CN107708796B - 用于控制性局部治疗剂递送的电穿孔系统 - Google Patents

用于控制性局部治疗剂递送的电穿孔系统 Download PDF

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Publication number
CN107708796B
CN107708796B CN201680037448.8A CN201680037448A CN107708796B CN 107708796 B CN107708796 B CN 107708796B CN 201680037448 A CN201680037448 A CN 201680037448A CN 107708796 B CN107708796 B CN 107708796B
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China
Prior art keywords
electroporation
probe
electric field
array
electrode
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CN201680037448.8A
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English (en)
Chinese (zh)
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CN107708796A (zh
Inventor
G·D·休斯利
N·H·洛弗尔
J·品尤
E·N·克劳福德
C·布朗
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NewSouth Innovations Pty Ltd
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NewSouth Innovations Pty Ltd
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Priority claimed from AU2015902456A external-priority patent/AU2015902456A0/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0541—Cochlear electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056—Transvascular endocardial electrode systems
    • A61N1/057—Anchoring means; Means for fixing the head inside the heart
    • A61N1/0573—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook
    • A61N1/0575—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00107—Coatings on the energy applicator
    • A61B2018/00154—Coatings on the energy applicator containing and delivering drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00767—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Neurology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Robotics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
CN201680037448.8A 2015-06-25 2016-06-24 用于控制性局部治疗剂递送的电穿孔系统 Active CN107708796B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015902456 2015-06-25
AU2015902456A AU2015902456A0 (en) 2015-06-25 Electroporation system for controlled localized therapeutics delivery
PCT/AU2016/050546 WO2016205895A1 (en) 2015-06-25 2016-06-24 Electroporation system for controlled localized therapeutics delivery

Publications (2)

Publication Number Publication Date
CN107708796A CN107708796A (zh) 2018-02-16
CN107708796B true CN107708796B (zh) 2021-10-26

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CN201680037448.8A Active CN107708796B (zh) 2015-06-25 2016-06-24 用于控制性局部治疗剂递送的电穿孔系统

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Country Link
US (1) US11213671B2 (enExample)
EP (1) EP3313505A4 (enExample)
JP (2) JP6987642B2 (enExample)
CN (1) CN107708796B (enExample)
AU (1) AU2016282210B2 (enExample)
NZ (1) NZ737871A (enExample)
WO (1) WO2016205895A1 (enExample)

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JP6987642B2 (ja) * 2015-06-25 2022-01-05 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 治療学的物質の局所的送達を制御する電気穿孔法システム
DE102016110137A1 (de) * 2016-06-01 2017-12-07 Medizinische Hochschule Hannover Formadaptives medizinisches Implantat sowie Verwendung einer elektrischen Signalquelle
EP3366653A1 (en) * 2017-02-23 2018-08-29 Ibanez Botella, Juan Miguel System for water disinfection using electroporation
GB2568287A (en) 2017-11-10 2019-05-15 Sisaf Ltd Apparatus and methods for the transdermal delivery of active agents
CN109893244B (zh) * 2017-12-08 2024-04-19 Igea有限公司 电穿孔过程使用的手持件的可扩展电极的操纵和控制系统
CN111869238B (zh) * 2018-03-13 2022-05-13 科利耳有限公司 耳蜗中的电场使用方法及系统
US11376423B2 (en) 2018-05-15 2022-07-05 Cochlear Limited Medical electroporation
CN109157280A (zh) * 2018-08-10 2019-01-08 重庆大学 不可逆电穿孔组织消融效果动态实时评估设备
JP7489116B2 (ja) * 2018-12-13 2024-05-23 ニューサウス イノヴェイションズ プロプライエタリィ リミティッド 分子エレクトロトランスファーを制御するための方法及びシステム
CA3124709C (en) * 2019-02-04 2025-04-08 Univ Rutgers DEVICE AND METHOD FOR ELECTROTRANSFERRING TISSUE USING A MICROELECTRODE
ES2913759T3 (es) * 2019-06-13 2022-06-06 Lonza Cologne Gmbh Método y dispositivo para controlar el nivel de llenado en una cámara
AU2020367208A1 (en) * 2019-10-18 2022-04-14 Newsouth Innovations Pty Limited Electrotransfer therapeutic delivery device, system and method
US11690671B1 (en) * 2022-12-09 2023-07-04 Field Medical, Inc. Tissue ablation catheter with an insulator between inner and outer electrodes
US12329447B2 (en) 2022-12-09 2025-06-17 Field Medical, Inc. Tissue ablation catheter with an insulator between inner and outer electrodes
CN119950008A (zh) * 2025-02-05 2025-05-09 天津市鹰泰利安康医疗科技有限责任公司 一种用于软骨组织的不可逆电穿孔重生的智能化控制方法及系统

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US7127284B2 (en) * 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
US8209006B2 (en) 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
EP1682217A4 (en) * 2003-11-13 2008-04-30 Alza Corp SYSTEM UDN PROCEDURE FOR THE TRANSDERMAL LEVY
JP2006296511A (ja) * 2005-04-15 2006-11-02 Transcutaneous Technologies Inc 外用剤、外用剤の塗布方法、イオントフォレーシス装置及び経皮パッチ
US20080045880A1 (en) * 2006-02-11 2008-02-21 Rune Kjeken Device and method for single-needle in vivo electroporation
EP1981581B1 (en) * 2006-02-11 2016-04-13 Genetronics, Inc. Device for single-needle in vivo electroporation
US9198733B2 (en) * 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US20120191032A1 (en) 2009-07-15 2012-07-26 Newsouth Innovations Pty. Limited Method of providing agents to the cochlea
US20120089009A1 (en) * 2010-10-11 2012-04-12 Omary Reed A Methods and apparatus to deliver nanoparticles to tissue using electronanotherapy
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CN102329819B (zh) * 2011-09-27 2012-12-19 西北农林科技大学 一种siRNA 转染哺乳类动物胚胎的电穿孔方法
US11013917B2 (en) * 2013-06-21 2021-05-25 Newsouth Innovations Pty Limited Method and apparatus for close-field electroporation
JP6987642B2 (ja) * 2015-06-25 2022-01-05 ニューサウス・イノベーションズ・ピーティーワイ・リミテッド 治療学的物質の局所的送達を制御する電気穿孔法システム

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Also Published As

Publication number Publication date
JP2021191422A (ja) 2021-12-16
CN107708796A (zh) 2018-02-16
WO2016205895A1 (en) 2016-12-29
EP3313505A1 (en) 2018-05-02
HK1250676A1 (zh) 2019-01-11
AU2016282210A1 (en) 2017-12-21
EP3313505A4 (en) 2018-06-06
NZ737871A (en) 2023-02-24
JP6987642B2 (ja) 2022-01-05
US20180169399A1 (en) 2018-06-21
JP2018518314A (ja) 2018-07-12
US11213671B2 (en) 2022-01-04
AU2016282210B2 (en) 2021-05-06

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