AU2012395989B2 - Oral care composition - Google Patents
Oral care composition Download PDFInfo
- Publication number
- AU2012395989B2 AU2012395989B2 AU2012395989A AU2012395989A AU2012395989B2 AU 2012395989 B2 AU2012395989 B2 AU 2012395989B2 AU 2012395989 A AU2012395989 A AU 2012395989A AU 2012395989 A AU2012395989 A AU 2012395989A AU 2012395989 B2 AU2012395989 B2 AU 2012395989B2
- Authority
- AU
- Australia
- Prior art keywords
- acid
- composition according
- oral
- oral care
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 194
- 239000002253 acid Substances 0.000 claims abstract description 76
- 239000000872 buffer Substances 0.000 claims abstract description 64
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims abstract description 44
- 150000003839 salts Chemical class 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 32
- 239000007864 aqueous solution Substances 0.000 claims description 28
- 210000000214 mouth Anatomy 0.000 claims description 27
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 26
- 239000011734 sodium Substances 0.000 claims description 26
- 229910052708 sodium Inorganic materials 0.000 claims description 26
- 239000000606 toothpaste Substances 0.000 claims description 25
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 24
- 241000124008 Mammalia Species 0.000 claims description 23
- -1 fluoride ions Chemical class 0.000 claims description 23
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 21
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 17
- 229940034610 toothpaste Drugs 0.000 claims description 17
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 16
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims description 16
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 claims description 16
- TYFQFVWCELRYAO-UHFFFAOYSA-N suberic acid Chemical compound OC(=O)CCCCCCC(O)=O TYFQFVWCELRYAO-UHFFFAOYSA-N 0.000 claims description 16
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 16
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 15
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 15
- 239000001630 malic acid Substances 0.000 claims description 15
- 235000011090 malic acid Nutrition 0.000 claims description 15
- 239000001530 fumaric acid Substances 0.000 claims description 13
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims description 8
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 8
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 8
- 239000001361 adipic acid Substances 0.000 claims description 8
- 235000011037 adipic acid Nutrition 0.000 claims description 8
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims description 8
- 230000003139 buffering effect Effects 0.000 claims description 8
- 208000002925 dental caries Diseases 0.000 claims description 8
- 235000013922 glutamic acid Nutrition 0.000 claims description 8
- 239000004220 glutamic acid Substances 0.000 claims description 8
- 239000002324 mouth wash Substances 0.000 claims description 8
- 239000011975 tartaric acid Substances 0.000 claims description 8
- 235000002906 tartaric acid Nutrition 0.000 claims description 8
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 7
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 7
- 239000000551 dentifrice Substances 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 6
- 230000003247 decreasing effect Effects 0.000 claims description 6
- 239000001384 succinic acid Substances 0.000 claims description 6
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 claims description 4
- 229960001245 olaflur Drugs 0.000 claims description 4
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 4
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims description 4
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- 235000011087 fumaric acid Nutrition 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
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- 239000011698 potassium fluoride Substances 0.000 claims description 2
- 235000003270 potassium fluoride Nutrition 0.000 claims description 2
- 239000011775 sodium fluoride Substances 0.000 claims description 2
- 235000013024 sodium fluoride Nutrition 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 230000001089 mineralizing effect Effects 0.000 claims 1
- 229940091249 fluoride supplement Drugs 0.000 description 29
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 27
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- 230000002378 acidificating effect Effects 0.000 description 9
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- 239000004094 surface-active agent Substances 0.000 description 9
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- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 8
- 239000002585 base Substances 0.000 description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 8
- 239000006072 paste Substances 0.000 description 8
- 229920001223 polyethylene glycol Polymers 0.000 description 8
- 239000003981 vehicle Substances 0.000 description 8
- 229920001400 block copolymer Polymers 0.000 description 7
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 7
- 229940043256 calcium pyrophosphate Drugs 0.000 description 7
- 239000003086 colorant Substances 0.000 description 7
- 229920001577 copolymer Polymers 0.000 description 7
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
- 230000002272 anti-calculus Effects 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 210000003296 saliva Anatomy 0.000 description 6
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- 229910019142 PO4 Inorganic materials 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 235000001465 calcium Nutrition 0.000 description 5
- 210000003298 dental enamel Anatomy 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 239000003906 humectant Substances 0.000 description 5
- 235000021317 phosphate Nutrition 0.000 description 5
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 5
- 235000019832 sodium triphosphate Nutrition 0.000 description 5
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 4
- 239000003082 abrasive agent Substances 0.000 description 4
- 239000004599 antimicrobial Substances 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 4
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- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 4
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- 238000002360 preparation method Methods 0.000 description 4
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- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 description 4
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 4
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- 229960002675 xylitol Drugs 0.000 description 1
- 229940085658 zinc citrate trihydrate Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2012/074286 WO2014086391A1 (en) | 2012-12-03 | 2012-12-03 | Oral care composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012395989A1 AU2012395989A1 (en) | 2015-05-28 |
| AU2012395989B2 true AU2012395989B2 (en) | 2015-08-27 |
Family
ID=47263392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012395989A Active AU2012395989B2 (en) | 2012-12-03 | 2012-12-03 | Oral care composition |
Country Status (16)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3377026B1 (en) * | 2015-12-22 | 2022-02-02 | Colgate-Palmolive Company | Oral care compositions comprising zinc amino acid halides |
| JP7058344B2 (ja) | 2018-03-29 | 2022-04-21 | ザ プロクター アンド ギャンブル カンパニー | 歯肉健康を促進するための口腔ケア組成物 |
| WO2019183886A1 (en) | 2018-03-29 | 2019-10-03 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| CN111989083B (zh) | 2018-03-29 | 2024-02-13 | 宝洁公司 | 用于促进牙龈健康的口腔护理组合物 |
| MX385756B (es) * | 2018-03-29 | 2025-03-18 | Procter & Gamble | Composiciones para el cuidado bucal para promover la salud de las encías. |
| US20210093549A1 (en) | 2019-09-30 | 2021-04-01 | The Procter & Gamble Company | Fluoride-Free Anticavity Oral Care Compositions |
| JP2022549842A (ja) | 2019-09-30 | 2022-11-29 | ザ プロクター アンド ギャンブル カンパニー | 歯科用バイオフィルムの治療のための歯磨剤組成物 |
| BR112022004344A2 (pt) | 2019-09-30 | 2022-05-31 | Procter & Gamble | Composições dentifrícias para o tratamento de biofilme dental |
| WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
| WO2021179014A1 (en) * | 2020-03-06 | 2021-09-10 | Colgate-Palmolive Company | Toothpastes containing calcium carbonate, xanthan gum and polyacrylic acid polymer |
| AU2021267252A1 (en) * | 2020-05-05 | 2022-11-10 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| MX2022013037A (es) * | 2020-05-05 | 2022-11-09 | Procter & Gamble | Composiciones para el cuidado bucal que comprenden acido dicarboxilico. |
| US20230133630A1 (en) * | 2021-11-04 | 2023-05-04 | The Procter & Gamble Company | Oral Care Compositions Comprising Dicarboxylic Acid |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0162574A2 (en) * | 1984-04-18 | 1985-11-27 | JOHNSON & JOHNSON | Oral hygiene compositions |
| US20030124068A1 (en) * | 2000-07-24 | 2003-07-03 | Yamagishi Atsushi | Oral preparation |
| WO2004039343A1 (en) * | 2002-10-31 | 2004-05-13 | Kao Corporation | Oral preparation and chewing gum |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5288480A (en) | 1987-01-30 | 1994-02-22 | Colgate-Palmolive Co. | Antiplaque antibacterial oral composition |
| EP0691124A1 (en) | 1994-07-07 | 1996-01-10 | Sara Lee/DE N.V. | Mouth care products |
| RU2179454C2 (ru) * | 2000-05-24 | 2002-02-20 | Чухаджян Ара Гарникович | Лечебно-профилактические самоклеящиеся пленки местного действия для доставки дозированных количеств фтор-ионов |
| US20060140883A1 (en) * | 2004-12-29 | 2006-06-29 | Colgate-Palmolive Company | Oral care compositions containing a eucalyptus extract |
-
2012
- 2012-12-03 AU AU2012395989A patent/AU2012395989B2/en active Active
- 2012-12-03 EP EP12794353.8A patent/EP2925285B1/en active Active
- 2012-12-03 CN CN201280077473.0A patent/CN105530910B/zh active Active
- 2012-12-03 IN IN3991DEN2015 patent/IN2015DN03991A/en unknown
- 2012-12-03 US US14/648,187 patent/US20150297477A1/en not_active Abandoned
- 2012-12-03 CA CA2890903A patent/CA2890903C/en active Active
- 2012-12-03 RU RU2015121111A patent/RU2642614C2/ru active
- 2012-12-03 WO PCT/EP2012/074286 patent/WO2014086391A1/en active Application Filing
- 2012-12-03 KR KR1020157017573A patent/KR20150091153A/ko not_active Withdrawn
- 2012-12-03 MX MX2015007012A patent/MX354428B/es active IP Right Grant
- 2012-12-03 BR BR112015012808-4A patent/BR112015012808B1/pt active IP Right Grant
-
2013
- 2013-11-20 TW TW104126478A patent/TW201618744A/zh unknown
- 2013-11-20 TW TW102142176A patent/TW201440796A/zh unknown
- 2013-12-03 AR ARP130104470A patent/AR093716A1/es unknown
-
2015
- 2015-05-14 IL IL238845A patent/IL238845B/en active IP Right Grant
- 2015-05-19 PH PH12015501104A patent/PH12015501104A1/en unknown
- 2015-05-22 ZA ZA2015/03655A patent/ZA201503655B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0162574A2 (en) * | 1984-04-18 | 1985-11-27 | JOHNSON & JOHNSON | Oral hygiene compositions |
| US20030124068A1 (en) * | 2000-07-24 | 2003-07-03 | Yamagishi Atsushi | Oral preparation |
| WO2004039343A1 (en) * | 2002-10-31 | 2004-05-13 | Kao Corporation | Oral preparation and chewing gum |
Also Published As
| Publication number | Publication date |
|---|---|
| PH12015501104A1 (en) | 2015-07-27 |
| BR112015012808A2 (pt) | 2017-07-11 |
| WO2014086391A1 (en) | 2014-06-12 |
| RU2015121111A (ru) | 2017-01-11 |
| EP2925285B1 (en) | 2018-08-08 |
| IN2015DN03991A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-10-02 |
| EP2925285A1 (en) | 2015-10-07 |
| MX2015007012A (es) | 2015-09-28 |
| RU2642614C2 (ru) | 2018-01-25 |
| MX354428B (es) | 2018-03-05 |
| US20150297477A1 (en) | 2015-10-22 |
| CA2890903A1 (en) | 2014-06-12 |
| BR112015012808B1 (pt) | 2018-12-11 |
| CA2890903C (en) | 2020-04-14 |
| ZA201503655B (en) | 2019-12-18 |
| IL238845B (en) | 2019-02-28 |
| CN105530910A (zh) | 2016-04-27 |
| IL238845A0 (en) | 2015-06-30 |
| AU2012395989A1 (en) | 2015-05-28 |
| CN105530910B (zh) | 2018-09-18 |
| TW201440796A (zh) | 2014-11-01 |
| KR20150091153A (ko) | 2015-08-07 |
| AR093716A1 (es) | 2015-06-17 |
| TW201618744A (zh) | 2016-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |