AU2012234284B2 - Bispecific anti-CXCR7 immunoglobulin single variable domains - Google Patents

Bispecific anti-CXCR7 immunoglobulin single variable domains Download PDF

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Publication number
AU2012234284B2
AU2012234284B2 AU2012234284A AU2012234284A AU2012234284B2 AU 2012234284 B2 AU2012234284 B2 AU 2012234284B2 AU 2012234284 A AU2012234284 A AU 2012234284A AU 2012234284 A AU2012234284 A AU 2012234284A AU 2012234284 B2 AU2012234284 B2 AU 2012234284B2
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AU
Australia
Prior art keywords
single variable
immunoglobulin single
variable domain
variable domains
amino add
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2012234284A
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English (en)
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AU2012234284A1 (en
Inventor
Francis Descamps
Maria Gonzalez Pajuelo
Regorius Leurs
David Andre Baptist Maussang-Detaille
Pascal Gerard Merchiers
Martine Smit
Catelijne Stortelers
Philippe Van Rompaey
Maarten Van Roy
Peter Vanlandschoot
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Ablynx NV
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Ablynx NV
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Publication of AU2012234284A1 publication Critical patent/AU2012234284A1/en
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Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2012234284A 2011-03-28 2012-03-28 Bispecific anti-CXCR7 immunoglobulin single variable domains Ceased AU2012234284B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161468250P 2011-03-28 2011-03-28
US61/468,250 2011-03-28
US201161540272P 2011-09-28 2011-09-28
US61/540,272 2011-09-28
US201261600263P 2012-02-17 2012-02-17
US61/600,263 2012-02-17
PCT/EP2012/055499 WO2012130874A1 (en) 2011-03-28 2012-03-28 Bispecific anti-cxcr7 immunoglobulin single variable domains

Publications (2)

Publication Number Publication Date
AU2012234284A1 AU2012234284A1 (en) 2013-03-28
AU2012234284B2 true AU2012234284B2 (en) 2015-10-08

Family

ID=45952494

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012234284A Ceased AU2012234284B2 (en) 2011-03-28 2012-03-28 Bispecific anti-CXCR7 immunoglobulin single variable domains

Country Status (7)

Country Link
US (3) US20150158948A9 (enExample)
EP (1) EP2691418A1 (enExample)
JP (1) JP6181040B2 (enExample)
CN (1) CN103917560B (enExample)
AU (1) AU2012234284B2 (enExample)
CA (1) CA2831415A1 (enExample)
WO (1) WO2012130874A1 (enExample)

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EP2552962B1 (en) 2010-03-26 2016-03-23 Ablynx N.V. Immunoglobulin single variable domains directed against cxcr7
WO2014081029A1 (ja) * 2012-11-26 2014-05-30 学校法人近畿大学 抗がん剤による末梢神経障害の予防、治療、または軽減剤
LT3248986T (lt) 2014-05-16 2022-03-25 Ablynx Nv Imunoglobulino kintami domenai
CN108350063A (zh) * 2015-09-14 2018-07-31 星系生物科技责任有限公司 针对血管生成因子的高度有效的单克隆抗体
NO2768984T3 (enExample) 2015-11-12 2018-06-09
HUE057241T2 (hu) * 2015-11-13 2022-04-28 Ablynx Nv Javított, szérumalbumint kötõ immunoglobulin variábilis domének
IL300122A (en) 2015-11-18 2023-03-01 Merck Sharp ַ& Dohme Llc Substances that bind to PD1 and/or LAG3
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WO2017220645A1 (en) * 2016-06-23 2017-12-28 Ablynx N.V. Improved pharmacokinetic assays for immunoglobulin single variable domains
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Also Published As

Publication number Publication date
EP2691418A1 (en) 2014-02-05
US20140178390A1 (en) 2014-06-26
US20140227270A1 (en) 2014-08-14
US9994639B2 (en) 2018-06-12
CN103917560B (zh) 2017-05-24
JP2014511680A (ja) 2014-05-19
AU2012234284A1 (en) 2013-03-28
US20180355048A1 (en) 2018-12-13
US20150158948A9 (en) 2015-06-11
JP6181040B2 (ja) 2017-08-16
CA2831415A1 (en) 2012-10-04
WO2012130874A1 (en) 2012-10-04
CN103917560A (zh) 2014-07-09

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