AU2015221431B2 - Novel 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione derivative compounds - Google Patents
Novel 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione derivative compounds Download PDFInfo
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- AU2015221431B2 AU2015221431B2 AU2015221431A AU2015221431A AU2015221431B2 AU 2015221431 B2 AU2015221431 B2 AU 2015221431B2 AU 2015221431 A AU2015221431 A AU 2015221431A AU 2015221431 A AU2015221431 A AU 2015221431A AU 2015221431 B2 AU2015221431 B2 AU 2015221431B2
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- pyrazine
- dioxol
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- -1 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione derivative compounds Chemical class 0.000 title claims description 19
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- 238000000034 method Methods 0.000 claims description 26
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 24
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461943825P | 2014-02-24 | 2014-02-24 | |
| US61/943,825 | 2014-02-24 | ||
| PCT/BR2015/000023 WO2015123748A1 (pt) | 2014-02-24 | 2015-02-24 | "NOVOS COMPOSTOS DERIVADOS DE 6,7-DIHIDRO-3H-OXAZOLO [3,4-a] PIRAZINA-5,8-DIONA " |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2015221431A1 AU2015221431A1 (en) | 2016-09-29 |
| AU2015221431A8 AU2015221431A8 (en) | 2016-11-24 |
| AU2015221431B2 true AU2015221431B2 (en) | 2018-04-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015221431A Active AU2015221431B2 (en) | 2014-02-24 | 2015-02-24 | Novel 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione derivative compounds |
Country Status (19)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021007636A1 (pt) | 2019-07-15 | 2021-01-21 | Biolab Sanus Farmaceutica Ltda | Estereoisômeros do composto 3-(benzo[d][1,3]dioxol-5-il)-7-(1-hidroxipropan-2-il)-1-(1 h-indol-3-il)-6,7-dihidro-3 h-oxazol[3,4-a]pirazina-5,8-diona e seu uso como antitumoral e inibidor da enzima fosfodiesterase |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110195976A1 (en) * | 2008-09-30 | 2011-08-11 | Biolab Sanus Farmaceutica Ltda. | Compounds derived from 2-(3-methylenedioxy)-benzoyl indol |
| US20120040988A1 (en) * | 2010-08-13 | 2012-02-16 | Biolab Sanus Farmaceutica Ltda. | DERIVATIVES OF 6,7-DIHYDRO-3H-OXAZOLO[3,4-a]PYRAZINE-5,8-DIONE |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2445625C (en) * | 2001-06-05 | 2010-07-27 | Lilly Icos Llc | Pyrazino'1',2':1,6!pyrido'3,4-b!indole1,4-dione derivatives |
| AR045950A1 (es) * | 2003-10-09 | 2005-11-16 | Speedel Experimenta Ag | Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos. |
| BRPI0903803B1 (pt) * | 2009-09-30 | 2019-07-09 | Biolab Sanus Farmacêutica Ltda. | Composto, processo de preparação, composição farmacêutica e uso dos compostos |
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2015
- 2015-02-23 AR ARP150100529A patent/AR099523A1/es active IP Right Grant
- 2015-02-24 CA CA2940225A patent/CA2940225C/en active Active
- 2015-02-24 KR KR1020167026361A patent/KR102408431B1/ko active Active
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2016
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- 2016-09-21 ZA ZA2016/06522A patent/ZA201606522B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110195976A1 (en) * | 2008-09-30 | 2011-08-11 | Biolab Sanus Farmaceutica Ltda. | Compounds derived from 2-(3-methylenedioxy)-benzoyl indol |
| US20120040988A1 (en) * | 2010-08-13 | 2012-02-16 | Biolab Sanus Farmaceutica Ltda. | DERIVATIVES OF 6,7-DIHYDRO-3H-OXAZOLO[3,4-a]PYRAZINE-5,8-DIONE |
Also Published As
| Publication number | Publication date |
|---|---|
| CL2016002125A1 (es) | 2016-12-30 |
| PL3133072T3 (pl) | 2019-10-31 |
| AR099523A1 (es) | 2016-07-27 |
| CA2940225A1 (en) | 2015-08-27 |
| MX369840B (es) | 2019-11-22 |
| AU2015221431A1 (en) | 2016-09-29 |
| EP3133072A4 (en) | 2017-08-09 |
| JP6636463B2 (ja) | 2020-01-29 |
| KR20160116028A (ko) | 2016-10-06 |
| TR201910896T4 (tr) | 2019-08-21 |
| EP3133072B1 (en) | 2019-05-01 |
| WO2015123748A1 (pt) | 2015-08-27 |
| UY36010A (es) | 2015-09-30 |
| US20150239903A1 (en) | 2015-08-27 |
| BR112016019609A2 (enrdf_load_stackoverflow) | 2017-08-22 |
| IL247330B (en) | 2020-10-29 |
| EP3133072A1 (en) | 2017-02-22 |
| CA2940225C (en) | 2021-12-28 |
| AU2015221431A8 (en) | 2016-11-24 |
| US9359378B2 (en) | 2016-06-07 |
| MX2016010912A (es) | 2016-11-30 |
| JP2017506263A (ja) | 2017-03-02 |
| PT3133072T (pt) | 2019-07-26 |
| IL247330A0 (en) | 2016-09-29 |
| KR102408431B1 (ko) | 2022-06-13 |
| BR112016019609B1 (pt) | 2022-06-14 |
| ES2734063T3 (es) | 2019-12-04 |
| HUE044993T2 (hu) | 2019-11-28 |
| ZA201606522B (en) | 2018-04-25 |
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Free format text: IN VOL 30 , NO 39 , PAGE(S) 5755 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME BIOLAB SANUS FARMACEUTICA LTDA, APPLICATION NO. 2015221431, UNDER INID (54) CORRECT THE TITLE TO READ NOVEL 6,7-DIHYDRO-3H-OXAZOLO(3,4-A)PYRAZINE-5,8-DIONE DERIVATIVE COMPOUNDS |
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