AU2013289984B2 - Use of CART19 to deplete normal B cells to induce tolerance - Google Patents

Use of CART19 to deplete normal B cells to induce tolerance Download PDF

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Publication number
AU2013289984B2
AU2013289984B2 AU2013289984A AU2013289984A AU2013289984B2 AU 2013289984 B2 AU2013289984 B2 AU 2013289984B2 AU 2013289984 A AU2013289984 A AU 2013289984A AU 2013289984 A AU2013289984 A AU 2013289984A AU 2013289984 B2 AU2013289984 B2 AU 2013289984B2
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cells
cell
car
pct
genetically modified
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AU2013289984A1 (en
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Carl H. June
Michael D. Kalos
Bruce L. Levine
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University of Pennsylvania Penn
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University of Pennsylvania Penn
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2013289984A 2012-07-13 2013-07-12 Use of CART19 to deplete normal B cells to induce tolerance Active AU2013289984B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2018203756A AU2018203756B2 (en) 2012-07-13 2018-05-29 Use of cart19 to deplete normal b cells to induce tolerance
AU2020200315A AU2020200315B2 (en) 2012-07-13 2020-01-16 Use of cart19 to deplete normal b cells to induce tolerance

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261671508P 2012-07-13 2012-07-13
US61/671,508 2012-07-13
PCT/US2013/050293 WO2014012001A2 (en) 2012-07-13 2013-07-12 Use of cart19 to deplete normal b cells to induce tolerance

Related Child Applications (1)

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AU2018203756A Division AU2018203756B2 (en) 2012-07-13 2018-05-29 Use of cart19 to deplete normal b cells to induce tolerance

Publications (2)

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AU2013289984A1 AU2013289984A1 (en) 2015-01-22
AU2013289984B2 true AU2013289984B2 (en) 2018-03-08

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AU2013289984A Active AU2013289984B2 (en) 2012-07-13 2013-07-12 Use of CART19 to deplete normal B cells to induce tolerance
AU2018203756A Active AU2018203756B2 (en) 2012-07-13 2018-05-29 Use of cart19 to deplete normal b cells to induce tolerance
AU2020200315A Active AU2020200315B2 (en) 2012-07-13 2020-01-16 Use of cart19 to deplete normal b cells to induce tolerance

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AU2020200315A Active AU2020200315B2 (en) 2012-07-13 2020-01-16 Use of cart19 to deplete normal b cells to induce tolerance

Country Status (13)

Country Link
US (3) US20150290244A1 (enExample)
EP (1) EP2872184B1 (enExample)
JP (5) JP2015523386A (enExample)
KR (1) KR102216083B1 (enExample)
CN (2) CN120393001A (enExample)
AU (3) AU2013289984B2 (enExample)
BR (1) BR112015000657B1 (enExample)
CA (1) CA2876734A1 (enExample)
EA (2) EA201992742A3 (enExample)
ES (1) ES2835232T3 (enExample)
IN (1) IN2015DN00139A (enExample)
MX (2) MX382772B (enExample)
WO (1) WO2014012001A2 (enExample)

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Publication number Publication date
KR20150030750A (ko) 2015-03-20
EP2872184A4 (en) 2016-03-30
EA201590209A1 (ru) 2015-08-31
WO2014012001A3 (en) 2015-04-23
JP2025129358A (ja) 2025-09-04
JP2018135363A (ja) 2018-08-30
AU2018203756B2 (en) 2019-10-24
AU2018203756A1 (en) 2018-06-21
MX2018009820A (es) 2022-08-24
EA201992742A2 (ru) 2020-09-30
CA2876734A1 (en) 2014-01-16
EP2872184A2 (en) 2015-05-20
BR112015000657A2 (pt) 2017-06-27
EA034644B1 (ru) 2020-03-02
EA201992742A3 (ru) 2020-12-30
IN2015DN00139A (enExample) 2015-06-12
AU2013289984A1 (en) 2015-01-22
AU2020200315B2 (en) 2021-11-04
EP2872184B1 (en) 2020-09-16
JP2015523386A (ja) 2015-08-13
CN104884095A (zh) 2015-09-02
US20150290244A1 (en) 2015-10-15
US20180271907A1 (en) 2018-09-27
MX2015000433A (es) 2016-04-28
JP2022173331A (ja) 2022-11-18
CN120393001A (zh) 2025-08-01
AU2020200315A1 (en) 2020-02-06
WO2014012001A2 (en) 2014-01-16
KR102216083B1 (ko) 2021-02-17
MX382772B (es) 2025-03-11
US20240261328A1 (en) 2024-08-08
ES2835232T3 (es) 2021-06-22
BR112015000657A8 (pt) 2018-01-16
BR112015000657B1 (pt) 2023-12-05
JP2020158541A (ja) 2020-10-01

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