AU2014339035A1 - Sirna and their use in methods and compositions for inhibiting the expression of the ORAI1 gene - Google Patents

Sirna and their use in methods and compositions for inhibiting the expression of the ORAI1 gene Download PDF

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Publication number
AU2014339035A1
AU2014339035A1 AU2014339035A AU2014339035A AU2014339035A1 AU 2014339035 A1 AU2014339035 A1 AU 2014339035A1 AU 2014339035 A AU2014339035 A AU 2014339035A AU 2014339035 A AU2014339035 A AU 2014339035A AU 2014339035 A1 AU2014339035 A1 AU 2014339035A1
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Prior art keywords
seq
sirna
orail
cells
eye
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Abandoned
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AU2014339035A
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Inventor
Ana Isabel Jimenez
Tamara Martinez
Covadonga Paneda
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Sylentis SA
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Sylentis SA
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
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    • C12N2310/33Chemical structure of the base
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/335Modified T or U
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    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2014339035A 2013-10-22 2014-10-21 Sirna and their use in methods and compositions for inhibiting the expression of the ORAI1 gene Abandoned AU2014339035A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20130382415 EP2865758A1 (fr) 2013-10-22 2013-10-22 ARNsi et leur utilisation dans des procédés et des compositions pour inhiber l'expression du gène ORAI1
EP13382415.1 2013-10-22
PCT/EP2014/072514 WO2015059122A2 (fr) 2013-10-22 2014-10-21 Arnsi et leur utilisation dans des procédés et des compositions pour inhiber l'expression du gène orai1

Publications (1)

Publication Number Publication Date
AU2014339035A1 true AU2014339035A1 (en) 2016-05-12

Family

ID=49474353

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014339035A Abandoned AU2014339035A1 (en) 2013-10-22 2014-10-21 Sirna and their use in methods and compositions for inhibiting the expression of the ORAI1 gene

Country Status (13)

Country Link
US (2) US10167473B2 (fr)
EP (2) EP2865758A1 (fr)
JP (1) JP2016535592A (fr)
KR (1) KR20160078384A (fr)
CN (1) CN107223154A (fr)
AU (1) AU2014339035A1 (fr)
BR (1) BR112016008786A2 (fr)
CA (1) CA2928515A1 (fr)
IL (1) IL245123A0 (fr)
MX (1) MX2016005042A (fr)
RU (1) RU2689607C2 (fr)
SG (2) SG11201603113WA (fr)
WO (1) WO2015059122A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017018029B1 (pt) * 2015-03-20 2021-06-15 Unilever Ip Holdings B.V. Molécula de sirna, método para a redução da perspiração, composição antiperspirante e uso de uma composição antiperspirante
MA44908A (fr) * 2015-09-08 2018-07-18 Sylentis Sau Molécules d'arnsi et leur utilisation dans des procédés et des compositions pour inhiber l'expression du gène nrarp
WO2017042239A1 (fr) * 2015-09-08 2017-03-16 Sylentis Sau Molécules d'arnsi et leur utilisation dans des procédés et des compositions pour l'inhibition de l'expression du gène chi3l1
WO2017096326A1 (fr) 2015-12-02 2017-06-08 Massachusetts Institute Of Technology Méthode de production efficace de neurones à partir de cellules non neuronales
CN105477637A (zh) * 2015-12-16 2016-04-13 孙荣距 Orai1基因沉默在血管内皮细胞钙超载损伤中的应用
EP4419681A1 (fr) * 2021-10-22 2024-08-28 Association Française contre les Myopathies (AFM) Méthode de traitement de myopathie à agrégats tubulaires et de syndrome de stormorken

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CZ308053B6 (cs) 2000-12-01 2019-11-27 Max Planck Gesellschaft Izolovaná molekula dvouřetězcové RNA, způsob její výroby a její použití
SI3222724T1 (sl) * 2002-08-05 2019-03-29 Silence Therapeutics Gmbh Nadaljnje nove oblike molekul interferenčne RNA
US7250496B2 (en) * 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
DK2284266T3 (da) * 2002-11-14 2014-01-13 Thermo Fisher Scient Biosciences Inc sIRNA-MOLEKYLE MOD TP53
WO2005062937A2 (fr) 2003-12-22 2005-07-14 University Of Massachusetts Procedes et compositions d'amelioration de l'efficacite de la specificite d'un siarn a extremite emoussee simple et double
AU2005276245C1 (en) * 2004-08-23 2015-02-26 Sylentis S.A.U. Treatment of eye disorders characterized by an elevated introacular pressure by siRNAs
CN101467046A (zh) 2006-04-10 2009-06-24 皇后医学中心 Crac调节剂及其在药物发现中的用途
TW201336514A (zh) * 2006-04-13 2013-09-16 Alcon Res Ltd RNA干擾(RNAi)所媒介之與脾酪胺酸激酶相關之發炎症狀的抑制作用(二)
GB0608838D0 (en) 2006-05-04 2006-06-14 Novartis Ag Organic compounds
JP2010507387A (ja) 2006-10-25 2010-03-11 クアーク・ファーマスーティカルス、インコーポレイテッド 新規のsiRNAおよびその使用方法
WO2008104978A2 (fr) 2007-02-28 2008-09-04 Quark Pharmaceuticals, Inc. Nouvelles structures d'arnsi
US8431536B2 (en) * 2007-03-05 2013-04-30 The University Of Queensland Target for breast cancer therapy and/or diagnosis
JP5646997B2 (ja) 2007-10-03 2014-12-24 クォーク ファーマシューティカルズ インコーポレーティッドQuark Pharmaceuticals,Inc. 新規siRNA構造
GB0801888D0 (en) 2008-02-01 2008-03-12 Isis Innovation Treatment of mast cell related disorders
US20120165265A1 (en) 2009-02-26 2012-06-28 Dolmetsch Ricardo E Calcium Signaling Modulators Involving STIM and ORAI Proteins
US20120264231A1 (en) 2009-06-19 2012-10-18 Immune Disease Institute, Inc. Assay for orai calcium channel regulators
CA2767225A1 (fr) * 2009-07-06 2011-01-13 Alnylam Pharmaceuticals, Inc. Compositions et procedes pour ameliorer la production d'un produit biologique
US8993612B2 (en) 2009-10-08 2015-03-31 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer
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KR101237036B1 (ko) 2009-11-04 2013-02-25 성균관대학교산학협력단 안티센스 가닥에 의한 오프-타겟 효과를 최소화한 신규한 siRNA 구조 및 그 용도
CN102827843A (zh) * 2012-09-25 2012-12-19 陈志南 一种针对Orai1基因、抑制肿瘤增殖和转移的shRNA及其应用

Also Published As

Publication number Publication date
RU2016119354A (ru) 2017-12-01
WO2015059122A3 (fr) 2015-08-20
SG11201603113WA (en) 2016-05-30
WO2015059122A2 (fr) 2015-04-30
JP2016535592A (ja) 2016-11-17
US20190106700A1 (en) 2019-04-11
IL245123A0 (en) 2016-06-30
BR112016008786A2 (pt) 2017-10-03
MX2016005042A (es) 2016-08-17
KR20160078384A (ko) 2016-07-04
US20160304880A1 (en) 2016-10-20
SG10201802865PA (en) 2018-05-30
RU2689607C2 (ru) 2019-05-28
EP3060663A2 (fr) 2016-08-31
CN107223154A (zh) 2017-09-29
EP2865758A1 (fr) 2015-04-29
CA2928515A1 (fr) 2015-04-30
RU2016119354A3 (fr) 2018-04-28
US10167473B2 (en) 2019-01-01

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