AU2014333542B2 - Labelling compounds and their use in assays - Google Patents
Labelling compounds and their use in assays Download PDFInfo
- Publication number
- AU2014333542B2 AU2014333542B2 AU2014333542A AU2014333542A AU2014333542B2 AU 2014333542 B2 AU2014333542 B2 AU 2014333542B2 AU 2014333542 A AU2014333542 A AU 2014333542A AU 2014333542 A AU2014333542 A AU 2014333542A AU 2014333542 B2 AU2014333542 B2 AU 2014333542B2
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- AU
- Australia
- Prior art keywords
- propan
- compound
- ferrocenylmethoxy
- substrate
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 244000052613 viral pathogen Species 0.000 description 1
- 238000001075 voltammogram Methods 0.000 description 1
- AWSFICBXMUKWSK-UHFFFAOYSA-N ytterbium(3+) Chemical compound [Yb+3] AWSFICBXMUKWSK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
- C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
- G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/113—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being electroactive, e.g. redox labels
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1317787.8 | 2013-10-08 | ||
| GBGB1317787.8A GB201317787D0 (en) | 2013-10-08 | 2013-10-08 | Labelling compounds and their use in assays |
| GB1413931.5 | 2014-08-06 | ||
| GB201413931A GB201413931D0 (en) | 2014-08-06 | 2014-08-06 | Labelling compounds and their use in assays |
| PCT/GB2014/053031 WO2015052516A1 (en) | 2013-10-08 | 2014-10-08 | Labelling compounds and their use in assays |
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| AU2014333542A1 AU2014333542A1 (en) | 2016-04-14 |
| AU2014333542B2 true AU2014333542B2 (en) | 2019-08-01 |
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| AU2014333542A Expired - Fee Related AU2014333542B2 (en) | 2013-10-08 | 2014-10-08 | Labelling compounds and their use in assays |
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| US (3) | US9822398B2 (enExample) |
| EP (1) | EP3055317B1 (enExample) |
| JP (1) | JP2016540724A (enExample) |
| CN (1) | CN105722847A (enExample) |
| AU (1) | AU2014333542B2 (enExample) |
| BR (1) | BR112016006955A2 (enExample) |
| CA (1) | CA2924750A1 (enExample) |
| EA (1) | EA201690434A1 (enExample) |
| ES (1) | ES2663397T3 (enExample) |
| WO (1) | WO2015052516A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB201021896D0 (en) | 2010-12-22 | 2011-02-02 | Atlas Genetics Ltd | Novel compounds and their use in analytical methods |
| AU2016367306B2 (en) * | 2015-12-09 | 2021-04-22 | Medizinische Universität Wien | Monomaleimide-functionalized platinum compounds for cancer therapy |
| CN106866748B (zh) * | 2017-03-29 | 2018-05-15 | 厦门云凡医药科技有限公司 | 化合物的制备方法 |
| CN112630283B (zh) * | 2020-12-18 | 2023-01-17 | 河南城建学院 | (e, e)-1,1′-双(2-吡啶乙烯基)二茂铁作为电化学传感器的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012085591A1 (en) * | 2010-12-22 | 2012-06-28 | Atlas Genetics Limited | Novel ferrocene labels for electrochemical assay and their use in analytical methods |
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| DE3855770T2 (de) * | 1987-03-31 | 1997-05-07 | Idemitsu Kosan Co | Ferrocenderivate, diese enthaltende oberflächenaktive stoffe und verfahren zur herstellung dünner organischer filme |
| JPH0283386A (ja) * | 1988-09-20 | 1990-03-23 | Idemitsu Kosan Co Ltd | 新規フェロセン誘導体，それを含有する界面活性剤及び有機薄膜の製造方法 |
| US6753143B2 (en) | 2000-05-01 | 2004-06-22 | Clinical Micro Sensors, Inc. | Target analyte detection using asymmetrical self-assembled monolayers |
| US20030143556A1 (en) | 2001-04-03 | 2003-07-31 | Gary Blackburn | Nucleic acid reactions using labels with different redox potentials |
| GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| GB0316075D0 (en) | 2003-07-09 | 2003-08-13 | Molecular Sensing Plc | Protease detection assay |
| FR2888240B1 (fr) * | 2005-07-11 | 2007-09-07 | Biomerieux Sa | Monomeres electropolymerisables solubles en solution aqueuse et sondes electroactives susceptibles d'etre obtenues avec de tels monomeres |
| EP2220102B1 (en) * | 2007-11-06 | 2014-04-16 | Clinical Micro Sensors, Inc. | Baseless nucleotide analogues and uses thereof |
| GB0922097D0 (en) | 2009-12-17 | 2010-02-03 | Atlas Genetics Ltd | Microbial assay |
| GB201211157D0 (en) | 2012-06-22 | 2012-08-08 | Atlas Genetics Ltd | Novel compounds and their use in analytical methods |
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2014
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- 2014-10-08 US US15/026,454 patent/US9822398B2/en active Active
- 2014-10-08 WO PCT/GB2014/053031 patent/WO2015052516A1/en not_active Ceased
- 2014-10-08 ES ES14784356.9T patent/ES2663397T3/es active Active
- 2014-10-08 JP JP2016516600A patent/JP2016540724A/ja active Pending
- 2014-10-08 BR BR112016006955A patent/BR112016006955A2/pt not_active IP Right Cessation
- 2014-10-08 EP EP14784356.9A patent/EP3055317B1/en active Active
- 2014-10-08 AU AU2014333542A patent/AU2014333542B2/en not_active Expired - Fee Related
- 2014-10-08 EA EA201690434A patent/EA201690434A1/ru unknown
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2017
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2021
- 2021-04-05 US US17/222,484 patent/US11572592B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012085591A1 (en) * | 2010-12-22 | 2012-06-28 | Atlas Genetics Limited | Novel ferrocene labels for electrochemical assay and their use in analytical methods |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015052516A1 (en) | 2015-04-16 |
| AU2014333542A1 (en) | 2016-04-14 |
| US11572592B2 (en) | 2023-02-07 |
| US20180037937A1 (en) | 2018-02-08 |
| JP2016540724A (ja) | 2016-12-28 |
| EA201690434A1 (ru) | 2016-08-31 |
| ES2663397T3 (es) | 2018-04-12 |
| CA2924750A1 (en) | 2015-04-16 |
| CN105722847A (zh) | 2016-06-29 |
| US20220025440A1 (en) | 2022-01-27 |
| EP3055317A1 (en) | 2016-08-17 |
| US20160244815A1 (en) | 2016-08-25 |
| EP3055317B1 (en) | 2018-01-31 |
| US10968490B2 (en) | 2021-04-06 |
| BR112016006955A2 (pt) | 2017-08-01 |
| US9822398B2 (en) | 2017-11-21 |
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Legal Events
| Date | Code | Title | Description |
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| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |