AU2014369449B2 - Urea derivatives useful as kinase inhibitors - Google Patents
Urea derivatives useful as kinase inhibitors Download PDFInfo
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- AU2014369449B2 AU2014369449B2 AU2014369449A AU2014369449A AU2014369449B2 AU 2014369449 B2 AU2014369449 B2 AU 2014369449B2 AU 2014369449 A AU2014369449 A AU 2014369449A AU 2014369449 A AU2014369449 A AU 2014369449A AU 2014369449 B2 AU2014369449 B2 AU 2014369449B2
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- Prior art keywords
- tert
- oxy
- butyl
- naphthalen
- amino
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- 0 Cc(cc1)c(C)c(*)c1OCC(C=*)=CN=* Chemical compound Cc(cc1)c(C)c(*)c1OCC(C=*)=CN=* 0.000 description 4
- NUQXZGAPRUPKSX-UHFFFAOYSA-N CC(C)(C)c(cc1C(NCCN2CCOCC2)=O)cc(NC(Nc(cc2)c(cccc3)c3c2Oc2cc(Nc3cc(OCCOCCOCCOC)cc(OC)c3)ncc2)=O)c1OC Chemical compound CC(C)(C)c(cc1C(NCCN2CCOCC2)=O)cc(NC(Nc(cc2)c(cccc3)c3c2Oc2cc(Nc3cc(OCCOCCOCCOC)cc(OC)c3)ncc2)=O)c1OC NUQXZGAPRUPKSX-UHFFFAOYSA-N 0.000 description 1
- BLTPOXDSHVRFDF-UHFFFAOYSA-N CC(C)(C)c(cc1NC(Nc(cc2)c(cccc3)c3c2Oc2ccnc(Nc3cc(OC)cc(C(N)=O)c3)c2)=O)cc(C(NCCN2CCOCC2)=O)c1OC Chemical compound CC(C)(C)c(cc1NC(Nc(cc2)c(cccc3)c3c2Oc2ccnc(Nc3cc(OC)cc(C(N)=O)c3)c2)=O)cc(C(NCCN2CCOCC2)=O)c1OC BLTPOXDSHVRFDF-UHFFFAOYSA-N 0.000 description 1
- NZCDZOUZHSNTTN-UHFFFAOYSA-N CC(C)(C)c(cc1NC(Nc(cc2)c(cccc3)c3c2Oc2nc(Nc3ccc(CC(N4)=O)c4c3)ncc2)=O)cc(P(C)(C)=O)c1OC Chemical compound CC(C)(C)c(cc1NC(Nc(cc2)c(cccc3)c3c2Oc2nc(Nc3ccc(CC(N4)=O)c4c3)ncc2)=O)cc(P(C)(C)=O)c1OC NZCDZOUZHSNTTN-UHFFFAOYSA-N 0.000 description 1
- AINMJTFLNRNIQY-UHFFFAOYSA-N CC(C)(C)c(cc1P(C)(C)=O)cc(NC(Nc(c2ccccc22)ccc2Oc2cc(Nc3cc(OC)cc(C(NCCN(CC4)CCS4=O)=O)c3)ncc2)=O)c1OC Chemical compound CC(C)(C)c(cc1P(C)(C)=O)cc(NC(Nc(c2ccccc22)ccc2Oc2cc(Nc3cc(OC)cc(C(NCCN(CC4)CCS4=O)=O)c3)ncc2)=O)c1OC AINMJTFLNRNIQY-UHFFFAOYSA-N 0.000 description 1
- XZQTYVLGJRZSGX-UHFFFAOYSA-N CC(C)(C)c(cc1P(C)(C)=O)cc(NC(Nc(c2ccccc22)ccc2Oc2nc(NC3CCOCC3)ncc2)=O)c1OC Chemical compound CC(C)(C)c(cc1P(C)(C)=O)cc(NC(Nc(c2ccccc22)ccc2Oc2nc(NC3CCOCC3)ncc2)=O)c1OC XZQTYVLGJRZSGX-UHFFFAOYSA-N 0.000 description 1
- PDRRMIHGJSJJLS-UHFFFAOYSA-N CC(C)(C)c(cc1S(C)=O)cc(NC(Nc(c2ccccc22)ccc2Oc2ccnc(Nc3cc(OC)cc(C(NCCN(CC4)CCS4=O)=O)c3)c2)=O)c1OC Chemical compound CC(C)(C)c(cc1S(C)=O)cc(NC(Nc(c2ccccc22)ccc2Oc2ccnc(Nc3cc(OC)cc(C(NCCN(CC4)CCS4=O)=O)c3)c2)=O)c1OC PDRRMIHGJSJJLS-UHFFFAOYSA-N 0.000 description 1
- PDDNAHGLOMWAFZ-UHFFFAOYSA-N CC(C)(C)c(cc1SC)cc(NC(Nc(cc2)c(cccc3)c3c2O)=O)c1OC Chemical compound CC(C)(C)c(cc1SC)cc(NC(Nc(cc2)c(cccc3)c3c2O)=O)c1OC PDDNAHGLOMWAFZ-UHFFFAOYSA-N 0.000 description 1
- VUXYPGINGDSIOU-UHFFFAOYSA-N CC(C)(C)c1cc(NC(Nc(c2c3cccc2)ccc3Oc2ccnc(NC3=CCCC=C3)c2)=O)c(C)c(PC)c1 Chemical compound CC(C)(C)c1cc(NC(Nc(c2c3cccc2)ccc3Oc2ccnc(NC3=CCCC=C3)c2)=O)c(C)c(PC)c1 VUXYPGINGDSIOU-UHFFFAOYSA-N 0.000 description 1
- NCJDFVKYRGQKRY-UHFFFAOYSA-N CC(Nc(c1c2cccc1)ccc2Oc1ccnc(Nc2ccccc2)c1)=O Chemical compound CC(Nc(c1c2cccc1)ccc2Oc1ccnc(Nc2ccccc2)c1)=O NCJDFVKYRGQKRY-UHFFFAOYSA-N 0.000 description 1
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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| GB201416430A GB201416430D0 (en) | 2014-09-17 | 2014-09-17 | New compounds |
| GB1416430.5 | 2014-09-17 | ||
| PCT/GB2014/053781 WO2015092423A1 (en) | 2013-12-20 | 2014-12-19 | Urea derivatives useful as kinase inhibitors |
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| AU2014369449A1 AU2014369449A1 (en) | 2016-05-26 |
| AU2014369449B2 true AU2014369449B2 (en) | 2018-07-05 |
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| EP (1) | EP3083604A1 (enExample) |
| JP (1) | JP6514703B2 (enExample) |
| CN (2) | CN113717162A (enExample) |
| AU (1) | AU2014369449B2 (enExample) |
| CA (1) | CA2934199A1 (enExample) |
| WO (1) | WO2015092423A1 (enExample) |
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| AU2008337286B2 (en) | 2007-12-19 | 2014-08-07 | Cancer Research Technology Limited | Pyrido[2,3-b]pyrazine-8-substituted compounds and their use |
| JP5760010B2 (ja) | 2010-02-01 | 2015-08-05 | キャンサー・リサーチ・テクノロジー・リミテッド | 1−(5−tert−ブチル−2−フェニル−2H−ピラゾール−3−イル)−3−[2−フルオロ−4−(1−メチル−2−オキソ−2,3−ジヒドロ−1H−イミダゾ[4,5−B]ピリジン−7−イルオキシ)−フェニル]−尿素および関連化合物ならびに治療におけるそれらの使用 |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| WO2014140582A1 (en) | 2013-03-14 | 2014-09-18 | Respivert Limited | Kinase inhibitors |
| BR112015024671A2 (pt) | 2013-04-02 | 2017-07-18 | Respivert Ltd | derivados de ureia úteis como inibidores de quinase |
| US9771353B2 (en) | 2013-04-02 | 2017-09-26 | Topivert Pharma Limited | Kinase inhibitors based upon N-alkyl pyrazoles |
| GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
| PT3357919T (pt) | 2014-02-14 | 2020-02-20 | Respivert Ltd | Compostos heterocíclicos aromáticos como compostos antiinflamatórios |
| MA40774A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
| TW201730189A (zh) | 2015-12-23 | 2017-09-01 | 吉斯藥品公司 | 激酶抑制劑 |
| AU2017245888B2 (en) * | 2016-04-06 | 2021-05-13 | Oxular Acquisitions Limited | Kinase inhibitors |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| WO2019071144A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | USE OF P38 INHIBITORS TO REDUCE DUX4 EXPRESSION |
| AU2019216351B2 (en) | 2018-01-31 | 2024-07-25 | Deciphera Pharmaceuticals, Llc | Combination therapy for the treatment of mastocytosis |
| EP3746059B1 (en) | 2018-01-31 | 2026-03-04 | Deciphera Pharmaceuticals, LLC | Combination therapy for the treatment of gastrointestinal stromal tumors |
| WO2020185812A1 (en) | 2019-03-11 | 2020-09-17 | Teva Pharmaceuticals International Gmbh | Solid state forms of ripretinib |
| FI4013412T3 (fi) | 2019-08-12 | 2026-03-24 | Deciphera Pharmaceuticals Llc | Ripretinibi ruoansulatuskanavan stroomakasvaimien hoitoon |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| PL4084779T3 (pl) | 2019-12-30 | 2025-02-24 | Deciphera Pharmaceuticals, Llc | Kompozycje 1-(4-bromo-5-(1-etylo-7-(metyloamino)-2-okso-1,2-dihydro-1,6-naftyrydyn-3-ylo)-2-fluorofenylo)-3-fenylomocznika |
| AU2020419197B2 (en) | 2019-12-30 | 2023-08-31 | Deciphera Pharmaceuticals, Llc | Amorphous kinase inhibitor formulations and methods of use thereof |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
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2014
- 2014-12-19 WO PCT/GB2014/053781 patent/WO2015092423A1/en not_active Ceased
- 2014-12-19 CN CN202111067810.5A patent/CN113717162A/zh active Pending
- 2014-12-19 AU AU2014369449A patent/AU2014369449B2/en not_active Ceased
- 2014-12-19 JP JP2016541566A patent/JP6514703B2/ja not_active Expired - Fee Related
- 2014-12-19 EP EP14815839.7A patent/EP3083604A1/en not_active Withdrawn
- 2014-12-19 CN CN201480069332.3A patent/CN106029651A/zh active Pending
- 2014-12-19 CA CA2934199A patent/CA2934199A1/en not_active Abandoned
- 2014-12-19 US US15/105,912 patent/US9890185B2/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| US9890185B2 (en) | 2018-02-13 |
| JP2017502033A (ja) | 2017-01-19 |
| CN113717162A (zh) | 2021-11-30 |
| CN106029651A (zh) | 2016-10-12 |
| AU2014369449A1 (en) | 2016-05-26 |
| JP6514703B2 (ja) | 2019-05-15 |
| WO2015092423A1 (en) | 2015-06-25 |
| EP3083604A1 (en) | 2016-10-26 |
| US20160318958A1 (en) | 2016-11-03 |
| CA2934199A1 (en) | 2015-06-25 |
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