AU2015356643B2 - Methods and compositions using Klotho variant polypeptides - Google Patents

Methods and compositions using Klotho variant polypeptides Download PDF

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Publication number
AU2015356643B2
AU2015356643B2 AU2015356643A AU2015356643A AU2015356643B2 AU 2015356643 B2 AU2015356643 B2 AU 2015356643B2 AU 2015356643 A AU2015356643 A AU 2015356643A AU 2015356643 A AU2015356643 A AU 2015356643A AU 2015356643 B2 AU2015356643 B2 AU 2015356643B2
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klotho
seq
polypeptide
fgf23
fusion
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AU2015356643A1 (en
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Donglin Guo
Chikwendu Ibebunjo
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01031—Beta-glucuronidase (3.2.1.31)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Biophysics (AREA)
  • Hematology (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
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AU2015356643A 2014-12-04 2015-12-02 Methods and compositions using Klotho variant polypeptides Ceased AU2015356643B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462087516P 2014-12-04 2014-12-04
US62/087,516 2014-12-04
PCT/IB2015/059294 WO2016088059A1 (en) 2014-12-04 2015-12-02 Methods and compositions using klotho variant polypeptides

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AU2015356643A1 AU2015356643A1 (en) 2017-06-22
AU2015356643B2 true AU2015356643B2 (en) 2019-01-24

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AU2015356643A Ceased AU2015356643B2 (en) 2014-12-04 2015-12-02 Methods and compositions using Klotho variant polypeptides

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US (2) US10654909B2 (OSRAM)
EP (1) EP3227319B1 (OSRAM)
JP (1) JP2017537926A (OSRAM)
KR (1) KR20170084332A (OSRAM)
CN (1) CN107810201A (OSRAM)
AU (1) AU2015356643B2 (OSRAM)
BR (1) BR112017011398A2 (OSRAM)
CA (1) CA2969307A1 (OSRAM)
EA (1) EA201791238A1 (OSRAM)
MX (2) MX2017007303A (OSRAM)
TW (1) TW201628641A (OSRAM)
WO (1) WO2016088059A1 (OSRAM)

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CN111712519A (zh) * 2017-12-13 2020-09-25 耶鲁大学 用于治疗或预防内分泌fgf23-相关疾病的组合物和方法
US12227777B2 (en) * 2018-01-12 2025-02-18 New York University Soluble alpha-Klotho proteins, protein fragments, and uses thereof
US20220008520A1 (en) * 2018-11-21 2022-01-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for reducing age-related striated muscle and cognitive decline
CN112695049A (zh) * 2020-08-20 2021-04-23 山东兴瑞生物科技有限公司 修饰间充质干细胞的融合基因、质粒、修饰得到干细胞及制备方法
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US20240384250A1 (en) * 2021-09-03 2024-11-21 The Uab Research Foundation Fibroblast growth factor 23 modulating compounds
WO2024168241A2 (en) * 2023-02-10 2024-08-15 The Trustees Of Indiana University Stabilized fgf23 fusion proteins, compositions and a targeted therapy for hyperphosphatemia
EP4434534A1 (en) 2023-03-22 2024-09-25 ADvantage Therapeutics, Inc. Klotho mrna
WO2025101851A1 (en) * 2023-11-10 2025-05-15 Regeneron Pharmaceuticals, Inc. Engineered alpha klotho polypeptides and uses thereof
US20250376667A1 (en) * 2024-06-07 2025-12-11 Regeneron Pharmaceuticals, Inc. Engineered alpha klotho polypeptides and uses thereof

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