AU2015271608B9 - Use of anti-aging glycopeptides to enhance pancreatic cell health, survival and improve transplant outcome - Google Patents

Use of anti-aging glycopeptides to enhance pancreatic cell health, survival and improve transplant outcome Download PDF

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Publication number
AU2015271608B9
AU2015271608B9 AU2015271608A AU2015271608A AU2015271608B9 AU 2015271608 B9 AU2015271608 B9 AU 2015271608B9 AU 2015271608 A AU2015271608 A AU 2015271608A AU 2015271608 A AU2015271608 A AU 2015271608A AU 2015271608 B9 AU2015271608 B9 AU 2015271608B9
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AU
Australia
Prior art keywords
tert
alkyl
benzyl
group
trimethylsilyl
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AU2015271608A
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English (en)
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AU2015271608A1 (en
AU2015271608B2 (en
Inventor
A. M. James SHAPIRO
Lachlan Grant YOUNG
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PROTOKINETIX Inc
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Protokinetix Inc
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Publication of AU2015271608B2 publication Critical patent/AU2015271608B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physiology (AREA)
  • Virology (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AU2015271608A 2014-06-04 2015-06-02 Use of anti-aging glycopeptides to enhance pancreatic cell health, survival and improve transplant outcome Active AU2015271608B9 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462007626P 2014-06-04 2014-06-04
US62/007,626 2014-06-04
PCT/CA2015/050509 WO2015184544A1 (en) 2014-06-04 2015-06-02 Use of anti-aging glycopeptides to enhance pancreatic cell health, survival and improve transplant outcome

Publications (3)

Publication Number Publication Date
AU2015271608A1 AU2015271608A1 (en) 2017-01-12
AU2015271608B2 AU2015271608B2 (en) 2021-05-27
AU2015271608B9 true AU2015271608B9 (en) 2021-06-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015271608A Active AU2015271608B9 (en) 2014-06-04 2015-06-02 Use of anti-aging glycopeptides to enhance pancreatic cell health, survival and improve transplant outcome

Country Status (8)

Country Link
US (4) US20150352155A1 (enExample)
EP (1) EP3152297A4 (enExample)
JP (1) JP6801934B2 (enExample)
KR (1) KR102411834B1 (enExample)
CN (1) CN106661549B (enExample)
AU (1) AU2015271608B9 (enExample)
NZ (1) NZ727749A (enExample)
WO (1) WO2015184544A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3407876B1 (en) 2016-01-27 2022-01-12 Protokinetix Inc. Use of anti-aging glycoprotein for enhancing survival of neurosensory precursor cells
SI3411047T1 (sl) 2016-02-04 2021-09-30 Czap Research And Development, Llc Sredstva za nadzorovano sproščeni in stratificirani kompleks vključitve ciklodekstrina
KR20220137037A (ko) * 2020-01-24 2022-10-11 프로토키네틱스 인코포레이티드 이식편의 면역 거부의 억제를 위한 항-노화 글리코펩타이드들의 사용
CN115568282A (zh) * 2020-03-10 2023-01-03 普罗托基尼蒂克有限公司 抗衰老糖肽治疗干眼症、视网膜退行性疾病或眼部炎症的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2878851B1 (fr) * 2004-12-02 2007-02-09 Inst Nat Sciences Appliq Composes c-glycopeptides gem-difluores, leur preparation et leur utilisation en cryochirurgie et/ou cryopreservation
FR2900656A1 (fr) * 2006-05-03 2007-11-09 Inst Nat Sciences Appliq Composes c-glycopeptides gem-difluores, leur preparation et leur utilisation notamment pour la preservation de materiaux biologiques

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Affect of AAGP? on the functionality or transplanted islet cells in a diabetic mouse model", ProtoKinetix, (2007-01), URL: https://web.archive.org/web/20131102204306/ http://protokinetix.com/results/assays/In_V ivo.php, (2015-06-23) *
"ProtoKinetix' AAGPTM Improves Effectiveness of Diabetes Treatment", Business Wire., (2007-05-17), URL: http://www.businesswire.com/news/home/2007-05-17005270/en/ProtoKinetix-AAGP-TM- Improves-Effectiveness-Diabetes-Treatment, (2015-08-07) *
Tissue and Organ Integrity Molecular and biological attributes of lead AAGP molecule, (2010-03), URL: http://web.archive.org/web/20131102194100/ http://protokinetix.com/pdf/aagp-presentation-m arch-2010.pdf, (2015-08-07) *

Also Published As

Publication number Publication date
JP2017520275A (ja) 2017-07-27
NZ727749A (en) 2023-04-28
EP3152297A1 (en) 2017-04-12
JP6801934B2 (ja) 2020-12-16
US20170360844A1 (en) 2017-12-21
CA2950963A1 (en) 2015-12-10
KR102411834B1 (ko) 2022-06-21
CN106661549A (zh) 2017-05-10
AU2015271608A1 (en) 2017-01-12
WO2015184544A1 (en) 2015-12-10
US20230414675A1 (en) 2023-12-28
AU2015271608B2 (en) 2021-05-27
KR20170023029A (ko) 2017-03-02
US20150352155A1 (en) 2015-12-10
EP3152297A4 (en) 2018-01-31
CN106661549B (zh) 2022-02-11
US20210023142A1 (en) 2021-01-28

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