AU2013310924B2 - Method for producing antibody molecules having inter-species, intra-target cross-reactivity - Google Patents

Method for producing antibody molecules having inter-species, intra-target cross-reactivity Download PDF

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Publication number
AU2013310924B2
AU2013310924B2 AU2013310924A AU2013310924A AU2013310924B2 AU 2013310924 B2 AU2013310924 B2 AU 2013310924B2 AU 2013310924 A AU2013310924 A AU 2013310924A AU 2013310924 A AU2013310924 A AU 2013310924A AU 2013310924 B2 AU2013310924 B2 AU 2013310924B2
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AU
Australia
Prior art keywords
species
target
antigen
immune library
reactivity
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AU2013310924A
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English (en)
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AU2013310924A8 (en
AU2013310924A1 (en
Inventor
Christophe Frederic Jerome Blanchetot
Johannes Joseph Wilhelmus De Haard
Sebastian Paul VAN DER WONING
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ArgenX BVBA
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ArgenX BVBA
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Publication of AU2013310924A1 publication Critical patent/AU2013310924A1/en
Publication of AU2013310924A8 publication Critical patent/AU2013310924A8/en
Priority to AU2017204188A priority Critical patent/AU2017204188A1/en
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Publication of AU2013310924B2 publication Critical patent/AU2013310924B2/en
Assigned to ARGENX BVBA reassignment ARGENX BVBA Request for Assignment Assignors: ARGEN-X NV
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2013310924A 2012-08-31 2013-08-30 Method for producing antibody molecules having inter-species, intra-target cross-reactivity Active AU2013310924B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017204188A AU2017204188A1 (en) 2012-08-31 2017-06-21 Method for producing antibody molecules having inter-species, intra-target cross-reactivity

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261695664P 2012-08-31 2012-08-31
US61/695,664 2012-08-31
PCT/EP2013/067979 WO2014033252A1 (en) 2012-08-31 2013-08-30 Method for producing antibody molecules having inter-species, intra-target cross-reactivity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017204188A Division AU2017204188A1 (en) 2012-08-31 2017-06-21 Method for producing antibody molecules having inter-species, intra-target cross-reactivity

Publications (3)

Publication Number Publication Date
AU2013310924A1 AU2013310924A1 (en) 2015-01-29
AU2013310924A8 AU2013310924A8 (en) 2015-04-30
AU2013310924B2 true AU2013310924B2 (en) 2017-08-03

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2013310924A Active AU2013310924B2 (en) 2012-08-31 2013-08-30 Method for producing antibody molecules having inter-species, intra-target cross-reactivity
AU2017204188A Abandoned AU2017204188A1 (en) 2012-08-31 2017-06-21 Method for producing antibody molecules having inter-species, intra-target cross-reactivity

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017204188A Abandoned AU2017204188A1 (en) 2012-08-31 2017-06-21 Method for producing antibody molecules having inter-species, intra-target cross-reactivity

Country Status (10)

Country Link
US (1) US20150203840A1 (enExample)
EP (2) EP2890711B1 (enExample)
JP (1) JP6391574B2 (enExample)
CN (1) CN104583238A (enExample)
AU (2) AU2013310924B2 (enExample)
CA (1) CA2878712A1 (enExample)
DK (1) DK2890711T3 (enExample)
IL (1) IL236523B (enExample)
IN (1) IN2015DN00140A (enExample)
WO (1) WO2014033252A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2828753C (en) 2011-03-16 2022-07-26 arGEN-X BV Antibodies to cd70
EP3786187A1 (en) 2013-08-01 2021-03-03 Université catholique de Louvain Antibody binding a complex of human glycoprotein a repetitions predominant (garp) and latent tgf-beta-1
US10391168B1 (en) 2014-08-22 2019-08-27 University Of Bern Anti-CD70 combination therapy
CA3030099A1 (en) 2016-07-08 2018-01-11 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
GB201612337D0 (en) 2016-07-15 2016-08-31 Argen-X N V Ant-il-22r antibodies
JP2020517242A (ja) 2017-04-21 2020-06-18 スターテン・バイオテクノロジー・ベー・フェー 抗ＡｐｏＣ３抗体およびその使用方法
GB201707561D0 (en) 2017-05-11 2017-06-28 Argenx Bvba GARP-TGF-beta antibodies
BR112020008514A2 (pt) 2017-10-31 2020-10-20 Staten Biotechnology B.V. anticorpos anti-apoc3 e métodos de uso dos mesmos
US10538583B2 (en) 2017-10-31 2020-01-21 Staten Biotechnology B.V. Anti-APOC3 antibodies and compositions thereof
CN111712258B (zh) 2017-12-12 2024-03-15 开拓免疫医疗公司 抗trem2抗体和相关方法
GB201800649D0 (en) 2018-01-16 2018-02-28 Argenx Bvba CD70 Combination Therapy
WO2019151865A1 (en) 2018-02-05 2019-08-08 Stichting Vu Inverse agonistic anti-us28 antibodies
WO2020080941A1 (en) 2018-10-16 2020-04-23 Umc Utrecht Holding B.V. Anti- low-density lipoprotein receptor-related protein 5/6 antibodies
EP4277706A1 (en) 2021-01-15 2023-11-22 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Inducers of senescence, in combination with a selective death receptor 5 (dr5) agonist, for use in a method of treating cancer
EP4612180A1 (en) 2022-10-31 2025-09-10 Stichting Amsterdam UMC Single domain anti-cd169 antibodies
WO2024101989A1 (en) 2022-11-08 2024-05-16 Stichting Amsterdam UMC Activation inducible antigen receptors for adoptive immunotherapy
EP4631501A1 (en) 2024-04-09 2025-10-15 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Combinations of a calcium homeostasis disruptor with a death receptor 5 agonist for treating cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004085476A2 (en) * 2003-03-24 2004-10-07 Zymogenetics, Inc. Anti-il-22ra antibodies and binding partners and methods of using in inflammation
EP2316852A1 (en) * 2002-11-08 2011-05-04 Ablynx N.V. Stabilized single domain antibodies

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JP4460155B2 (ja) * 1997-12-05 2010-05-12 ザ・スクリプス・リサーチ・インステイチユート マウス抗体のヒト化
CN1735629B (zh) * 2002-11-08 2012-05-09 埃博灵克斯股份有限公司 针对肿瘤坏死因子-α的单结构域抗体及其用途
CN1845937A (zh) * 2003-03-24 2006-10-11 津莫吉尼蒂克斯公司 抗il－20抗体和结合伴侣以及在炎症中的使用方法
CN101228188A (zh) * 2005-06-21 2008-07-23 佐马技术有限公司 IL-1β结合抗体及其片段
TWI417301B (zh) * 2006-02-21 2013-12-01 Wyeth Corp 對抗人類介白素-２２（ｉｌ-２２）之抗體及其用途
GB2461546B (en) * 2008-07-02 2010-07-07 Argen X Bv Antigen binding polypeptides
US8444976B2 (en) 2008-07-02 2013-05-21 Argen-X B.V. Antigen binding polypeptides
JP6184695B2 (ja) * 2009-12-04 2017-08-23 ジェネンテック， インコーポレイテッド 多重特異性抗体、抗体アナログ、組成物、及び方法
GB2476681B (en) 2010-01-04 2012-04-04 Argen X Bv Humanized camelid VH, VK and VL immunoglobulin domains
GB201002238D0 (en) * 2010-02-10 2010-03-31 Affitech As Antibodies
MX385858B (es) * 2010-11-24 2025-03-18 Lexicon Pharmaceuticals Inc Anticuerpos que se unen a notum pectinacetilesterasa.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2316852A1 (en) * 2002-11-08 2011-05-04 Ablynx N.V. Stabilized single domain antibodies
WO2004085476A2 (en) * 2003-03-24 2004-10-07 Zymogenetics, Inc. Anti-il-22ra antibodies and binding partners and methods of using in inflammation

Also Published As

Publication number Publication date
CN104583238A (zh) 2015-04-29
JP2015530087A (ja) 2015-10-15
AU2017204188A1 (en) 2017-07-13
IL236523A0 (en) 2015-02-26
AU2013310924A8 (en) 2015-04-30
IN2015DN00140A (enExample) 2015-06-12
JP6391574B2 (ja) 2018-09-26
EP2977386A1 (en) 2016-01-27
CA2878712A1 (en) 2014-03-06
DK2890711T3 (en) 2017-02-27
IL236523B (en) 2018-12-31
EP2890711A1 (en) 2015-07-08
WO2014033252A1 (en) 2014-03-06
EP2890711B1 (en) 2017-01-04
AU2013310924A1 (en) 2015-01-29
US20150203840A1 (en) 2015-07-23

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Free format text: IN VOL 29 , NO 3 , PAGE(S) 551 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME ARGEN-X BV, APPLICATION NO. 2013310924, UNDER INID (71) CORRECT THE APPLICANT NAME TO ARGEN-X NV

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