AU2016282210B2 - Electroporation system for controlled localized therapeutics delivery - Google Patents

Electroporation system for controlled localized therapeutics delivery Download PDF

Info

Publication number
AU2016282210B2
AU2016282210B2 AU2016282210A AU2016282210A AU2016282210B2 AU 2016282210 B2 AU2016282210 B2 AU 2016282210B2 AU 2016282210 A AU2016282210 A AU 2016282210A AU 2016282210 A AU2016282210 A AU 2016282210A AU 2016282210 B2 AU2016282210 B2 AU 2016282210B2
Authority
AU
Australia
Prior art keywords
electroporation
probe
electrodes
array
electric field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2016282210A
Other languages
English (en)
Other versions
AU2016282210A1 (en
Inventor
Cherylea BROWNE
Edward Norman CRAWFORD
Gary David Housley
Nigel Hamilton Lovell
Jeremy PINYON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NewSouth Innovations Pty Ltd
Original Assignee
NewSouth Innovations Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2015902456A external-priority patent/AU2015902456A0/en
Application filed by NewSouth Innovations Pty Ltd filed Critical NewSouth Innovations Pty Ltd
Publication of AU2016282210A1 publication Critical patent/AU2016282210A1/en
Application granted granted Critical
Publication of AU2016282210B2 publication Critical patent/AU2016282210B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0541—Cochlear electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056—Transvascular endocardial electrode systems
    • A61N1/057—Anchoring means; Means for fixing the head inside the heart
    • A61N1/0573—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook
    • A61N1/0575—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00107—Coatings on the energy applicator
    • A61B2018/00154—Coatings on the energy applicator containing and delivering drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00767—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Neurology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Robotics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
AU2016282210A 2015-06-25 2016-06-24 Electroporation system for controlled localized therapeutics delivery Active AU2016282210B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015902456 2015-06-25
AU2015902456A AU2015902456A0 (en) 2015-06-25 Electroporation system for controlled localized therapeutics delivery
PCT/AU2016/050546 WO2016205895A1 (en) 2015-06-25 2016-06-24 Electroporation system for controlled localized therapeutics delivery

Publications (2)

Publication Number Publication Date
AU2016282210A1 AU2016282210A1 (en) 2017-12-21
AU2016282210B2 true AU2016282210B2 (en) 2021-05-06

Family

ID=57584417

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016282210A Active AU2016282210B2 (en) 2015-06-25 2016-06-24 Electroporation system for controlled localized therapeutics delivery

Country Status (7)

Country Link
US (1) US11213671B2 (cg-RX-API-DMAC7.html)
EP (1) EP3313505A4 (cg-RX-API-DMAC7.html)
JP (2) JP6987642B2 (cg-RX-API-DMAC7.html)
CN (1) CN107708796B (cg-RX-API-DMAC7.html)
AU (1) AU2016282210B2 (cg-RX-API-DMAC7.html)
NZ (1) NZ737871A (cg-RX-API-DMAC7.html)
WO (1) WO2016205895A1 (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ737871A (en) * 2015-06-25 2023-02-24 Newsouth Innovations Pty Ltd Electroporation system for controlled localized therapeutics delivery
DE102016110137A1 (de) * 2016-06-01 2017-12-07 Medizinische Hochschule Hannover Formadaptives medizinisches Implantat sowie Verwendung einer elektrischen Signalquelle
EP3366653A1 (en) * 2017-02-23 2018-08-29 Ibanez Botella, Juan Miguel System for water disinfection using electroporation
GB2568287A (en) 2017-11-10 2019-05-15 Sisaf Ltd Apparatus and methods for the transdermal delivery of active agents
CN109893244B (zh) * 2017-12-08 2024-04-19 Igea有限公司 电穿孔过程使用的手持件的可扩展电极的操纵和控制系统
US12005254B2 (en) 2018-03-13 2024-06-11 Cochlear Limited Electrical field usage in cochleas
US11376423B2 (en) 2018-05-15 2022-07-05 Cochlear Limited Medical electroporation
CN109157280A (zh) * 2018-08-10 2019-01-08 重庆大学 不可逆电穿孔组织消融效果动态实时评估设备
AU2019396834B2 (en) * 2018-12-13 2025-07-31 Newsouth Innovations Pty Limited Method and system for controlling molecular electrotransfer
EP3750983B1 (en) * 2019-06-13 2022-02-23 Lonza Cologne GmbH Method and device for controlling the filling level in a chamber
EP4045137B1 (en) 2019-10-18 2025-04-30 NewSouth Innovations Pty Limited Electrotransfer therapeutic delivery device and system
CN115420911B (zh) * 2022-07-22 2025-12-23 华东理工大学 一种利用扫描电化学显微镜（secm）检测不可逆电穿孔程度的方法
US11690671B1 (en) * 2022-12-09 2023-07-04 Field Medical, Inc. Tissue ablation catheter with an insulator between inner and outer electrodes
US12329447B2 (en) 2022-12-09 2025-06-17 Field Medical, Inc. Tissue ablation catheter with an insulator between inner and outer electrodes
CN119950008A (zh) * 2025-02-05 2025-05-09 天津市鹰泰利安康医疗科技有限责任公司 一种用于软骨组织的不可逆电穿孔重生的智能化控制方法及系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014201511A1 (en) * 2013-06-21 2014-12-24 Gary David Housley Method and apparatus for close-field electroporation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7127284B2 (en) * 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
BRPI0416044A (pt) * 2003-11-13 2007-01-02 Alza Corp sistema e método para distribuição transdérmica
JP2006296511A (ja) * 2005-04-15 2006-11-02 Transcutaneous Technologies Inc 外用剤、外用剤の塗布方法、イオントフォレーシス装置及び経皮パッチ
CA3063263C (en) * 2006-02-11 2024-01-16 Genetronics, Inc. Device and method for single-needle in vivo electroporation
US20080045880A1 (en) * 2006-02-11 2008-02-21 Rune Kjeken Device and method for single-needle in vivo electroporation
US9198733B2 (en) * 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
EP2453856B1 (en) 2009-07-15 2019-02-20 NewSouth Innovations Pty Limited Agent provided to the cochlea and cochlear implant
US20120089009A1 (en) * 2010-10-11 2012-04-12 Omary Reed A Methods and apparatus to deliver nanoparticles to tissue using electronanotherapy
KR102081868B1 (ko) * 2011-06-28 2020-02-26 이노비오 파마수티컬즈, 인크. 최소 침습 피부 전기천공 장치
CN102329819B (zh) * 2011-09-27 2012-12-19 西北农林科技大学 一种siRNA 转染哺乳类动物胚胎的电穿孔方法
NZ737871A (en) * 2015-06-25 2023-02-24 Newsouth Innovations Pty Ltd Electroporation system for controlled localized therapeutics delivery

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014201511A1 (en) * 2013-06-21 2014-12-24 Gary David Housley Method and apparatus for close-field electroporation

Also Published As

Publication number Publication date
JP2018518314A (ja) 2018-07-12
EP3313505A4 (en) 2018-06-06
AU2016282210A1 (en) 2017-12-21
HK1250676A1 (zh) 2019-01-11
JP6987642B2 (ja) 2022-01-05
US11213671B2 (en) 2022-01-04
US20180169399A1 (en) 2018-06-21
CN107708796A (zh) 2018-02-16
CN107708796B (zh) 2021-10-26
NZ737871A (en) 2023-02-24
WO2016205895A1 (en) 2016-12-29
EP3313505A1 (en) 2018-05-02
JP2021191422A (ja) 2021-12-16

Similar Documents

Publication Publication Date Title
AU2016282210B2 (en) Electroporation system for controlled localized therapeutics delivery
JP5059786B2 (ja) 単針生体内エレクトロポレーションのための装置および方法
AU734611B2 (en) Electrodes and electrode arrays
ES2902988T3 (es) Electrodo y procedimiento de electropermeabilización sin contacto
EP3737464A1 (en) Methods and systems for stimulation for glial modulation
Hart et al. The Application of Electric Fields in Biology and
US20210330371A1 (en) Methods, systems, and apparatuses for tissue ablation using a modulated exponential decay pulse
JP2023543301A (ja) 腫瘍治療電場を形成するための植込み可能アレイ
WO2014201511A1 (en) Method and apparatus for close-field electroporation
WO2005123183A2 (en) Electroporation device and method for delivery to ocular tissue
CA2478614C (en) Electromanipulation device and method
JP7651191B2 (ja) 電気導入による治療用物質の送達装置、システム及び方法
US20240238450A1 (en) Electroporation gene therapy for tissue barriers
US11497913B1 (en) Micro-fabricated electrode arrays with flexible substrate for highly charge-efficient and selective stimulation of nerve tissue
AU2019396834B2 (en) Method and system for controlling molecular electrotransfer
HK1250676B (zh) 用於控制性局部治疗剂递送的电穿孔系统
Pinyon et al. Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics:“A Spoonful of Sugar Helps the Medicine Go Down”
Housley et al. Cochlear implant close-field electroporation
Lai Development and Characterisation of Gene Electrotransfer Hardware and Protocols Directed to the Treatment of Parkinson's Disease
Housley et al. Cochlear Implant Close-Field Electroporation
Hoff et al. Electromanipulation device and method
Hoff et al. Electromanipulation method
Mir Electrochemotherapy and Electric Pulses
MX2008008981A (es) Dispositivo y metodo para electropermeacion in vivo de una sola aguja

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)