AU2015335788B2 - Thiazolyl-containing compounds for treating proliferative diseases - Google Patents

Thiazolyl-containing compounds for treating proliferative diseases Download PDF

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Publication number
AU2015335788B2
AU2015335788B2 AU2015335788A AU2015335788A AU2015335788B2 AU 2015335788 B2 AU2015335788 B2 AU 2015335788B2 AU 2015335788 A AU2015335788 A AU 2015335788A AU 2015335788 A AU2015335788 A AU 2015335788A AU 2015335788 B2 AU2015335788 B2 AU 2015335788B2
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Australia
Prior art keywords
substituted
alkyl
unsubstituted
carbamate
certain embodiments
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AU2015335788A1 (en
Inventor
Sara Jean Buhrlage
Hwan Geun Choi
Nathanael S. Gray
Steven P. Treon
Yuan Xiong
Guang Yang
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2015335788A 2014-10-22 2015-10-22 Thiazolyl-containing compounds for treating proliferative diseases Active AU2015335788B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462067178P 2014-10-22 2014-10-22
US62/067,178 2014-10-22
PCT/US2015/056899 WO2016065138A1 (en) 2014-10-22 2015-10-22 Thiazolyl-containing compounds for treating proliferative diseases

Publications (2)

Publication Number Publication Date
AU2015335788A1 AU2015335788A1 (en) 2017-05-04
AU2015335788B2 true AU2015335788B2 (en) 2020-07-30

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Family Applications (1)

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AU2015335788A Active AU2015335788B2 (en) 2014-10-22 2015-10-22 Thiazolyl-containing compounds for treating proliferative diseases

Country Status (7)

Country Link
US (3) US10112957B2 (https=)
EP (2) EP3715346B1 (https=)
JP (1) JP6788583B2 (https=)
AU (1) AU2015335788B2 (https=)
CA (1) CA2965178C (https=)
IL (1) IL251790B (https=)
WO (1) WO2016065138A1 (https=)

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US10112957B2 (en) 2014-10-22 2018-10-30 Dana-Farber Cancer Institute, Inc. Thiazolyl-containing compounds for treating proliferative diseases
RS61991B1 (sr) * 2016-07-14 2021-07-30 Lilly Co Eli Derivati pirazolilaminobenzimidazola kao jak inhibitori
CN110099684B (zh) * 2016-11-03 2022-11-11 科尔沃斯制药股份有限公司 用于调节白介素-2诱导性t细胞激酶的化合物和方法
KR102328682B1 (ko) * 2018-08-27 2021-11-18 주식회사 대웅제약 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물
CN109265455B (zh) * 2018-11-09 2020-08-18 新发药业有限公司 一种达沙替尼的制备方法
MX2022010391A (es) * 2020-02-26 2022-09-05 Daewoong Pharmaceutical Co Ltd Metodo de preparacion de derivados de amina heterociclica.
EP4087574A4 (en) * 2020-03-06 2024-01-17 National Health Research Institutes PYRIMIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USES
WO2024111626A1 (ja) * 2022-11-25 2024-05-30 カルナバイオサイエンス株式会社 新規チアゾール誘導体

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Also Published As

Publication number Publication date
CA2965178A1 (en) 2016-04-28
IL251790A0 (en) 2017-06-29
US10844077B2 (en) 2020-11-24
US20190119301A1 (en) 2019-04-25
AU2015335788A1 (en) 2017-05-04
EP3209648A4 (en) 2018-07-25
US10112957B2 (en) 2018-10-30
EP3209648A1 (en) 2017-08-30
US20170233411A1 (en) 2017-08-17
US10464949B2 (en) 2019-11-05
US20200165267A1 (en) 2020-05-28
EP3715346B1 (en) 2024-01-03
EP3209648B1 (en) 2020-03-11
IL251790B (en) 2019-08-29
JP6788583B2 (ja) 2020-11-25
CA2965178C (en) 2023-09-26
JP2017537886A (ja) 2017-12-21
EP3715346A1 (en) 2020-09-30
WO2016065138A1 (en) 2016-04-28

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