AU2015339134B2 - Methods and compositions using GDF15 polypeptides for increasing red blood cells - Google Patents

Methods and compositions using GDF15 polypeptides for increasing red blood cells Download PDF

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Publication number
AU2015339134B2
AU2015339134B2 AU2015339134A AU2015339134A AU2015339134B2 AU 2015339134 B2 AU2015339134 B2 AU 2015339134B2 AU 2015339134 A AU2015339134 A AU 2015339134A AU 2015339134 A AU2015339134 A AU 2015339134A AU 2015339134 B2 AU2015339134 B2 AU 2015339134B2
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AU
Australia
Prior art keywords
gdf15
amino acid
polypeptide
acid sequence
seq
Prior art date
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Ceased
Application number
AU2015339134A
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English (en)
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AU2015339134A1 (en
Inventor
Ravindra Kumar
Naga Venkata Sai Rajasekhar Suragani
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Acceleron Pharma Inc
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Acceleron Pharma Inc
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Publication of AU2015339134A1 publication Critical patent/AU2015339134A1/en
Application granted granted Critical
Publication of AU2015339134B2 publication Critical patent/AU2015339134B2/en
Priority to AU2021232680A priority Critical patent/AU2021232680A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2015339134A 2014-10-30 2015-10-29 Methods and compositions using GDF15 polypeptides for increasing red blood cells Ceased AU2015339134B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021232680A AU2021232680A1 (en) 2014-10-30 2021-09-14 Methods and compositions using GDF15 polypeptides for increasing red blood cells

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462072889P 2014-10-30 2014-10-30
US62/072,889 2014-10-30
PCT/US2015/058116 WO2016069925A1 (en) 2014-10-30 2015-10-29 Methods and compositions using gdf15 polypeptides for increasing red blood cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021232680A Division AU2021232680A1 (en) 2014-10-30 2021-09-14 Methods and compositions using GDF15 polypeptides for increasing red blood cells

Publications (2)

Publication Number Publication Date
AU2015339134A1 AU2015339134A1 (en) 2017-04-27
AU2015339134B2 true AU2015339134B2 (en) 2021-06-17

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Family Applications (2)

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AU2015339134A Ceased AU2015339134B2 (en) 2014-10-30 2015-10-29 Methods and compositions using GDF15 polypeptides for increasing red blood cells
AU2021232680A Abandoned AU2021232680A1 (en) 2014-10-30 2021-09-14 Methods and compositions using GDF15 polypeptides for increasing red blood cells

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AU2021232680A Abandoned AU2021232680A1 (en) 2014-10-30 2021-09-14 Methods and compositions using GDF15 polypeptides for increasing red blood cells

Country Status (6)

Country Link
US (2) US10603359B2 (enExample)
EP (2) EP3922259B1 (enExample)
JP (2) JP6663428B2 (enExample)
AU (2) AU2015339134B2 (enExample)
CA (1) CA2964808C (enExample)
WO (1) WO2016069925A1 (enExample)

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US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
AU2015339134B2 (en) * 2014-10-30 2021-06-17 Acceleron Pharma Inc. Methods and compositions using GDF15 polypeptides for increasing red blood cells
EP3370754B1 (en) 2015-11-04 2026-04-29 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating ineffective erythropoiesis
US10336812B2 (en) * 2016-05-10 2019-07-02 Janssen Biotech, Inc. GDF15 fusion proteins and uses thereof
KR102433503B1 (ko) 2016-05-24 2022-08-18 노보 노르디스크 에이/에스 Mic-1 화합물 및 이것의 사용
TWI724392B (zh) 2018-04-06 2021-04-11 美商美國禮來大藥廠 生長分化因子15促效劑化合物及其使用方法
MY205905A (en) 2018-10-22 2024-11-20 Janssen Pharmaceutica Nv Glucagon like peptide 1 (glp1)-growth differentiation factor 15 (gdf15) fusion proteins and uses thereof
CA3161302A1 (en) * 2019-11-26 2021-06-03 Yuhan Corporation Long-acting gdf15 fusion protein and pharmaceutical composition comprising same
US12209112B2 (en) * 2022-09-15 2025-01-28 The Chinese University Of Hong Kong Methods of preventing or treating diseases, conditions, or disorders associated with chemotherapy
CN119386165A (zh) * 2024-12-19 2025-02-07 郑州大学 Gdf15在制备治疗don中毒的药物中的应用及其药物

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2013113008A1 (en) * 2012-01-26 2013-08-01 Amgen Inc. Growth differentiation factor 15 (gdf-15) polypeptides

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CA2672758C (en) 2006-12-18 2019-07-30 Acceleron Pharma Inc. Activin-actrii antagonists and uses for increasing red blood cell levels
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Also Published As

Publication number Publication date
JP7154241B2 (ja) 2022-10-17
CA2964808A1 (en) 2016-05-06
JP2017533910A (ja) 2017-11-16
EP3212213B1 (en) 2021-04-28
WO2016069925A1 (en) 2016-05-06
US20200397863A1 (en) 2020-12-24
JP2020073603A (ja) 2020-05-14
US10603359B2 (en) 2020-03-31
EP3922259A1 (en) 2021-12-15
JP6663428B2 (ja) 2020-03-11
CA2964808C (en) 2023-06-27
US20180207236A1 (en) 2018-07-26
AU2021232680A1 (en) 2021-10-07
AU2015339134A1 (en) 2017-04-27
EP3212213A4 (en) 2018-05-30
US11642394B2 (en) 2023-05-09
EP3922259B1 (en) 2026-04-01
EP3212213A1 (en) 2017-09-06

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired