AU2012296907B2 - Combination therapy with an anti - CD19 antibody and a nitrogen mustard - Google Patents

Combination therapy with an anti - CD19 antibody and a nitrogen mustard Download PDF

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Publication number
AU2012296907B2
AU2012296907B2 AU2012296907A AU2012296907A AU2012296907B2 AU 2012296907 B2 AU2012296907 B2 AU 2012296907B2 AU 2012296907 A AU2012296907 A AU 2012296907A AU 2012296907 A AU2012296907 A AU 2012296907A AU 2012296907 B2 AU2012296907 B2 AU 2012296907B2
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lymphoma
seq
sequence
region
hodgkin
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AU2012296907A
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AU2012296907A1 (en
Inventor
Jutta AMERSDORFER
Susanne KROHN
Lisa Rojkjaer
Stefan Steidl
Mark Winderlich
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Incyte Corp
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Incyte Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2012296907A 2011-08-16 2012-08-14 Combination therapy with an anti - CD19 antibody and a nitrogen mustard Active AU2012296907B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161523861P 2011-08-16 2011-08-16
EP11177658 2011-08-16
US61/523,861 2011-08-16
EP11177658.9 2011-08-16
US201261647539P 2012-05-16 2012-05-16
US61/647,539 2012-05-16
US201261654097P 2012-06-01 2012-06-01
US61/654,097 2012-06-01
PCT/EP2012/065906 WO2013024097A1 (en) 2011-08-16 2012-08-14 Combination therapy with an anti - cd19 antibody and a nitrogen mustard

Publications (2)

Publication Number Publication Date
AU2012296907A1 AU2012296907A1 (en) 2013-12-05
AU2012296907B2 true AU2012296907B2 (en) 2017-01-05

Family

ID=47714801

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012296907A Active AU2012296907B2 (en) 2011-08-16 2012-08-14 Combination therapy with an anti - CD19 antibody and a nitrogen mustard

Country Status (24)

Country Link
US (3) US20140255427A1 (cg-RX-API-DMAC7.html)
EP (2) EP4062936A1 (cg-RX-API-DMAC7.html)
JP (1) JP6184952B2 (cg-RX-API-DMAC7.html)
KR (3) KR20200058583A (cg-RX-API-DMAC7.html)
CN (1) CN103732252B (cg-RX-API-DMAC7.html)
AU (1) AU2012296907B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013033919B1 (cg-RX-API-DMAC7.html)
CA (2) CA2841875C (cg-RX-API-DMAC7.html)
CY (1) CY1125122T1 (cg-RX-API-DMAC7.html)
DK (1) DK2744515T3 (cg-RX-API-DMAC7.html)
ES (1) ES2909722T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20220228T1 (cg-RX-API-DMAC7.html)
HU (1) HUE058350T2 (cg-RX-API-DMAC7.html)
IL (1) IL230293B (cg-RX-API-DMAC7.html)
LT (1) LT2744515T (cg-RX-API-DMAC7.html)
MX (1) MX354479B (cg-RX-API-DMAC7.html)
PL (1) PL2744515T3 (cg-RX-API-DMAC7.html)
PT (1) PT2744515T (cg-RX-API-DMAC7.html)
RS (1) RS63238B1 (cg-RX-API-DMAC7.html)
RU (1) RU2625222C2 (cg-RX-API-DMAC7.html)
SG (1) SG10201606785UA (cg-RX-API-DMAC7.html)
SI (1) SI2744515T1 (cg-RX-API-DMAC7.html)
SM (1) SMT202200159T1 (cg-RX-API-DMAC7.html)
WO (1) WO2013024097A1 (cg-RX-API-DMAC7.html)

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CA2951427A1 (en) * 2014-06-16 2015-12-23 Xencor, Inc. Treatment for chronic lymphocytic leukemia (cll)
CA2986175A1 (en) * 2015-05-26 2016-12-01 Morphosys Ag Combination of an anti-cd19 antibody and a bruton's tyrosine kinase inhibitor and uses thereof
AU2016311136B2 (en) 2015-08-21 2022-02-17 Incyte Corporation Combinations and uses thereof
EP3436070A4 (en) 2016-03-29 2019-11-27 University of Southern California AGAINST CANCER, CHIMERIC ANTIGEN RECEPTORS
MA45124B1 (fr) * 2016-05-30 2021-05-31 Morphosys Ag Procédés permettant de prédire un bénéfice thérapeutique d'une thérapie anti-cd19 chez des patients
IL266216B2 (en) * 2016-10-28 2023-09-01 Morphosys Ag Combination of anti-cd19 antibody with bcl-2 inhibitor and uses thereof
IL266892B2 (en) 2016-12-02 2025-10-01 Univ Southern California Artificial immune receptors and methods of using them
PL3630177T3 (pl) * 2017-05-31 2024-04-08 Morphosys Ag Paradygmat leczenia dla leczenia skojarzonego przeciwciałem anty-cd19 i wenetoklaksem
KR20200030337A (ko) 2018-09-12 2020-03-20 주식회사 녹십자랩셀 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물
KR20240131370A (ko) * 2021-12-22 2024-08-30 인사이트 코포레이션 항-cd19 항체 요법을 위한 치료 패러다임

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DE69909459T2 (de) * 1998-04-21 2004-05-27 Micromet Ag Cd19xcd3 spezifische polypeptide und deren verwendung
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MXPA03002262A (es) 2000-09-18 2003-10-15 Idec Pharma Corp Terapia de combinacion para tratamiento de enfermedades autoinmunes usando una combinacion de anticuerpos inmunorreguladores/supresores de celulas b.
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Also Published As

Publication number Publication date
EP4062936A1 (en) 2022-09-28
CN103732252B (zh) 2017-11-10
PT2744515T (pt) 2022-05-19
EP2744515A1 (en) 2014-06-25
PL2744515T3 (pl) 2022-05-30
BR112013033919A2 (pt) 2017-12-19
HUE058350T2 (hu) 2022-07-28
US20140255427A1 (en) 2014-09-11
CN103732252A (zh) 2014-04-16
CA2841875A1 (en) 2013-02-21
WO2013024097A1 (en) 2013-02-21
RU2014103492A (ru) 2015-09-27
CA2841875C (en) 2021-11-02
DK2744515T3 (da) 2022-03-28
ES2909722T3 (es) 2022-05-10
MX354479B (es) 2018-03-07
IL230293B (en) 2019-01-31
US20240366756A1 (en) 2024-11-07
HRP20220228T1 (hr) 2022-05-13
KR20140064873A (ko) 2014-05-28
JP6184952B2 (ja) 2017-08-23
NZ617770A (en) 2016-01-29
SMT202200159T1 (it) 2022-05-12
US20200353077A1 (en) 2020-11-12
RS63238B1 (sr) 2022-06-30
SI2744515T1 (sl) 2022-05-31
LT2744515T (lt) 2022-04-25
MX2013014933A (es) 2014-04-16
CY1125122T1 (el) 2024-12-13
BR112013033919B1 (pt) 2022-11-16
SG10201606785UA (en) 2016-10-28
JP2014525926A (ja) 2014-10-02
EP2744515B1 (en) 2022-02-09
CA3137321A1 (en) 2013-02-21
KR102115203B1 (ko) 2020-05-28
RU2625222C2 (ru) 2017-07-12
KR20190107749A (ko) 2019-09-20
KR20200058583A (ko) 2020-05-27

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Free format text: FORMER OWNER(S): MORPHOSYS AG