AU2013226404B2 - Replacement therapy for dental caries - Google Patents

Replacement therapy for dental caries Download PDF

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Publication number
AU2013226404B2
AU2013226404B2 AU2013226404A AU2013226404A AU2013226404B2 AU 2013226404 B2 AU2013226404 B2 AU 2013226404B2 AU 2013226404 A AU2013226404 A AU 2013226404A AU 2013226404 A AU2013226404 A AU 2013226404A AU 2013226404 B2 AU2013226404 B2 AU 2013226404B2
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AU
Australia
Prior art keywords
polynucleotide
gene
mutation
mutans
recombinant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013226404A
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English (en)
Other versions
AU2013226404A1 (en
Inventor
Jeffrey D. Hillman
James Leif Smith
Shawanda R. WILSON-STANFORD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas A&M University System
Oragenics Inc
Original Assignee
Texas A&M University System
Oragenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas A&M University System, Oragenics Inc filed Critical Texas A&M University System
Publication of AU2013226404A1 publication Critical patent/AU2013226404A1/en
Application granted granted Critical
Publication of AU2013226404B2 publication Critical patent/AU2013226404B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G4/123—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
AU2013226404A 2012-02-27 2013-02-22 Replacement therapy for dental caries Ceased AU2013226404B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261603693P 2012-02-27 2012-02-27
US201261603661P 2012-02-27 2012-02-27
US61/603,693 2012-02-27
US61/603,661 2012-02-27
PCT/US2013/027340 WO2013130351A1 (en) 2012-02-27 2013-02-22 Replacement therapy for dental caries

Publications (2)

Publication Number Publication Date
AU2013226404A1 AU2013226404A1 (en) 2014-08-21
AU2013226404B2 true AU2013226404B2 (en) 2017-11-30

Family

ID=49083172

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2013226404A Ceased AU2013226404B2 (en) 2012-02-27 2013-02-22 Replacement therapy for dental caries
AU2013226402A Ceased AU2013226402B2 (en) 2012-02-27 2013-02-22 Variants of the lantibiotic MU1140 and other lantibiotics with improved pharmacological properties and structural features

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2013226402A Ceased AU2013226402B2 (en) 2012-02-27 2013-02-22 Variants of the lantibiotic MU1140 and other lantibiotics with improved pharmacological properties and structural features

Country Status (10)

Country Link
US (2) US9260488B2 (https=)
EP (3) EP2833902A4 (https=)
JP (2) JP6309902B2 (https=)
CN (2) CN104302307B (https=)
AU (2) AU2013226404B2 (https=)
BR (2) BR112014020659A2 (https=)
CA (2) CA2865395A1 (https=)
HK (2) HK1205519A1 (https=)
MX (2) MX369443B (https=)
WO (2) WO2013130351A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019529344A (ja) * 2016-07-15 2019-10-17 イントレキソン コーポレーション ランチビオティックバリアントおよびその使用
US10577399B2 (en) 2016-10-28 2020-03-03 The Texas A&M University System Modified lantibiotics and methods of making and using the modified lantibiotics
CN113039196B (zh) 2018-10-31 2025-03-18 株式会社村田制作所 抗革兰氏阴性菌化合物
CU24691B1 (es) * 2018-11-01 2024-01-10 Biofouling Tech Inc Dispositivo y método para reducir la bioincustración sobre un sustrato parcial o totalmente sumergido en un ambiente acuoso
CA3128389A1 (en) * 2019-03-08 2020-09-17 Fraunhofer Usa, Inc. Novel antimicrobial lantibiotic peptide and uses thereof
CN118490568B (zh) * 2024-07-16 2024-10-18 南昌怀特科技有限公司 一种用于牙齿美白的抑菌凝胶及其制备方法与应用

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20060198793A1 (en) * 1997-06-10 2006-09-07 University Of Florida Research Foundation Antimicrobial polypeptide, nucleic acid, and methods of use

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US4366246A (en) 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
US5516682A (en) * 1988-07-05 1996-05-14 University Of Maryland Subtilin variant of enhanced stability and activity
GB9423404D0 (en) * 1994-11-19 1995-01-11 Biotech & Biolog Scien Res Production of nisin
US6964760B2 (en) * 1997-06-10 2005-11-15 University Of Florida Research Foundation Antimicrobial polypeptide, nucleic acid, and methods of use
US5932469A (en) * 1997-06-10 1999-08-03 University Of Florida Antimicrobial polypeptide, nucleic acid, and methods of use
US6251478B1 (en) 1999-12-22 2001-06-26 Balchem Corporation Sensitive substance encapsulation
EP1483366B1 (en) * 2002-02-22 2010-04-14 Blis Technologies Limited Antimicrobial composition
AU2006279749B2 (en) 2005-08-12 2012-12-20 Oragenics, Inc. Differentially protected orthogonal lanthionine technology
US20090215985A1 (en) * 2005-08-12 2009-08-27 Oragenics, Inc. Differentially protected orthogonal lanthionine technology
WO2007044745A1 (en) * 2005-10-11 2007-04-19 Biosynexus Incorporated Lantibiotic and mupirocin compositions for treating bacterial infections
CA2690267A1 (en) * 2007-06-12 2008-12-18 The University Of British Columbia Small cationic antimicrobial peptides
DK2176284T3 (da) * 2007-07-20 2013-10-14 Univ Minnesota Lantibiotika og anvendelser deraf
IE20080365A1 (en) * 2008-05-09 2010-03-16 Univ College Cork Nat Univ Ie Nisin derivatives and the use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060198793A1 (en) * 1997-06-10 2006-09-07 University Of Florida Research Foundation Antimicrobial polypeptide, nucleic acid, and methods of use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Gupta S et al, "'Use a thorn to draw a thorn' replacement therapy for prevention of dental caries", International Journal of Clinical Pediatric Dentistry, 2010, 3(3):125-137 *
Wang B-Y et al, "Interactions between oral bacteria: inhibition of Streptococcus mutans bacteriocin production by Streptococcus gordonii", Applied and Environmental Mircobiology, 2005, 71(1):354-362 *

Also Published As

Publication number Publication date
CN104302307A (zh) 2015-01-21
AU2013226402A1 (en) 2014-08-21
US20150044146A1 (en) 2015-02-12
WO2013130351A1 (en) 2013-09-06
EP2833902A1 (en) 2015-02-11
EP2820036A1 (en) 2015-01-07
BR112014020659A2 (pt) 2017-06-27
CA2865395A1 (en) 2013-09-06
WO2013130349A1 (en) 2013-09-06
EP2820036B1 (en) 2018-06-06
US9260488B2 (en) 2016-02-16
AU2013226402B2 (en) 2017-05-18
EP3219325A1 (en) 2017-09-20
CN104321338A (zh) 2015-01-28
CA2865405C (en) 2021-11-16
HK1205458A1 (en) 2015-12-18
BR112014020656A2 (pt) 2017-06-27
EP2833902A4 (en) 2016-04-06
CA2865405A1 (en) 2013-09-06
US20150125503A1 (en) 2015-05-07
EP2820036A4 (en) 2016-01-20
MX2014010143A (es) 2015-04-08
MX2014010151A (es) 2015-01-14
JP6297506B2 (ja) 2018-03-20
JP6309902B2 (ja) 2018-04-11
JP2015509715A (ja) 2015-04-02
EP3219325B1 (en) 2019-11-06
HK1205519A1 (en) 2015-12-18
AU2013226404A1 (en) 2014-08-21
US9963488B2 (en) 2018-05-08
CN104302307B (zh) 2018-10-26
MX369443B (es) 2019-11-08
CN104321338B (zh) 2018-10-19
JP2015509945A (ja) 2015-04-02
WO2013130349A8 (en) 2014-01-09
MX358060B (es) 2018-08-03

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