA 转染哺乳类动物胚胎的电穿孔方法
EP3010582B1 (en) * 2013-06-21 2021-04-28 Newsouth Innovations Pty Limited Method and apparatus for close-field electroporation
NZ737871A (en) * 2015-06-25 2023-02-24 Newsouth Innovations Pty Ltd Electroporation system for controlled localized therapeutics delivery

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021191422A (ja) * 2015-06-25 2021-12-16 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 治療学的物質の局所的送達を制御する電気穿孔法システム

Also Published As

Publication number Publication date
EP3313505B1 (en) 2026-04-01
EP3313505A4 (en) 2018-06-06
US11213671B2 (en) 2022-01-04
JP2021191422A (ja) 2021-12-16
CN107708796B (zh) 2021-10-26
JP2018518314A (ja) 2018-07-12
EP3313505A1 (en) 2018-05-02
NZ737871A (en) 2023-02-24
US20180169399A1 (en) 2018-06-21
AU2016282210A1 (en) 2017-12-21
WO2016205895A1 (en) 2016-12-29
AU2016282210B2 (en) 2021-05-06
HK1250676A1 (zh) 2019-01-11
CN107708796A (zh) 2018-02-16

Similar Documents

Publication Publication Date Title
JP2021191422A (ja) 治療学的物質の局所的送達を制御する電気穿孔法システム
US10994133B2 (en) Methods for enhancing and modulating reversible and irreversible electroporation lesions by manipulating pulse waveforms
JP5059786B2 (ja) 単針生体内エレクトロポレーションのための装置および方法
US8936630B2 (en) Optical stimulation therapy
AU734611B2 (en) Electrodes and electrode arrays
US11351368B2 (en) Megahertz compression of nanosecond pulse bursts
WO2019139883A1 (en) Methods and systems for stimulation for glial modulation
Hart et al. The Application of Electric Fields in Biology and
CA2478614C (en) Electromanipulation device and method
WO2014201511A1 (en) Method and apparatus for close-field electroporation
Henry et al. Review of neuromodulation techniques and technological limitations
JP7651191B2 (ja) 電気導入による治療用物質の送達装置、システム及び方法
Lau et al. A novel ex vivo assay to define charge-balanced electrical stimulation parameters for neural precursor cell activation in vivo
Kim et al. Micro‐Coil Neuromodulation at Single‐Cell and Circuit Levels for Inhibiting Natural Neuroactivity, Neutralizing Electric Neural Excitation, and Suppressing Seizures
US11497913B1 (en) Micro-fabricated electrode arrays with flexible substrate for highly charge-efficient and selective stimulation of nerve tissue
Tzoneva Influence of electric field on cell behavior. Electrotreatment of cells for biomedical applications
Gupta et al. Electrical stimulation: Biological insights and therapeutic applications
HK1250676B (en) Electroporation system for controlled localized therapeutics delivery
Lai Development and Characterisation of Gene Electrotransfer Hardware and Protocols Directed to the Treatment of Parkinson's Disease
Karkhaneh et al. Electrical and Physical Stimulation in Tissue Engineering
WO2017035682A1 (en) Magnetogenetics and uses thereof
Dev Neuromodulation of the Gut-Brain Axis and Its Influence on Sleep in Space
WO2025179289A1 (en) Transcranial magnetic stimulation implants and methods of use
Loudin et al. Delivery of information and power to the implant, integration of the electrode array with the retina, and safety of chronic stimulation
HK40052647B (en) Megahertz compression of nanosecond pulse bursts

Legal Events

Date Code Title Description
A529 Written submission of copy of amendment under article 34 pct

Free format text: JAPANESE INTERMEDIATE CODE: A529

Effective date: 20180213

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190522

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190522

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200629

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200721

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201019

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20210420

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210819

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20210819

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20210820

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20210929

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20211005

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20211130

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20211201

R150 Certificate of patent or registration of utility model

Ref document number: 6987642

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250