AU2014228861B2 - Rapidly dispersible dosage form of topiramate - Google Patents

Rapidly dispersible dosage form of topiramate Download PDF

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Publication number
AU2014228861B2
AU2014228861B2 AU2014228861A AU2014228861A AU2014228861B2 AU 2014228861 B2 AU2014228861 B2 AU 2014228861B2 AU 2014228861 A AU2014228861 A AU 2014228861A AU 2014228861 A AU2014228861 A AU 2014228861A AU 2014228861 B2 AU2014228861 B2 AU 2014228861B2
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AU
Australia
Prior art keywords
dosage form
drug
wax
matrix
coated particles
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AU2014228861A
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AU2014228861A1 (en
Inventor
Lauren BEACH
Jules Jacob
Donald C. Monkhouse
Henry L. Surprenant
Thomas G. West
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Aprecia Pharmaceuticals LLC
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Aprecia Pharmaceuticals LLC
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Publication of AU2014228861A1 publication Critical patent/AU2014228861A1/en
Assigned to Aprecia Pharmaceuticals LLC reassignment Aprecia Pharmaceuticals LLC Request for Assignment Assignors: APRECIA PHARMACEUTICALS COMPANY
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Publication of AU2014228861B2 publication Critical patent/AU2014228861B2/en
Priority to AU2018220049A priority Critical patent/AU2018220049B2/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5015Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2014228861A 2013-03-15 2014-03-14 Rapidly dispersible dosage form of topiramate Active AU2014228861B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018220049A AU2018220049B2 (en) 2013-03-15 2018-08-22 Rapidly dispersible dosage form of topiramate

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361791592P 2013-03-15 2013-03-15
US61/791,592 2013-03-15
PCT/US2014/029168 WO2014144661A1 (en) 2013-03-15 2014-03-14 Rapidly dispersible dosage form of topiramate

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018220049A Division AU2018220049B2 (en) 2013-03-15 2018-08-22 Rapidly dispersible dosage form of topiramate

Publications (2)

Publication Number Publication Date
AU2014228861A1 AU2014228861A1 (en) 2015-10-08
AU2014228861B2 true AU2014228861B2 (en) 2018-05-24

Family

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AU2014228861A Active AU2014228861B2 (en) 2013-03-15 2014-03-14 Rapidly dispersible dosage form of topiramate
AU2018220049A Active AU2018220049B2 (en) 2013-03-15 2018-08-22 Rapidly dispersible dosage form of topiramate

Family Applications After (1)

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Country Status (10)

Country Link
US (2) US9492380B2 (cg-RX-API-DMAC7.html)
EP (1) EP2968181B1 (cg-RX-API-DMAC7.html)
JP (1) JP6466399B2 (cg-RX-API-DMAC7.html)
CN (1) CN105050588B (cg-RX-API-DMAC7.html)
AU (2) AU2014228861B2 (cg-RX-API-DMAC7.html)
CA (1) CA2906172C (cg-RX-API-DMAC7.html)
ES (1) ES2761407T3 (cg-RX-API-DMAC7.html)
HK (1) HK1213473A1 (cg-RX-API-DMAC7.html)
MX (1) MX365914B (cg-RX-API-DMAC7.html)
WO (1) WO2014144661A1 (cg-RX-API-DMAC7.html)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2187873T3 (pl) * 2007-08-13 2019-01-31 Abuse Deterrent Pharmaceutical Llc Leki odporne na nadużywanie, metoda stosowania i metoda wytwarzania
AU2014228990B2 (en) 2013-03-15 2017-02-02 Aprecia Pharmaceuticals LLC Rapid disperse dosage form containing levetiracetam
US9339489B2 (en) 2013-03-15 2016-05-17 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
CN104586871B (zh) * 2014-12-27 2018-01-16 北京罗诺强施医药技术研发中心有限公司 包含托吡酯的药物组合物
US20160243036A1 (en) * 2015-02-25 2016-08-25 Intelgenx Corp. Film dosage forms containing amorphous active agents
KR20180014778A (ko) 2015-06-03 2018-02-09 트리아스텍 인코포레이티드 제형 및 이의 용도
WO2017175792A1 (ja) * 2016-04-06 2017-10-12 アステラス製薬株式会社 速溶出性三次元造形物、速溶出性三次元造形物用フィラメント及び速溶出性三次元造形物用材料
CA3035692C (en) 2016-09-02 2024-04-09 Novo Futura Ivs Disposable grill and method of manufacturing a disposable grill
CA3051614A1 (en) 2017-01-26 2018-08-02 Triastek, Inc. Dosage forms of controlled release at specific gastrointestinal sites
CN107252418B (zh) * 2017-05-17 2020-06-23 西安棣加生物科技有限公司 一种3d打印技术制备治疗低钾血症的口腔速崩片的方法
CN107213126B (zh) * 2017-05-17 2020-06-23 西安棣加生物科技有限公司 一种3d打印技术制备治疗高磷血症的口腔速崩片的方法
US10703549B2 (en) * 2017-06-30 2020-07-07 The Procter And Gamble Company Water soluble containers and methods of making them
JP7719602B2 (ja) * 2017-11-02 2025-08-06 ザンボン エス.ピー.エー. サフィナミドを含む医薬組成物
WO2019131753A1 (ja) * 2017-12-26 2019-07-04 東和薬品株式会社 環状口腔内崩壊錠
CN116270513A (zh) 2018-01-09 2023-06-23 南京三迭纪医药科技有限公司 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型
CN112218617A (zh) 2018-04-10 2021-01-12 潘纳西亚比奥马特斯公司 利用附加制造技术制备个性化营养配方和药物配方的方法和系统
CA3112618A1 (en) * 2018-09-14 2020-03-19 Merck Patent Gmbh Process for the preparation of a coated solid pharmaceutical dosage form
MX2021004318A (es) * 2018-10-15 2021-05-27 Aprecia Pharmaceuticals LLC Metodo y sistema para crear una forma de dosificacion dentro de un empaque.
WO2020104837A1 (en) 2018-11-21 2020-05-28 Rosemont Pharmaceuticals Limited Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability
SG11202108659XA (en) 2019-02-22 2021-09-29 Catalent Uk Swindon Zydis Ltd Minimizing aeration of suspensions during in-line mixing
WO2020169992A1 (en) 2019-02-22 2020-08-27 Catalent U.K. Swindon Zydis Limited Minimizing agglomeration of drug particle coating material during storage to stabilize disintegration times of pharmaceutical products
WO2020169989A1 (en) 2019-02-22 2020-08-27 Catalent U.K. Swindon Zydis Limited Minimizing agglomeration, aeration, and preserving the coating of pharmaceutical compositions comprising ibuprofen
KR20210130720A (ko) 2019-02-22 2021-11-01 카탈렌트 유.케이. 스윈던 지디스 리미티드 수성 현탁액에서 무용매 혼합 공정에 의해 생성된 기능적으로-코팅된 api 입자 보존
EP4029380A4 (en) * 2019-09-13 2023-09-13 Meiji Co., Ltd SOLID FOOD AND SOLID MILK
MX2022016117A (es) 2020-06-26 2023-04-05 Aprecia Pharmaceuticals LLC Tabletas rapidamente orodispersables que tienen una cavidad interior.
CA3189404A1 (en) 2020-07-31 2022-02-03 Catalent U.K. Swindon Zydis Limited Pharmaceutical compositions comprising coated api
WO2024108082A1 (en) 2022-11-18 2024-05-23 Aprecia Pharmaceuticals LLC Orodispersive dosage forms containing droxidopa

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030143268A1 (en) * 2001-10-29 2003-07-31 Therics, Inc. System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form
WO2005065647A2 (en) * 2003-12-29 2005-07-21 Alza Corporation, Inc. Drug granule coatings that impart smear resistance during mechanical compression
US20060099245A1 (en) * 2000-08-01 2006-05-11 Manoj Kumar Hydrodynamically balancing oral drug delivery system with biphasic release
US20080085306A1 (en) * 2006-08-31 2008-04-10 Spherics, Inc. Topiramate compositions and methods of enhancing its bioavailability

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548022A (en) 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
US4513006A (en) 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives
US4642903A (en) 1985-03-26 1987-02-17 R. P. Scherer Corporation Freeze-dried foam dosage form
US4855326A (en) 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
EP0418596A3 (en) 1989-09-21 1991-10-23 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
US5178878A (en) 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
US5578322A (en) 1990-11-30 1996-11-26 Yamanouchi Pharmaceutical Co., Ltd. Quick release coated preparation
DE4200821A1 (de) 1992-01-15 1993-07-22 Bayer Ag Geschmacksmaskierte pharmazeutische mittel
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
US5380473A (en) 1992-10-23 1995-01-10 Fuisz Technologies Ltd. Process for making shearform matrix
EP0804170B1 (en) 1993-07-09 2001-11-14 R.P. Scherer Corporation Method for making freeze dried drug dosage forms
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US5738875A (en) 1994-10-28 1998-04-14 R.P. Scherer Corporation Process for preparing solid pharmaceutical dosage forms
US5607697A (en) 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
EP0973507B1 (en) 1997-02-20 2009-01-21 Massachussets Institute of Technology Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same
FR2766089B1 (fr) 1997-07-21 2000-06-02 Prographarm Lab Comprime multiparticulaire perfectionne a delitement rapide
UA65607C2 (uk) * 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
ATE265852T1 (de) 1999-07-09 2004-05-15 Ortho Mcneil Pharm Inc Geschmackskaschierte flüssige arzneizubereitungen
AU5060499A (en) * 1999-08-04 2001-03-05 Ranbaxy Laboratories Limited Hydrodynamically balanced oral drug delivery system
DE19940944B4 (de) 1999-08-31 2006-10-12 Grünenthal GmbH Retardierte, orale, pharmazeutische Darreichungsformen
US7276252B2 (en) * 2000-05-18 2007-10-02 Massachusetts Institute Of Technology Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form
AU2002254036A1 (en) 2001-03-05 2002-09-19 Ortho-Mcneil Pharmaceutical, Inc. Taste masked pharmaceutical compositions
WO2003041690A2 (en) * 2001-10-29 2003-05-22 Therics, Inc. Three-dimensional suspension printing of dosage forms
FR2838647B1 (fr) 2002-04-23 2006-02-17 Particules enrobees a liberation prolongee, leur procede de preparation et comprimes les contenant
AU2003259417A1 (en) * 2002-09-04 2004-03-29 Ranbaxy Laboratories Limited Taste masked dosage forms and processes for their preparation
US20060159758A1 (en) 2002-12-11 2006-07-20 Rajesh Gandhi Coating composition for taste masking coating and methods for their application and use
EP1620075B1 (en) 2003-05-07 2020-06-24 Samyang Biopharmaceuticals Corporation Highly plastic granules for making fast melting tablets
FR2858556B1 (fr) 2003-08-06 2006-03-10 Galenix Innovations Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
WO2005020961A1 (en) 2003-08-28 2005-03-10 Sandoz Ag Pharmaceutical composition comprising anticonvulsant with taste mask coating
JP2008507508A (ja) * 2004-07-22 2008-03-13 株式會社アモーレパシフィック トピラメート徐放性製剤及びその製造方法
US20060127479A1 (en) 2004-10-08 2006-06-15 Natrajan Kumaraperumal Solvent free taste masked pharmaceutical compositions
US20060182796A1 (en) 2005-02-03 2006-08-17 Abrika Pharmaceuticals, Inc. Taste masked pharmaceutical compositions
US20070092553A1 (en) 2005-10-21 2007-04-26 Pfab Lp Compositions and methods of making rapidly dissolving lonically masked formulations
CN102218044A (zh) * 2006-12-04 2011-10-19 苏佩努斯制药公司 托吡酯的增强的立即释放制剂
CN101842085B (zh) * 2007-10-31 2013-01-30 麦克内尔-Ppc股份有限公司 口腔崩解剂型
WO2009106824A2 (en) * 2008-02-25 2009-09-03 Cipla Limited Pharmaceutical formulations
EP2397161B1 (en) 2009-02-12 2019-09-25 Fuji Chemical Industry Co., Ltd. Disintegrating particle composition and rapidly disintegrating compression-molded material comprising same
US20100285130A1 (en) 2009-05-06 2010-11-11 Monosol Rx, Llc Coating of complexed actives in film formulations
US20120076858A1 (en) 2009-06-04 2012-03-29 Basf Se Orally Disintegrating Dosage Forms Containing Taste-Masked Active Ingredients
US20120207836A1 (en) * 2009-08-19 2012-08-16 Bayer Pharma Aktiengesellschaft Drug delivery systems (wafer) for pediatric use
UY33173A (cg-RX-API-DMAC7.html) * 2010-01-08 2011-07-29 Eurand Inc
JP6133009B2 (ja) * 2010-08-11 2017-05-24 協和発酵キリン株式会社 トピラマート顆粒
US9381154B2 (en) * 2011-06-09 2016-07-05 Xerox Corporation Direct inkjet fabrication of drug delivery devices

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060099245A1 (en) * 2000-08-01 2006-05-11 Manoj Kumar Hydrodynamically balancing oral drug delivery system with biphasic release
US20030143268A1 (en) * 2001-10-29 2003-07-31 Therics, Inc. System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form
WO2005065647A2 (en) * 2003-12-29 2005-07-21 Alza Corporation, Inc. Drug granule coatings that impart smear resistance during mechanical compression
US20080085306A1 (en) * 2006-08-31 2008-04-10 Spherics, Inc. Topiramate compositions and methods of enhancing its bioavailability

Also Published As

Publication number Publication date
WO2014144661A1 (en) 2014-09-18
US9492380B2 (en) 2016-11-15
HK1214768A1 (en) 2016-08-05
ES2761407T3 (es) 2020-05-19
JP2016514686A (ja) 2016-05-23
MX365914B (es) 2019-06-20
US20150366801A1 (en) 2015-12-24
EP2968181A1 (en) 2016-01-20
EP2968181B1 (en) 2019-10-16
EP2968181A4 (en) 2016-04-13
WO2014144661A4 (en) 2014-11-13
CN105050588B (zh) 2019-01-15
WO2014144661A8 (en) 2015-08-27
JP6466399B2 (ja) 2019-02-06
AU2014228861A1 (en) 2015-10-08
AU2018220049B2 (en) 2020-07-09
CA2906172A1 (en) 2014-09-18
AU2018220049A1 (en) 2018-09-06
US20160361335A1 (en) 2016-12-15
HK1213473A1 (zh) 2016-07-08
CA2906172C (en) 2021-12-21
US10420785B2 (en) 2019-09-24
CN105050588A (zh) 2015-11-11
MX2015012135A (es) 2015-11-25

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