AU2012315586B2 - Aromatic-cationic peptides and methods for using same - Google Patents

Aromatic-cationic peptides and methods for using same Download PDF

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Publication number
AU2012315586B2
AU2012315586B2 AU2012315586A AU2012315586A AU2012315586B2 AU 2012315586 B2 AU2012315586 B2 AU 2012315586B2 AU 2012315586 A AU2012315586 A AU 2012315586A AU 2012315586 A AU2012315586 A AU 2012315586A AU 2012315586 B2 AU2012315586 B2 AU 2012315586B2
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Australia
Prior art keywords
renal
peptide
revascularization procedure
subject
aras
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AU2012315586A
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AU2012315586A1 (en
Inventor
Lilach O. Lerman
Stephen C. Textor
D. Travis Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stealth Biotherapeutics Inc
Mayo Clinic in Florida
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Mayo Foundation for Medical Education and Research
Stealth Biotherapeutics Inc
Mayo Clinic in Florida
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Application filed by Mayo Foundation for Medical Education and Research, Stealth Biotherapeutics Inc, Mayo Clinic in Florida filed Critical Mayo Foundation for Medical Education and Research
Publication of AU2012315586A1 publication Critical patent/AU2012315586A1/en
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Publication of AU2012315586B2 publication Critical patent/AU2012315586B2/en
Priority to AU2017248477A priority Critical patent/AU2017248477B2/en
Priority to AU2018253546A priority patent/AU2018253546A1/en
Assigned to MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, STEALTH BIOTHERAPEUTICS INC. reassignment MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Request for Assignment Assignors: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, STEALTH PEPTIDES INTERNATIONAL, INC.
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2012315586A 2011-09-29 2012-09-28 Aromatic-cationic peptides and methods for using same Active AU2012315586B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2017248477A AU2017248477B2 (en) 2011-09-29 2017-10-18 Aromatic-cationic peptides and methods for using same
AU2018253546A AU2018253546A1 (en) 2011-09-29 2018-10-24 Aromatic-cationic peptides and methods for using same

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201161540910P 2011-09-29 2011-09-29
US61/540,910 2011-09-29
US201161558177P 2011-11-10 2011-11-10
US61/558,177 2011-11-10
US201261596455P 2012-02-08 2012-02-08
US61/596,455 2012-02-08
US201261642282P 2012-05-03 2012-05-03
US61/642,282 2012-05-03
US201261681444P 2012-08-09 2012-08-09
US61/681,444 2012-08-09
PCT/US2012/058091 WO2013049697A1 (en) 2011-09-29 2012-09-28 Aromatic-cationic peptides and methods for using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017248477A Division AU2017248477B2 (en) 2011-09-29 2017-10-18 Aromatic-cationic peptides and methods for using same

Publications (2)

Publication Number Publication Date
AU2012315586A1 AU2012315586A1 (en) 2014-05-08
AU2012315586B2 true AU2012315586B2 (en) 2017-07-20

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Family Applications (3)

Application Number Title Priority Date Filing Date
AU2012315586A Active AU2012315586B2 (en) 2011-09-29 2012-09-28 Aromatic-cationic peptides and methods for using same
AU2017248477A Active AU2017248477B2 (en) 2011-09-29 2017-10-18 Aromatic-cationic peptides and methods for using same
AU2018253546A Abandoned AU2018253546A1 (en) 2011-09-29 2018-10-24 Aromatic-cationic peptides and methods for using same

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AU2017248477A Active AU2017248477B2 (en) 2011-09-29 2017-10-18 Aromatic-cationic peptides and methods for using same
AU2018253546A Abandoned AU2018253546A1 (en) 2011-09-29 2018-10-24 Aromatic-cationic peptides and methods for using same

Country Status (8)

Country Link
US (3) US9988422B2 (cg-RX-API-DMAC7.html)
EP (1) EP2760460B1 (cg-RX-API-DMAC7.html)
JP (2) JP6157481B2 (cg-RX-API-DMAC7.html)
CN (3) CN107496899A (cg-RX-API-DMAC7.html)
AU (3) AU2012315586B2 (cg-RX-API-DMAC7.html)
CA (2) CA3123992C (cg-RX-API-DMAC7.html)
HK (1) HK1249406A1 (cg-RX-API-DMAC7.html)
WO (1) WO2013049697A1 (cg-RX-API-DMAC7.html)

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CA2858550A1 (en) * 2011-12-09 2013-06-13 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
EP3626252A1 (en) 2013-03-01 2020-03-25 Stealth Biotherapeutics Corp Methods and compositions for the prevention or treatment of barth syndrome
US10793597B2 (en) 2013-03-01 2020-10-06 Stealth Biotherapeutics Corp Methods for the treatment of mitochondrial diseases associated with a mutation in SURF 1 or POLG gene resulting in a disruption of mitochondrial oxidative phosphorylation
EP3586864A1 (en) * 2013-05-14 2020-01-01 Stealth Biotherapeutics Corp Methods for the prevention or treatment of left ventricle remodeling
US10047395B2 (en) 2013-06-26 2018-08-14 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions
CA2916492A1 (en) 2013-06-27 2014-12-31 Stealth Biotherapeutics Corp Peptide therapeutics and methods for using same
CA2920020C (en) * 2013-08-02 2023-03-14 Stealth Biotherapeutics Corp Methods and compositions for the prevention and treatment of friedreich's ataxia
WO2016004067A1 (en) * 2014-06-30 2016-01-07 Stealth Biotherapeutics Corp Aromatic-cationic peptide formulations, compositions and methods of use
CA3008466C (en) 2015-12-18 2023-06-20 Talengen International Limited Method for preventing or treating radiation and chemical damage
CA3010321A1 (en) * 2015-12-31 2017-07-06 Scott Duncan Therapeutic compositions including peptides and uses thereof
US10870678B2 (en) 2016-04-11 2020-12-22 Arcuate Therapeutics, Inc. Chiral peptides
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US11034724B2 (en) 2017-04-05 2021-06-15 Stealth Biotherapeutics Corp. Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2
IL305687B2 (en) * 2017-12-15 2024-12-01 Stealth Biotherapeutics Inc Mitochondria-targeting peptides
US11795196B2 (en) 2017-12-15 2023-10-24 Stealth Biotherapeutics Inc. Mitochondria-targeting peptides
US10676506B2 (en) 2018-01-26 2020-06-09 Stealth Biotherapeutics Corp. Crystalline bis- and tris-hydrochloride salt of elamipretide
FR3079142B1 (fr) * 2018-03-23 2020-11-27 Matieres Premieres Int Composition veterinaire comprenant de la superoxyde dismutase et au moins un hydrolysat de proteines riche en peptides bioassimilables
US12002199B2 (en) * 2018-09-28 2024-06-04 The Board Of Regents Of The University Of Texas System Methods, apparatuses, and systems for 3-D phenotyping and physiological characterization of brain lesions and surrounding tissue
CN117881411A (zh) 2021-06-01 2024-04-12 艾迪雅生物有限责任公司 用于眼部药物的延长释放药物递送系统和使用方法
JP2024521373A (ja) * 2021-06-01 2024-05-31 アイディア バイオ，エルエルシー 硝子体内ミトコンドリア標的化ペプチドプロドラッグおよび使用方法
CN113718029A (zh) * 2021-10-22 2021-11-30 中国人民解放军北部战区总医院 S100a4蛋白在动脉粥样硬化性肾动脉狭窄诊断中的应用
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EP4491132A4 (en) * 2022-03-31 2025-06-18 Terumo Kabushiki Kaisha PROGRAM, INFORMATION PROCESSING METHOD AND INFORMATION PROCESSING DEVICE

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Also Published As

Publication number Publication date
JP6157481B2 (ja) 2017-07-05
CA3123992A1 (en) 2013-04-04
EP2760460A1 (en) 2014-08-06
WO2013049697A1 (en) 2013-04-04
US11420998B2 (en) 2022-08-23
EP2760460A4 (en) 2015-06-24
CA2850520A1 (en) 2013-04-04
AU2017248477A1 (en) 2017-11-09
AU2018253546A1 (en) 2018-11-22
US20140235529A1 (en) 2014-08-21
CN106913860A (zh) 2017-07-04
JP2017165772A (ja) 2017-09-21
CN103987397A (zh) 2014-08-13
US20180327450A1 (en) 2018-11-15
AU2012315586A1 (en) 2014-05-08
WO2013049697A9 (en) 2014-08-07
HK1249406A1 (zh) 2018-11-02
JP2014530212A (ja) 2014-11-17
CN107496899A (zh) 2017-12-22
US20200223887A1 (en) 2020-07-16
JP6465927B2 (ja) 2019-02-06
AU2017248477B2 (en) 2018-08-02
EP2760460B1 (en) 2019-11-20
CA2850520C (en) 2021-08-31
US9988422B2 (en) 2018-06-05
CA3123992C (en) 2024-06-04

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Owner name: STEALTH BIOTHERAPEUTICS INC.

Free format text: FORMER OWNER(S): STEALTH PEPTIDES INTERNATIONAL, INC.; MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Owner name: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Free format text: FORMER OWNER(S): STEALTH PEPTIDES INTERNATIONAL, INC.; MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH