AU2015206271B2 - Receptor targeting constructs and uses thereof - Google Patents

Receptor targeting constructs and uses thereof Download PDF

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Publication number
AU2015206271B2
AU2015206271B2 AU2015206271A AU2015206271A AU2015206271B2 AU 2015206271 B2 AU2015206271 B2 AU 2015206271B2 AU 2015206271 A AU2015206271 A AU 2015206271A AU 2015206271 A AU2015206271 A AU 2015206271A AU 2015206271 B2 AU2015206271 B2 AU 2015206271B2
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payload
cancer
met
inlb
cells
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AU2015206271A1 (en
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Lali K. Medina-Kauwe
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Cedars-Sinai Medical Center
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Cedars-Sinai Medical Center
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
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    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2015206271A 2014-01-17 2015-01-16 Receptor targeting constructs and uses thereof Active AU2015206271B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020203434A AU2020203434B2 (en) 2014-01-17 2020-05-25 Receptor Targeting Constructs And Uses Thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461928903P 2014-01-17 2014-01-17
US61/928,903 2014-01-17
PCT/US2015/011870 WO2015109264A1 (en) 2014-01-17 2015-01-16 Receptor targeting constructs and uses thereof

Related Child Applications (1)

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AU2020203434A Division AU2020203434B2 (en) 2014-01-17 2020-05-25 Receptor Targeting Constructs And Uses Thereof

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AU2015206271A1 AU2015206271A1 (en) 2016-07-07
AU2015206271B2 true AU2015206271B2 (en) 2020-02-27

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US (3) US10183078B2 (enExample)
EP (2) EP3096773B1 (enExample)
JP (3) JP6608370B2 (enExample)
KR (1) KR102434541B1 (enExample)
CN (1) CN106413738B (enExample)
AU (2) AU2015206271B2 (enExample)
BR (1) BR112016016202A2 (enExample)
IL (1) IL246668B (enExample)
MX (1) MX381016B (enExample)
RU (1) RU2682335C2 (enExample)
WO (1) WO2015109264A1 (enExample)
ZA (1) ZA201605237B (enExample)

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WO2010085665A2 (en) 2009-01-23 2010-07-29 Cedars-Sinai Medical Center Targeted delivery system
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RU2674146C2 (ru) 2013-05-08 2018-12-07 Седарс-Синай Медикал Центр Нацеленные корролы, проявляющие опухолевую токсичность и предназначенные для мрт
WO2015109264A1 (en) 2014-01-17 2015-07-23 Cedars-Sinai Medical Center Receptor targeting constructs and uses thereof
JP6728056B2 (ja) 2014-04-04 2020-07-22 シーダーズ—シナイ メディカル センター Ｈｅｒ３標的ナノ粒子によりトラスツズマブ耐性ｈｅｒ２＋乳癌を標的にすること
CA3039040A1 (en) * 2016-10-03 2018-04-12 Eos Biosciences, Inc. Functional rna and small-molecule drug therapeutic complexes and nanoparticle delivery vehicles
CN108865147B (zh) * 2018-06-01 2021-05-18 福州大学 一种埃罗替尼保护的铂银纳米簇及其制备方法
RU2688422C1 (ru) * 2018-06-07 2019-05-21 Светлана Александровна Ермолаева Рекомбинантный интерналин В 321, полученный с помощью штамма Escherichia coli
WO2020028562A1 (en) * 2018-07-31 2020-02-06 Loma Linda University Snail sirna-loaded mesoporous silica nanoparticles
JP7729627B2 (ja) 2020-03-15 2025-08-26 ナノキャリー セラピューティクス リミテッド ナノデリバリーシステムならびにその治療および診断上の使用
KR102827437B1 (ko) 2021-08-30 2025-07-02 연세대학교 산학협력단 림프종의 예방 또는 치료를 위한 림프종 세포 특이적 약물 전달체 및 이의 제조방법
CN119868271A (zh) * 2024-12-30 2025-04-25 沈阳药科大学 一种化疗药物与免疫刺激剂共递送的功能性聚合物胶束及其制备方法和应用

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