AU2012238668B2

AU2012238668B2 - Waterproof, quick-drying, and water vapor-permeable fabric bandages

Info

Publication number: AU2012238668B2
Application number: AU2012238668A
Authority: AU
Inventors: Carsten Hartkopf; Juana Kirsten; Florian RANDOLPH
Original assignee: Beiersdorf AG
Current assignee: Beiersdorf AG
Priority date: 2011-04-08
Filing date: 2012-04-05
Publication date: 2016-03-03
Anticipated expiration: 2032-04-05
Also published as: DE102011007060A1; WO2012136764A1; EP2694001A1; AU2012238668A1

Abstract

The invention relates to a self-adhesive skin dressing with a layer structure made of hydrophobic and/or oleophobic fabric, a liquid-tight and preferably water vapor-permeable layer, and a preferably water vapor-permeable adhesive, said liquid-tight layer being arranged so as to face the skin. The skin dressing offers the user an advantageous fabric feel with simultaneous moisture-regulating properties.

Description

- 1 WATERPROOF, QUICK-DRYING, AND WATER-VAPOR-PERMEABLE FABRIC BANDAGES FIELD OF THE INVENTION [0001] The present invention relates to self-adhesive skin dressings. BACKGROUND OF THE INVENTION [0002] Any discussion of the prior art throughout the specification should in no way be considered as an admission that such prior art is widely known or forms part of common general knowledge in the field. [0003] A range of materials are known for wound bindings, plasters, skin dressings and tapes for fixing wound dressings and for stabilizing joints, for example. [0004] The different materials, from fabric and films to laminates, are used for different purposes and types of application. [0005] Classical fabric plasters are not watertight and therefore do not protect the wound against water. In addition, they become wet when the hands are washed, as a result of which the adhesive force is reduced, the wear comfort is impaired and the appearance is degraded. [0006] Watertight fabric plasters are therefore so far unknown. [0007] If water-tightness is required, it is necessary to switch to film plasters. However, these films have the disadvantage that they do not have a feel which is pleasant to the user. [0008] Textile wound dressings, e.g. based on cotton, viscose, PE or PP, in combination with occlusive carrier materials can produce a moist healing environment for the wound. In doing so, however, there is a risk of maceration of the skin if too much moisture is accumulated under the occlusive carrier material. Maceration means a softening of the skin surrounding the wound due to liquid, which can lead to a softened skin barrier and/or loss of adhesion. A softened skin barrier can lead to wound healing complications such as infections, for example.

-2 [0009] EP 826083 A2 describes fabrics which are designed to be liquid-tight and gas permeable in that they have been treated with a thermosetting thixotropic polymer compound containing biologically active molecules. The fabrics can be used in protective clothing and wound treatment products. [0010] The state of the art is to coat fibers of a fabric with hydrophilic polymer (e.g. acrylic resin) or to treat the fabric with fluorochemicals or silicones in order to render it water-repellent and gas-permeable. [0011] US 4454191 discloses a watertight and moisture-repellent fabric. This describes a coating with polyorganosiloxanes to make the fabric watertight but permeable to water vapor. In doing so, the feel when touching the fabric is not changed. [0012] Fabrics, which can be rendered watertight and breathable by laminating with a polyurethane film, are described in EP 1260565 Al. [0013] Widely differing textiles, which are constructed with widely differing coatings to be watertight and, at the same time, permeable to air, are disclosed in DE 3835016 A2, JP 02249645, JP 63230337, JP 59158252 and WO 2009044875. Mention must be made here of the clothing industry as the main application of these textiles. [0014] Wound bindings, such as BandAid@ Tough Strips Waterproof or Nexcare@ Heavy Duty Clear & Tough, which constitute film plasters with integral fabric structure, are known from the trade. [0015] Existing plasters which are really watertight always have a film-like feel and therefore cannot be perceived as fabric bandages. [0016] It is desirable to provide wound bindings which are liquid-tight, water-vapor permeable, do not exhibit any maceration and yet provide a fabric-like feel for the user. [0017] EP 673657 describes an adhesive bandage, wherein a textile composite material is provided with an adhesive layer on the side facing the skin and, on the opposite side, a film with water vapor permeability and water impermeability is laminated onto the textile composite. The textile composite material is constructed from elastomer fibers. With this plaster structure, in which the fabric faces the skin, the fabric, which lies under a watertight film, can soak up liquid by means of the open edges due to capillary effects. As a result of these capillary -3 effects, moisture from the edge of the dressing can penetrate the wound dressing and lead to the problems described, for example maceration. [0018] This problem is described and welding of the open edges is offered as a solution in EP 673657. [0019] The self-adhesive products based on watertight textiles described in the prior art (wound bindings, tapes) essentially have two disadvantages: they lose their textile feel in that the watertight layer is attached to the side facing away from the skin, and the textile below the watertight layer absorbs liquid at the open edges by means of capillary forces. SUMMARY OF THE INVENTION [0020] It is an object of the present invention to overcome or ameliorate at least one of the disadvantages of the prior art, or to provide a useful alternative. [0021] To this end, a first aspect of the present invention provides a self-adhesive skin dressing comprising: a fabric layer of hydrophobic and/or oleophobic fabric and/or fabric with hydrophobic and/or oleophobic finish, a liquid-tight layer on the complete skin side of the fabric layer, the liquid-tight layer being coated with an adhesive compound on the side facing the skin, wherein one or more active ingredients are contained in the liquid-tight layer and/or the adhesive compound. [0022] A second aspect of the present invention provides the use of a layer of hydrophobic and/or oleophobic fabric and/or fabric with hydrophobic and/or oleophobic finish, the fabric layer being provided on the complete side facing the skin with a liquid-tight layer which in turn is coated with an adhesive compound on the side facing the skin and on which a wound dressing is arranged in order to produce a self-adhesive plaster for wound treatment, wherein one or more active ingredients are contained in the liquid-tight layer and/or the adhesive compound. [0023] A third aspect of the present invention provides the use of a layer of hydrophobic and/or oleophobic fabric and/or fabric with hydrophobic and/or oleophobic finish, the fabric layer being provided on the complete side facing the skin with a liquid-tight layer which in turn is coated with an adhesive compound on the side facing the skin and on which a wound -4 dressing may be arranged and one or more pharmaceutical active ingredients are contained in the liquid-tight layer, and/or the adhesive compound for the purpose of producing transdermal therapeutic skin dressings. [0024] Advantageously, the skin dressing according to the present invention offers the user a fabric feel with simultaneous moisture-regulating properties. DETAILED DESCRIPTION [0025] The invention is a self-adhesive skin dressing comprising a layer of hydrophobic and/or oleophobic fabric (2), the hydrophobized or oleophobized fabric layer (2) being provided on the side facing the skin with a liquid-tight layer (3) which in turn is coated with a preferably water-vapor-permeable adhesive compound (4) on the side facing the skin. In doing so, the liquid-tight and preferably water-vapor-permeable layer (3) can be applied as a dispersion or a melt, for example, directly onto the fabric (2) or laminated onto the fabric in the form of a film. [0026] The fabric (2) is rendered hydrophobic and/or oleophobic (water and/or oil-repellent) by appropriate finishing (1). The fabric can be hydrophobized or oleophobized (1) by means of a fluorocarbon finish or by the use of 100% synthetic yarn. That is to say, the fabric can be oleophobic or hydrophobic per se (synthetic yarn, Teflon etc.) and/or be made oleophobic or hydrophobic by means of appropriate treatment/finishing. [0027] All suitable chemicals which are known for the purpose and for use in wound treatment products and tapes or bandages, such as paraffins, aluminum and/or zirconium salts of organic acids, fluorocarbons, alkylsilanes, dimethylpolysiloxanes, waxes and/or mixtures thereof, are a possibility for the hydrophobic and/or oleophobic finish (1). The possible ways of hydrophobizing or oleophobizing described in EP 826083 A2 are part of the present disclosure. Oleophobizing and/or hydrophobizing the fabric by treating suitable materials (1) can be carried out, for example, by coating, impregnation or other suitable treatment measures, and a hydrophobic and/or oleophobic layer or fabric (2) is obtained in this way. [0028] Hydrophobizing and oleophobizing with paraffin-based chemicals (such as Phobol APK for example) and fluorocarbons is preferred. In a particularly preferred embodiment, the hydrophobizing and/or oleophobizing is carried out dispensing entirely with such paraffin based chemicals, e.g. by simple oleophobizing with the help of fluorocarbons.

-5 [0029] Skin dressings according to the invention are understood to mean wound bindings, tapes, bandages, patches, plasters, pads and dressings. The dressings can be designed to be free from active ingredients and also to contain active ingredients. [0030] Self-adhesive means that the skin dressing remains stuck to the skin over a certain period of time without further additional fixing means. The time period and the adhesive force can, of course, be individually matched to the required circumstances. A wound plaster is therefore to be provided with a higher adhesive force and adhesive duration than a cosmetic pad. The self-adhesion is achieved by means of the adhesive layer (4). [0031] The adhesive compound can be selected from different compounds, such as (poly-)acrylates, rubber (natural or synthetic), polyurethane, silicone or hydrocolloids for example. [0032] The coating with advantageously water-vapor-permeable adhesive compound (4) can be carried out in different ways. A full-surface coating with a water-vapor-permeable adhesive compound, e.g. made of polyacrylate, silicone or polyurethane, is preferred. However, the adhesive compound can also be only partially applied (e.g. silk screen printing, applied in strips) in order to achieve good or better water vapor permeability. In this case, occlusive adhesive compounds, e.g. based on natural and/or synthetic rubber, can also be used in addition to the adhesive compounds already listed. For better absorption and conduction of water vapor, a hydrocolloid, e.g. carboxymethycellu lose or Na salts of polyacrylic acid, can be added to the adhesive compound. Hot melt compounds as well as adhesive compounds based on solvents, including water, are also a possibility for the adhesive compound. The adhesive compound can also contain medicinal, dermatological or cosmetic active ingredients which are released to the skin over time. [0033] The adhesive compound (4) is preferably selected from polyacrylates, silicones, polyurethanes, natural and/or synthetic rubber and/or hydrocolloids. [0034] The adhesive compound (4) is applied over the full surface or partially on the liquid tight layer (3). The application as well as the type of adhesive compound can in turn be individually matched to the required circumstances depending on the requirement. [0035] The adhesive compound (4) can be made up of one or more different adhesive compounds. Likewise, the layer (3) can be coated with different adhesive compounds at -6 different points. This enables the adhesion of the dressing according to the invention to be individually matched to required conditions such as adhesion to joints, on facial skin, in very hairy areas etc. [0036] In contrast to skin dressings and wound bindings found in the prior art, in the dressing according to the invention, the liquid-tight layer (3) is applied, for example laminated, onto the fabric on the side facing the skin. A layer obtained from acrylate dispersion is preferred as the liquid-tight and preferably gas-permeable, and therefore water-vapor permeable and breathable, layer (3). Alternatively and according to the invention advantageously, silicone, polyurethane (PU) dispersion, PU film or a direct coating with PU or acrylate can also be used as the liquid-tight layer. Alternatively, according to the invention, a layer (3) obtained from a polyurethane or actylate dispersion is preferably used. [0037] According to the invention, the layer (3) can advantageously be produced by means of a laminated-on water-vapor-permeable film, e.g. made of polyurethane, copolyester or made of a microporous film, e.g. made of PE, PP, polyamide, polyester, polyether ester or PTFE, or a free-flowing polymer layer, e.g. made of silicone, polyurethane or polyacrylate, applied, for example, from the melt, from a dispersion or a solution. [0038] The liquid-tight layer (3) can comprise two or more layers and, if necessary, also different layer materials. Advantageously, the liquid-tight layer (3) can comprise a microporous film made of polyolefin, in particular polyethylene. [0039] The film, which in certain instances may be flexible, can be applied by pouring, extruding, laminating or lining. Suppliers of known films are established film manufacturers, such as the companies SNEF (Smith & Nephew Extruded Films) or Epurex, for example. [0040] According to the invention, a film with a "water vapor transmission rate (WVTR)" of more than 300 g/m2 in 24h is considered to be water-vapor-permeable. [0041] Advantageously, the layer (3) has a breathability and a water-vapor-permeability of > 350 g/m2/24h according to the method set out in Example 1. [0042] Advantageously, the layer (3) has a thickness of approx. 10 to 100 pm and/or a weight per unit area of 10 to 100 g/m2.

-7 [0043] As a result of the layer structure according to the invention, the fabric coating (2) faces the side facing away from the skin and provides the user with the required fabric feel which he perceives and notices externally. The fabric layer (2) faces outwards and can therefore be perceived as such by the user. [0044] Soaking of the upper fabric layer is reduced or prevented due to the oleophoby or hydrophoby of the fabric (2) or the hydrophobic or oleophobic design (1) of the fabric (2). [0045] Placing the film (3) directly facing the skin and the fabric (2) facing outwards (facing away from the skin) has previously been unsuccessful due to the requirement that the fabric is to be kept dry. [0046] In the embodiment of self-adhesive plasters with combinations of fabric and watertight layers known in the prior art, the watertight layer always faces outwards, away from the skin. Although the fabric is kept dry, the product loses its typical fabric feel and is perceived rather as a film product. [0047] A further advantage of the structure according to the invention is that the fabric can dry more quickly if it is ever wetted by liquid or becomes wet. The hydrophobizing and/or oleophobizing prevents the fabric fibers themselves being soaked with liquid. Liquid can therefore only penetrate into or through the intermediate spaces between the fibers of the fabric. The watertight layer below the fabric ensures that the liquid does not penetrate deeper but remains at the surface where it can quickly evaporate. Furthermore, a decisive advantage is that, in contrast to plaster structures in which the fabric faces the skin, no capillary effects, which are able to draw moisture from the edge of the dressing into the wound dressing, can occur. [0048] As described in EP 673657 A2, in which the fleece which lies below a watertight film is capable of soaking up liquid by means of the open edges due to capillary effects, the structure according to the invention easily avoids these disadvantages in that the fabric faces outwards and the watertight layer is arranged underneath it facing the adhesive compound and the skin. [0049] The product structure according to the invention therefore does not have the serious disadvantages of a loss of textile feel and the lateral soaking up of liquid under an outward facing watertight layer.

-8 [0050] A fabric is understood to be any form of textile, such as fabrics, interlaced yarns, knitted fabrics, fleeces etc. Basically, all, especially textile, carrier materials, which are suitable for self-adhesive wound treatment products, tapes and bandages as well as patches and pads, are a possibility. The basic fibers or yarns are usually made of cotton, viscose, cellulose acetate, polyester, PE, PP, polyamide and mixtures thereof - however, other materials are also conceivable. [0051] Advantageously, the weight per unit area of the fabric layer (2) is chosen to be in the range from 50 to 250 g/m2, particularly advantageously in the range from 70 - 180 g/m2. [0052] Advantageously, the liquid-tight layer (3) and/or the adhesive compound (4) are permeable to water vapor, i.e. they have a "water vapor transmission rate (WVTR)" of more than 300 g/m2 in 24h. The dressings which are so equipped are then also permeable to water vapor. These embodiments are preferred, as they prevent maceration. A further advantage of this water-vapor-permeable embodiment is that it counteracts a reduction in the adhesive force on the skin, which can be caused by an accumulation of moisture at the boundary layer between the skin and the adhesive compound. [0053] Advantageously, the bond between the fabric (2) and the liquid-tight and preferably water-vapor-permeable layer (3) and the bond of the liquid-tight layer (3) and the adhesive compound (4) are considerably stronger than the adhesion of the product (e.g. plaster, tapes etc.) with the skin and/or to itself. For example, when a plaster is used on the finger, one end of the plaster can be stuck to the other end of the plaster on the side which faces away from the skin. [0054] The adhesive forces in the bond of the layers (2) and (3) and also (3) and (4) are ideally approximately equal in order to avoid delamination. The difference in the adhesive force between the different layers of the dressing and its adhesive force with respect to the skin and/or to itself prevents damage to and disintegration of the skin dressing when it is removed from the skin. [0055] Normal plasters, tapes etc. have an adhesive force on the skin in the range from 20 to 200 cN/cm. Preferably they have an adhesive force on the skin in the range from 40 to 160 cN/cm. However, according to the invention, regardless of the specific adhesive force of the dressings according to the invention on the skin, the adhesive force between the layers (2) and (3) and also (3) and (4) must preferably be chosen to be greater.

-9 [0056] The bond of the layers (2), (3) and (4) is therefore sufficiently adequate to fulfill the necessary application characteristics as a self-adhesive dressing when stuck to the skin and for it to be removed from the point of application after use without leaving a residue. [0057] The adhesive force between the layers (2) and (3) can be determined, for example, as follows: a 20 cm long strip of the watertight fabric, consisting of layers (2) and (3), is stuck to a steel plate with double sided adhesive tape so that the layer (3) forms the still freely accessible surface. A second, longer strip of the same watertight fabric is stuck to the first strip with superglue so that a permanent bond is produced between the two layers (3) of the two strips. The steel plate is then clamped vertically in a tensile testing machine and the longer of the two strips is peeled off at an angle of 1800 with the help of the tensile testing machine (peeling speed 300 mm/min, pre-measurement distance 20 mm). In doing so, a separation of the two layers (2) and (3) may occur on one of the two strips. The force required (separating force) is measured over a measuring distance of 200 mm and the mean value is formed. [0058] The adhesive force (bond) between the layers (2) and (3) determined in this way should be greater than 3 N/cm, preferably greater than 5 N/cm and particularly preferably greater than 7 N/cm. [0059] The adhesive force between the layers (3) and (4) can be determined, for example, as follows: a 20 cm long strip of the adhesive-coated watertight fabric, consisting of layers (2), (3) and (4), is stuck to a steel plate with double-sided adhesive tape so that the layer (4) forms the still freely accessible surface. A longer strip of an adhesive tape (tesa 4651) is stuck to the first strip so that a permanent bond is produced between the adhesive compound of the tesa 4651 adhesive tape and the layer (4) of the strip which is fixed to the steel plate. The steel plate is then clamped vertically in a tensile testing machine and the strip of tesa 4651 adhesive tape is peeled off at an angle of 1800 with the help of the tensile testing machine (peeling speed 300 mm/min, pre-measurement distance 20 mm). In doing so, a separation of the two layers (3) and (4) may occur on the strip fixed to the steel plate. The force required (separating force) is measured over a measuring distance of 200 mm and the mean value is formed. [0060] The adhesive force (bond) between the layers (3) and (4) determined in this way should be greater than 3 N/cm, preferably greater than 4 N/cm and particularly preferably greater than 6 N/cm.

-10 [0061] The bond between the layers (2), (3) and (4) can be adjusted in the preferred adhesive force ranges by appropriate choice of the layer materials and/or their treatment as well as the way in which the process is conducted and the setting of the process parameters. [0062] The dressings according to the invention, particularly designed as wound treatment products, i.e. as wound plasters, are perceived by the consumer as textile plasters and signal and guarantee a stability and robustness as well as "naturalness" and breathability. Film plasters of the prior art, on the other hand, seem rather dimensionally unstable and "flimsy", "chemical" (like plastic) and impermeable to air. [0063] Textile plasters of the prior art again become soaked in contact with water and lose their shape and become unsightly. The dressings according to the invention do not have these disadvantages. [0064] The stability, in particular the dimensional stability, of the plaster according to the invention, which goes hand in hand with the water-tightness of the fabric, guarantees a more stable functionality, such as the protection of a wound, than usual textile or film plasters do. [0065] Both the textile plaster properties (e.g. the appearance and feel) and the film plaster properties (e.g. the water-tightness) are combined in the plaster according to the invention. [0066] The plaster according to the invention is therefore preferred by the user due to the textile character and a "more natural" perception. [0067] Figure 1 and 1 a respectively show a schematic structure of the fabric bandage according to the invention. The fabric (2) with hydrophobic and/or oleophobic finish (1) is provided on the side facing the skin with a watertight, preferably breathable, layer (3), e.g. a laminated-on PU film or an applied acrylate layer. An adhesive layer (4), which provides the adhesion of the plaster to the skin, is in turn applied to this layer (3). [0068] If the dressing according to the invention is designed as a wound treatment product, one or more wound dressing(s) (5) can be applied to the adhesive layer (4). [0069] The wound dressings are preferably made of textile (e.g. fleece material, interlaced yarn etc.) or consist of hydrocolloids, alginates, hydrogels or polyurethanes (e.g. foams).

- 11 [0070] The dressing according to the invention can include active ingredients and function as a transdermal system. [0071] As transdermal systems, depending on the choice of active ingredients, in particular the fields of application of pain therapy and/or rheumatic ailments are preferred, as here the dressings can remain on the skin for longer. [0072] Known pharmaceutical and/or cosmetic active ingredients can be chosen for the active ingredients. The active ingredient or ingredients are preferably chosen from the group coenzyme Q10, 3-(menthoxy)propane-1,2-diol, ((1 R,2S,5R)-N-(2-(2-pyridinyl)ethyl)-2-ispropyl 5-methylcyclohexancarboxamide), AGR (alpha-glucosylrutin), glycerylglucose, ibuprofen and its salts, etofenamate, indometacin, diclofenac and its salts, acetylsalicylic acid, licochalcone A, bakuchiol, aciclovir, decandiol, carnitine, n-4-butyl-resorcinol, magnolol, honokiol, paeonol, salicylic acid and capsinoides, such as capsaicin, nonivamide or capsicum extract. [0073] The active ingredient or ingredients are advantageously included in a proportion of 0.001 - 10 weight%, preferably 0.01 - 5 weight%, particularly preferably 0.05 - 1 weight%, preferably 0.01 - 0.5 weight%, referred to the total mass of the layer in the dressing which includes them. [0074] However, active ingredient concentrations of more than 10 weight% can be realized in the dressings according to the invention; for example, a proportion of salicylic acid up to 60 weight% referred to the total mass of the layer which includes salicylic acid is therefore possible and preferred. [0075] On the one hand, the active ingredients can be incorporated in the adhesive compound (4) and/or in the liquid-tight layer (3). With an adhesive coating in the form of a grid, for example, active ingredients can therefore pass from the layer (3) and at the same time other active ingredients can pass from the adhesive compound (4) into or onto the skin. An optional additional dressing (5) can also contain one or more active ingredients. [0076] One or more active ingredients can be contained in each, or also in all simultaneously, of the liquid-tight layer (3), the adhesive compound (4) and/or the dressing (5). [0077] If the active ingredients are pharmaceutical active ingredients, transdermal therapeutic dressings can be produced.

-12 [0078] Transdermal therapeutic skin dressings can be produced by means of a layer of hydrophobic and/or oleophobic fabric (2) and/or fabric (2) with hydrophobic and/or oleophobic finish (1), the fabric layer (2) being provided on the side facing the skin with a liquid-tight layer (3) which in turn is coated with an adhesive compound (4) on the side facing the skin and which contains one or more pharmaceutical active ingredients in the liquid-tight layer (3) and/or the adhesive compound (4). [0079] Likewise, one or more optionally provided dressings (5) can contain the active ingredient or ingredients. [0080] The dressings according to the invention can advantageously be used for the following areas of application: - Wound treatment - Fixing of compresses, bandages etc. and, particularly in the case of wound treatment, supporting and fixing (immobilizing) joints - For the protection of the skin or wounds when washing hands, showering, bathing and/or swimming - For the protection of the skin or wounds in outdoor activities (e.g. gardening, handworking activities, sport) [0081] The oleophobic and hydrophobic finish of the outward-facing layer (2) and also the liquid-tight layer (3) protect the skin and wounds against external effects such as dirt and water. In particular, they protect users against rain or snow, for example. [0082] In addition, this protection against water according to the invention enables moisture sensitive components, for example, to be also integrated within the dressings. The moisture sensitive components can be protected against water in the dressing according to the invention. [0083] Moisture-sensitive components also include technical devices, such as sensors, e.g. for measuring physiological parameters. Products and areas of application for recording and monitoring body functions, such as temperature, heart rate, pH value of the skin etc., can therefore be implemented with the dressings according to the invention.

-13 [0084] On the one hand, the dressings can therefore include active ingredients, which may be sensitive to moisture, and, on the other, include components which have to be protected against moisture. [0085] An inventive embodiment of the dressing includes one or more moisture-sensitive components, in particular sensors for measuring physiological parameters. [0086] The following examples illustrate the skin dressings according to the invention. Example 1 [0087] A dressing is made from transversely elastic fabric with a weight per unit area of 100 g/m 2 , warp threads made of viscose (number of threads 35/cm) and weft threads made of polyamide (number of threads 14/cm). The hydrophobic/oleophobic finishing is carried out with 1-3% Phobol APK (paraffin with aluminum salt) and 0.5-1.5% fluorocarbon (e.g. Rucostar EEE6 or EEW6, Ruco-Guard AFC6 or AFR6, from Rudolf Chemie). [0088] The liquid-tight layer was obtained by applying a polyacrylate layer (e.g. Ruco-Coat AC 3330 and Ruco-Coat AC 7510 from Rudolf Chemie) with a weight per unit area of 50 80 g/m2 directly onto the fabric. This laminate was subsequently coated with a UV-wettable acrylate adhesive compound (e.g. Sanicare UV 4450-21, Henkel) with a mass application of 65 g/m2 and a UV dose of 75 mJ/cm2. [0089] Plasters were then stamped out and a fleece wound dressing made of polypropylene was placed centrally thereon in the form of an island dressing. [0090] The water vapor permeability was determined to be approx. 400 g/m2/24h. [0091] The water vapor permeability was determined in accordance with ASTM E 96 (WVTR, water method), with the following data: * The opening of the test vessel is 804 mm 2 * The material is preconditioned for 24 hours at 23 ± 2 OC and 50 ± 5% rel. humidity (RH) * The distance between the surface of the water in the test vessel and the sample is 35 ± 5 mm -14 * The test vessel populated with samples is re-weighed after 24 hours during which it has been stored in the climate cabinet at 37 ± 1.50C and 30 ± 3% RH [0092] According to the test method described below for determining the impermeability to liquid, the product was liquid-tight. [0093] Method for determining the impermeability to liquid: [0094] 500 ml of tap water are put into a glass beaker. 2 g of liquid hand soap (e.g. Nivea Creme Soft) and 1 mm of sodium hydroxide solution (45%) are stirred in. The plaster to be tested is stuck to a glass plate (5 cm x 20 cm), and a piece of pH indicator paper, which changes to blue in the alkaline range, is placed under the wound dressing. [0095] Together with the glass plate, the plaster which is stuck to it in this way is immersed in the prepared solution in the glass beaker. [0096] If the color has not changed within a time period of 20 minutes, the tested product is liquid-tight. Example 2 [0097] Fabric: 100% polyester [0098] Hydrophobic finish 1-3% Phobol APK (paraffin with aluminum salt) [0099] The liquid-tight layer was obtained by applying a polyacrylate layer (e.g. Ruco-Coat AC 3330 and Ruco-Coat AC 7510) with a weight per unit area of 50-80 g/m2 directly onto the fabric. This laminate was coated with a UV-wettable acrylate adhesive compound (e.g. Sanicare UV 4450-21, Henkel) with a mass application of 65 g/m2 and a UV dose of 75 mJ/cm2. [00100] Plasters were then stamped out and a fleece wound dressing made of polypropylene was placed centrally thereon in the form of an island dressing. [00101] The water vapor permeability was determined to be approx. 400 g/m2/24h. [00102] The product was likewise liquid-tight in the test described under Example 1.

- 15 Example 3 [00103] Fabric: 100% cotton, weight per unit area 170 g/m2, warp threads: 170/10 cm, 60x1 tex, weft threads: 145/10 cm, 34x1 tex [00104] Hydrophobic/oleophobic finish: 1-3% Phobol APK + 0.5-1.5% fluorocarbon (e.g. Rucostar EEE6 from Rudolf Chemie) [00105] A 20 pm thick polyurethane film was laminated onto the fabric using a PU hot melt adhesive. This laminate was coated with a UV-wettable acrylate adhesive compound (e.g. Sanicare UV 4450-21, Henkel) with a mass application of 65 g/m2 and a UV dose of 75 mJ/cm2. [00106] Plasters were then stamped out and a fleece wound dressing made of polypropylene was placed centrally thereon in the form of an island dressing. [00107] The water vapor permeability was determined to be approx. 600 g/m2/24h. [00108] The product was liquid-tight in the test described under Example 1. Example 4 [00109] A dressing is made from transversely elastic fabric with a weight per unit area of 160 g/m2, warp threads made of cotton (number of threads 22/cm) and weft threads made of polyamide (number of threads 10/cm). The hydrophobic/oleophobic finishing is carried out with 1-3% Phobol APK (paraffin with aluminum salt) and 0.5-1.5% fluorocarbon (e.g. Rucostar EEE6 from Rudolf Chemie). [00110] The liquid-tight layer was obtained by applying a polyacrylate layer (e.g. obtained from Bayer AG's Impranil range, e.g. Impranil DLH, Impranil DLN, Impranil DLV/1) with a weight per unit area of 40-70 g/m2 directly onto the fabric [00111] This laminate was coated with a UV-wettable acrylate adhesive compound (e.g. Sanicare UV 4450-21, Henkel) with a mass application of 65 g/m2 and a UV dose of 75 mJ/cm2.

-16 [00112] Plasters were then stamped out and a fleece wound dressing made of polypropylene was placed centrally thereon in the form of an island dressing. [00113] The water vapor permeability was determined to be approx. 450 g/m2/24h. [00114] The product was liquid-tight in the test described under Example 1. Example 5 [00115] A watertight and water-vapor-permeable fabric (from the company KOB) was used for the layer (2). [00116] This was coated with a UV-wettable acrylate adhesive compound (e.g. Sanicare UV 4450-21, Henkel) with a mass application of 75 g/m2 and a UV dose of 75 mJ/cm2. [00117] Plasters were then stamped out and a fleece wound dressing made of polypropylene was placed centrally thereon in the form of an island dressing. [00118] The water vapor permeability was determined to be approx. 450 g/m2/24h. [00119] The product was liquid-tight in the test described under Example 1. [00120] Dressings according to the above examples can therefore be equally advantageously produced with a fabric layer (2) which includes a hydrophobic finish without paraffin. Example 6 [00121] A dressing is made from transversely elastic fabric with a weight per unit area of 100 g/m2, warp threads made of viscose (number of threads 35/cm) and weft threads made of polyamide (number of threads 14/cm). The hydrophobic/oleophobic finishing is carried out with 0.5 -1.5% fluorocarbon (e.g. Rucostar EEE6). [00122] The liquid-tight layer was obtained by applying a polyacrylate layer (e.g. Ruco-Coat AC 3330 and Ruco-Coat AC 7510 from Rudolf Chemie) with a weight per unit area of 40 70 g/m2 directly onto the fabric. This laminate was subsequently coated with a UV-wettable -17 acrylate adhesive compound (e.g. Sanicare UV 4450-21, Henkel) with a mass application of 65 g/m2 and a UV dose of 75 mJ/cm2. [00123] Plasters were then stamped out and a fleece wound dressing made of polypropylene was placed centrally thereon in the form of an island dressing. [00124] Unless the context clearly requires otherwise, throughout the description and the claims, the words "comprise", "comprising", and the like are to be construed in an inclusive sense as opposed to an exclusive or exhaustive sense; that is to say, in the sense of "including, but not limited to". [00125] Although the invention has been described with reference to specific examples it will be appreciated by those skilled in the art that the invention may be embodied in many other forms.

Claims

1. A self-adhesive skin dressing comprising: a fabric layer of hydrophobic and/or oleophobic fabric and/or fabric with hydrophobic and/or oleophobic finish, a liquid-tight layer on the complete skin side of the fabric layer, the liquid-tight layer being coated with an adhesive compound on the side facing the skin, wherein one or more active ingredients are contained in the liquid-tight layer and/or the adhesive compound.

2. The dressing as claimed in claim 1, wherein the liquid-tight layer is water-vapor permeable.

3. The dressing as claimed in claim 1 or 2, wherein the liquid-tight layer is made of polyurethanes and/or acrylates.

4. The dressing as claimed in any one of the preceding claims, wherein the liquid-tight layer is made of silicone.

5. The dressing as claimed in claim 1 or 2, wherein the liquid-tight layer is made of a microporous film made of polyolefin, in particular polyethylene.

6. The dressing as claimed in any one of the preceding claims, wherein the oleophobizing and/or hydrophobizing of the fabric is carried out by treating with paraffins, aluminum and/or zirconium salts of organic acids, fluorocarbons, alkylsilanes, dimethylpolysiloxanes, waxes and/or mixtures thereof.

7. The dressing as claimed in any one of the preceding claims, wherein the adhesive compound is selected from polyacrylates, silicones, polyurethanes, natural and/or synthetic rubber, hydrocolloids.

8. The dressing as claimed in any one of the preceding claims, wherein the bond between the fabric and the liquid-tight layer and the bond of the liquid-tight layer and the adhesive compound are stronger than the adhesion of the dressing with the skin and/or to itself. -19

9. The dressing as claimed in any one of the preceding claims, wherein the bond between the fabric and the liquid-tight layer is greater than 3 N/cm.

10. The dressing as claimed in any one of the preceding claims, wherein the bond between the fabric and the liquid-tight layer is greater than 5 N/cm.

11. The dressing as claimed in any one of the preceding claims, wherein the bond between the fabric and the liquid-tight layer is greater than 7 N/cm.

12. The dressing as claimed in any one of the preceding claims, wherein the bond between the liquid-tight layer and the adhesive compound is greater than 4 N/cm.

13. The dressing as claimed in any one of the preceding claims, wherein the bond between the liquid-tight layer and the adhesive compound is greater than 6 N/cm.

14. The dressing as claimed in any one of the preceding claims as a wound treatment product in which one or more wound dressings are arranged on the adhesive compound.

15. The dressing as claimed in any one of the preceding claims, wherein one or more active ingredients are contained in the dressing.

16. The use of a layer of hydrophobic and/or oleophobic fabric and/or fabric with hydrophobic and/or oleophobic finish, the fabric layer being provided on the complete side facing the skin with a liquid-tight layer which in turn is coated with an adhesive compound on the side facing the skin and on which a wound dressing is arranged in order to produce a self adhesive plaster for wound treatment wherein one or more active ingredients are contained in the liquid-tight layer and/or the adhesive compound.

17. The use of a layer of hydrophobic and/or oleophobic fabric and/or fabric with hydrophobic and/or oleophobic finish, the fabric layer being provided on the complete side facing the skin with a liquid-tight layer which in turn is coated with an adhesive compound on the side facing the skin and on which a wound dressing may be arranged and one or more pharmaceutical active ingredients are contained in the liquid-tight layer, and/or the adhesive compound for the purpose of producing transdermal therapeutic skin dressings.