AU2015253258B9 - Receptacle portion of transdermal drug delivery apparatus and methods - Google Patents
Receptacle portion of transdermal drug delivery apparatus and methods Download PDFInfo
- Publication number
- AU2015253258B9 AU2015253258B9 AU2015253258A AU2015253258A AU2015253258B9 AU 2015253258 B9 AU2015253258 B9 AU 2015253258B9 AU 2015253258 A AU2015253258 A AU 2015253258A AU 2015253258 A AU2015253258 A AU 2015253258A AU 2015253258 B9 AU2015253258 B9 AU 2015253258B9
- Authority
- AU
- Australia
- Prior art keywords
- housing
- microneedle assembly
- assembly
- receptacle
- support
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000013271 transdermal drug delivery Methods 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims description 23
- 230000033001 locomotion Effects 0.000 claims abstract description 69
- 239000012528 membrane Substances 0.000 claims description 99
- 239000000463 material Substances 0.000 claims description 47
- 239000000853 adhesive Substances 0.000 claims description 40
- 230000001070 adhesive effect Effects 0.000 claims description 40
- 239000012530 fluid Substances 0.000 claims description 27
- 230000004044 response Effects 0.000 claims description 21
- 230000002093 peripheral effect Effects 0.000 claims description 15
- 238000004891 communication Methods 0.000 claims description 12
- 238000005452 bending Methods 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 description 52
- 239000013583 drug formulation Substances 0.000 description 47
- 230000007246 mechanism Effects 0.000 description 24
- 230000014759 maintenance of location Effects 0.000 description 21
- 238000012377 drug delivery Methods 0.000 description 15
- 229940079593 drug Drugs 0.000 description 13
- 239000003814 drug Substances 0.000 description 13
- 238000007789 sealing Methods 0.000 description 13
- 238000003466 welding Methods 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 9
- 230000001681 protective effect Effects 0.000 description 6
- 230000007704 transition Effects 0.000 description 6
- 238000007906 compression Methods 0.000 description 5
- 230000006835 compression Effects 0.000 description 5
- 238000005192 partition Methods 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 229910052710 silicon Inorganic materials 0.000 description 4
- 239000010703 silicon Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 230000004913 activation Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 229920001195 polyisoprene Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 239000003522 acrylic cement Substances 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000004049 embossing Methods 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 239000012229 microporous material Substances 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000001020 plasma etching Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000013464 silicone adhesive Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461996158P | 2014-04-30 | 2014-04-30 | |
| US61/996,158 | 2014-04-30 | ||
| PCT/US2015/028158 WO2015168215A1 (en) | 2014-04-30 | 2015-04-29 | Receptacle portion of transdermal drug delivery apparatus and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2015253258A1 AU2015253258A1 (en) | 2016-11-17 |
| AU2015253258B2 AU2015253258B2 (en) | 2019-08-29 |
| AU2015253258B9 true AU2015253258B9 (en) | 2019-09-05 |
Family
ID=54359269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015253258A Ceased AU2015253258B9 (en) | 2014-04-30 | 2015-04-29 | Receptacle portion of transdermal drug delivery apparatus and methods |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11040183B2 (enExample) |
| EP (1) | EP3137150B1 (enExample) |
| JP (1) | JP6561069B2 (enExample) |
| KR (2) | KR20220026606A (enExample) |
| CN (1) | CN106232172B (enExample) |
| AU (1) | AU2015253258B9 (enExample) |
| BR (1) | BR112016023597A2 (enExample) |
| CA (2) | CA3160375C (enExample) |
| MX (1) | MX376608B (enExample) |
| RU (1) | RU2667305C2 (enExample) |
| WO (1) | WO2015168215A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101711350B1 (ko) * | 2016-07-25 | 2017-03-02 | 김미영 | 피부용 수동식 인젝터기 |
| KR102006937B1 (ko) * | 2017-09-29 | 2019-08-02 | 이승준 | 주사장치 |
| EP3574941A1 (en) * | 2018-05-28 | 2019-12-04 | Sensile Medical AG | Drug delivery device with needle actuation mechanism |
| DE102019200563A1 (de) * | 2019-01-17 | 2020-07-23 | Lts Lohmann Therapie-Systeme Ag | Applikator |
| KR20220110273A (ko) | 2019-12-05 | 2022-08-05 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 항-pd-1 또는 항-pd-l1 치료제를 림프 전달 장치를 통해 투여하여 암을 치료하는 방법 |
| CN117813128A (zh) | 2021-01-22 | 2024-04-02 | 索伦托药业有限公司 | 用于微升级淋巴递送冠状病毒疫苗的装置 |
| IL322176A (en) | 2021-03-01 | 2025-09-01 | Deka Products Lp | Medical material dispensing device, system and method |
| US12161832B2 (en) | 2021-03-01 | 2024-12-10 | Deka Products Limited Partnership | Medical agent dispensing systems, methods, and apparatuses |
| US12357804B2 (en) | 2021-03-01 | 2025-07-15 | Deka Products Limited Partnership | Medical agent dispensing systems, methods, and apparatuses |
| WO2022192594A2 (en) | 2021-03-11 | 2022-09-15 | Sorrento Therapeutics, Inc. | Nucleic acid molecules and vaccines comprising same for the prevention and treatment of coronavirus infections and disease |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US11452474B1 (en) | 2021-04-14 | 2022-09-27 | Satio, Inc. | Dual lever dermal patch system |
| CA3221925A1 (en) | 2021-06-09 | 2022-12-15 | Sorrento Therapeutics, Inc. | Method of treating cancer by administration of an anti-pd-1 or anti-pd-l1 therapeutic agent via a lymphatic microneedle delivery device |
| US20250120905A1 (en) | 2021-08-18 | 2025-04-17 | Vivasor, Inc | Therapeutic agents targeting the lymphatic system |
| WO2025129128A1 (en) | 2023-12-15 | 2025-06-19 | Vivasor, Inc. | Compositions and methods for non-viral delivery of therapeutic compounds |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130158468A1 (en) * | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
| US20130345638A1 (en) * | 2012-06-25 | 2013-12-26 | Flugen, Inc. | Multiple drug delivery device |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5279544A (en) | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
| US6623457B1 (en) | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
| US6656147B1 (en) * | 2000-07-17 | 2003-12-02 | Becton, Dickinson And Company | Method and delivery device for the transdermal administration of a substance |
| US6855131B2 (en) * | 2000-10-13 | 2005-02-15 | Alza Corporation | Microprotrusion member retainer for impact applicator |
| US6830562B2 (en) | 2001-09-27 | 2004-12-14 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
| US6780171B2 (en) | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
| US7670314B2 (en) | 2004-02-17 | 2010-03-02 | Children's Hospital Medical Center | Injection device for administering a vaccine |
| WO2006015299A2 (en) | 2004-07-30 | 2006-02-09 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
| EP1790375A4 (en) | 2004-08-12 | 2009-06-17 | Hisamitsu Pharmaceutical Co | TRANSDERMAL MEDICINE ADMINISTRATION WITH MICRONADEL |
| US20080009801A1 (en) | 2004-12-02 | 2008-01-10 | Nickel Janice H | Method for dispensing material into a drug delivery device |
| JPWO2007091608A1 (ja) | 2006-02-10 | 2009-07-02 | 久光製薬株式会社 | マイクロニードル付き経皮薬物投与装置 |
| US9370621B2 (en) | 2008-12-16 | 2016-06-21 | Medtronic Minimed, Inc. | Needle insertion systems and methods |
| WO2010126174A1 (en) | 2009-05-01 | 2010-11-04 | Nanbu Plastics Co., Ltd. | Transdermal administration device |
| US10010706B2 (en) * | 2009-07-31 | 2018-07-03 | 3M Innovative Properties Company | Hollow microneedle arrays |
| WO2011075100A1 (en) * | 2009-12-16 | 2011-06-23 | Becton, Dickinson And Company | Self-injection device |
| US8328757B2 (en) | 2010-01-08 | 2012-12-11 | Wisconsin Alumni Research Foundation | Bladder arrangement for microneedle-based drug delivery device |
| US20110172637A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Drug delivery device including tissue support structure |
| US20110172609A1 (en) | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Microneedle component assembly for drug delivery device |
| US9173994B2 (en) | 2010-08-20 | 2015-11-03 | Purdue Research Foundation | Touch-actuated micropump for transdermal drug delivery and method of use |
| US8814831B2 (en) | 2010-11-30 | 2014-08-26 | Becton, Dickinson And Company | Ballistic microneedle infusion device |
| EP2654582B1 (en) * | 2010-12-22 | 2017-05-31 | Valeritas, Inc. | Microneedle patch applicator |
| CN102327656B (zh) * | 2011-10-18 | 2013-05-08 | 清华大学 | 一次性阵列式微型注射针头 |
| US20130211289A1 (en) * | 2012-01-25 | 2013-08-15 | Tasso, Inc. | Handheld Device for Drawing, Collecting, and Analyzing Bodily Fluid |
| EP2906285B1 (en) * | 2012-10-10 | 2019-06-12 | 3M Innovative Properties Company | Applicator for applying a microneedle device to skin |
| JP6566964B2 (ja) * | 2014-04-30 | 2019-08-28 | ソレント・セラピューティクス・インコーポレイテッド | 経皮的薬物送達装置および方法 |
-
2015
- 2015-04-29 KR KR1020227005041A patent/KR20220026606A/ko not_active Withdrawn
- 2015-04-29 CA CA3160375A patent/CA3160375C/en active Active
- 2015-04-29 RU RU2016143584A patent/RU2667305C2/ru not_active IP Right Cessation
- 2015-04-29 US US15/305,206 patent/US11040183B2/en not_active Expired - Fee Related
- 2015-04-29 AU AU2015253258A patent/AU2015253258B9/en not_active Ceased
- 2015-04-29 KR KR1020167031960A patent/KR102365067B1/ko active Active
- 2015-04-29 CN CN201580019996.3A patent/CN106232172B/zh not_active Expired - Fee Related
- 2015-04-29 CA CA2945003A patent/CA2945003C/en active Active
- 2015-04-29 EP EP15785287.2A patent/EP3137150B1/en active Active
- 2015-04-29 JP JP2016563064A patent/JP6561069B2/ja not_active Expired - Fee Related
- 2015-04-29 WO PCT/US2015/028158 patent/WO2015168215A1/en not_active Ceased
- 2015-04-29 MX MX2016013612A patent/MX376608B/es active IP Right Grant
- 2015-04-29 BR BR112016023597A patent/BR112016023597A2/pt not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130158468A1 (en) * | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
| US20130345638A1 (en) * | 2012-06-25 | 2013-12-26 | Flugen, Inc. | Multiple drug delivery device |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2016143584A (ru) | 2018-05-08 |
| MX2016013612A (es) | 2017-02-02 |
| MX376608B (es) | 2025-03-04 |
| RU2667305C2 (ru) | 2018-09-18 |
| CA3160375C (en) | 2024-04-30 |
| CA3160375A1 (en) | 2015-11-05 |
| CA2945003A1 (en) | 2015-11-05 |
| AU2015253258A1 (en) | 2016-11-17 |
| WO2015168215A1 (en) | 2015-11-05 |
| JP6561069B2 (ja) | 2019-08-14 |
| EP3137150B1 (en) | 2019-09-04 |
| KR20220026606A (ko) | 2022-03-04 |
| US11040183B2 (en) | 2021-06-22 |
| CN106232172B (zh) | 2020-05-22 |
| CA2945003C (en) | 2022-08-09 |
| KR102365067B1 (ko) | 2022-02-21 |
| KR20160146841A (ko) | 2016-12-21 |
| RU2016143584A3 (enExample) | 2018-05-08 |
| US20170043148A1 (en) | 2017-02-16 |
| JP2017514576A (ja) | 2017-06-08 |
| EP3137150A4 (en) | 2017-12-13 |
| CN106232172A (zh) | 2016-12-14 |
| BR112016023597A2 (pt) | 2017-08-15 |
| EP3137150A1 (en) | 2017-03-08 |
| AU2015253258B2 (en) | 2019-08-29 |
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| AU2015253258B9 (en) | Receptacle portion of transdermal drug delivery apparatus and methods | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: SORRENTO THERAPEUTICS, INC. Free format text: FORMER APPLICANT(S): KIMBERLY-CLARK WORLDWIDE, INC. |
|
| SREP | Specification republished | ||
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |