AU2015204597B2 - Compositions and methods for treatment of abnormal cell growth - Google Patents

Compositions and methods for treatment of abnormal cell growth Download PDF

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Publication number
AU2015204597B2
AU2015204597B2 AU2015204597A AU2015204597A AU2015204597B2 AU 2015204597 B2 AU2015204597 B2 AU 2015204597B2 AU 2015204597 A AU2015204597 A AU 2015204597A AU 2015204597 A AU2015204597 A AU 2015204597A AU 2015204597 B2 AU2015204597 B2 AU 2015204597B2
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AU
Australia
Prior art keywords
pharmaceutically acceptable
composition
acceptable salt
pharmaceutical composition
weight
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AU2015204597A
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English (en)
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AU2015204597A1 (en
Inventor
Paul Okwabi Nkansah
Mahesh Padval
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Verastem Inc
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Verastem Inc
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Publication of AU2015204597A1 publication Critical patent/AU2015204597A1/en
Assigned to PFIZER INC., VERASTEM, INC. reassignment PFIZER INC. Amend patent request/document other than specification (104) Assignors: PFIZER, INC., VERASTEM, INC.
Application granted granted Critical
Publication of AU2015204597B2 publication Critical patent/AU2015204597B2/en
Priority to AU2020210153A priority Critical patent/AU2020210153B2/en
Priority to AU2022256144A priority patent/AU2022256144B2/en
Priority to AU2025204843A priority patent/AU2025204843A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AU2015204597A 2014-01-09 2015-01-09 Compositions and methods for treatment of abnormal cell growth Active AU2015204597B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2020210153A AU2020210153B2 (en) 2014-01-09 2020-07-27 Compositions and methods for treatment of abnormal cell growth
AU2022256144A AU2022256144B2 (en) 2014-01-09 2022-10-19 Compositions and methods for treatment of abnormal cell growth
AU2025204843A AU2025204843A1 (en) 2014-01-09 2025-06-26 Compositions and methods for treatment of abnormal cell growth

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461925467P 2014-01-09 2014-01-09
US61/925,467 2014-01-09
PCT/US2015/010810 WO2015106096A1 (en) 2014-01-09 2015-01-09 Compositions and methods for treatment of abnormal cell growth

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020210153A Division AU2020210153B2 (en) 2014-01-09 2020-07-27 Compositions and methods for treatment of abnormal cell growth

Publications (2)

Publication Number Publication Date
AU2015204597A1 AU2015204597A1 (en) 2016-07-21
AU2015204597B2 true AU2015204597B2 (en) 2020-04-30

Family

ID=52434976

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2015204597A Active AU2015204597B2 (en) 2014-01-09 2015-01-09 Compositions and methods for treatment of abnormal cell growth
AU2020210153A Active AU2020210153B2 (en) 2014-01-09 2020-07-27 Compositions and methods for treatment of abnormal cell growth
AU2022256144A Active AU2022256144B2 (en) 2014-01-09 2022-10-19 Compositions and methods for treatment of abnormal cell growth
AU2025204843A Pending AU2025204843A1 (en) 2014-01-09 2025-06-26 Compositions and methods for treatment of abnormal cell growth

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2020210153A Active AU2020210153B2 (en) 2014-01-09 2020-07-27 Compositions and methods for treatment of abnormal cell growth
AU2022256144A Active AU2022256144B2 (en) 2014-01-09 2022-10-19 Compositions and methods for treatment of abnormal cell growth
AU2025204843A Pending AU2025204843A1 (en) 2014-01-09 2025-06-26 Compositions and methods for treatment of abnormal cell growth

Country Status (15)

Country Link
US (3) US20150190346A1 (OSRAM)
EP (2) EP3900726A1 (OSRAM)
JP (5) JP6647204B2 (OSRAM)
KR (3) KR102444494B1 (OSRAM)
CN (3) CN115708827A (OSRAM)
AU (4) AU2015204597B2 (OSRAM)
BR (1) BR112016016021B1 (OSRAM)
CA (1) CA2936283C (OSRAM)
DK (1) DK3091981T3 (OSRAM)
ES (1) ES2870562T3 (OSRAM)
IL (2) IL246667B (OSRAM)
MX (2) MX384259B (OSRAM)
NZ (2) NZ721934A (OSRAM)
SG (2) SG10201805890QA (OSRAM)
WO (1) WO2015106096A1 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3795157A4 (en) * 2018-05-15 2022-03-23 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Pharmaceutical composition comprising small molecule egfr inhibitor and preparation method therefor
JP2022547358A (ja) * 2019-09-13 2022-11-14 ジ インスティテュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル 治療組成物、組み合わせ、及び使用方法
WO2021191812A1 (en) * 2020-03-27 2021-09-30 Pfizer Inc. Treatment of type 2 diabetes or obesity or overweight with 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl} piperidin-1-yl)methyl]-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof
SI3965742T1 (sl) * 2020-04-24 2023-10-30 Dr. Falk Pharma Gmbh Sistemska formulacija piridinonskega derivata za bolezni, povezane s tg2
US11873296B2 (en) 2022-06-07 2024-01-16 Verastem, Inc. Solid forms of a dual RAF/MEK inhibitor
CN117582504A (zh) * 2022-08-15 2024-02-23 海创药业股份有限公司 一种治疗卵巢癌的联合用药物

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2008129380A1 (en) * 2007-04-18 2008-10-30 Pfizer Products Inc. Sulfonyl amide derivatives for the treatment of abnormal cell growth

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DE69837903T2 (de) * 1997-08-11 2008-02-14 Pfizer Products Inc., Groton Feste pharmazeutische Dispersionen mit erhöhter Bioverfügbarkeit
CA2534371A1 (en) * 2003-08-04 2005-02-10 Pfizer Products Inc. Dosage forms providing controlled release of cholesteryl ester transfer protein inhibitors and immediate release of hmg-coa reductase inhibitors
WO2006061712A2 (en) * 2004-12-10 2006-06-15 Pfizer Inc. Use of mek inhibitors in treating abnormal cell growth
HUE035931T2 (hu) * 2008-08-13 2018-06-28 Vertex Pharma N-[2,4-bis(1,1-dimetiletil)-5-hidroxipenil]-1,4-dihidro-4-oxokinolin-3-karboxamid gyógyszerészeti készítménye és annak alkalmazása
WO2011112922A2 (en) * 2010-03-11 2011-09-15 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical formulations comprising the same
AU2011293658B2 (en) * 2010-08-23 2015-03-05 Vertex Pharmaceuticals Incorporated Pharmaceutical composition of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
CN103491964A (zh) * 2011-03-08 2014-01-01 扎里卡斯药品有限公司 固体分散体制剂及其使用方法
EP2572731A1 (en) * 2011-09-26 2013-03-27 Abbott GmbH & Co. KG Formulations based on solid dispersions
ES2945387T3 (es) * 2014-02-07 2023-06-30 Verastem Inc Procedimientos y composiciones para tratar el crecimiento celular anormal
AU2016286091B2 (en) * 2015-06-29 2021-02-04 Verastem, Inc. Therapeutic compositions, combinations, and methods of use

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WO2008129380A1 (en) * 2007-04-18 2008-10-30 Pfizer Products Inc. Sulfonyl amide derivatives for the treatment of abnormal cell growth

Non-Patent Citations (5)

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JAMES C. DINUNZIO ET AL, "Production of advanced solid dispersions for enhanced bioavailability of itraconazole using KinetiSol Dispersing", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, (2010-09-01), vol. 36, no. 9, pages 1064 - 1078 *
R N. Shamma et al, "Soluplus: A novel polymeric solubilizer for optimization of Carvedilol solid dispersion: Formulation", Powder Technology, (2013), vol. 237, page 406-414 *
Shu Li et al., "Enhanced Bioavailability of a Poorly Water-Soluble Weakly Basic Compound Using a Combination Approach of Solubilization Agents and Precipitation Inhibitors: A Case Study", Molecular Pharmaceutics *
WILLIAM CURATOLO ET AL, "Utility of Hydroxypropylmethylcellulose Acetate Succinate (HPMCAS) for Initiation and Maintenance of Drug Supersaturation in the GI Milieu", PHARMACEUTICAL RESEARCH, (2009-03-10), vol. 26, no. 6,pages 1419 - 1431 *
Y. KANG ET AL, "Role of Focal Adhesion Kinase in Regulating YB-1-Mediated Paclitaxel Resistance in Ovarian Cancer", JNCI JOURNAL OF THE NATIONAL CANCER INSTITUTE, (2013-10-02), vol. 105, no. 19,pages 1485 - 1495 *

Also Published As

Publication number Publication date
MX384259B (es) 2025-03-14
CN115708827A (zh) 2023-02-24
JP2022001587A (ja) 2022-01-06
EP3900726A1 (en) 2021-10-27
CN119868364A (zh) 2025-04-25
MX2021008225A (es) 2021-08-11
CA2936283C (en) 2023-02-28
SG11201605588YA (en) 2016-08-30
KR20160104725A (ko) 2016-09-05
AU2015204597A1 (en) 2016-07-21
AU2025204843A1 (en) 2025-07-17
JP2020007355A (ja) 2020-01-16
NZ760233A (en) 2022-04-29
AU2020210153B2 (en) 2022-07-21
BR112016016021A2 (pt) 2017-09-19
US20230104303A1 (en) 2023-04-06
AU2022256144A1 (en) 2022-11-24
JP2025084892A (ja) 2025-06-03
NZ721934A (en) 2022-04-29
ES2870562T3 (es) 2021-10-27
WO2015106096A1 (en) 2015-07-16
JP6647204B2 (ja) 2020-02-14
KR20240159639A (ko) 2024-11-05
IL292054A (en) 2022-06-01
JP2023065568A (ja) 2023-05-12
IL246667A0 (en) 2016-08-31
US20200038331A1 (en) 2020-02-06
KR20220130251A (ko) 2022-09-26
CN106102744A (zh) 2016-11-09
BR112016016021B1 (pt) 2023-01-10
IL246667B (en) 2022-05-01
US20150190346A1 (en) 2015-07-09
JP2017502062A (ja) 2017-01-19
AU2022256144B2 (en) 2025-04-03
AU2020210153A1 (en) 2020-08-13
EP3091981B1 (en) 2021-03-10
EP3091981A1 (en) 2016-11-16
DK3091981T3 (da) 2021-05-31
CA2936283A1 (en) 2015-07-16
KR102444494B1 (ko) 2022-09-20
MX2016009056A (es) 2017-01-23
SG10201805890QA (en) 2018-08-30
BR112016016021A8 (pt) 2018-04-17

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