AU2014230111A1 - Macrocyclic RIP2 kinase inhibitors - Google Patents
Macrocyclic RIP2 kinase inhibitors Download PDFInfo
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- AU2014230111A1 AU2014230111A1 AU2014230111A AU2014230111A AU2014230111A1 AU 2014230111 A1 AU2014230111 A1 AU 2014230111A1 AU 2014230111 A AU2014230111 A AU 2014230111A AU 2014230111 A AU2014230111 A AU 2014230111A AU 2014230111 A1 AU2014230111 A1 AU 2014230111A1
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- 125000001425 triazolyl group Chemical group 0.000 description 1
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
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- Emergency Medicine (AREA)
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- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2013/066732 | 2013-03-15 | ||
| GBGB1304714.7A GB201304714D0 (en) | 2013-03-15 | 2013-03-15 | Macrocyclic RIP2 Kinase inhibitors |
| GB1304714.7 | 2013-03-15 | ||
| EP2013066732 | 2013-03-15 | ||
| PCT/EP2014/055139 WO2014140299A1 (en) | 2013-03-15 | 2014-03-14 | Macrocyclic rip2 kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
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| AU2014230111A1 true AU2014230111A1 (en) | 2015-10-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| AU2014230111A Abandoned AU2014230111A1 (en) | 2013-03-15 | 2014-03-14 | Macrocyclic RIP2 kinase inhibitors |
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| Country | Link |
|---|---|
| US (1) | US20160024114A1 (https=) |
| JP (1) | JP2016510796A (https=) |
| KR (1) | KR20150133765A (https=) |
| CN (1) | CN105228625A (https=) |
| AU (1) | AU2014230111A1 (https=) |
| BR (1) | BR112015022982A2 (https=) |
| CA (1) | CA2906257A1 (https=) |
| EA (1) | EA201591773A1 (https=) |
| HK (1) | HK1218263A1 (https=) |
| IL (1) | IL241250A0 (https=) |
| MX (1) | MX2015012526A (https=) |
| SG (1) | SG11201507594YA (https=) |
| WO (1) | WO2014140299A1 (https=) |
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| WO2016146651A1 (en) * | 2015-03-16 | 2016-09-22 | Oncodesign Sa | Macrocyclic activin-like receptor kinase inhibitors |
| WO2017198753A1 (en) | 2016-05-19 | 2017-11-23 | Universiteit Antwerpen | Bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of par-related diseases |
| BR112019001607A2 (pt) * | 2016-07-28 | 2019-04-30 | Tp Therapeutics, Inc. | inibidores macrocíclicos de quinases |
| KR102719387B1 (ko) * | 2017-01-26 | 2024-10-21 | 한미약품 주식회사 | 이미다조피리다진 화합물 |
| US11358973B2 (en) * | 2018-04-16 | 2022-06-14 | Shenzhen Targetrx, Inc. | Di(hetero)aryl macrocyclic compound for inhibiting protein kinase activity |
| AU2019364336B2 (en) | 2018-10-22 | 2023-11-16 | Alumis Inc. | TYK2 inhibitors and uses thereof |
| UA129879C2 (uk) * | 2020-01-31 | 2025-08-27 | Онкодизайн Пресіжн Медісін (Опм) | Макроциклічні інгібітори rip2-кінази |
| JP2025532532A (ja) * | 2022-09-07 | 2025-10-01 | 蘇州朗睿生物医薬有限公司 | 大環状イミダゾ［１，２－ｂ］ピリダジン誘導体並びにその調製方法及び用途 |
| WO2025212514A2 (en) * | 2024-04-02 | 2025-10-09 | Interline Therapeutics, Inc. | Methods of treating inflammatory diseases |
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| AUPQ120999A0 (en) * | 1999-06-25 | 1999-07-22 | Industrial Automation Services Pty Ltd | Vibration suppressing piston |
| JP2004089182A (ja) * | 2002-06-24 | 2004-03-25 | Takeda Chem Ind Ltd | がんの予防・治療剤 |
| TWI547494B (zh) * | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| CA2849999A1 (en) * | 2011-09-30 | 2013-04-04 | Oncodesign S.A. | Macrocyclic flt3 kinase inhibitors |
| BR112014007654A8 (pt) * | 2011-09-30 | 2018-06-12 | Ipsen Pharma | Inibidores de lrrk2 quinase macrocíclicos. |
| TW201444850A (zh) * | 2013-03-15 | 2014-12-01 | Ipsen Pharma Sas | 巨環ｌｒｒｋ２激酶抑制劑 |
| WO2014140313A1 (en) * | 2013-03-15 | 2014-09-18 | Oncodesign S.A. | Macrocyclic salt-inducible kinase inhibitors |
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2014
- 2014-03-14 JP JP2015562211A patent/JP2016510796A/ja not_active Withdrawn
- 2014-03-14 MX MX2015012526A patent/MX2015012526A/es unknown
- 2014-03-14 HK HK16106342.4A patent/HK1218263A1/zh unknown
- 2014-03-14 EA EA201591773A patent/EA201591773A1/ru unknown
- 2014-03-14 KR KR1020157029469A patent/KR20150133765A/ko not_active Withdrawn
- 2014-03-14 CA CA2906257A patent/CA2906257A1/en not_active Abandoned
- 2014-03-14 CN CN201480023821.5A patent/CN105228625A/zh active Pending
- 2014-03-14 WO PCT/EP2014/055139 patent/WO2014140299A1/en not_active Ceased
- 2014-03-14 BR BR112015022982A patent/BR112015022982A2/pt not_active IP Right Cessation
- 2014-03-14 SG SG11201507594YA patent/SG11201507594YA/en unknown
- 2014-03-14 US US14/776,889 patent/US20160024114A1/en not_active Abandoned
- 2014-03-14 AU AU2014230111A patent/AU2014230111A1/en not_active Abandoned
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2015
- 2015-09-07 IL IL241250A patent/IL241250A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL241250A0 (en) | 2015-11-30 |
| EA201591773A1 (ru) | 2016-01-29 |
| BR112015022982A2 (pt) | 2017-07-18 |
| HK1218263A1 (zh) | 2017-02-10 |
| KR20150133765A (ko) | 2015-11-30 |
| CN105228625A (zh) | 2016-01-06 |
| SG11201507594YA (en) | 2015-10-29 |
| US20160024114A1 (en) | 2016-01-28 |
| CA2906257A1 (en) | 2014-09-18 |
| MX2015012526A (es) | 2016-04-26 |
| WO2014140299A1 (en) | 2014-09-18 |
| JP2016510796A (ja) | 2016-04-11 |
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| Date | Code | Title | Description |
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| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |