AU2015360360B2 - Substituted 2-anilinopyrimidine derivatives as EGFR modulators - Google Patents
Substituted 2-anilinopyrimidine derivatives as EGFR modulators Download PDFInfo
- Publication number
- AU2015360360B2 AU2015360360B2 AU2015360360A AU2015360360A AU2015360360B2 AU 2015360360 B2 AU2015360360 B2 AU 2015360360B2 AU 2015360360 A AU2015360360 A AU 2015360360A AU 2015360360 A AU2015360360 A AU 2015360360A AU 2015360360 B2 AU2015360360 B2 AU 2015360360B2
- Authority
- AU
- Australia
- Prior art keywords
- cancer
- methyl
- pharmaceutically acceptable
- compound
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- SEGWIIQNKLKQQT-UHFFFAOYSA-N CN(C)CCCc(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c2n[n](C)c3ccccc23)ccn1 Chemical compound CN(C)CCCc(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c2n[n](C)c3ccccc23)ccn1 SEGWIIQNKLKQQT-UHFFFAOYSA-N 0.000 description 3
- JFHZBQRUZXXWCG-UHFFFAOYSA-N CCOc(cc(c(NC(C=C)=O)c1)OCCN(C)C)c1Nc1nc(-c2c[nH]c3ccccc23)ccn1 Chemical compound CCOc(cc(c(NC(C=C)=O)c1)OCCN(C)C)c1Nc1nc(-c2c[nH]c3ccccc23)ccn1 JFHZBQRUZXXWCG-UHFFFAOYSA-N 0.000 description 2
- OAXQKPPMQLREDM-UHFFFAOYSA-N CN(C)CCCc(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c2c(cccc3)[n]3nc2)ccn1 Chemical compound CN(C)CCCc(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c2c(cccc3)[n]3nc2)ccn1 OAXQKPPMQLREDM-UHFFFAOYSA-N 0.000 description 2
- ZRQMURIELJVSCH-UHFFFAOYSA-N CN(C)CCOc(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c2n[n](C)c3ccccc23)ccn1 Chemical compound CN(C)CCOc(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c2n[n](C)c3ccccc23)ccn1 ZRQMURIELJVSCH-UHFFFAOYSA-N 0.000 description 2
- KHOYUEASLIXESL-UHFFFAOYSA-N CCCCc(cc(c(Nc1nc(-c2c[n](C)c3ccccc23)ccn1)c1)OC)c1NC(C=C)=O Chemical compound CCCCc(cc(c(Nc1nc(-c2c[n](C)c3ccccc23)ccn1)c1)OC)c1NC(C=C)=O KHOYUEASLIXESL-UHFFFAOYSA-N 0.000 description 1
- UTDICVFAOMSHNP-UHFFFAOYSA-N C[n]1nc(cccc2)c2c1-c1ccnc(Nc(c(OC)c2)cc(NC(C(Cl)=C)=O)c2OC)n1 Chemical compound C[n]1nc(cccc2)c2c1-c1ccnc(Nc(c(OC)c2)cc(NC(C(Cl)=C)=O)c2OC)n1 UTDICVFAOMSHNP-UHFFFAOYSA-N 0.000 description 1
- NEKLIYWZWBTFEE-UHFFFAOYSA-N Cc([n](C)c1ccccc11)c1-c1ccnc(Nc(cc(c(OCCN(C)C)c2)NC(C=C)=O)c2OC)n1 Chemical compound Cc([n](C)c1ccccc11)c1-c1ccnc(Nc(cc(c(OCCN(C)C)c2)NC(C=C)=O)c2OC)n1 NEKLIYWZWBTFEE-UHFFFAOYSA-N 0.000 description 1
- GVVYBCFPHBMQMN-UHFFFAOYSA-N Cc([n](C)c1ccccc11)c1-c1ccnc(Nc(cc2NC(C=C)=O)c(C)cc2OCCN(C)C)n1 Chemical compound Cc([n](C)c1ccccc11)c1-c1ccnc(Nc(cc2NC(C=C)=O)c(C)cc2OCCN(C)C)n1 GVVYBCFPHBMQMN-UHFFFAOYSA-N 0.000 description 1
- GWSMZIXYBWKXEI-UHFFFAOYSA-N Cc([n](C)c1ccccc11)c1-c1ccnc(Nc2cc(NC(C(Cl)=C)=O)c(CCCN(C)C)cc2OC)n1 Chemical compound Cc([n](C)c1ccccc11)c1-c1ccnc(Nc2cc(NC(C(Cl)=C)=O)c(CCCN(C)C)cc2OC)n1 GWSMZIXYBWKXEI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462090869P | 2014-12-11 | 2014-12-11 | |
| US62/090,869 | 2014-12-11 | ||
| US201562166883P | 2015-05-27 | 2015-05-27 | |
| US62/166,883 | 2015-05-27 | ||
| PCT/US2015/065286 WO2016094821A2 (en) | 2014-12-11 | 2015-12-11 | Substituted 2-anilinopyrimidine derivatives as egfr modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015360360A1 AU2015360360A1 (en) | 2017-06-08 |
| AU2015360360B2 true AU2015360360B2 (en) | 2020-06-25 |
Family
ID=56108380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015360360A Active AU2015360360B2 (en) | 2014-12-11 | 2015-12-11 | Substituted 2-anilinopyrimidine derivatives as EGFR modulators |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10590111B2 (enExample) |
| EP (1) | EP3229798A4 (enExample) |
| JP (2) | JP6709786B2 (enExample) |
| KR (1) | KR20170098865A (enExample) |
| CN (3) | CN112457298B (enExample) |
| AU (1) | AU2015360360B2 (enExample) |
| BR (1) | BR112017012272A2 (enExample) |
| CA (1) | CA2970185C (enExample) |
| CO (1) | CO2017006962A2 (enExample) |
| EA (1) | EA036453B1 (enExample) |
| HK (1) | HK1245634A1 (enExample) |
| IL (1) | IL252554A0 (enExample) |
| MX (1) | MX382869B (enExample) |
| PH (1) | PH12017501057A1 (enExample) |
| SG (2) | SG11201704685TA (enExample) |
| TW (1) | TWI618704B (enExample) |
| WO (1) | WO2016094821A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105085489B (zh) | 2014-11-05 | 2019-03-01 | 益方生物科技（上海）有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
| WO2016094821A2 (en) * | 2014-12-11 | 2016-06-16 | Beta Pharma, Inc. | Substituted 2-anilinopyrimidine derivatives as egfr modulators |
| MX2018013602A (es) | 2016-05-11 | 2019-08-22 | Beta Pharma Inc | Derivados de 2-anilinopirimidina como agentes terapeuticos para el tratamiento de canceres cerebrales. |
| SG11201809751XA (en) | 2016-05-26 | 2018-12-28 | Zeno Royalties & Milestones Llc | Egfr inhibitor compounds |
| TW201800404A (zh) * | 2016-06-17 | 2018-01-01 | 貝達醫藥公司 | N-(2-(2-(二甲基胺基)乙氧基)-4-甲氧基-5-((4-(1-甲基-1h-吲哚-3-基)嘧啶-2-基)胺基)苯基)丙烯醯胺及其結晶型式之醫藥鹽 |
| CN106243044A (zh) * | 2016-06-30 | 2016-12-21 | 浙江大学 | 含卤代丙烯酰胺侧链的嘧啶类衍生物及制备和应用 |
| JP6740452B2 (ja) * | 2016-07-26 | 2020-08-12 | 深▲セン▼市塔吉瑞生物医▲薬▼有限公司Ｓｈｅｎｚｈｅｎ ＴａｒｇｅｔＲｘ，Ｉｎｃ． | プロテインチロシンキナーゼの活性を阻害するためのアミノピリミジン系化合物 |
| TW201904577A (zh) | 2017-06-16 | 2019-02-01 | 美商貝達醫藥公司 | N-(2-(2-二甲胺基)乙氧基)-4-甲氧基-5-((4-(1-甲基-1h-吲哚-3-基)嘧啶-2-基)胺基)苯基)丙烯醯胺及其鹽之醫藥調配物 |
| CN109503573A (zh) * | 2017-09-14 | 2019-03-22 | 昆明圣加南生物科技有限公司 | 2-取代苯胺基嘧啶衍生物及其用途 |
| CN107935995A (zh) * | 2017-11-28 | 2018-04-20 | 中山大学 | 一种新型2‑苯胺基嘧啶衍生物及其在制备抗肿瘤药物中的应用 |
| CN108017633A (zh) * | 2018-01-30 | 2018-05-11 | 天津大学 | N-[5-(嘧啶-2-氨基)-2,4-二取代苯基]-2-氟代丙烯酰胺衍生物及应用 |
| SG11202012312UA (en) * | 2018-06-18 | 2021-01-28 | UCB Biopharma SRL | Gremlin-1 antagonist for the prevention and treatment of cancer |
| CA3112043A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| EP4034121A4 (en) * | 2019-09-23 | 2023-10-18 | Beta Pharma, Inc. | TREATMENT OF EGFR MUTANT-RELATED CANCERS USING A COMBINATION OF EGFR AND CDK4/6 INHIBITORS |
| US20210161897A1 (en) | 2019-11-12 | 2021-06-03 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
| AU2021211871A1 (en) | 2020-01-20 | 2022-09-08 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
| US20210369709A1 (en) | 2020-05-27 | 2021-12-02 | Astrazeneca Ab | EGFR TKIs FOR USE IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER |
| JP2024527402A (ja) * | 2021-07-13 | 2024-07-24 | エイシア セラピューティクス， インコーポレイテッド | 複素環式化合物およびその用途 |
| IL315848A (en) | 2022-03-31 | 2024-11-01 | Astrazeneca Ab | Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in combination with an AKT inhibitor for cancer treatment |
| US20240116926A1 (en) | 2022-04-28 | 2024-04-11 | Astrazeneca Ab | Heteroaromatic compounds |
| CA3249080A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Condensed bicyclic heteroaromatic compounds and their use in the treatment of cancer |
| WO2023209088A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Bicyclic heteroaromatic compounds and their use in the treatment of cancer |
| WO2023209090A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Bicyclic heteroaromatic compounds and their application in the treatment of cancer |
| KR20250029133A (ko) | 2022-06-27 | 2025-03-04 | 아스트라제네카 아베 | 암 치료를 위한 표피성장인자 수용체 티로신 키나제 억제제를 포함하는 조합물 |
| CN119654152A (zh) | 2022-07-08 | 2025-03-18 | 阿斯利康(瑞典)有限公司 | 与hgf-受体抑制剂组合用于治疗癌症的表皮生长因子受体酪氨酸激酶抑制剂 |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001047922A2 (en) * | 1999-12-24 | 2001-07-05 | Aventis Pharma Limited | Azaindoles |
| US20080146565A1 (en) * | 2006-12-08 | 2008-06-19 | Roche Palo Alto Llc | JNK modulators |
| WO2010059711A1 (en) * | 2008-11-18 | 2010-05-27 | Wisconsin Alumni Research Foundation | Sigma-1 receptor ligands and methods of use |
| WO2010129053A2 (en) * | 2009-05-05 | 2010-11-11 | Dana Farber Cancer Institute | Egfr inhibitors and methods of treating disorders |
| US7943616B2 (en) * | 2001-06-21 | 2011-05-17 | Aventis Pharmaceuticals Inc. | Azaindoles for inhibiting aurora2 and other kinases |
| US20120316135A1 (en) * | 2011-05-04 | 2012-12-13 | Ariad Pharmaceuticals, Inc. | Compounds for Inhibiting Cell Proliferation in EGFR-Driven Cancers |
| WO2013014448A1 (en) * | 2011-07-27 | 2013-01-31 | Astrazeneca Ab | 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer |
| WO2015195228A1 (en) * | 2014-06-19 | 2015-12-23 | Ariad Pharmaceuticals, Inc. | Heteroaryl compounds for kinase inhibition |
| WO2016070816A1 (zh) * | 2014-11-05 | 2016-05-12 | 上海页岩科技有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013204563B2 (en) * | 2012-05-05 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| CN104860941B (zh) | 2014-02-25 | 2017-03-22 | 上海海雁医药科技有限公司 | 2,4‑二取代苯‑1,5‑二胺衍生物及其应用以及由其制备的药物组合物和药用组合物 |
| CN113121575A (zh) * | 2014-08-25 | 2021-07-16 | 四川海思科制药有限公司 | 一种(取代的苯基)(取代的嘧啶)胺基衍生物及其制备方法和药物用途 |
| CN105461695B (zh) | 2014-09-29 | 2018-03-27 | 齐鲁制药有限公司 | 嘧啶或三嗪衍生物及其制备方法和用途 |
| WO2016094821A2 (en) * | 2014-12-11 | 2016-06-16 | Beta Pharma, Inc. | Substituted 2-anilinopyrimidine derivatives as egfr modulators |
-
2015
- 2015-12-11 WO PCT/US2015/065286 patent/WO2016094821A2/en not_active Ceased
- 2015-12-11 BR BR112017012272-3A patent/BR112017012272A2/pt not_active IP Right Cessation
- 2015-12-11 EA EA201790921A patent/EA036453B1/ru unknown
- 2015-12-11 AU AU2015360360A patent/AU2015360360B2/en active Active
- 2015-12-11 CN CN202011112986.3A patent/CN112457298B/zh active Active
- 2015-12-11 CA CA2970185A patent/CA2970185C/en active Active
- 2015-12-11 JP JP2017530208A patent/JP6709786B2/ja active Active
- 2015-12-11 TW TW104141810A patent/TWI618704B/zh not_active IP Right Cessation
- 2015-12-11 HK HK18104991.1A patent/HK1245634A1/zh unknown
- 2015-12-11 SG SG11201704685TA patent/SG11201704685TA/en unknown
- 2015-12-11 SG SG10201909060S patent/SG10201909060SA/en unknown
- 2015-12-11 CN CN201580067776.8A patent/CN108024993B/zh active Active
- 2015-12-11 CN CN202011112988.2A patent/CN112375067B/zh active Active
- 2015-12-11 MX MX2017007664A patent/MX382869B/es unknown
- 2015-12-11 US US15/534,838 patent/US10590111B2/en active Active
- 2015-12-11 KR KR1020177019147A patent/KR20170098865A/ko not_active Ceased
- 2015-12-11 EP EP15867768.2A patent/EP3229798A4/en not_active Ceased
-
2017
- 2017-05-28 IL IL252554A patent/IL252554A0/en active IP Right Grant
- 2017-06-07 PH PH12017501057A patent/PH12017501057A1/en unknown
- 2017-07-11 CO CONC2017/0006962A patent/CO2017006962A2/es unknown
-
2020
- 2020-03-16 US US16/819,539 patent/US11414401B2/en active Active
- 2020-05-25 JP JP2020090467A patent/JP7181558B2/ja active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001047922A2 (en) * | 1999-12-24 | 2001-07-05 | Aventis Pharma Limited | Azaindoles |
| US7943616B2 (en) * | 2001-06-21 | 2011-05-17 | Aventis Pharmaceuticals Inc. | Azaindoles for inhibiting aurora2 and other kinases |
| US20080146565A1 (en) * | 2006-12-08 | 2008-06-19 | Roche Palo Alto Llc | JNK modulators |
| WO2010059711A1 (en) * | 2008-11-18 | 2010-05-27 | Wisconsin Alumni Research Foundation | Sigma-1 receptor ligands and methods of use |
| WO2010129053A2 (en) * | 2009-05-05 | 2010-11-11 | Dana Farber Cancer Institute | Egfr inhibitors and methods of treating disorders |
| US20120316135A1 (en) * | 2011-05-04 | 2012-12-13 | Ariad Pharmaceuticals, Inc. | Compounds for Inhibiting Cell Proliferation in EGFR-Driven Cancers |
| WO2013014448A1 (en) * | 2011-07-27 | 2013-01-31 | Astrazeneca Ab | 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer |
| US20130053409A1 (en) * | 2011-07-27 | 2013-02-28 | Astrazeneca Ab | 2-(2,4,5-substituted-anilino) pyrimidine compounds |
| WO2015195228A1 (en) * | 2014-06-19 | 2015-12-23 | Ariad Pharmaceuticals, Inc. | Heteroaryl compounds for kinase inhibition |
| WO2016070816A1 (zh) * | 2014-11-05 | 2016-05-12 | 上海页岩科技有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
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| Date | Code | Title | Description |
|---|---|---|---|
| HB | Alteration of name in register |
Owner name: BETA PHARMA, INC. Free format text: FORMER NAME(S): BETA PHARMA, INC. Owner name: BETA PHARMA (SHANGHAI) CO., LTD. Free format text: FORMER NAME(S): BETA PHARMA, INC. |
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| FGA | Letters patent sealed or granted (standard patent) |