AU2013240141B2 - Diaspirin crosslinked PEGgylated hemoglobin - Google Patents
Diaspirin crosslinked PEGgylated hemoglobin Download PDFInfo
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- AU2013240141B2 AU2013240141B2 AU2013240141A AU2013240141A AU2013240141B2 AU 2013240141 B2 AU2013240141 B2 AU 2013240141B2 AU 2013240141 A AU2013240141 A AU 2013240141A AU 2013240141 A AU2013240141 A AU 2013240141A AU 2013240141 B2 AU2013240141 B2 AU 2013240141B2
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- hemoglobin
- hemoglobin tetramer
- conjugate
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| US201261617639P | 2012-03-29 | 2012-03-29 | |
| US61/617,639 | 2012-03-29 | ||
| PCT/US2013/032694 WO2013148375A1 (en) | 2012-03-29 | 2013-03-15 | Diaspirin crosslinked pegylated hemoglobin |
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| AU2013240141A1 AU2013240141A1 (en) | 2014-11-13 |
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| SG10201912805SA (en) * | 2014-12-19 | 2020-02-27 | Aragon Pharmaceuticals Inc | Process for the preparation of a diarylthiohydantoin compound |
| CN105017515A (zh) * | 2015-07-20 | 2015-11-04 | 湖南华腾制药有限公司 | 聚乙二醇修饰物的制备方法 |
| CN106421805B (zh) * | 2016-09-14 | 2019-06-04 | 中国人民解放军军事医学科学院野战输血研究所 | 一种右旋糖酐交联血红蛋白氧载体及其制备方法与应用 |
| CA3070172A1 (en) | 2017-07-18 | 2019-01-24 | VirTech Bio, Inc. | Blood substitutes comprising hemoglobin and methods of making |
| WO2022184005A1 (en) | 2021-03-01 | 2022-09-09 | Billion King International Limited | Thiosuccinyl-crosslinked hemoglobin conjugates and methods of use and preparation thereof |
| CN114146165B (zh) * | 2021-12-02 | 2022-08-12 | 润方（北京）生物医药研究院有限公司 | 一种聚合血红蛋白在制备防治呼吸衰竭药物中的应用 |
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| US4529719A (en) | 1983-05-04 | 1985-07-16 | Tye Ross W | Modified crosslinked stroma-free tetrameric hemoglobin |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| CA1312009C (en) | 1986-11-10 | 1992-12-29 | Carl W. Rausch | Extra pure semi-synthetic blood substitute |
| US5234903A (en) | 1989-11-22 | 1993-08-10 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute |
| US5585484A (en) | 1995-04-19 | 1996-12-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Hemoglobin crosslinkers |
| US6627738B2 (en) | 1995-09-15 | 2003-09-30 | Duke University | No-modified hemoglobins and uses therefor |
| AU2002320628A1 (en) | 2001-07-19 | 2003-03-03 | Albert Einstein College Of Medecine Of Yeshiva University | Size enhanced hemoglobins: surface decoration and crosslinking of the protein with polyoxy akylene glycols |
| US20050164915A1 (en) * | 2002-04-01 | 2005-07-28 | Sangart, Inc. | Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| US20030153491A1 (en) | 2002-01-11 | 2003-08-14 | Winslow Robert M. | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| US7144989B2 (en) | 2002-03-25 | 2006-12-05 | Albert Einstein College Of Medicine Of Yeshiva University | Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof |
| CA2511494A1 (en) | 2002-12-23 | 2004-07-15 | Seetharama A. Acharya | Non-hypertensive polyethylene glycol-modified hemoglobin as oxygen carrier |
| KR100512483B1 (ko) | 2003-05-07 | 2005-09-05 | 선바이오(주) | 신규한 폴리에틸렌글리콜-말레이미드 유도체의 합성방법 |
| AU2005279780B2 (en) * | 2004-08-31 | 2011-02-03 | Sangart, Inc. | Methods to enhance hemodynamic stability using oxygen carrying compositions |
| WO2006096774A2 (en) * | 2005-03-07 | 2006-09-14 | Sangart, Inc. | Composition and methods for delivering carbon monoxide (co) and nitric ozide (no) co to tissue using heme proteins as carriers |
| US8741832B2 (en) | 2005-06-10 | 2014-06-03 | Albert Einstein College Of Medicine Of Yeshiva University | Pegylated albumin and uses thereof |
| US7504377B2 (en) * | 2006-10-23 | 2009-03-17 | Ikor, Inc. | Nitric oxide-blocked cross-linked tetrameric hemoglobin |
| CN102859364A (zh) * | 2010-02-25 | 2013-01-02 | 桑格特公司 | 通过减少反应物比例制备聚乙二醇-血红蛋白缀合物的方法 |
| US20130052232A1 (en) | 2011-08-31 | 2013-02-28 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking |
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Non-Patent Citations (2)
| Title |
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| JOSEPH A. WALDER ET AL, "Diaspirins that crosslink .beta. chains of hemoglobin: bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate", BIOCHEMISTRY, (19791001), vol. 18, no. 20, pages 4265 - 4270 * |
| MANJULA B N ET AL, "Cys-93-BB-succinimidophenyl polyethylene glycol 2000 hemoglobin A", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 275, no. 8, pages 5527 - 5534 * |
Also Published As
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| CN104379160A (zh) | 2015-02-25 |
| EP2830638B1 (en) | 2021-05-05 |
| WO2013148375A1 (en) | 2013-10-03 |
| JP2015514086A (ja) | 2015-05-18 |
| US10029001B2 (en) | 2018-07-24 |
| AU2013240141A1 (en) | 2014-11-13 |
| KR102144139B1 (ko) | 2020-08-12 |
| EP2830638A4 (en) | 2015-12-16 |
| JP2019089789A (ja) | 2019-06-13 |
| MX358785B (es) | 2018-09-04 |
| KR20150009533A (ko) | 2015-01-26 |
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| EP2830638A1 (en) | 2015-02-04 |
| HK1207560A1 (en) | 2016-02-05 |
| JP6668515B2 (ja) | 2020-03-18 |
| MX2014011763A (es) | 2015-08-07 |
| US20150087590A1 (en) | 2015-03-26 |
| CA2908236A1 (en) | 2013-10-03 |
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