AU2015279428B2 - Methods for the preparation of 1,3-benzodioxole heterocyclic compounds - Google Patents
Methods for the preparation of 1,3-benzodioxole heterocyclic compounds Download PDFInfo
- Publication number
- AU2015279428B2 AU2015279428B2 AU2015279428A AU2015279428A AU2015279428B2 AU 2015279428 B2 AU2015279428 B2 AU 2015279428B2 AU 2015279428 A AU2015279428 A AU 2015279428A AU 2015279428 A AU2015279428 A AU 2015279428A AU 2015279428 B2 AU2015279428 B2 AU 2015279428B2
- Authority
- AU
- Australia
- Prior art keywords
- formula
- compound
- defined above
- chloro
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14173397 | 2014-06-23 | ||
| EP14173397.2 | 2014-06-23 | ||
| PCT/EP2015/063942 WO2015197534A2 (en) | 2014-06-23 | 2015-06-22 | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015279428A1 AU2015279428A1 (en) | 2017-01-05 |
| AU2015279428B2 true AU2015279428B2 (en) | 2018-02-15 |
Family
ID=50980952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015279428A Ceased AU2015279428B2 (en) | 2014-06-23 | 2015-06-22 | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9908894B2 (OSRAM) |
| EP (1) | EP3157930B1 (OSRAM) |
| JP (1) | JP6785666B2 (OSRAM) |
| KR (1) | KR20170016894A (OSRAM) |
| CN (1) | CN106459081B (OSRAM) |
| AU (1) | AU2015279428B2 (OSRAM) |
| BR (1) | BR112016029510A2 (OSRAM) |
| CA (1) | CA2953284A1 (OSRAM) |
| DK (1) | DK3157930T3 (OSRAM) |
| ES (1) | ES2702451T3 (OSRAM) |
| IL (1) | IL249336A0 (OSRAM) |
| MX (1) | MX2016016378A (OSRAM) |
| PL (1) | PL3157930T3 (OSRAM) |
| PT (1) | PT3157930T (OSRAM) |
| RU (1) | RU2697251C2 (OSRAM) |
| TW (1) | TW201613934A (OSRAM) |
| WO (1) | WO2015197534A2 (OSRAM) |
| ZA (1) | ZA201608442B (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3007432A1 (en) * | 2015-12-18 | 2017-06-22 | Leo Pharma A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
| WO2018234299A1 (en) * | 2017-06-20 | 2018-12-27 | Leo Pharma A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
| CN111727191B (zh) | 2017-12-15 | 2024-01-05 | 联合疗法公司 | 取代的氮杂环丁烷二氢噻吩并吡啶类化合物及其作为磷酸二酯酶抑制剂的用途 |
| USD914676S1 (en) | 2018-05-11 | 2021-03-30 | Samsung Electronics Co., Ltd. | Notebook computer |
| IL284815B2 (en) | 2019-01-15 | 2025-10-01 | Union Therapeutics As | Modified-release tablet formulations containing phosphodiesterase inhibitors |
| AU2022245186A1 (en) | 2021-03-22 | 2023-10-05 | UNION therapeutics A/S | Treatment of hidradenitis suppurativa with orismilast |
| GB202205715D0 (en) | 2022-04-19 | 2022-06-01 | Union Therapeutics As | Treatment of neutrophilic dermatoses |
| GB202306663D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Combination therapy |
| GB202306662D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Dosage regimen |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008104175A2 (en) * | 2007-02-28 | 2008-09-04 | Leo Pharma A/S | Novel phosphodiesterase inhibitors |
| WO2011160632A1 (en) * | 2010-06-24 | 2011-12-29 | Leo Pharma A/S | Benzodioxole or benzodioxepine heterocyclic compounds phosphodiesterase inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514996B2 (en) * | 1995-05-19 | 2003-02-04 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxole |
| AU705690B2 (en) * | 1995-05-19 | 1999-05-27 | Kyowa Hakko Kogyo Co. Ltd. | Oxygen-containing heterocyclic compounds |
| DE10205274A1 (de) * | 2002-02-08 | 2003-08-21 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen |
| US20050245750A1 (en) * | 2002-07-03 | 2005-11-03 | Kyowa Hakko Kogyo Co., Ltd. | Process for preparing 1,3-benzodioxole-2-spirocycloalkane derivative |
| CN101490004B (zh) * | 2006-07-14 | 2012-01-11 | 奇斯药制品公司 | 作为磷酸二酯酶抑制剂的1-苯基-2-吡啶基烯基醇的衍生物 |
| KR101507717B1 (ko) | 2006-12-22 | 2015-04-08 | 레오 파마 에이/에스 | Ｐｄｅ4 억제제로서 유용한 치환된 아세토페논 |
| UA98639C2 (en) * | 2007-02-28 | 2012-06-11 | Лео Фарма А/С | Phosphodiesterase inhibitors |
| WO2014096018A1 (en) * | 2012-12-19 | 2014-06-26 | Leo Pharma A/S | Methods for the preparation of substituted acetophenones |
| CA3007432A1 (en) * | 2015-12-18 | 2017-06-22 | Leo Pharma A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
-
2015
- 2015-06-22 CA CA2953284A patent/CA2953284A1/en not_active Abandoned
- 2015-06-22 PT PT15730183T patent/PT3157930T/pt unknown
- 2015-06-22 DK DK15730183.9T patent/DK3157930T3/en active
- 2015-06-22 WO PCT/EP2015/063942 patent/WO2015197534A2/en not_active Ceased
- 2015-06-22 ES ES15730183T patent/ES2702451T3/es active Active
- 2015-06-22 TW TW104120096A patent/TW201613934A/zh unknown
- 2015-06-22 RU RU2017101808A patent/RU2697251C2/ru active
- 2015-06-22 EP EP15730183.9A patent/EP3157930B1/en active Active
- 2015-06-22 KR KR1020167037002A patent/KR20170016894A/ko not_active Withdrawn
- 2015-06-22 PL PL15730183T patent/PL3157930T3/pl unknown
- 2015-06-22 CN CN201580033483.8A patent/CN106459081B/zh active Active
- 2015-06-22 MX MX2016016378A patent/MX2016016378A/es unknown
- 2015-06-22 AU AU2015279428A patent/AU2015279428B2/en not_active Ceased
- 2015-06-22 BR BR112016029510A patent/BR112016029510A2/pt not_active IP Right Cessation
- 2015-06-22 US US15/320,227 patent/US9908894B2/en active Active
- 2015-06-22 JP JP2016572800A patent/JP6785666B2/ja active Active
-
2016
- 2016-12-01 IL IL249336A patent/IL249336A0/en unknown
- 2016-12-07 ZA ZA2016/08442A patent/ZA201608442B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008104175A2 (en) * | 2007-02-28 | 2008-09-04 | Leo Pharma A/S | Novel phosphodiesterase inhibitors |
| WO2011160632A1 (en) * | 2010-06-24 | 2011-12-29 | Leo Pharma A/S | Benzodioxole or benzodioxepine heterocyclic compounds phosphodiesterase inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2953284A1 (en) | 2015-12-30 |
| AU2015279428A1 (en) | 2017-01-05 |
| BR112016029510A2 (pt) | 2017-08-22 |
| JP6785666B2 (ja) | 2020-11-18 |
| ES2702451T3 (es) | 2019-03-01 |
| TW201613934A (en) | 2016-04-16 |
| KR20170016894A (ko) | 2017-02-14 |
| WO2015197534A3 (en) | 2016-03-17 |
| CN106459081B (zh) | 2019-09-10 |
| PL3157930T3 (pl) | 2019-04-30 |
| EP3157930A2 (en) | 2017-04-26 |
| MX2016016378A (es) | 2017-10-16 |
| US9908894B2 (en) | 2018-03-06 |
| CN106459081A (zh) | 2017-02-22 |
| US20170137438A1 (en) | 2017-05-18 |
| RU2017101808A3 (OSRAM) | 2019-01-22 |
| WO2015197534A2 (en) | 2015-12-30 |
| IL249336A0 (en) | 2017-02-28 |
| JP2017520547A (ja) | 2017-07-27 |
| DK3157930T3 (en) | 2019-01-21 |
| RU2697251C2 (ru) | 2019-08-13 |
| PT3157930T (pt) | 2018-12-24 |
| EP3157930B1 (en) | 2018-10-17 |
| ZA201608442B (en) | 2018-05-30 |
| RU2017101808A (ru) | 2018-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |