AU2014318839B2 - Compositions and methods for the delivery of molecules into live cells - Google Patents

Compositions and methods for the delivery of molecules into live cells Download PDF

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Publication number
AU2014318839B2
AU2014318839B2 AU2014318839A AU2014318839A AU2014318839B2 AU 2014318839 B2 AU2014318839 B2 AU 2014318839B2 AU 2014318839 A AU2014318839 A AU 2014318839A AU 2014318839 A AU2014318839 A AU 2014318839A AU 2014318839 B2 AU2014318839 B2 AU 2014318839B2
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Australia
Prior art keywords
cell
cells
dtat
compound
amino acid
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AU2014318839A
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AU2014318839A1 (en
Inventor
Jean-Philippe PELLOIS
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Texas A&M University System
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Texas A&M University System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2014318839A 2013-09-10 2014-09-10 Compositions and methods for the delivery of molecules into live cells Active AU2014318839B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361876006P 2013-09-10 2013-09-10
US61/876,006 2013-09-10
PCT/US2014/055021 WO2015038662A1 (en) 2013-09-10 2014-09-10 Compositions and methods for the delivery of molecules into live cells

Publications (2)

Publication Number Publication Date
AU2014318839A1 AU2014318839A1 (en) 2016-03-31
AU2014318839B2 true AU2014318839B2 (en) 2019-12-05

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ID=52666235

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014318839A Active AU2014318839B2 (en) 2013-09-10 2014-09-10 Compositions and methods for the delivery of molecules into live cells

Country Status (7)

Country Link
US (2) US9662404B2 (https=)
EP (1) EP3043811B1 (https=)
JP (1) JP6659546B2 (https=)
AU (1) AU2014318839B2 (https=)
CA (1) CA2923664C (https=)
ES (1) ES2794599T3 (https=)
WO (1) WO2015038662A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2981716C (en) 2015-04-10 2022-04-12 Feldan Bio Inc. Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same
FR3048698B1 (fr) 2016-03-11 2021-03-05 Univ Claude Bernard Lyon Inhibiteurs de l'interaction bcl2 l10 / recepteur ip3
CN110291100B (zh) * 2016-10-12 2024-06-11 费尔丹生物公司 用于将多肽负荷从细胞外空间递送至靶真核细胞的胞质溶胶和/或细胞核的合理设计的合成肽穿梭剂，其用途、与其相关的方法和试剂盒
US11629170B2 (en) 2016-10-12 2023-04-18 Feldan Bio Inc. Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic cell, uses thereof, methods and kits relating to same
EP3604520A4 (en) * 2017-03-22 2020-12-16 Kyoto University PEPTIDE FOR CYTOSOLIC ADMINISTRATION
US11821003B2 (en) 2017-08-14 2023-11-21 Sanford Burnham Prebys Medical Discovery Institute Cardiogenic mesoderm formation regulators
WO2020091535A1 (ko) * 2018-11-02 2020-05-07 순천향대학교 산학협력단 점막 투과 촉진용 펩타이드 및 이를 포함하는 조성물
JP2022512977A (ja) 2018-11-08 2022-02-07 サメイション バイオ， インコーポレイテッド ミニヌクレオソームコアタンパク質及び核酸送達における使用
KR102201154B1 (ko) * 2019-03-26 2021-01-12 가천대학교 산학협력단 폴리글루타메이트-TAT-Cre 융합 단백질의 제조방법
CA3040645A1 (en) 2019-04-18 2020-10-18 Feldan Bio Inc. Peptide-based non-proteinaceous cargo delivery
AU2021254697A1 (en) 2020-04-13 2022-11-10 Summation Bio Inc. Modified mini-nucleosome core proteins and use in nucleic acid delivery

Citations (3)

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WO1999047173A2 (en) * 1998-03-19 1999-09-23 University Of Medicine And Dentistry Of New Jersey Carrier for in vivo delivery of a therapeutic agent
WO2009067757A1 (en) * 2007-11-30 2009-06-04 Cytomatrix Pty Ltd Methods of inducing pluripotency involving oct4 protein
WO2010115052A2 (en) * 2009-04-03 2010-10-07 The Mclean Hospital Corporation Induced pluripotent stem cells

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
AU2006325030B2 (en) 2005-12-16 2012-07-26 Cellectis Cell penetrating peptide conjugates for delivering nucleic acids into cells
WO2010059806A2 (en) * 2008-11-20 2010-05-27 Cedars-Sinai Medical Center Generation of induced pluripotent stem cells without the use of viral vectors
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
EP4321168A3 (en) * 2010-07-13 2024-04-24 Yale University, Inc. Environmentally sensitive compositions
WO2012090150A2 (en) 2010-12-27 2012-07-05 Compugen Ltd New cell-penetrating peptides and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047173A2 (en) * 1998-03-19 1999-09-23 University Of Medicine And Dentistry Of New Jersey Carrier for in vivo delivery of a therapeutic agent
WO2009067757A1 (en) * 2007-11-30 2009-06-04 Cytomatrix Pty Ltd Methods of inducing pluripotency involving oct4 protein
WO2010115052A2 (en) * 2009-04-03 2010-10-07 The Mclean Hospital Corporation Induced pluripotent stem cells

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ARCHANA CHUGH ET AL: "Translocation of cell-penetrating peptides and delivery of their cargoes in triticale microspores", PLANT CELL REPORTS, vol. 28, no. 5, 15 March 2009 (2009-03-15), pages 801-810 *
CARSTEN RUDOLPH ET AL: PHARMACEUTICAL RESEARCH, vol. 21, no. 9, 1September2004 (2004-09-01), pages 1662-1669 *
KROSL J ET AL: "In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein", NATURE MEDICINE, vol. 9, no. 11, 1 November 2003 (2003-11-01 ), pages 1428-1432 *
LEE SOO-JIN ET AL: "Enhancement of gene delivery using novel homodimeric tat peptide formed by disulfide bond.", JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY AUG 2011, vol. 21, no. 8, August 2011 (2011-08), pages 802-807 *
WAN LI ET AL: AIDS RESEARCH AND THERAPY, vol. 3, no. 1, 24 April 2006 (2006-04-24), page 12 *

Also Published As

Publication number Publication date
JP2016530303A (ja) 2016-09-29
US20150099690A1 (en) 2015-04-09
CA2923664A1 (en) 2015-03-19
CA2923664C (en) 2023-05-02
WO2015038662A1 (en) 2015-03-19
US20170258933A1 (en) 2017-09-14
ES2794599T3 (es) 2020-11-18
US9662404B2 (en) 2017-05-30
EP3043811A4 (en) 2017-09-20
JP6659546B2 (ja) 2020-03-04
EP3043811B1 (en) 2020-03-25
EP3043811A1 (en) 2016-07-20

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