AU2012284127A1 - Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto - Google Patents

Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto Download PDF

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Publication number
AU2012284127A1
AU2012284127A1 AU2012284127A AU2012284127A AU2012284127A1 AU 2012284127 A1 AU2012284127 A1 AU 2012284127A1 AU 2012284127 A AU2012284127 A AU 2012284127A AU 2012284127 A AU2012284127 A AU 2012284127A AU 2012284127 A1 AU2012284127 A1 AU 2012284127A1
Authority
AU
Australia
Prior art keywords
formula
compound
alkyl
pct
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2012284127A
Other languages
English (en)
Inventor
Roland E. Dolle
Bertrand Le Bourdonnec
Pierre Martin
Christian Steffen MOESSNER
Dirk Jost Spielvogel
Felix Herbert Spindler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adolor Corp
Original Assignee
Adolor Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adolor Corp filed Critical Adolor Corp
Publication of AU2012284127A1 publication Critical patent/AU2012284127A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2012284127A 2011-07-18 2012-07-17 Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto Abandoned AU2012284127A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161508817P 2011-07-18 2011-07-18
US61/508,817 2011-07-18
PCT/US2012/047082 WO2013012871A1 (en) 2011-07-18 2012-07-17 Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto

Publications (1)

Publication Number Publication Date
AU2012284127A1 true AU2012284127A1 (en) 2013-05-02

Family

ID=47558430

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012284127A Abandoned AU2012284127A1 (en) 2011-07-18 2012-07-17 Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto

Country Status (9)

Country Link
US (1) US20150045556A1 (es)
EP (1) EP2734041A4 (es)
CN (1) CN103917096A (es)
AU (1) AU2012284127A1 (es)
CA (1) CA2842183A1 (es)
HK (1) HK1199794A1 (es)
IL (1) IL230506A0 (es)
IN (1) IN2014DN00137A (es)
WO (1) WO2013012871A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103804431A (zh) * 2014-02-25 2014-05-21 中国人民解放军第四军医大学 一种手性二茂铁双膦配体及其制备方法
EP3421455B1 (en) * 2017-06-29 2019-03-27 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of chiral 3-amino-piperidins, useful intermediates for the preparation of tofacitinib
KR102606188B1 (ko) 2017-08-02 2023-11-23 버텍스 파마슈티칼스 인코포레이티드 피롤리딘 화합물을 제조하기 위한 공정
MA51039A (fr) 2017-12-08 2020-10-14 Vertex Pharma Procédés pour préparer des modulateurs du régulateur de la conductance transmembranaire de la mucoviscidose

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86061A (en) * 1987-04-16 1992-07-15 Lilly Co Eli Derivatives of trans-3,4-isomer of 4-methyl-4-phenyl-piperidines,process for their preparation and pharmaceutical compositions containing them
US5536858A (en) * 1994-02-12 1996-07-16 Hoffmann-La Roche Inc. Tetrasulfonated diphosphine compounds and metal complexes thereof for asymmetric catalytic reactions
US5553858A (en) * 1995-06-28 1996-09-10 Mckoon; Carl T. Golf putter
US6057456A (en) * 1997-10-16 2000-05-02 Yale University Transition metal-catalyzed process for preparing alpha-arylated carbonyl-containing compounds
US6900228B1 (en) * 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
TWI254043B (en) * 1999-06-08 2006-05-01 Hoffmann La Roche Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor
US6794510B2 (en) * 2002-08-08 2004-09-21 Adolor Corporation Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
DK2379491T3 (da) * 2008-12-18 2013-04-08 Hoffmann La Roche Fremgangsmåde til syntese af amino-methyl-tetralinderivater

Also Published As

Publication number Publication date
IN2014DN00137A (es) 2015-05-22
WO2013012871A1 (en) 2013-01-24
IL230506A0 (en) 2014-03-31
HK1199794A1 (en) 2015-07-24
CA2842183A1 (en) 2013-01-24
US20150045556A1 (en) 2015-02-12
EP2734041A4 (en) 2015-03-25
CN103917096A (zh) 2014-07-09
EP2734041A1 (en) 2014-05-28

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application