AU2012298750A1 - Combination treatments for Hepatitis C - Google Patents
Combination treatments for Hepatitis C Download PDFInfo
- Publication number
- AU2012298750A1 AU2012298750A1 AU2012298750A AU2012298750A AU2012298750A1 AU 2012298750 A1 AU2012298750 A1 AU 2012298750A1 AU 2012298750 A AU2012298750 A AU 2012298750A AU 2012298750 A AU2012298750 A AU 2012298750A AU 2012298750 A1 AU2012298750 A1 AU 2012298750A1
- Authority
- AU
- Australia
- Prior art keywords
- inhibitor
- methyl
- hcv
- imidazol
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000005176 Hepatitis C Diseases 0.000 title claims abstract description 42
- 238000011284 combination treatment Methods 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 365
- 150000003839 salts Chemical class 0.000 claims abstract description 95
- 238000000034 method Methods 0.000 claims abstract description 76
- 239000003814 drug Substances 0.000 claims abstract description 74
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 68
- 238000011282 treatment Methods 0.000 claims abstract description 57
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 47
- 241000711549 Hepacivirus C Species 0.000 claims description 233
- 239000003112 inhibitor Substances 0.000 claims description 192
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 82
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims description 80
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 75
- -1 methylpropyl Chemical group 0.000 claims description 74
- 229940079322 interferon Drugs 0.000 claims description 64
- 102000014150 Interferons Human genes 0.000 claims description 63
- 108010050904 Interferons Proteins 0.000 claims description 63
- 239000000203 mixture Substances 0.000 claims description 61
- 125000000217 alkyl group Chemical group 0.000 claims description 56
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 54
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical group N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 52
- 239000000134 cyclophilin inhibitor Substances 0.000 claims description 50
- 229940122806 Cyclophilin inhibitor Drugs 0.000 claims description 49
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims description 48
- 229940127073 nucleoside analogue Drugs 0.000 claims description 47
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims description 46
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- 230000037353 metabolic pathway Effects 0.000 claims description 41
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- YFXGICNMLCGLHJ-RSKRLRQZSA-N 2,2-dimethylpropyl (2s)-2-[[[(2r,3r,4r,5r)-5-(2-amino-6-methoxypurin-9-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-naphthalen-1-yloxyphosphoryl]amino]propanoate Chemical compound C1=CC=C2C(OP(=O)(N[C@@H](C)C(=O)OCC(C)(C)C)OC[C@H]3O[C@H]([C@]([C@@H]3O)(C)O)N3C=4N=C(N)N=C(C=4N=C3)OC)=CC=CC2=C1 YFXGICNMLCGLHJ-RSKRLRQZSA-N 0.000 claims description 6
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- HYCFQLFXXDLCPF-GONGHQDWSA-N methyl n-[(2s)-1-[(2s)-2-[5-[4-[4-[2-[6-[(2s)-2-(methoxycarbonylamino)-3-methylbutanoyl]-2,6-diazaspiro[3.4]octan-7-yl]-1h-imidazol-5-yl]phenyl]phenyl]-1h-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate Chemical compound COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C1=NC=C(C=2C=CC(=CC=2)C=2C=CC(=CC=2)C=2NC(=NC=2)C2N(CC3(CNC3)C2)C(=O)[C@@H](NC(=O)OC)C(C)C)N1 HYCFQLFXXDLCPF-GONGHQDWSA-N 0.000 claims description 2
- WKAFMWGZGBCGNK-PRABGMNFSA-N methyl n-[(2s)-1-[(2s)-2-[5-[4-[4-[2-[6-[(2s)-2-(methoxycarbonylamino)-3-methylbutanoyl]-2-(methylcarbamoyl)-2,6-diazaspiro[3.4]octan-7-yl]-1h-imidazol-5-yl]phenyl]phenyl]-1h-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate Chemical compound C1N(C(=O)NC)CC21CN(C(=O)[C@@H](NC(=O)OC)C(C)C)C(C=1NC(=CN=1)C=1C=CC(=CC=1)C=1C=CC(=CC=1)C=1NC(=NC=1)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)OC)C(C)C)C2 WKAFMWGZGBCGNK-PRABGMNFSA-N 0.000 claims description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
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- Organic Chemistry (AREA)
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- Virology (AREA)
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- Mycology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US201161526798P | 2011-08-24 | 2011-08-24 | |
| US61/526,798 | 2011-08-24 | ||
| US201161529358P | 2011-08-31 | 2011-08-31 | |
| US61/529,358 | 2011-08-31 | ||
| US201261617813P | 2012-03-30 | 2012-03-30 | |
| US61/617,813 | 2012-03-30 | ||
| PCT/US2012/052216 WO2013028953A1 (en) | 2011-08-24 | 2012-08-24 | Combination treatments for hepatitis c |
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| AU2012298750A1 true AU2012298750A1 (en) | 2014-03-13 |
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| PE20120993A1 (es) * | 2009-09-04 | 2012-08-22 | Janssen Pharmaceuticals Inc | Derivados bifenilicos como antivirales |
| KR101975233B1 (ko) | 2011-08-17 | 2019-05-07 | 글락소스미스클라인 엘엘씨 | 치료 방법 |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| PT107894A (pt) | 2011-10-21 | 2014-10-31 | Abbvie Inc | Métodos para o tratamento de hcv compreendendo pelo menos dois agentes antivirais de actuação directa, ribavirina, mas não interferão. |
| GB2515942A (en) | 2011-10-21 | 2015-01-07 | Abbvie Inc | Combination treatment (e.g. with ABT-072 or ABT-333) of DAAs for use in treating HCV |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CN105705511A (zh) | 2013-04-12 | 2016-06-22 | 艾其林医药公司 | 用于治疗hcv的氘化核苷前药 |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| EP3019196B1 (en) * | 2013-07-09 | 2018-06-06 | Bristol-Myers Squibb Company | Combinations of hepatitis c virus inhibitors |
| WO2015009744A1 (en) | 2013-07-17 | 2015-01-22 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of hcv |
| CN104725365B (zh) * | 2013-12-23 | 2019-02-26 | 南京圣和药业股份有限公司 | 丙型肝炎病毒抑制剂及其应用 |
| CA2935089C (en) * | 2013-12-31 | 2018-11-27 | Nanjing Sanhome Pharmaceutical Co., Ltd. | 9,9,10,10-tetrafluoro-9,10-dihydrophenanthrene hepatitis c virus inhibitor and application thereof |
| CN106279121B (zh) * | 2014-01-21 | 2019-05-24 | 杭州普晒医药科技有限公司 | 一种化合物的盐及晶型或无定型物、其制备方法、含有它们的药物组合物和用途 |
| SG11201703645XA (en) * | 2014-11-10 | 2017-06-29 | Glaxosmithkline Intellectual Property (No 2) Ltd | Long acting pharmaceutical compositions for hepatitis c |
| MA41812A (fr) * | 2015-03-27 | 2018-01-30 | Janssen Pharmaceuticals Inc | Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc |
| US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US11192914B2 (en) | 2016-04-28 | 2021-12-07 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| CN110693887B (zh) * | 2019-05-17 | 2022-06-17 | 歌礼药业（浙江）有限公司 | 包含索磷布韦和拉维达韦的片剂及其制备方法 |
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| US20100158862A1 (en) * | 2006-08-11 | 2010-06-24 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US8329159B2 (en) * | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8303944B2 (en) * | 2006-08-11 | 2012-11-06 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7704992B2 (en) * | 2008-02-13 | 2010-04-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| ES2435799T3 (es) * | 2008-10-09 | 2013-12-23 | Anadys Pharmaceuticals, Inc. | Un método de inhibición del virus de la hepatitis C mediante combinación de una 5,6-dihidro-1H-piridin-2-ona y de uno o más compuestos antivirales adicionales |
| WO2010062821A1 (en) * | 2008-11-28 | 2010-06-03 | Glaxosmithkline Llc | Anti-viral compounds, compositions, and methods of use |
| MX2011007195A (es) * | 2009-01-07 | 2013-07-12 | Scynexis Inc | Derivado de ciclosporina para el uso en el tratamiento de infección de virus de hepatitis c (vhc) y virus de inmunodeficiencia humana (vih). |
| MX363732B (es) * | 2009-05-13 | 2019-04-01 | Gilead Pharmasset Llc Star | Compuestos antivirales. |
| PE20120993A1 (es) * | 2009-09-04 | 2012-08-22 | Janssen Pharmaceuticals Inc | Derivados bifenilicos como antivirales |
| US8415374B2 (en) * | 2009-10-12 | 2013-04-09 | Bristol-Myers Squibb Company | Combinations of hepatitis C virus inhibitors |
| US8377980B2 (en) * | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CA2784748A1 (en) * | 2009-12-18 | 2011-06-23 | Idenix Pharmaceuticals, Inc. | 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors |
| WO2012040126A1 (en) * | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
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2012
- 2012-08-24 CA CA2845321A patent/CA2845321A1/en not_active Abandoned
- 2012-08-24 PH PH1/2014/500386A patent/PH12014500386A1/en unknown
- 2012-08-24 KR KR1020147007736A patent/KR20140065427A/ko not_active Withdrawn
- 2012-08-24 CN CN201280052257.0A patent/CN103917095A/zh active Pending
- 2012-08-24 JP JP2014527322A patent/JP2014527061A/ja active Pending
- 2012-08-24 EA EA201490254A patent/EA201490254A1/ru unknown
- 2012-08-24 WO PCT/US2012/052216 patent/WO2013028953A1/en not_active Ceased
- 2012-08-24 MX MX2014002171A patent/MX2014002171A/es unknown
- 2012-08-24 SG SG2014010490A patent/SG2014010490A/en unknown
- 2012-08-24 US US14/240,420 patent/US20140234253A1/en not_active Abandoned
- 2012-08-24 BR BR112014004182A patent/BR112014004182A2/pt not_active IP Right Cessation
- 2012-08-24 EP EP12826268.0A patent/EP2747569A4/en not_active Withdrawn
- 2012-08-24 HK HK14112612.7A patent/HK1198869A1/xx unknown
- 2012-08-24 AU AU2012298750A patent/AU2012298750A1/en not_active Abandoned
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2014
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- 2014-02-24 CR CR20140086A patent/CR20140086A/es unknown
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2017
- 2017-04-20 JP JP2017083252A patent/JP2017165746A/ja active Pending
Also Published As
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| BR112014004182A2 (pt) | 2017-03-14 |
| IL230844A0 (en) | 2014-03-31 |
| HK1198869A1 (en) | 2015-06-19 |
| EA201490254A1 (ru) | 2014-07-30 |
| KR20140065427A (ko) | 2014-05-29 |
| EP2747569A1 (en) | 2014-07-02 |
| CN103917095A (zh) | 2014-07-09 |
| CR20140086A (es) | 2014-05-02 |
| JP2014527061A (ja) | 2014-10-09 |
| CO6890100A2 (es) | 2014-03-10 |
| WO2013028953A1 (en) | 2013-02-28 |
| SG2014010490A (en) | 2014-04-28 |
| MX2014002171A (es) | 2014-04-25 |
| JP2017165746A (ja) | 2017-09-21 |
| CL2014000428A1 (es) | 2014-08-01 |
| US20140234253A1 (en) | 2014-08-21 |
| PH12014500386A1 (en) | 2019-10-07 |
| CA2845321A1 (en) | 2013-02-28 |
| EP2747569A4 (en) | 2015-07-08 |
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