JP2016540724A - 標識用化合物およびアッセイにおけるそれらの使用 - Google Patents

標識用化合物およびアッセイにおけるそれらの使用 Download PDF

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Publication number
JP2016540724A
JP2016540724A JP2016516600A JP2016516600A JP2016540724A JP 2016540724 A JP2016540724 A JP 2016540724A JP 2016516600 A JP2016516600 A JP 2016516600A JP 2016516600 A JP2016516600 A JP 2016516600A JP 2016540724 A JP2016540724 A JP 2016540724A
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JP
Japan
Prior art keywords
propan
ferrocenylmethoxy
compound
tert
cyanoethyl
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Pending
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JP2016516600A
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English (en)
Japanese (ja)
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JP2016540724A5 (enExample
Inventor
バリー・ジェイ・マーシュ
クリストファー・ジー・フロスト
ジョナサン・シャープ
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Binx Health Ltd
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Atlas Genetics Ltd
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Filing date
Publication date
Priority claimed from GBGB1317787.8A external-priority patent/GB201317787D0/en
Priority claimed from GB201413931A external-priority patent/GB201413931D0/en
Application filed by Atlas Genetics Ltd filed Critical Atlas Genetics Ltd
Publication of JP2016540724A publication Critical patent/JP2016540724A/ja
Publication of JP2016540724A5 publication Critical patent/JP2016540724A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/113—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being electroactive, e.g. redox labels

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
JP2016516600A 2013-10-08 2014-10-08 標識用化合物およびアッセイにおけるそれらの使用 Pending JP2016540724A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1317787.8A GB201317787D0 (en) 2013-10-08 2013-10-08 Labelling compounds and their use in assays
GB1317787.8 2013-10-08
GB1413931.5 2014-08-06
GB201413931A GB201413931D0 (en) 2014-08-06 2014-08-06 Labelling compounds and their use in assays
PCT/GB2014/053031 WO2015052516A1 (en) 2013-10-08 2014-10-08 Labelling compounds and their use in assays

Publications (2)

Publication Number Publication Date
JP2016540724A true JP2016540724A (ja) 2016-12-28
JP2016540724A5 JP2016540724A5 (enExample) 2017-11-16

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JP2016516600A Pending JP2016540724A (ja) 2013-10-08 2014-10-08 標識用化合物およびアッセイにおけるそれらの使用

Country Status (10)

Country Link
US (3) US9822398B2 (enExample)
EP (1) EP3055317B1 (enExample)
JP (1) JP2016540724A (enExample)
CN (1) CN105722847A (enExample)
AU (1) AU2014333542B2 (enExample)
BR (1) BR112016006955A2 (enExample)
CA (1) CA2924750A1 (enExample)
EA (1) EA201690434A1 (enExample)
ES (1) ES2663397T3 (enExample)
WO (1) WO2015052516A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201021896D0 (en) 2010-12-22 2011-02-02 Atlas Genetics Ltd Novel compounds and their use in analytical methods
ES2898704T3 (es) * 2015-12-09 2022-03-08 Univ Wien Med Compuestos de platino funcionalizados con monomaleimida para la terapia del cáncer
CN106866748B (zh) * 2017-03-29 2018-05-15 厦门云凡医药科技有限公司 化合物的制备方法
CN112630283B (zh) * 2020-12-18 2023-01-17 河南城建学院 (e, e)-1,1′-双(2-吡啶乙烯基)二茂铁作为电化学传感器的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0283386A (ja) * 1988-09-20 1990-03-23 Idemitsu Kosan Co Ltd 新規フェロセン誘導体，それを含有する界面活性剤及び有機薄膜の製造方法
US20020121314A1 (en) * 2000-05-01 2002-09-05 Clinical Micro Sensors Target analyte detection using asymmetrical self-assembled monolayers
US20030143556A1 (en) * 2001-04-03 2003-07-31 Gary Blackburn Nucleic acid reactions using labels with different redox potentials
WO2012085591A1 (en) * 2010-12-22 2012-06-28 Atlas Genetics Limited Novel ferrocene labels for electrochemical assay and their use in analytical methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3855770T2 (de) * 1987-03-31 1997-05-07 Idemitsu Kosan Co Ferrocenderivate, diese enthaltende oberflächenaktive stoffe und verfahren zur herstellung dünner organischer filme
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
GB0316075D0 (en) 2003-07-09 2003-08-13 Molecular Sensing Plc Protease detection assay
FR2888240B1 (fr) * 2005-07-11 2007-09-07 Biomerieux Sa Monomeres electropolymerisables solubles en solution aqueuse et sondes electroactives susceptibles d'etre obtenues avec de tels monomeres
WO2009061941A2 (en) 2007-11-06 2009-05-14 Osmetech Molecular Diagnostics Baseless nucleotide analogues and uses thereof
GB0922097D0 (en) 2009-12-17 2010-02-03 Atlas Genetics Ltd Microbial assay
GB201211157D0 (en) * 2012-06-22 2012-08-08 Atlas Genetics Ltd Novel compounds and their use in analytical methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0283386A (ja) * 1988-09-20 1990-03-23 Idemitsu Kosan Co Ltd 新規フェロセン誘導体，それを含有する界面活性剤及び有機薄膜の製造方法
US20020121314A1 (en) * 2000-05-01 2002-09-05 Clinical Micro Sensors Target analyte detection using asymmetrical self-assembled monolayers
US20030143556A1 (en) * 2001-04-03 2003-07-31 Gary Blackburn Nucleic acid reactions using labels with different redox potentials
WO2012085591A1 (en) * 2010-12-22 2012-06-28 Atlas Genetics Limited Novel ferrocene labels for electrochemical assay and their use in analytical methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
IHARA, T. ET AL., SUPRAMOLECULAR CHEMISTRY, vol. Vol. 21, No. 3-4, JPN6018020401, 2009, pages 207 - 217, ISSN: 0003949619 *
SIEMELING, U. ET AL., JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 475, JPN6018020404, 1994, pages 229 - 232, ISSN: 0003949620 *

Also Published As

Publication number Publication date
WO2015052516A1 (en) 2015-04-16
US9822398B2 (en) 2017-11-21
EP3055317B1 (en) 2018-01-31
CA2924750A1 (en) 2015-04-16
US20160244815A1 (en) 2016-08-25
US11572592B2 (en) 2023-02-07
US10968490B2 (en) 2021-04-06
EA201690434A1 (ru) 2016-08-31
US20180037937A1 (en) 2018-02-08
CN105722847A (zh) 2016-06-29
BR112016006955A2 (pt) 2017-08-01
US20220025440A1 (en) 2022-01-27
AU2014333542B2 (en) 2019-08-01
ES2663397T3 (es) 2018-04-12
AU2014333542A1 (en) 2016-04-14
EP3055317A1 (en) 2016-08-17

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