AU2014295442B2 - Cancer therapy with a parvovirus combined with a Bcl-2 inhibitor - Google Patents

Cancer therapy with a parvovirus combined with a Bcl-2 inhibitor Download PDF

Info

Publication number
AU2014295442B2
AU2014295442B2 AU2014295442A AU2014295442A AU2014295442B2 AU 2014295442 B2 AU2014295442 B2 AU 2014295442B2 AU 2014295442 A AU2014295442 A AU 2014295442A AU 2014295442 A AU2014295442 A AU 2014295442A AU 2014295442 B2 AU2014295442 B2 AU 2014295442B2
Authority
AU
Australia
Prior art keywords
parvovirus
bcl
abt
inhibitor
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2014295442A
Other languages
English (en)
Other versions
AU2014295442A1 (en
Inventor
Karsten Geletneky
Junwei Li
Antonio Marchini
Jean Rommelaere
Lea Schroeder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Universitaet Heidelberg
Original Assignee
Deutsches Krebsforschungszentrum DKFZ
Universitaet Heidelberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforschungszentrum DKFZ, Universitaet Heidelberg filed Critical Deutsches Krebsforschungszentrum DKFZ
Publication of AU2014295442A1 publication Critical patent/AU2014295442A1/en
Assigned to DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTES, Ruprecht-Karls-Univerisitat Heidelberg reassignment DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTES Amend patent request/document other than specification (104) Assignors: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTES, RUPRECHT-KARLS-UNIVERISTAT HEIDELBERG
Application granted granted Critical
Publication of AU2014295442B2 publication Critical patent/AU2014295442B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14311—Parvovirus, e.g. minute virus of mice
    • C12N2750/14332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2014295442A 2013-07-22 2014-07-22 Cancer therapy with a parvovirus combined with a Bcl-2 inhibitor Active AU2014295442B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13003664.3 2013-07-22
EP20130003664 EP2829284A1 (en) 2013-07-22 2013-07-22 Cancer therapy with a parvovirus combined with a Bcl-2 inhibitor
PCT/EP2014/002001 WO2015010782A1 (en) 2013-07-22 2014-07-22 Cancer therapy with a parvovirus combined with a bcl-2 inhibitor

Publications (2)

Publication Number Publication Date
AU2014295442A1 AU2014295442A1 (en) 2015-12-24
AU2014295442B2 true AU2014295442B2 (en) 2017-06-15

Family

ID=48856486

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014295442A Active AU2014295442B2 (en) 2013-07-22 2014-07-22 Cancer therapy with a parvovirus combined with a Bcl-2 inhibitor

Country Status (8)

Country Link
US (2) US9889169B2 (enExample)
EP (2) EP2829284A1 (enExample)
JP (2) JP6195988B2 (enExample)
AU (1) AU2014295442B2 (enExample)
CA (1) CA2914420C (enExample)
DK (1) DK3024491T3 (enExample)
ES (1) ES2636768T3 (enExample)
WO (1) WO2015010782A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3069724A1 (en) * 2015-03-19 2016-09-21 Deutsches Krebsforschungszentrum Lung cancer therapy with a rodent parvovirus
SG11201807965YA (en) * 2016-03-15 2018-10-30 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors
CA3017773A1 (en) * 2016-03-17 2017-09-21 Deutsches Krebsforschungszentrum Lung cancer therapy with a parvovirus
EP3225253A1 (en) * 2016-04-01 2017-10-04 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts Cancer therapy with an oncolytic virus combined with a checkpoint inhibitor
CN106177955B (zh) * 2016-08-18 2018-03-16 广州威溶特医药科技有限公司 Bcl‑xL抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用
AU2018270515A1 (en) * 2017-05-19 2019-12-05 The Regents Of The University Of California Antibody chemically induced dimerizer (abCID) as molecular switches for regulating cellular therapies
EP3657172A1 (en) 2018-11-22 2020-05-27 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Method for predicting the clinical response of oncolytic parvovirus h1 (h-1pv) treatment in a patient suspected of suffering from cancer by measuring the expression levels of laminins and/or galectins as biomarkers in a patient´s sample
US20240041833A1 (en) 2020-12-21 2024-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Pharmaceutical combination product comprising a protoparvovirus and an antiviral benzimidazole and uses thereof for treating cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009083232A1 (en) * 2007-12-28 2009-07-09 Deutsches Krebsforschungszentrum Parvovirus cancer therapy and combination with chemotherapy
WO2011113600A1 (en) * 2010-03-17 2011-09-22 Deutsches Krebsforschungszentrum Cancer therapy with a parvovirus combined with an hdac inhibitor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009083232A1 (en) * 2007-12-28 2009-07-09 Deutsches Krebsforschungszentrum Parvovirus cancer therapy and combination with chemotherapy
WO2011113600A1 (en) * 2010-03-17 2011-09-22 Deutsches Krebsforschungszentrum Cancer therapy with a parvovirus combined with an hdac inhibitor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BAJWA, N. et al., 'Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review'. Expert Opin Ther Pat. 2012. 22(1): 37-55 *
MOORE, V. et a., 'Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737'. The Journal of Clinical Investigation. 2007. 117(1): 112-121 *

Also Published As

Publication number Publication date
US9889169B2 (en) 2018-02-13
AU2014295442A1 (en) 2015-12-24
DK3024491T3 (en) 2017-07-31
WO2015010782A1 (en) 2015-01-29
US10406185B2 (en) 2019-09-10
EP3024491B1 (en) 2017-05-10
JP6195988B2 (ja) 2017-09-13
US20160082056A1 (en) 2016-03-24
EP3024491A1 (en) 2016-06-01
ES2636768T3 (es) 2017-10-09
JP2017155057A (ja) 2017-09-07
JP2016525131A (ja) 2016-08-22
CA2914420A1 (en) 2015-01-29
US20180117104A1 (en) 2018-05-03
WO2015010782A8 (en) 2016-01-14
CA2914420C (en) 2019-04-16
EP2829284A1 (en) 2015-01-28

Similar Documents

Publication Publication Date Title
AU2014295442B2 (en) Cancer therapy with a parvovirus combined with a Bcl-2 inhibitor
EP2431045B1 (en) Pancreatic cancer therapy with a parvovirus
EP2590663B1 (en) Use of parvovirus for eliminating cancer stem cells (cscs)
JP2019203027A (ja) パルボウイルスを用いたベバシズマブを併用するがん治療
AU2012269386B2 (en) Oncolytic virotherapy for the therapy of sarcoma
US20190076494A1 (en) Lung cancer therapy with a parvovirus
EP3069724A1 (en) Lung cancer therapy with a rodent parvovirus

Legal Events

Date Code Title Description
TH Corrigenda

Free format text: IN VOL 30 , NO 3 , PAGE(S) 240 UNDER THE HEADING CHANGE OF NAMES(S) OF APPLICANT(S), SECTION 104 - 2014 UNDER THE NAME DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTES; RUPRECHTKARLS-UNIVERISITAT HEIDELBERG, APPLICATION NO. 2014295442, UNDER INID (71) CORRECT THE APPLICANT NAME TO DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTES; RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG

FGA Letters patent sealed or granted (standard patent)