AU2013209620B2 - Chromatographic media for storage and delivery of therapeutic biologics and small molecules - Google Patents

Chromatographic media for storage and delivery of therapeutic biologics and small molecules Download PDF

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Publication number
AU2013209620B2
AU2013209620B2 AU2013209620A AU2013209620A AU2013209620B2 AU 2013209620 B2 AU2013209620 B2 AU 2013209620B2 AU 2013209620 A AU2013209620 A AU 2013209620A AU 2013209620 A AU2013209620 A AU 2013209620A AU 2013209620 B2 AU2013209620 B2 AU 2013209620B2
Authority
AU
Australia
Prior art keywords
certain embodiments
composite material
relates
stabilizing agent
composite materials
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2013209620A
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English (en)
Other versions
AU2013209620A1 (en
Inventor
John A. Chickosky
Charles H. Honeyman
Molly S. Mcglaughlin
Amro Ragheb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Millipore Ltd
Original Assignee
Merck Millipore Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Millipore Ltd filed Critical Merck Millipore Ltd
Publication of AU2013209620A1 publication Critical patent/AU2013209620A1/en
Application granted granted Critical
Publication of AU2013209620B2 publication Critical patent/AU2013209620B2/en
Assigned to MERCK MILLIPORE LTD. reassignment MERCK MILLIPORE LTD. Request for Assignment Assignors: NATRIX SEPARATIONS INC.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2013209620A 2012-01-19 2013-01-18 Chromatographic media for storage and delivery of therapeutic biologics and small molecules Active AU2013209620B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261588312P 2012-01-19 2012-01-19
US61/588,312 2012-01-19
PCT/US2013/022057 WO2013109825A1 (en) 2012-01-19 2013-01-18 Chromatographic media for storage and delivery of therapeutic biologics and small molecules

Publications (2)

Publication Number Publication Date
AU2013209620A1 AU2013209620A1 (en) 2014-08-28
AU2013209620B2 true AU2013209620B2 (en) 2017-06-15

Family

ID=48797397

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013209620A Active AU2013209620B2 (en) 2012-01-19 2013-01-18 Chromatographic media for storage and delivery of therapeutic biologics and small molecules

Country Status (10)

Country Link
US (2) US20130189322A1 (https=)
EP (1) EP2804634B1 (https=)
JP (2) JP6552822B2 (https=)
KR (1) KR102113296B1 (https=)
AU (1) AU2013209620B2 (https=)
CA (2) CA3124806C (https=)
DK (1) DK2804634T3 (https=)
ES (1) ES2750211T3 (https=)
IN (1) IN2014DN06817A (https=)
WO (1) WO2013109825A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2015114330A (ru) 2012-09-17 2016-11-10 У.Р. Грейс Энд Ко.-Конн. Хроматографические среды и устройства
WO2015013542A1 (en) 2013-07-25 2015-01-29 Bio-Rad Laboratories, Inc. Enhanced functionality and delivery of a protein from a porous substrate
FR3012978A1 (fr) * 2013-11-12 2015-05-15 Biocarecell Filtre biocompatible et procede de fabrication d'un filtre biocompatible.
US11229896B2 (en) 2014-01-16 2022-01-25 W.R. Grace & Co.—Conn. Affinity chromatography media and chromatography devices
JP6914189B2 (ja) 2014-05-02 2021-08-04 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ 官能化担体材料並びに官能化担体材料を作製及び使用する方法
IS3008B (is) * 2014-05-14 2018-12-15 Calor ehf Stöðgandi lausnir fyrir prótín og peptíð
CN107921407B (zh) 2015-06-05 2022-07-05 格雷斯公司 生物处理吸附澄清剂及其制备和使用方法
EP3781192A1 (en) * 2018-04-16 2021-02-24 Merck Patent GmbH Additives for protein formulations to improve thermal stability

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090029438A1 (en) * 2003-02-19 2009-01-29 Childs Ronald F Composite materials comprising supported porous gels
US20100178210A1 (en) * 2004-05-24 2010-07-15 Genvault Corporation Stable protein storage and stable nucleic acid storage in recoverable form

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059654A (en) * 1983-02-14 1991-10-22 Cuno Inc. Affinity matrices of modified polysaccharide supports
ATE68524T1 (de) * 1985-07-09 1991-11-15 Quadrant Bioresources Ltd Beschuetzung von proteinen und aehnlichem.
US5492821A (en) * 1990-11-14 1996-02-20 Cargill, Inc. Stabilized polyacrylic saccharide protein conjugates
US5159049A (en) * 1991-04-22 1992-10-27 Allen Robert C Method for stabilizing polyacrylamide gels
US5583162A (en) * 1994-06-06 1996-12-10 Biopore Corporation Polymeric microbeads and method of preparation
US6284282B1 (en) * 1998-04-29 2001-09-04 Genentech, Inc. Method of spray freeze drying proteins for pharmaceutical administration
SE9904475D0 (sv) * 1999-12-08 1999-12-08 Artursson Nucleic acid delivery system
US6896894B2 (en) * 2001-10-30 2005-05-24 Battelle Memorial Institute Proteins stabilized with polysaccharide gums
EP1471891A4 (en) * 2002-02-08 2007-04-11 Alkermes Inc POLYMER BASED COMPOSITIONS WITH DELAYED RELEASE
US20040137004A1 (en) * 2002-03-19 2004-07-15 Glenn Gregory M Patch for transcutaneous immunization
US6666281B2 (en) 2002-03-19 2003-12-23 Deere & Company Bearing guard for a ground-working implement
US7785769B2 (en) * 2003-07-25 2010-08-31 The United States of America as reprsented by the Secretary of the Navy Immobilization of oligonucleotides and proteins in sugar-containing hydrogels
AU2005231532B2 (en) 2004-04-08 2010-01-07 Merck Millipore Ltd. Membrane stacks
US8133840B2 (en) * 2004-06-07 2012-03-13 Natrix Separations Inc. Stable composite material comprising supported porous gels

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090029438A1 (en) * 2003-02-19 2009-01-29 Childs Ronald F Composite materials comprising supported porous gels
US20100178210A1 (en) * 2004-05-24 2010-07-15 Genvault Corporation Stable protein storage and stable nucleic acid storage in recoverable form

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KANANI et al., "Separation of human plasma proteins HSA and HIgG using high-capacity macroporous gel-filled membranes", Biochemical Engineering Journal, 2007, vol 35, pages 295-300 *

Also Published As

Publication number Publication date
CA2861932C (en) 2021-09-14
EP2804634A1 (en) 2014-11-26
KR102113296B1 (ko) 2020-06-02
ES2750211T3 (es) 2020-03-25
JP2015504092A (ja) 2015-02-05
IN2014DN06817A (https=) 2015-05-22
KR20140117529A (ko) 2014-10-07
US20130189322A1 (en) 2013-07-25
AU2013209620A1 (en) 2014-08-28
EP2804634B1 (en) 2019-08-28
CA2861932A1 (en) 2013-07-27
US20200069602A1 (en) 2020-03-05
EP2804634A4 (en) 2015-07-22
CA3124806C (en) 2023-09-26
JP6552822B2 (ja) 2019-07-31
JP2019011341A (ja) 2019-01-24
DK2804634T3 (da) 2019-11-04
CA3124806A1 (en) 2013-07-27
WO2013109825A1 (en) 2013-07-25

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PC Assignment registered

Owner name: MERCK MILLIPORE LTD.

Free format text: FORMER OWNER(S): NATRIX SEPARATIONS INC.