AU2015287674B2 - Topical antiviral compositions and methods of using the same - Google Patents

Topical antiviral compositions and methods of using the same Download PDF

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Publication number
AU2015287674B2
AU2015287674B2 AU2015287674A AU2015287674A AU2015287674B2 AU 2015287674 B2 AU2015287674 B2 AU 2015287674B2 AU 2015287674 A AU2015287674 A AU 2015287674A AU 2015287674 A AU2015287674 A AU 2015287674A AU 2015287674 B2 AU2015287674 B2 AU 2015287674B2
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AU
Australia
Prior art keywords
methods
same
antiviral compositions
topical antiviral
topical
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AU2015287674A
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AU2015287674A1 (en
Inventor
Ryan DOXEY
Kimberly MCHALE
Nathan Stasko
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Ligand Pharmaceuticals Inc
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Ligand Pharmaceuticals Inc
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Assigned to LNHC, INC. reassignment LNHC, INC. Request for Assignment Assignors: NOVAN, INC.
Assigned to LIGAND PHARMACEUTICALS INCORPORATED reassignment LIGAND PHARMACEUTICALS INCORPORATED Request for Assignment Assignors: LNHC, INC.
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2015287674A 2014-07-11 2015-07-10 Topical antiviral compositions and methods of using the same Active AU2015287674B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462023587P 2014-07-11 2014-07-11
US62/023,587 2014-07-11
US201562139176P 2015-03-27 2015-03-27
US62/139,176 2015-03-27
PCT/US2015/039908 WO2016007834A1 (en) 2014-07-11 2015-07-10 Topical antiviral compositions and methods of using the same

Publications (2)

Publication Number Publication Date
AU2015287674A1 AU2015287674A1 (en) 2017-01-19
AU2015287674B2 true AU2015287674B2 (en) 2019-11-21

Family

ID=55064948

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015287674A Active AU2015287674B2 (en) 2014-07-11 2015-07-10 Topical antiviral compositions and methods of using the same

Country Status (10)

Country Link
US (1) US10322081B2 (https=)
EP (2) EP3166593B1 (https=)
JP (1) JP6651499B2 (https=)
KR (1) KR102495101B1 (https=)
CN (1) CN106659675B (https=)
AU (1) AU2015287674B2 (https=)
BR (1) BR112017000456B1 (https=)
CA (1) CA2954061C (https=)
ES (1) ES2807200T3 (https=)
WO (1) WO2016007834A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006006432D1 (de) 2005-03-24 2009-06-04 Nolabs Ab Kosmetische behandlung mit stickoxid, vorrichtung zur durchführung dieser behandlung und herstellungsverfahren dafür
ES2731298T3 (es) 2005-05-27 2019-11-14 Univ North Carolina Chapel Hill Partículas de liberación de óxido nítrico para agentes terapéuticos de óxido nítrico y aplicaciones biomédicas
CN101801521B (zh) 2007-05-14 2015-06-17 纽约州立大学研究基金会 生物膜中细菌细胞内的生理学分散响应诱导
WO2013029009A1 (en) 2011-08-24 2013-02-28 Novan, Inc. Tunable nitric oxide-releasing macromolecules having multiple nitric oxide donor structures
AU2013232576B2 (en) 2012-03-14 2016-09-01 Ligand Pharmaceuticals Incorporated Nitric oxide releasing pharmaceutical compositions
KR102321169B1 (ko) 2013-08-08 2021-11-02 노반, 인크. 국소 조성물 및 그의 사용 방법
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
CA2919733A1 (en) 2014-08-08 2016-02-08 Novan, Inc. Topical compositions and methods of using the same
EP3423100A4 (en) 2016-03-02 2019-10-16 Novan, Inc. COMPOSITIONS FOR THE TREATMENT OF INFLAMMATION AND METHOD FOR THE TREATMENT THEREOF
CN109310630A (zh) 2016-04-13 2019-02-05 诺万公司 用于治疗感染的组合物、系统、试剂盒和方法
US11534382B2 (en) 2017-06-19 2022-12-27 Novan, Inc. Topical compositions and methods of using the same
US11285171B2 (en) 2018-03-01 2022-03-29 Novan, Inc. Nitric oxide releasing suppositories and methods of use thereof
CN111989095A (zh) 2018-04-16 2020-11-24 上海岸阔医药科技有限公司 预防或治疗肿瘤疗法副作用的方法
CN108355166B (zh) * 2018-05-15 2021-02-19 黄冈师范学院 一种介孔生物活性玻璃/金属有机框架支架材料及制备方法
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
MX368750B (es) * 2018-08-31 2019-10-15 Cell Therapy And Tech S A De C V Composiciones farmaceuticas semisolidas de base oleosa conteniendo pirfenidona para su aplicacion en la reparacion tisular.
EP4389148A3 (en) * 2019-06-19 2024-09-25 Zylo Therapeutics, Inc. Sulfur functionalized monoliths and particles derived from the same as nitric oxide carriers for pharmaceutical and cosmetic applications
EP4093205A4 (en) * 2020-02-07 2024-02-21 KNOW Bio, LLC Nitric oxide-releasing antibacterial compounds, formulations, and methods pertaining thereto

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090068248A1 (en) * 2002-05-07 2009-03-12 The United States Of America, As Represented By The Secretary, Department Of He Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
WO2013006608A1 (en) * 2011-07-05 2013-01-10 Novan, Inc. Topical compositions

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9125712D0 (en) 1991-12-03 1992-01-29 Smithkline Beecham Plc Skin care composition
DE4237453C1 (https=) 1992-11-06 1993-08-19 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
JP3739100B2 (ja) 1993-07-30 2006-01-25 救急薬品工業株式会社 低温架橋型ゲル剤
US5840759A (en) 1993-10-08 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
GB9804469D0 (en) * 1998-03-02 1998-04-29 Univ Aberdeen Antiviral composition
US6709681B2 (en) 1995-02-17 2004-03-23 Aberdeen University Acidified nitrite as an antimicrobial agent
US5968001A (en) 1996-05-14 1999-10-19 Bristol-Myers Squibb Company Wound dressings with leak prevention seal
US5968528A (en) 1997-05-23 1999-10-19 The Procter & Gamble Company Skin care compositions
US20020013304A1 (en) 1997-10-28 2002-01-31 Wilson Leland F. As-needed administration of an androgenic agent to enhance female sexual desire and responsiveness
US6319913B1 (en) 1997-11-10 2001-11-20 Cellegy Pharmaceuticals, Inc. Penetration enhancing and irritation reducing systems
US6103266A (en) 1998-04-22 2000-08-15 Tapolsky; Gilles H. Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues
US6103275A (en) 1998-06-10 2000-08-15 Nitric Oxide Solutions Systems and methods for topical treatment with nitric oxide
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
FR2780888B1 (fr) 1998-07-09 2000-10-13 Benac Lotion nettoyante et traitante destinee au traitement des comedons
US6238683B1 (en) 1998-12-04 2001-05-29 Johnson & Johnson Consumer Companies, Inc. Anhydrous topical skin preparations
US6479058B1 (en) 1999-09-02 2002-11-12 Mccadden Michael E. Composition for the topical treatment of poison ivy and other forms of contact dermatitis
US6719997B2 (en) 2000-06-30 2004-04-13 Dermatrends, Inc. Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers
US6475500B2 (en) 2000-07-10 2002-11-05 The Procter & Gamble Company Anhydrous cosmetic compositions
GB0021317D0 (en) 2000-08-30 2000-10-18 Queen Mary & Westfield College Transdermal pharmaceutical delivery composition
GB0022084D0 (en) 2000-09-08 2000-10-25 Univ Aberdeen Treatment of multiply antibiotic-resistant organisms
AU2002228652A1 (en) 2000-11-27 2002-06-03 The University Of Akron Treatment of disorders using polyethylenimine diazeniumdiolate
US6780849B2 (en) 2000-12-21 2004-08-24 Scimed Life Systems, Inc. Lipid-based nitric oxide donors
GB0119011D0 (en) 2001-08-03 2001-09-26 Univ Aberdeen Treatment of nail infections
US6703046B2 (en) 2001-10-04 2004-03-09 Medtronic Ave Inc. Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use
JP2003286153A (ja) 2002-01-24 2003-10-07 Shiseido Co Ltd 皮膚外用組成物
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US20080031907A1 (en) 2002-10-25 2008-02-07 Foamix Ltd. Cosmetic and pharmaceutical foam
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US20080206161A1 (en) 2002-10-25 2008-08-28 Dov Tamarkin Quiescent foamable compositions, steroids, kits and uses thereof
US20050271596A1 (en) 2002-10-25 2005-12-08 Foamix Ltd. Vasoactive kit and composition and uses thereof
US20070292359A1 (en) 2002-10-25 2007-12-20 Foamix Ltd. Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof
US20070292461A1 (en) 2003-08-04 2007-12-20 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US20080317679A1 (en) 2002-10-25 2008-12-25 Foamix Ltd. Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US20040202684A1 (en) 2003-04-08 2004-10-14 David Djerassi Personalized interactive natural cosmetics
WO2005003032A1 (en) 2003-07-03 2005-01-13 The University Court Of The University Of St Andrews Zeolites for delivery of nitric oxide
WO2005004984A1 (en) 2003-07-14 2005-01-20 Power Paper Ltd. Device and method for the treatment of pilosebaceous disorders
US20080069779A1 (en) 2003-08-04 2008-03-20 Foamix Ltd. Foamable vehicle and vitamin and flavonoid pharmaceutical compositions thereof
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US20070166255A1 (en) 2004-11-22 2007-07-19 Gupta Shyam K Treatment of Topical Discomforts Including Acne, Sunburn, Diaper Rash, Wound, Wrinkles and Dandruff/Hair Loss by Natural Lignans via Fatty Acid Desaturase Inhibition
NZ556202A (en) 2005-01-04 2010-03-26 Teikoku Pharma Usa Inc Cooling topical patch preparation
PL1861130T3 (pl) 2005-02-11 2009-02-27 Nolabs Ab Urządzenie i sposób leczenia grzybicy skóry, a w szczególności grzybicy paznokci
KR20070105331A (ko) 2005-02-11 2007-10-30 노랩스 에이비 일산화질소를 포함하는 신경병증의 치료 장치, 방법 및용도
EP1690554A1 (en) 2005-02-11 2006-08-16 NOLabs AB Device for treatment of infections, including dermatophytosis and onychomycosis
EP1757278A1 (en) 2005-08-23 2007-02-28 NOLabs AB Device, system, and method comprising microencapsulated liquid for release of nitric oxide from a polymer
EP1704876A1 (en) * 2005-03-24 2006-09-27 NOLabs AB Cosmetic treatment, device for performing said treatment and manufacturing method thereof
DE602006006432D1 (de) 2005-03-24 2009-06-04 Nolabs Ab Kosmetische behandlung mit stickoxid, vorrichtung zur durchführung dieser behandlung und herstellungsverfahren dafür
AU2006298442A1 (en) 2005-05-09 2007-04-12 Foamix Ltd. Saccharide foamable compositions
ES2731298T3 (es) 2005-05-27 2019-11-14 Univ North Carolina Chapel Hill Partículas de liberación de óxido nítrico para agentes terapéuticos de óxido nítrico y aplicaciones biomédicas
US20080152596A1 (en) 2005-07-19 2008-06-26 Foamix Ltd. Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof
US9983874B2 (en) * 2006-03-16 2018-05-29 International Business Machines Corporation Structure for a circuit function that implements a load when reservation lost instruction to perform cacheline polling
US7744928B2 (en) 2006-04-14 2010-06-29 Advanced Cardiovascular Systems, Inc. Methods and compositions for treatment of lesioned sites of body vessels
EP2029106A2 (en) 2006-06-07 2009-03-04 Foamix Ltd. Foamable vehicle comprising polypropylene glycol alkyl ether and pharmaceutical compositions thereof
US8333997B2 (en) 2006-06-21 2012-12-18 Albert Einstein College Of Medicine Of Yeshiva University Compositions for sustained release of nitric oxide, methods of preparing same and uses thereof
WO2008110872A2 (en) 2006-06-23 2008-09-18 Foamix Ltd. Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses
PT2494959E (pt) 2006-07-05 2015-02-20 Foamix Pharmaceuticals Ltd Veículo formador de espuma de ácido dicarboxílico e suas composições farmacêuticas
GB0616350D0 (en) 2006-08-17 2006-09-27 Univ St Andrews Adsorption and release of nitric oxide in metal organic frameworks
JP2010502690A (ja) 2006-09-08 2010-01-28 フォーミックス エルティーディー． 有色または着色可能発泡性組成物
GB0618711D0 (en) 2006-09-22 2006-11-01 Univ Exeter Agricultural treatment
EP2073794A2 (en) 2006-11-14 2009-07-01 Foamix Ltd. Stable non-alcoholic foamable pharmaceutical emulsion compositions with an unctuous emollient and their uses
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
AU2007355106A1 (en) 2006-11-29 2008-12-18 Foamix Ltd. Foamable waterless compositions with modulating agents
US20080292560A1 (en) 2007-01-12 2008-11-27 Dov Tamarkin Silicone in glycol pharmaceutical and cosmetic compositions with accommodating agent
US20100178319A1 (en) 2007-03-27 2010-07-15 Lars Lindgren Topical Dermal Delivery Device For Nitric Oxide Delivery
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US8617100B2 (en) 2007-09-04 2013-12-31 Foamix Ltd. Device for delivery of a foamable composition
EP2209472A1 (en) 2007-10-12 2010-07-28 The University of North Carolina at Chapel Hill Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents
CA2706797A1 (en) 2007-11-19 2009-05-28 Stiefel Laboratories, Inc. Topical cosmetic skin lightening compositions and methods of use thereof
US20090130029A1 (en) 2007-11-21 2009-05-21 Foamix Ltd. Glycerol ethers vehicle and pharmaceutical compositions thereof
WO2009069006A2 (en) 2007-11-30 2009-06-04 Foamix Ltd. Foam containing benzoyl peroxide
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
CA2711703A1 (en) 2008-01-08 2009-07-16 Foamix Ltd. Sensation modifying topical composition foam
FR2929278A1 (fr) 2008-04-01 2009-10-02 Centre Nat Rech Scient Solide hybride cristallin poreux pour l'adsorption et la liberation de gaz a interet biologique.
US20120141384A1 (en) 2008-05-06 2012-06-07 Dov Tamarkin Antibacterial conjugated boronic acids and pharmaceutical compositions thereof
EP2334279A4 (en) 2008-10-16 2013-03-20 Novan Inc STAIN OXIDE RELEASING PARTICLES FOR MOUTH CARE APPLICATIONS
WO2010116467A1 (ja) * 2009-03-30 2010-10-14 Ｎｅｃディスプレイソリューションズ株式会社 画像表示装置、及び画像処理方法
WO2011022652A1 (en) 2009-08-21 2011-02-24 Novan, Inc. Topical gels
CA2771389C (en) * 2009-08-21 2019-04-09 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same
BR112012008508A2 (pt) 2009-10-13 2017-06-13 Novan Inc revestimento de sol-gel, substrato, método para produzir um revestimento de sol-gel
JP2013514347A (ja) 2009-12-16 2013-04-25 シャスン ファーマシューティカルズ リミテッド デクスイブプロフェン経皮ヒドロゲルの組成物
WO2011085484A1 (en) * 2010-01-13 2011-07-21 Nitric Solutions Inc. Antimicrobial nitric oxide compositions
EP2560634A1 (en) 2010-04-23 2013-02-27 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
EP2665763B1 (en) 2011-01-20 2015-08-26 Novan, Inc. Temperature controlled sol-gel co-condensation
WO2012118829A2 (en) 2011-02-28 2012-09-07 Novan, Inc. Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same
CA2835320A1 (en) * 2011-05-09 2012-11-15 Topical Therapeutic Agent (Tta) Ltd. Nitric oxide-sequestering topical formulations
WO2013006613A1 (en) 2011-07-05 2013-01-10 Novan, Inc. Methods of manufacturing topical compositions and apparatus for same
WO2013029009A1 (en) 2011-08-24 2013-02-28 Novan, Inc. Tunable nitric oxide-releasing macromolecules having multiple nitric oxide donor structures
US9669041B2 (en) 2011-10-27 2017-06-06 Novan, Inc. Nitric oxide releasing bath compositions and methods of using the same
US20150111973A1 (en) 2012-03-13 2015-04-23 Novan, Inc. Methods of modulating steroid hormone activity
AU2013232576B2 (en) 2012-03-14 2016-09-01 Ligand Pharmaceuticals Incorporated Nitric oxide releasing pharmaceutical compositions
CN106986952B (zh) 2012-08-17 2020-03-10 北卡罗来纳大学查珀尔希尔分校 水溶性的释放一氧化氮的聚葡糖胺和其用途
US9187501B2 (en) 2012-08-28 2015-11-17 The University Of North Carolina At Chapel Hill Nitric oxide-releasing nanorods and their methods of use
US9855211B2 (en) 2013-02-28 2018-01-02 Novan, Inc. Topical compositions and methods of using the same
KR102321169B1 (ko) 2013-08-08 2021-11-02 노반, 인크. 국소 조성물 및 그의 사용 방법
WO2016160089A1 (en) 2015-03-27 2016-10-06 Novan, Inc. Topical antiviral compositions, delivery systems, and methods of using the same
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
WO2016010988A1 (en) 2014-07-14 2016-01-21 Novan, Inc. Nitric oxide releasing nail coating compositions, nitric oxide releasing nail coatings, and methods of using the same
CA2919733A1 (en) 2014-08-08 2016-02-08 Novan, Inc. Topical compositions and methods of using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090068248A1 (en) * 2002-05-07 2009-03-12 The United States Of America, As Represented By The Secretary, Department Of He Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
WO2013006608A1 (en) * 2011-07-05 2013-01-10 Novan, Inc. Topical compositions

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AU2015287674A1 (en) 2017-01-19
CN106659675A (zh) 2017-05-10
CA2954061A1 (en) 2016-01-14
EP3166593A4 (en) 2018-02-07
CA2954061C (en) 2023-01-24
BR112017000456A2 (pt) 2017-11-07
US20170216197A1 (en) 2017-08-03
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BR112017000456B1 (pt) 2022-12-13

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