AU2015364253B2 - Synergistic co-administration of computationally optimized broadly reactive antigens for H1N1 influenza - Google Patents
Synergistic co-administration of computationally optimized broadly reactive antigens for H1N1 influenza Download PDFInfo
- Publication number
- AU2015364253B2 AU2015364253B2 AU2015364253A AU2015364253A AU2015364253B2 AU 2015364253 B2 AU2015364253 B2 AU 2015364253B2 AU 2015364253 A AU2015364253 A AU 2015364253A AU 2015364253 A AU2015364253 A AU 2015364253A AU 2015364253 B2 AU2015364253 B2 AU 2015364253B2
- Authority
- AU
- Australia
- Prior art keywords
- administration
- influenza
- synergistic
- reactive antigens
- computationally optimized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 206010069767 H1N1 influenza Diseases 0.000 title abstract 4
- 201000010740 swine influenza Diseases 0.000 title abstract 4
- 238000011260 co-administration Methods 0.000 title abstract 3
- 230000002195 synergetic effect Effects 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 101710154606 Hemagglutinin Proteins 0.000 abstract 4
- 101710093908 Outer capsid protein VP4 Proteins 0.000 abstract 4
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 abstract 4
- 101710176177 Protein A56 Proteins 0.000 abstract 4
- 239000000185 hemagglutinin Substances 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 230000001932 seasonal effect Effects 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094772P | 2014-12-19 | 2014-12-19 | |
| US62/094,772 | 2014-12-19 | ||
| PCT/US2015/066882 WO2016100922A1 (en) | 2014-12-19 | 2015-12-18 | Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015364253A1 AU2015364253A1 (en) | 2017-06-29 |
| AU2015364253B2 true AU2015364253B2 (en) | 2020-01-23 |
Family
ID=56127736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015364253A Ceased AU2015364253B2 (en) | 2014-12-19 | 2015-12-18 | Synergistic co-administration of computationally optimized broadly reactive antigens for H1N1 influenza |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10220086B2 (https=) |
| EP (1) | EP3233116A4 (https=) |
| JP (2) | JP6764408B2 (https=) |
| CN (1) | CN107530417A (https=) |
| AU (1) | AU2015364253B2 (https=) |
| CA (1) | CA2970158A1 (https=) |
| WO (1) | WO2016100922A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2970158A1 (en) * | 2014-12-19 | 2016-06-23 | Oregon Health & Science University | Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza |
| ES2991988T3 (es) | 2017-10-30 | 2024-12-05 | Takeda Pharmaceuticals Co | Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica |
| WO2019108319A1 (en) * | 2017-12-01 | 2019-06-06 | Kemin Industries, Inc. | Compositions containing euglena gracilis for viral protection and related methods |
| US12521430B2 (en) | 2018-03-28 | 2026-01-13 | Sanofi Pasteur Inc. | Methods of generating broadly protective vaccine compositions comprising neuraminidase |
| WO2020092207A1 (en) * | 2018-10-28 | 2020-05-07 | University Of Georgia Research Foundation | Broadly reactive immunogens of influenza virus, compositions, and methods of use thereof |
| JP2024522193A (ja) * | 2021-06-10 | 2024-06-11 | ユニバーシティ オブ ジョージア リサーチ ファウンデイション， インコーポレイテッド | 免疫原としての広範囲反応性ウイルス抗原、その組成物及び使用方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100221284A1 (en) * | 2001-05-30 | 2010-09-02 | Saech-Sisches Serumwerk Dresden | Novel vaccine composition |
| USH2283H1 (en) * | 2009-04-27 | 2013-09-03 | Novartis Ag | Vaccines for protecting against influenza |
| CA2868330A1 (en) * | 2012-03-30 | 2013-10-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses |
| SG11201503989PA (en) * | 2012-11-27 | 2015-06-29 | Univ Pittsburgh | Computationally optimized broadly reactive antigens for h1n1 influenza |
| KR20150138184A (ko) * | 2013-02-11 | 2015-12-09 | 노바백스, 인코포레이티드 | 호흡기 세포 융합 바이러스 및 인플루엔자를 위한 조합 백신 |
| CA2970158A1 (en) * | 2014-12-19 | 2016-06-23 | Oregon Health & Science University | Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza |
| US10927151B2 (en) | 2015-06-09 | 2021-02-23 | Sanofi Pasteur Inc. | Methods of optimizing nucleotide sequences encoding engineered influenza proteins |
| US20200237898A1 (en) * | 2015-09-21 | 2020-07-30 | Oregon Health & Science University | Vaccines intelligently produced by epitope recombination (viper) for influenza |
-
2015
- 2015-12-18 CA CA2970158A patent/CA2970158A1/en not_active Abandoned
- 2015-12-18 CN CN201580076587.7A patent/CN107530417A/zh active Pending
- 2015-12-18 AU AU2015364253A patent/AU2015364253B2/en not_active Ceased
- 2015-12-18 EP EP15871236.4A patent/EP3233116A4/en not_active Withdrawn
- 2015-12-18 WO PCT/US2015/066882 patent/WO2016100922A1/en not_active Ceased
- 2015-12-18 US US15/537,081 patent/US10220086B2/en active Active
- 2015-12-18 JP JP2017533485A patent/JP6764408B2/ja not_active Expired - Fee Related
-
2019
- 2019-01-25 US US16/258,094 patent/US10925957B2/en not_active Expired - Fee Related
-
2020
- 2020-08-03 JP JP2020131336A patent/JP2020186252A/ja active Pending
Non-Patent Citations (1)
| Title |
|---|
| B. M. GILES ET AL, A Computationally Optimized Hemagglutinin Virus-Like Particle Vaccine Elicits Broadly Reactive Antibodies that Protect Nonhuman Primates from H5N1 Infection, THE JOURNAL OF INFECTIOUS DISEASES, 2012, vol. 205(10), pg 1562 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20170368164A1 (en) | 2017-12-28 |
| JP6764408B2 (ja) | 2020-09-30 |
| WO2016100922A1 (en) | 2016-06-23 |
| JP2020186252A (ja) | 2020-11-19 |
| CA2970158A1 (en) | 2016-06-23 |
| EP3233116A1 (en) | 2017-10-25 |
| US20190175721A1 (en) | 2019-06-13 |
| US10925957B2 (en) | 2021-02-23 |
| US10220086B2 (en) | 2019-03-05 |
| JP2018501258A (ja) | 2018-01-18 |
| CN107530417A (zh) | 2018-01-02 |
| AU2015364253A1 (en) | 2017-06-29 |
| EP3233116A4 (en) | 2018-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2016100926A8 (en) | Synergistic co-administration of computationally optimized broadly reactive antigens for human and avian h5n1 influenza | |
| MX2020013153A (es) | Metodos y composiciones para inducir inmunidad protectora contra la infeccion por virus de inmunodeficiencia humana. | |
| AU2015364253B2 (en) | Synergistic co-administration of computationally optimized broadly reactive antigens for H1N1 influenza | |
| EP4691484A3 (en) | Influenza mrna vaccines | |
| MX2021006931A (es) | Antigenos del virus de la inmunodeficiencia humana, vectores, composiciones y metodos de uso de estos. | |
| AU2015286723B2 (en) | Influenza virus vaccines and uses thereof | |
| MX2021001053A (es) | Vacunas contra virus de la influenza y sus usos. | |
| MX342716B (es) | Vacunas para su uso en la profilaxis y tratamiento de la enfermedad del virus de influenza. | |
| AU2015286721B2 (en) | Influenza virus vaccines and uses thereof | |
| PH12019501569A1 (en) | Universal influenza vaccine compositions | |
| PH12014500369A1 (en) | Influenza h5 vaccines | |
| NZ739260A (en) | Inactivated canine influenza vaccines and methods of making and uses thereof | |
| MY183072A (en) | Methods and compositions for inducing protective immunity against filovirus infection | |
| EP3939604A3 (en) | Influenza hemagglutinin protein vaccines | |
| WO2015195218A8 (en) | Polyvalent influenza virus-like particles (vlps) and use as vaccines | |
| EA201290897A1 (ru) | Вакцины для пандемического гриппа | |
| EP3599247A3 (en) | Recombinant hemagglutinin protein of influenza virus and vaccine containing the same | |
| MX2015010763A (es) | Proteinas h5 del virus de la gripe h5n1 para uso como un medicamento. | |
| IL259451A (en) | Live virus with accumulation of dengue fever of a weakened nature and vaccination of dengue fever containing identical antigens | |
| ZA201700164B (en) | Influenza virus vaccines and uses thereof | |
| HK40013539A (en) | Signature-based human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using the same | |
| HK1173963A (en) | Vaccines for pandemic influenza |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |